{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:44:52Z","timestamp":1791863092357,"version":"4.3.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","physicamedica.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physica Medica"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.ejmp.2026.107180","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:51:03Z","timestamp":1789008663000},"page":"107180","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Adaptive workflow with EQD2 conversion for side effect prediction in prostate re-irradiation"],"prefix":"10.1016","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0023-4427","authenticated-orcid":false,"given":"Francesco La","family":"Fauci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Reggiori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Lobefalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Paganini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasqualina","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6989-0756","authenticated-orcid":false,"given":"Laura","family":"Breschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bresolin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"D\u2019Agostino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Stefanini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5634-333X","authenticated-orcid":false,"given":"Marco","family":"Pelizzoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Vigan\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8706-6480","authenticated-orcid":false,"given":"Nicola","family":"Lambri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Fassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Castellano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Calissi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0165-7931","authenticated-orcid":false,"given":"Pietro","family":"Mancosu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Tomatis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Scorsetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.ejmp.2026.107180_b0005","doi-asserted-by":"crossref","first-page":"e469","DOI":"10.1016\/S1470-2045(22)00447-8","article-title":"European Society for Radiotherapy and Oncology and European Organisation for Research and Treatment of Cancer consensus on re-irradiation: definition, reporting, and clinical decision making","volume":"23","author":"Andratschke","year":"2022","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ejmp.2026.107180_b0010","doi-asserted-by":"crossref","first-page":"7031","DOI":"10.3390\/curroncol30070510","article-title":"Twenty years of advancements in a radiotherapy facility: clinical protocols, technology, and management","volume":"30","author":"Tomatis","year":"2023","journal-title":"Curr Oncol"},{"key":"10.1016\/j.ejmp.2026.107180_b0015","unstructured":"Appelt AL, Andrzejewski P, Hoffman L, Kelly C, Michailidou C, Murrell DH, JH Pagett C, Portik D, R\u00f8nde HS, Serban M, Solomou N, Thompson C, Osorio EV, S West N, Zaila A, Popovic M. Cumulative dose evaluation in clinical reirradiation-consensus guidance on technical consideration by the ESTRO reirradiation focus group. Doi: doi.org\/10.1016\/j.radonc.2025.111313."},{"issue":"16","key":"10.1016\/j.ejmp.2026.107180_b0020","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/ab8533","article-title":"Consistent and invertible deformation vector fields for a breathing anthropomorphic phantom: a post-processing framework for the XCAT phantom","volume":"65","author":"Eiben","year":"2020","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ejmp.2026.107180_b0025","article-title":"Accuracy of reirradiation dose constraints for the mandible and carotids","volume":"37","author":"Bornedal","year":"2025","journal-title":"Phys Imaging Radiat Oncol"},{"key":"10.1016\/j.ejmp.2026.107180_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2024.110184","article-title":"Multi-centre evaluation of variation in cumulative dose assessment in reirradiation scenarios","volume":"194","author":"Hardcastle","year":"2024","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.ejmp.2026.107180_b0035","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/mp.15320","article-title":"Identification of modes of tumor regression in non-small cell lung cancer patients during radiotherapy","volume":"49","author":"Amugongo","year":"2022","journal-title":"Med Phys"},{"key":"10.1016\/j.ejmp.2026.107180_b0040","series-title":"In: Proceedings of the 21st International Conference on Information Processing in Medical Imaging (IPMI)","first-page":"447","article-title":"A non-rigid registration framework that accommodates resection and retraction","author":"Risholm","year":"2009"},{"issue":"3","key":"10.1016\/j.ejmp.2026.107180_b0045","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.ijrobp.2004.06.024","article-title":"Monte Carlo simulations with time-dependent geometries to investigate effects of organ motion with high temporal resolution","volume":"60","author":"Paganetti","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"10.1016\/j.ejmp.2026.107180_b0050","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.ijrobp.2009.12.045","article-title":"Acute and late toxicity in a randomized trial of conventional versus hypofractionated three-dimensional conformal radiotherapy for prostate cancer","volume":"79","author":"Arcangeli","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"10.1016\/j.ejmp.2026.107180_b0055","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.ijrobp.2025.09.053","article-title":"Dose Mapping using image Registration for Reirradiation: a Systematic Review","volume":"124","author":"Thiong'o","year":"2026","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejmp.2026.107180_b0060","doi-asserted-by":"crossref","first-page":"946","DOI":"10.2340\/1651-226X.2025.43567","article-title":"Clinical workflow for reirradiation: national consensus recommendations on imaging, treatment planning, dose accumulation, and treatment delivery","volume":"64","author":"Kaplan","year":"2025","journal-title":"Acta Oncol"},{"issue":"1","key":"10.1016\/j.ejmp.2026.107180_b0065","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ijrobp.2024.12.023","article-title":"Software support Tools for Reirradiation: a Report from Reirradiation Collaborative Group (ReCOG) 2024","volume":"122","author":"Matrosic","year":"2025","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"10.1016\/j.ejmp.2026.107180_b0070","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13014-021-01977-1","article-title":"An algorithm for thoracic re-irradiation using biologically effective dose: a common language on how to treat in a \u201cno-treat zone\u201d","volume":"17","author":"Brooks","year":"2022","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ejmp.2026.107180_b0075","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.radonc.2019.02.014","article-title":"Tolerance doses for late adverse events after hypofractionated radiotherapy for prostate cancer on trial NRG Oncology\/RTOG0415","volume":"19","author":"Thor","year":"2019","journal-title":"Radiother Oncol"},{"issue":"3","key":"10.1016\/j.ejmp.2026.107180_b0080","doi-asserted-by":"crossref","first-page":"155","DOI":"10.4103\/jmp.JMP_29_18","article-title":"Voxel based BED and EQD2 evaluation of the radiotherapy treatment plan","volume":"43","author":"Singh","year":"2018","journal-title":"J Med Phys"},{"issue":"2","key":"10.1016\/j.ejmp.2026.107180_b0085","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.ijrobp.2020.12.041","article-title":"CHHiP Trial Management Group. estimates of alpha\/beta (\u03b1\/\u03b2) ratios for individual late rectal toxicity endpoints: an analysis of the CHHiP trial","volume":"110","author":"Brand","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"10.1016\/j.ejmp.2026.107180_b0090","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.ijrobp.2022.08.030","article-title":"CHHiP Trial Management Group. the fraction size sensitivity of late genitourinary toxicity: analysis of alpha\/beta (\u03b1\/\u03b2) ratios in the CHHiP trial","volume":"115","author":"Brand","year":"2023","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejmp.2026.107180_b0095","series-title":"Basic Clinical Radiobiology","author":"Joiner","year":"2009"},{"issue":"6","key":"10.1016\/j.ejmp.2026.107180_b0100","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.adro.2020.07.017","article-title":"Stereotactic body radiation therapy reirradiation for locally recurrent rectal cancer: outcomes and toxicity","volume":"5","author":"Smith","year":"2020","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.ejmp.2026.107180_b0105","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.radonc.2021.09.010","article-title":"An international Delphi consensus for pelvic stereotactic ablative radiotherapy re-irradiation","volume":"164","author":"Slevin","year":"2021","journal-title":"Radiother Oncol"},{"issue":"2","key":"10.1016\/j.ejmp.2026.107180_b0110","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/jmrs.442","article-title":"Development of an automated radiotherapy dose accumulation workflow for locally advanced high-risk prostate cancer - a technical report","volume":"68","author":"Ong","year":"2021","journal-title":"J Med Radiat Sci"},{"key":"10.1016\/j.ejmp.2026.107180_b0115","first-page":"2022","article-title":"Predictive modelling for late rectal and urinary toxicities after prostate radiotherapy using planned and delivered dose. Front","volume":"12 :1084311","author":"Ong","year":"2022","journal-title":"Oncol"},{"issue":"11","key":"10.1016\/j.ejmp.2026.107180_b0120","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.clon.2020.07.023","article-title":"Complex clinical decision-making process of reirradiation","volume":"32","author":"Armstrong","year":"2020","journal-title":"Clin Oncol (R Coll Radiol)"},{"issue":"2","key":"10.1016\/j.ejmp.2026.107180_b0125","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.semradonc.2009.11.003","article-title":"Adaptive radiotherapy for lung cancer","volume":"20","author":"Sonke","year":"2010","journal-title":"Semin Radiat Oncol"},{"issue":"3","key":"10.1016\/j.ejmp.2026.107180_b0130","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.semradonc.2019.02.007","article-title":"Non-rigid image registration: theory and practice","volume":"29","author":"Sonke","year":"2019","journal-title":"Semin Radiat Oncol"},{"issue":"2","key":"10.1016\/j.ejmp.2026.107180_b0135","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.ijrobp.2011.05.049","article-title":"Day-to-day reproducibility of prostate intrafraction motion assessed by multiple kV and MV imaging of implanted markers during treatment","volume":"83","author":"Mutanga","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ejmp.2026.107180_b0140","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.phro.2020.06.005","article-title":"Delivered dose quantification in prostate radiotherapy using online 3D cine imaging and treatment log files on a combined 1.5T magnetic resonance imaging and linear accelerator system","volume":"15","author":"Kontaxis","year":"2020","journal-title":"Phys ImagingRadiat Oncol"},{"key":"10.1016\/j.ejmp.2026.107180_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2023.109527","article-title":"Applicability and usage of dose mapping\/accumulation in radiotherapy","volume":"182","author":"Murr","year":"2023","journal-title":"Radiother Oncol"},{"issue":"4","key":"10.1016\/j.ejmp.2026.107180_b0150","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.semradonc.2008.04.005","article-title":"The linear-quadratic model is inappropriate to model high dose per fraction effects in radiosurgery","volume":"18","author":"Kirkpatrick","year":"2008","journal-title":"Semin Radiat Oncol"},{"issue":"4","key":"10.1016\/j.ejmp.2026.107180_b0155","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3857\/roj.2015.33.4.265","article-title":"Radiobiological mechanisms of stereotactic body radiation therapy and stereotactic radiation surgery","volume":"33","author":"Kim","year":"2015","journal-title":"Radiat Oncol J"},{"issue":"3","key":"10.1016\/j.ejmp.2026.107180_b0160","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/jrr\/rrt138","article-title":"Applicability of the linear-quadratic model to single and fractionated radiotherapy schedules: an experimental study","volume":"55","author":"Miyakawa","year":"2014","journal-title":"J Radiat Res"},{"issue":"8","key":"10.1016\/j.ejmp.2026.107180_b0165","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/S1470-2045(16)30070-5","article-title":"Hypofractionated versus conventionally fractionated radiotherapy for patients with localised prostate cancer (HYPRO): final efficacy results from a randomised, multicentre, open-label, phase 3 trial","volume":"17","author":"Incrocci","year":"2016","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ejmp.2026.107180_b0170","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s13014-016-0681-z","article-title":"Dosimetric impact of different bladder and rectum filling during prostate cancer radiotherapy","volume":"11","author":"Chen","year":"2016","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ejmp.2026.107180_b0175","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/s13014-020-01681-6","article-title":"Strict bladder filling and rectal emptying during prostate SBRT: does it make a dosimetric or clinical difference?","volume":"15","author":"Byun","year":"2020","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ejmp.2026.107180_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2025.110741","article-title":"Radiobiologically equivalent deformable dose mapping for re-irradiation planning: Implementation, robustness, and dosimetric benefits","volume":"205","author":"Garc\u00eda-Alvarez","year":"2025","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ejmp.2026.107180_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2023.109545","article-title":"Treatment plan optimisation for reirradiation","volume":"182","author":"Murray","year":"2023","journal-title":"Radiother Oncol"},{"issue":"15","key":"10.1016\/j.ejmp.2026.107180_b0190","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.3390\/cancers15153831","article-title":"Brain re-irradiation robustly accounting for previously delivered dose","volume":"15","author":"Thompson","year":"2023","journal-title":"Cancers (Basel)"}],"container-title":["Physica Medica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1120179726002188?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1120179726002188?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:51:05Z","timestamp":1791859865000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1120179726002188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":38,"alternative-id":["S1120179726002188"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmp.2026.107180","relation":{},"ISSN":["1120-1797"],"issn-type":[{"value":"1120-1797","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adaptive workflow with EQD2 conversion for side effect prediction in prostate re-irradiation","name":"articletitle","label":"Article Title"},{"value":"Physica Medica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmp.2026.107180","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Associazione Italiana di Fisica Medica e Sanitaria. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107180"}}