{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:15:27Z","timestamp":1761862527321,"version":"build-2065373602"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1016\/j.ejogrb.2006.02.008","type":"journal-article","created":{"date-parts":[[2006,3,21]],"date-time":"2006-03-21T07:15:54Z","timestamp":1142925354000},"page":"231-235","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Leukemia inhibitory factor gene mutations in the population of infertile women are not restricted to nulligravid patients"],"prefix":"10.1016","volume":"127","author":[{"given":"Milena","family":"Kralickova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radek","family":"Sima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Vanecek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petr","family":"Sima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zdenek","family":"Rokyta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zdenka","family":"Ulcova-Gallova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Sucha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petr","family":"Uher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ondrej","family":"Hes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl. B","key":"10.1016\/j.ejogrb.2006.02.008_bib1","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1016\/S0143-4004(03)00134-6","article-title":"The chemokine connection: hormonal and embryonic regulation at the human maternal\u2013embryonic interface\u2014a review","volume":"24","author":"Dominguez","year":"2003","journal-title":"Placenta"},{"issue":"5","key":"10.1016\/j.ejogrb.2006.02.008_bib2","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/humupd\/4.5.465","article-title":"Molecular control of the implantation window","volume":"4","author":"Tabibzadeh","year":"1998","journal-title":"Hum Reprod Update"},{"issue":"2","key":"10.1016\/j.ejogrb.2006.02.008_bib3","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S1472-6483(10)61717-8","article-title":"Embryo\u2013maternal signalling: how the embryo starts talking to its mother to accomplish implantation","volume":"6","author":"Herrler","year":"2003","journal-title":"Reprod Biomed Online"},{"issue":"Suppl. 2","key":"10.1016\/j.ejogrb.2006.02.008_bib4","first-page":"165","article-title":"Genes associated with embryonic attachment and implantation and the role of progesterone","volume":"44","author":"Giudice","year":"1999","journal-title":"J Reprod Med"},{"key":"10.1016\/j.ejogrb.2006.02.008_bib5","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1017\/S0962279900001344","article-title":"Matrix metalloproteinases and their tissue inhibitors in endometrial remodelling and menstruation","volume":"5","author":"Salamonsen","year":"1996","journal-title":"Reprod Med Rev"},{"issue":"3","key":"10.1016\/j.ejogrb.2006.02.008_bib6","first-page":"137","article-title":"Molecules in blastocyst implantation. Role of matrix metalloproteinases, cytokines and growth factors","volume":"48","author":"Nardo","year":"2003","journal-title":"J Reprod Med"},{"issue":"6390","key":"10.1016\/j.ejogrb.2006.02.008_bib7","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/359076a0","article-title":"Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor","volume":"359","author":"Stewart","year":"1992","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.ejogrb.2006.02.008_bib8","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/mrd.1080390217","article-title":"Leukaemia inhibitory factor and the regulation of pre-implantation development of the mammalian embryo","volume":"39","author":"Stewart","year":"1994","journal-title":"Mol Reprod Dev"},{"issue":"1","key":"10.1016\/j.ejogrb.2006.02.008_bib9","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1677\/joe.0.1480095","article-title":"Leukaemia inhibitory factor in human endometrium throughout the menstrual cycle","volume":"148","author":"Vogiagis","year":"1996","journal-title":"J Endocrinol"},{"issue":"2","key":"10.1016\/j.ejogrb.2006.02.008_bib10","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1677\/joe.0.1600181","article-title":"Review: the role of leukaemia inhibitory factor in the establishment of pregnancy","volume":"160","author":"Vogiagis","year":"1999","journal-title":"J Endocrinol"},{"issue":"8","key":"10.1016\/j.ejogrb.2006.02.008_bib11","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1023\/A:1009457016871","article-title":"Leukemia inhibitory factor expression in different endometrial locations between fertile and infertile women throughout different menstrual phases","volume":"17","author":"Tsai","year":"2000","journal-title":"Assist Reprod Genet"},{"key":"10.1016\/j.ejogrb.2006.02.008_bib12","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1530\/jrf.0.1010421","article-title":"Leukemia inhibitory factor mRNA concentration peaks in human endometrium at the time of implantation and the blastocyst contains mRNA for the receptor at this time","volume":"101","author":"Charnock-Jones","year":"1994","journal-title":"J Reprod Fertil"},{"key":"10.1016\/j.ejogrb.2006.02.008_bib13","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3109\/08977199209046921","article-title":"Leukemia inhibitory factor\u2014a puzzling polyfunctional regulator","volume":"7","author":"Metcalf","year":"1992","journal-title":"Growth Factors"},{"issue":"6427","key":"10.1016\/j.ejogrb.2006.02.008_bib14","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/363361a0","article-title":"Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation","volume":"363","author":"Escary","year":"1993","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.ejogrb.2006.02.008_bib15","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1095\/biolreprod50.4.882","article-title":"Expression of leukemia inhibitory factor in human endometrium and placenta","volume":"50","author":"Kojima","year":"1994","journal-title":"Biol Reprod"},{"issue":"6","key":"10.1016\/j.ejogrb.2006.02.008_bib16","first-page":"1908","article-title":"Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in human endometrium","volume":"80","author":"Arici","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"10.1016\/j.ejogrb.2006.02.008_bib17","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1073\/pnas.93.7.3115","article-title":"Leukemia inhibitory factor (LIF) and LIF receptor expression in human endometrium suggests a potential autocrine\/paracrine function in regulating embryo implantation","volume":"93","author":"Cullinan","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"10.1016\/j.ejogrb.2006.02.008_bib18","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/S0002-9378(96)70114-X","article-title":"Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in the human fallopian tube","volume":"175","author":"Keltz","year":"1996","journal-title":"Am J Obstet Gynecol"},{"issue":"1\/2","key":"10.1016\/j.ejogrb.2006.02.008_bib19","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0165-0378(02)00012-8","article-title":"Leukemia inhibitory factor and interleukin-11: cytokines with key roles in implantation","volume":"57","author":"Robb","year":"2002","journal-title":"J Reprod Immunol"},{"issue":"2","key":"10.1016\/j.ejogrb.2006.02.008_bib20","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1530\/jrf.0.1010421","article-title":"Leukaemia inhibitory factor mRNA concentration peaks in human endometrium at the time of implantation and the blastocyst contains mRNA for the receptor at this time","volume":"101","author":"Charnock-Jones","year":"1994","journal-title":"J Reprod Fertil"},{"issue":"3","key":"10.1016\/j.ejogrb.2006.02.008_bib21","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/humrep\/12.3.569","article-title":"The production of leukaemia inhibitory factor by human endometrium: presence in uterine flushings and production by cells in culture","volume":"12","author":"Laird","year":"1997","journal-title":"Hum Reprod"},{"issue":"2","key":"10.1016\/j.ejogrb.2006.02.008_bib22","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1600-0897.1998.tb00345.x","article-title":"Endometrial leukemia inhibitory factor (LIF) as a possible cause of unexplained infertility and multiple failures of implantation","volume":"39","author":"Hambartsoumian","year":"1998","journal-title":"Am J Reprod Immunol"},{"issue":"9","key":"10.1016\/j.ejogrb.2006.02.008_bib23","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1093\/oxfordjournals.humrep.a136328","article-title":"In vitro endometrial secretion of human interleukin for DA cells\/leukaemia inhibitory factor by explant cultures from fertile and infertile women","volume":"10","author":"Delage","year":"1995","journal-title":"Hum Reprod"},{"issue":"1\/2","key":"10.1016\/j.ejogrb.2006.02.008_bib24","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0165-0378(01)00111-5","article-title":"Defective production of LIF, M-CSF and Th2-type cytokines by T cells at fetomaternal interface is associated with pregnancy loss","volume":"52","author":"Piccinni","year":"2001","journal-title":"J Reprod Immunol"},{"issue":"15","key":"10.1016\/j.ejogrb.2006.02.008_bib25","doi-asserted-by":"crossref","first-page":"8833","DOI":"10.1016\/S0021-9258(19)38963-X","article-title":"Structural organization of the genes for murine and human leukemia inhibitory factor. Evolutionary conservation of coding and non-coding regions","volume":"265","author":"Stahl","year":"1990","journal-title":"J Biol Chem"},{"issue":"8","key":"10.1016\/j.ejogrb.2006.02.008_bib26","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.4049\/jimmunol.162.8.4637","article-title":"Complex conserved organization of the mammalian leukemia inhibitory factor gene: regulated expression of intracellular and extracellular cytokines","volume":"162","author":"Haines","year":"1999","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.ejogrb.2006.02.008_bib27","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1432-1033.1992.tb16601.x","article-title":"Cross-species comparison of the sequence of the leukaemia inhibitory factor gene and its protein","volume":"204","author":"Willson","year":"1992","journal-title":"Eur J Biochem."},{"issue":"6","key":"10.1016\/j.ejogrb.2006.02.008_bib28","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1093\/molehr\/5.6.581","article-title":"Leukaemia inhibitory factor gene mutations in infertile women","volume":"5","author":"Giess","year":"1999","journal-title":"Mol Hum Reprod"},{"issue":"1","key":"10.1016\/j.ejogrb.2006.02.008_bib29","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0301-2115(03)00315-4","article-title":"Leukaemia inhibitory factor (LIF) gene mutations in women with unexplained infertility and recurrent failure of implantation after IVF and embryo transfer","volume":"112","author":"Steck","year":"2004","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"4","key":"10.1016\/j.ejogrb.2006.02.008_bib30","first-page":"1580","article-title":"Prevalence, phenotypic spectrum, and modes of inheritance of gonadotropin-releasing hormone receptor mutations in idiopathic hypogonadotropic hypogonadism","volume":"86","author":"Beranova","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"10.1016\/j.ejogrb.2006.02.008_bib31","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1210\/me.2004-0110","article-title":"Identification of genes regulated by leukaemia inhibitory factor in the mouse uterus at the time of implantation","volume":"18","author":"Sherwin","year":"2004","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.ejogrb.2006.02.008_bib32","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nri886","article-title":"Natural killer cells and pregnancy","volume":"2","author":"Moffett-King","year":"2002","journal-title":"Nat Rev Immunol"},{"issue":"9","key":"10.1016\/j.ejogrb.2006.02.008_bib33","first-page":"778","article-title":"The impact of stress in the maternofetal relationship: an immunological approach","volume":"31","author":"Ledee-Bataille","year":"2003","journal-title":"Gynecol Obstet Fertil"},{"key":"10.1016\/j.ejogrb.2006.02.008_bib34","first-page":"17","article-title":"Effects of short-term psychotherapy on the success of an in vitro fertilization\/embryo transfer program","volume":"141","author":"Brandt","year":"1991","journal-title":"Wien Med Wochenschr"},{"key":"10.1016\/j.ejogrb.2006.02.008_bib35","article-title":"Leukocyte subpopulations in the uteri of leukemia inhibitory factor knockout mice during early pregnancy","author":"Schofield","year":"2004","journal-title":"Biol Reprod"},{"key":"10.1016\/j.ejogrb.2006.02.008_bib36","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1749-6632.1997.tb48534.x","article-title":"Use of recombinant leukemia inhibitory factor in embryo implantation","volume":"828","author":"Borini","year":"1997","journal-title":"Ann NY Acad Sci"},{"issue":"Suppl. 2","key":"10.1016\/j.ejogrb.2006.02.008_bib37","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0015-0282(03)00772-6","article-title":"Effect of supplementation of leukemia inhibitory factor and epidermal growth factor on murine embryonic development in vitro, implantation, and outcome of offspring","volume":"80","author":"Cheung","year":"2003","journal-title":"Fertil Steril"},{"issue":"8","key":"10.1016\/j.ejogrb.2006.02.008_bib38","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/S0093-691X(02)01258-X","article-title":"Effect of leukemia inhibitory factor on bovine embryos produced in vitro under chemically defined conditions","volume":"59","author":"Sirisathien","year":"2003","journal-title":"Theriogenology"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211506001072?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211506001072?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:15:59Z","timestamp":1759554959000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211506001072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["S0301211506001072"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2006.02.008","relation":{},"ISSN":["0301-2115"],"issn-type":[{"type":"print","value":"0301-2115"}],"subject":[],"published":{"date-parts":[[2006,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Leukemia inhibitory factor gene mutations in the population of infertile women are not restricted to nulligravid patients","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2006.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}