{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:50:02Z","timestamp":1790383802285,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1016\/j.ejogrb.2007.06.015","type":"journal-article","created":{"date-parts":[[2007,8,2]],"date-time":"2007-08-02T07:27:04Z","timestamp":1186039624000},"page":"93-99","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Local profile of cytokines and nitric oxide in patients with bacterial vaginosis and cervical intraepithelial neoplasia"],"prefix":"10.1016","volume":"138","author":[{"given":"Beatriz M.","family":"Tavares-Murta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9ia D.","family":"de Resende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Q.","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddie Fernando C.","family":"Murta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2007.06.015_bib1","first-page":"1021","article-title":"An association of cervical inflammation with high-grade cervical neoplasia in women infected with oncogenic human papillomavirus (HPV)","volume":"10","author":"Castle","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.ejogrb.2007.06.015_bib2","first-page":"383","article-title":"Effect of concurrent lower genital tract infections on cervical cancer screening","volume":"73","author":"Schwebke","year":"1997","journal-title":"Genitourin Med"},{"key":"10.1016\/j.ejogrb.2007.06.015_bib3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/00007435-200201000-00010","article-title":"Interrelationships of bacterial vaginosis and cervical inflammation","volume":"29","author":"Schwebke","year":"2002","journal-title":"Sex Transm Dis"},{"key":"10.1016\/j.ejogrb.2007.06.015_bib4","first-page":"17","article-title":"The vaginal microbial ecosystem and resistance to HIV","volume":"14","author":"Hillier","year":"1998","journal-title":"AIDS"},{"key":"10.1016\/j.ejogrb.2007.06.015_bib5","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1159\/000079822","article-title":"Increased frequency of bacterial vaginosis and Chlamydia trachomatis in pregnant women with human Papilloma virus infection","volume":"58","author":"da Silva","year":"2004","journal-title":"Gynecol Obstet Invest"},{"key":"10.1016\/j.ejogrb.2007.06.015_bib6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/oxfordjournals.jncimonographs.a003478","article-title":"Genital tract infections, cervical inflammation, and antioxidant nutrients-assessing their roles as human papillomavirus cofactors","volume":"31","author":"Castle","year":"2003","journal-title":"J Natl Cancer Inst Monogr"},{"key":"10.1016\/j.ejogrb.2007.06.015_bib7","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nrc798","article-title":"Papillomaviruses and cancer: from basic studies to clinical application","volume":"2","author":"Zur Hausen","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ejogrb.2007.06.015_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/S0074-02762005000100001","article-title":"Immune response in cervical dysplasia induced by human papillomavirus: the influence of human immunodeficiency virus-1 co-infection\u2014Review","volume":"100","author":"Nicol","year":"2005","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.ejogrb.2007.06.015_bib9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1042\/bj2980249","article-title":"Nitric oxide synthases in mammals","volume":"298","author":"Knowles","year":"1994","journal-title":"Biochem J"},{"key":"10.1016\/j.ejogrb.2007.06.015_bib10","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1046\/j.1365-2567.2000.00142.x","article-title":"Nitric oxide and virus infection","volume":"101","author":"Akaike","year":"2000","journal-title":"Immunology"},{"key":"10.1016\/j.ejogrb.2007.06.015_bib11","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S0006-2952(98)00187-7","article-title":"Nitric oxide synthase activity in fresh cells from ovarian tumor tissue: relationship of enzyme activity with clinical parameters of patients with ovarian cancer","volume":"56","author":"Thomsen","year":"1998","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.ejogrb.2007.06.015_bib12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/bjc.1995.274","article-title":"Nitric oxide synthase activity in human breast cancer","volume":"72","author":"Thomsen","year":"1995","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ejogrb.2007.06.015_bib13","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/0002-9343(83)91112-9","article-title":"Nonspecific vaginitis: diagnostic criteria and microbial and epidemiologic associations","volume":"74","author":"Amsel","year":"1983","journal-title":"Am J Med"},{"key":"10.1016\/j.ejogrb.2007.06.015_bib14","doi-asserted-by":"crossref","first-page":"7764","DOI":"10.1073\/pnas.78.12.7764","article-title":"Nitrate biosynthesis in man","volume":"78","author":"Green","year":"1981","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ejogrb.2007.06.015_bib15","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00404-005-0740-4","article-title":"Relation between vaginal and endocervical pH in pre- and post-menopausal women","volume":"272","author":"Murta","year":"2005","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.ejogrb.2007.06.015_bib16","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/030089160609200305","article-title":"Atypical squamous cells of undetermined significance: analysis of microbiology, cytological criteria and clinical conduct","volume":"92","author":"Barcelos","year":"2006","journal-title":"Tumori"},{"key":"10.1016\/j.ejogrb.2007.06.015_bib17","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.humpath.2004.08.012","article-title":"Increased secretion patterns of interleukin-10 and tumor necrosis factor-alpha in cervical squamous intraepithelial lesions","volume":"35","author":"Azar","year":"2004","journal-title":"Hum Pathol"},{"key":"10.1016\/j.ejogrb.2007.06.015_bib18","first-page":"527","article-title":"Clinical and cervical cytokine response to treatment with oral or vaginal metronidazole for bacterial vaginosis during pregnancy: a randomized trial","volume":"102","author":"Yudin","year":"2003","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2007.06.015_bib19","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s101560050013","article-title":"Intravaginal bacterial flora in patients with uterine cervical cancer. High incidence of detection of Gardnerella vaginalis","volume":"5","author":"Mikamo","year":"1999","journal-title":"J Infect Chemother"},{"key":"10.1016\/j.ejogrb.2007.06.015_bib20","first-page":"806","article-title":"Relationship of abnormal vaginal flora, proinflammatory cytokines and idiopathic infertility in women undergoing IVF","volume":"46","author":"Spandorfer","year":"2001","journal-title":"J Reprod Med"},{"key":"10.1016\/j.ejogrb.2007.06.015_bib21","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1006\/gyno.1999.5358","article-title":"Increased IL-6 and IL-8 levels in cervicovaginal secretions of patients with cervical cancer","volume":"73","author":"Tjiong","year":"1999","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2007.06.015_bib22","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1136\/ijgc-00009577-200305000-00012","article-title":"A prognostic insight on in vivo expression of interleukin-6 in uterine cervical cancer","volume":"13","author":"Srivani","year":"2003","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.ejogrb.2007.06.015_bib23","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1006\/gyno.2001.6235","article-title":"Interleukin-6 in cervical cancer: the relationship with vascular endothelial growth factor","volume":"82","author":"Wei","year":"2001","journal-title":"Gynaecol Oncol"},{"key":"10.1016\/j.ejogrb.2007.06.015_bib24","first-page":"2632","article-title":"Clinical implications of expression of interleukin 8 related to angiogenesis in uterine cervical cancers","volume":"60","author":"Fujimoto","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.ejogrb.2007.06.015_bib25","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1034\/j.1600-0897.2003.01109.x","article-title":"Distinct T cell subsets and cytokine production in cultures derived from transformation zone and squamous intraepithelial lesion biopsies of the uterine cervix","volume":"49","author":"Jacobs","year":"2003","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.ejogrb.2007.06.015_bib26","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.virol.2005.01.029","article-title":"HPV 16, HPV 18, and HIV infection may influence cervical cytokine intralesional levels","volume":"334","author":"Fernandes","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.ejogrb.2007.06.015_bib27","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1128\/JVI.79.1.116-123.2005","article-title":"Macrophages kill human papillomavirus type 16 E6-expressing tumor cells by tumor necrosis factor alpha- and nitric oxide-dependent mechanisms","volume":"79","author":"Routes","year":"2005","journal-title":"J Virol"},{"key":"10.1016\/j.ejogrb.2007.06.015_bib28","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1006\/gyno.2001.6242","article-title":"Nitric oxide-dependent apoptosis in ovarian carcinoma cell lines","volume":"82","author":"Rieder","year":"2001","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2007.06.015_bib29","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1177\/030089160409000509","article-title":"Differential tumor microenvironment in human ovarian cystic tumors","volume":"90","author":"Tavares-Murta","year":"2004","journal-title":"Tumori"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211507002898?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211507002898?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:18:51Z","timestamp":1759555131000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211507002898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["S0301211507002898"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2007.06.015","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2008,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Local profile of cytokines and nitric oxide in patients with bacterial vaginosis and cervical intraepithelial neoplasia","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2007.06.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}