{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:11:20Z","timestamp":1791389480802,"version":"4.3.3"},"reference-count":37,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2005,5]]},"DOI":"10.1016\/j.ejogrb.2004.08.008","type":"journal-article","created":{"date-parts":[[2004,12,11]],"date-time":"2004-12-11T19:47:20Z","timestamp":1102794440000},"page":"45-52","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Polymorphisms of genes involved in homocysteine metabolism in preeclampsia and in uncomplicated pregnancies"],"prefix":"10.1016","volume":"120","author":[{"given":"Eva","family":"Also-Rallo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Lopez-Quesada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roser","family":"Urreizti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Ant\u00f2nia","family":"Vilaseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep M.","family":"Lailla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Balcells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Grinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2004.08.008_bib1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0146-0005(99)80059-7","article-title":"Prediction of preeclampsia","volume":"23","author":"Myatt","year":"1999","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1146\/annurev.med.49.1.31","article-title":"Homocysteine and cardiovascular disease","volume":"49","author":"Refsum","year":"1998","journal-title":"Ann Rev Med"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib3","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1093\/ajcn\/71.4.962","article-title":"Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland homocysteine study","volume":"71","author":"Vollset","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib4","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0025-7753(00)71554-5","article-title":"Homociste\u00edna y gestaci\u00f3n","volume":"115","author":"L\u00f3pez-Quesada ELl","year":"2000","journal-title":"Med Clin (Barc)"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib5","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/S0002-9378(98)70033-X","article-title":"Plasma homocysteine concentration is increased in preeclampsia and is associated with evidence of endothelial activation","volume":"179","author":"Powers","year":"1998","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib6","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/S0029-7844(97)00223-8","article-title":"Elevated homocysteine levels with preeclampsia","volume":"90","author":"Rajkovic","year":"1997","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib7","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0301-2115(02)00367-6","article-title":"Plasma total homocysteine in uncomplicated pregnancy and in preeclampsia","volume":"108","author":"Lopez-Quesada","year":"2003","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib8","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S0002-9378(99)70269-3","article-title":"Changes in homocysteine levels during normal pregnancy","volume":"180","author":"Walker","year":"1999","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib9","first-page":"414","article-title":"Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase","volume":"43","author":"Kang","year":"1988","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib10","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1046\/j.1365-2362.2001.00760.x","article-title":"Homocysteine and MTHFR 677C\u2192T allele in Spanish patients with premature coronary artery disease. Case control and family studies","volume":"31","author":"Pint\u00f3","year":"2001","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib11","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0140-6736(97)24038-9","article-title":"Genetic risk factor for unexplained recurrent early pregnancy loss","volume":"350","author":"Nelen","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib12","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1086\/301825","article-title":"A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?","volume":"62","author":"Van der Put","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib13","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1067\/mob.2000.105199","article-title":"A common mutation in the 5,10-methylenetetrahydrofolate reductase gene as a new risk factor for placental vasculopathy","volume":"182","author":"Van der Molen","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib14","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1055\/s-0038-1656110","article-title":"C > T MTHFR polymorphism and genetic susceptibility to preeclampsia","volume":"77","author":"Grandone","year":"1997","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib15","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1136\/jmg.34.6.525","article-title":"Methylenetetrahydrofolate reductase polymorphism and pre-eclampsia","volume":"34","author":"Sohda","year":"1997","journal-title":"J Med Genet"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib16","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1159\/000022954","article-title":"C677T methylenetetrahydrofolate reductase polymorphism is not a risk factor for pre-eclampsia\/eclampsia among Australian women","volume":"51","author":"Kaiser","year":"2001","journal-title":"Hum Hered"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib17","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1067\/mob.2001.109393","article-title":"Mutations in the gene for methylenetetrahydrofolate reductase, homocysteine levels, and vitamin status in women with a history of preeclampsia","volume":"184","author":"Lachmeijer","year":"2001","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib18","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1067\/mob.2001.110411","volume":"184","author":"Kim","year":"2001","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib19","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0378-1119(99)00431-X","article-title":"Molecular cloning, expression and physical mapping of the human methionine synthase reductase gene","volume":"240","author":"Leclerc","year":"1999","journal-title":"Gene"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib20","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0009-9120(03)00003-1","article-title":"Homocysteine and other plasma amino acids in preeclampsia and in pregnancies without complications","volume":"36","author":"L\u00f3pez Quesada","year":"2003","journal-title":"Clin Biochem"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib21","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S0301-2115(00)00497-8","article-title":"Hyperhomocysteinaemia: a risk factor for preeclampsia?","volume":"95","author":"Raijmakers","year":"2001","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib22","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0002-9378(98)70263-7","article-title":"Effects of folic acid and vitamin B6 supplementation on women with hyperhomocysteinemia and a history of preeclampsia or fetal growth restriction","volume":"179","author":"Leeda","year":"1998","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib23","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000010148","article-title":"Elevated second-trimester serum homocysteine levels and subsequent risk of preeclampsia","volume":"48","author":"Sorensen","year":"1999","journal-title":"Gynecol Obstet Invest"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib24","first-page":"762","article-title":"The 677 C-T methylenetetrahydrofolate reductase mutation does not predict increased maternal homocysteine during pregnancy","volume":"101","author":"Powers","year":"2003","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib25","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/ng0595-111","article-title":"A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase","volume":"10","author":"Frosst","year":"1995","journal-title":"Nature Genet"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib26","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1093\/oxfordjournals.aje.a010290","article-title":"5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review","volume":"151","author":"Botto","year":"2000","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib27","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1177\/107155769900600205","article-title":"Methylenetetrahydrofolate reductase polymorphism, folate, and susceptibility to preeclampsia","volume":"6","author":"Powers","year":"1999","journal-title":"J Soc Gynecol Investig"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib28","first-page":"277","article-title":"677 C\u2192T polymorphism of the methylenetetrahydrofolate reductase gene and preeclampsia","volume":"96","author":"Laivuori","year":"2000","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib29","first-page":"1085","article-title":"The methylenetetrahydrofolate reductase 677 C\u2192T polymorphism and preeclampsia in two populations","volume":"99","author":"Prasmusinto","year":"2002","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib30","first-page":"1324","article-title":"The molecular basis of homocystinuria due to cystathionine beta-synthase deficiency in Italian families, and report of four novel mutations","volume":"56","author":"Sebastio","year":"1995","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib31","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0021-9150(99)00297-X","article-title":"Polygenic influence on plasma homocysteine: association of two prevalent mutations, the 844ins68 of cystathionine beta-synthase and A(2756)G of methionine synthase, with lowered plasma homocysteine levels","volume":"149","author":"Tsai","year":"2000","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib32","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1034\/j.1399-0004.2000.580605.x","article-title":"Influence of 699C > T and 1080C > T polymorphisms of the cystathionine beta synthase gene on plasma homocysteine levels","volume":"58","author":"Aras","year":"2000","journal-title":"Clin Genet"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib33","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1086\/344209","article-title":"Maternal genetic effects, exerted by genes involved in homocysteine remethylation, influence the risk of spina bifida","volume":"71","author":"Doolin","year":"2002","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib34","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1006\/mgme.1999.2879","article-title":"A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida","volume":"67","author":"Wilson","year":"1999","journal-title":"Mol Gen Metab"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib35","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/00125817-200203000-00002","article-title":"A comprehensive review of genetic association studies","volume":"4","author":"Hirschhorn","year":"2002","journal-title":"Genet Med"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib36","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1006\/geno.1998.5437","article-title":"The human cystathionine beta-synthase (CBS) gene: complete sequence, alternative splicing, and polymorphisms","volume":"52","author":"Kraus","year":"1998","journal-title":"Genomics"},{"key":"10.1016\/j.ejogrb.2004.08.008_bib37","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1093\/hmg\/5.12.1867","article-title":"Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate\/cobalamin disorders","volume":"5","author":"Leclerc","year":"1996","journal-title":"Hum Molec Genet"}],"container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211504004713?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211504004713?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:13:48Z","timestamp":1759554828000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211504004713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["S0301211504004713"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2004.08.008","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2005,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polymorphisms of genes involved in homocysteine metabolism in preeclampsia and in uncomplicated pregnancies","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2004.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}