{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:02:47Z","timestamp":1792152167824,"version":"4.4.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1016\/j.ejogrb.2010.10.009","type":"journal-article","created":{"date-parts":[[2010,11,12]],"date-time":"2010-11-12T06:01:16Z","timestamp":1289541676000},"page":"141-145","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Maternal circulating osteoprotegerin and soluble RANKL in pre-eclamptic women"],"prefix":"10.1016","volume":"154","author":[{"given":"Nikolaos","family":"Vitoratos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Lambrinoudaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetrios","family":"Rizos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Armeni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Alexandrou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Creatsas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2010.10.009_bib0005","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0002-9378(85)90434-X","article-title":"Calcium metabolism in pregnancy and the perinatal period: a review","volume":"151","author":"Pitkin","year":"1985","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.ejogrb.2010.10.009_bib0010","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/BF01623007","article-title":"Osteoporosis in pregnancy","volume":"6","author":"Khovidhunkit","year":"1996","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.ejogrb.2010.10.009_bib0190","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/01.gco.0000175365.65835.ad","article-title":"Bone status during adolescence, pregnancy and lactation","volume":"17","author":"Ward","year":"2005","journal-title":"Curr Opin Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2010.10.009_bib0020","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/S0301-472X(99)00061-2","article-title":"Cell biology of the osteoclast","volume":"27","author":"Roodman","year":"1999","journal-title":"Exp Hematol"},{"key":"10.1016\/j.ejogrb.2010.10.009_bib0025","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0092-8674(00)80209-3","article-title":"Osteoprotegerin: a novel secreted protein involved in the regulation of bone density","volume":"89","author":"Simonet","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.ejogrb.2010.10.009_bib0030","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1210\/endo.139.3.5837","article-title":"Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG\/OCIF inhibits osteoclastogenesis in vitro","volume":"139","author":"Yasuda","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejogrb.2010.10.009_bib0035","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1196\/annals.1443.016","article-title":"RANK\/RANKL: regulators of immune responses and bone physiology","volume":"1143","author":"Leibbrandt","year":"2008","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.ejogrb.2010.10.009_bib0040","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S1359-6101(03)00027-3","article-title":"Biology of the TRANCE axis","volume":"14","author":"Walsh","year":"2003","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.ejogrb.2010.10.009_bib0045","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jsgi.2005.02.014","article-title":"Feto-maternal bone remodeling in normal pregnancy and preeclampsia","volume":"12","author":"Shaarawy","year":"2005","journal-title":"J Soc Gynecol Investig"},{"key":"10.1016\/j.ejogrb.2010.10.009_bib0050","first-page":"258","article-title":"Biochemical markers of maternal bone turnover are elevated in pre-eclampsia","volume":"108","author":"Anim-Nyame","year":"2001","journal-title":"BJOG"},{"issue":"3","key":"10.1016\/j.ejogrb.2010.10.009_bib0055","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ijgo.2004.12.007","article-title":"Bone turnover in preeclamptic and normotensive pregnancy","volume":"88","author":"Kumtepe","year":"2005","journal-title":"Int J Gynaecol Obstet"},{"issue":"June","key":"10.1016\/j.ejogrb.2010.10.009_bib0060","first-page":"708","article-title":"A longitudinal study of biochemical markers of bone turnover during normal pregnancy and pregnancies complicated by pre-eclampsia","volume":"109","author":"Anim-Nyame","year":"2002","journal-title":"BJOG: An Int J Obstet Gynaecol"},{"key":"10.1016\/j.ejogrb.2010.10.009_bib0065","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1677\/joe.0.1740353","article-title":"Serum osteoprotegerin\/osteoclastogenesis-inhibitory factor during pregnancy and lactation and the relationship with calcium-regulating hormones and bone turnover markers","volume":"174","author":"Uemura","year":"2002","journal-title":"J Endocrinol"},{"key":"10.1016\/j.ejogrb.2010.10.009_bib0070","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.ajog.2005.06.051","article-title":"Maternal plasma osteoprotegerin concentration in normal pregnancy","volume":"193","author":"Hong","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2010.10.009_bib0075","first-page":"785","volume":"365","author":"Sibai","year":"2005","journal-title":"Pre-eclampsia Lancet"},{"key":"10.1016\/j.ejogrb.2010.10.009_bib0080","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1053\/plac.2002.0819","article-title":"Recent insights into the pathogenesis of pre-eclampsia","volume":"23","author":"Roberts","year":"2002","journal-title":"Placenta"},{"key":"10.1016\/j.ejogrb.2010.10.009_bib0085","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1067\/mob.2000.107928","article-title":"Report of the national high blood pressure education program working group on high blood pressure in pregnancy","volume":"183","year":"2000","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"10.1016\/j.ejogrb.2010.10.009_bib0090","first-page":"715","article-title":"Report of the Canadian hypertension Society consensus conference. 1. Definitions, evaluation and classification of hypertensive disorders in pregnancy","volume":"157","author":"Helewa Michael","year":"1997","journal-title":"Can Med Assoc J"},{"issue":"1","key":"10.1016\/j.ejogrb.2010.10.009_bib0095","first-page":"93","article-title":"Hypertensive disorders of pregnancy","volume":"78","author":"Leeman","year":"2008","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.ejogrb.2010.10.009_bib0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejcb.2008.06.004","article-title":"Pathophysiological roles of osteoprotegerin (OPG)","volume":"88","author":"Reid","year":"2009","journal-title":"Eur J Cell Biol"},{"key":"10.1016\/j.ejogrb.2010.10.009_bib0105","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1161\/01.ATV.0000012303.37971.DA","article-title":"RANK ligand and osteoprotegerin: paracrine regulators of bone metabolism and vascular function","volume":"22","author":"Schoppet","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ejogrb.2010.10.009_bib0110","doi-asserted-by":"crossref","first-page":"20959","DOI":"10.1074\/jbc.C000290200","article-title":"Osteoprotegerin is an alpha vbeta 3-induced, NF-kappa B-dependent survival factor for endothelial cells","volume":"275","author":"Malyankar","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ejogrb.2010.10.009_bib0115","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1161\/01.CIR.0000127957.43874.BB","article-title":"Osteoprotegerin is a risk factor for progressive atherosclerosis and cardiovascular disease","volume":"109","author":"Kiechl","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.ejogrb.2010.10.009_bib0120","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.atherosclerosis.2008.09.033","article-title":"Osteoprotegerin, vascular calcification and atherosclerosis","volume":"204","author":"Van Campenhout","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ejogrb.2010.10.009_bib0125","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.bone.2003.11.005","article-title":"Recovery of pregnancy mediated bone loss during lactation","volume":"34","author":"Pearson","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.ejogrb.2010.10.009_bib0130","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1359\/jbmr.2000.15.3.557","article-title":"A detailed assessment of alterations in bone turnover, calcium homeostasis, and bone density in normal pregnancy","volume":"15","author":"Black","year":"2000","journal-title":"J Bone Miner Res"},{"issue":"9","key":"10.1016\/j.ejogrb.2010.10.009_bib0135","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1055\/s-2006-951627","article-title":"Biochemical markers of bone turnover during pregnancy: a longitudinal study","volume":"114","author":"Hellmeyer","year":"2006","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"10.1016\/j.ejogrb.2010.10.009_bib0140","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0301-2115(01)00319-0","article-title":"The concentrations of osteocalcin and degradation products of type I collagen in pregnant women with pre-eclampsia","volume":"98","author":"Gorzelak","year":"2001","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"11","key":"10.1016\/j.ejogrb.2010.10.009_bib0145","doi-asserted-by":"crossref","first-page":"5361","DOI":"10.1210\/jc.2003-030486","article-title":"Serum osteoprotegerin as a determinant of bone metabolism in a longitudinal study of human pregnancy and lactation","volume":"88","author":"Naylor","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"10.1016\/j.ejogrb.2010.10.009_bib0150","doi-asserted-by":"crossref","first-page":"3875","DOI":"10.1210\/en.2006-1467","article-title":"Weaning triggers a decrease in receptor activator of nuclear factor-kappaB ligand expression, widespread osteoclast apoptosis, and rapid recovery of bone mass after lactation in mice","volume":"148","author":"Ardeshirpour","year":"2007","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.ejogrb.2010.10.009_bib0155","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1093\/humupd\/dmq007","article-title":"An immunological insight into the origins of pre-eclampsia","volume":"16","author":"Laresgoiti-Servitje","year":"2010","journal-title":"Hum Reprod Update"},{"issue":"2","key":"10.1016\/j.ejogrb.2010.10.009_bib0160","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.mam.2007.02.006","article-title":"The role of the immune system in preeclampsia","volume":"28","author":"Saito","year":"2007","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.ejogrb.2010.10.009_bib0165","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.bone.2006.11.018","article-title":"Effect of bed rest during pregnancy on bone turnover markers in pregnant and postpartum women","volume":"40","author":"Kaji","year":"2007","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.ejogrb.2010.10.009_bib0170","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.apmr.2004.02.016","article-title":"Maternal osteoporosis after prolonged magnesium sulfate tocolysis therapy: a case report","volume":"86","author":"Hung","year":"2005","journal-title":"Arch Phys Med Rehabil"},{"issue":"1","key":"10.1016\/j.ejogrb.2010.10.009_bib0175","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1055\/s-2007-993897","article-title":"Long-term magnesium sulfate tocolysis and maternal osteoporosis in a triplet pregnancy: a case report","volume":"15","author":"Levav","year":"1998","journal-title":"Am J Perinatol"},{"issue":"5","key":"10.1016\/j.ejogrb.2010.10.009_bib0180","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1097\/01.hjh.0000222762.84605.03","article-title":"Antihypertensive drugs clonidine, diazoxide, hydralazine and furosemide regulate the production of cytokines by placentas and peripheral blood mononuclear cells in normal pregnancy","volume":"24","author":"Xu","year":"2006","journal-title":"J Hypertens"},{"issue":"3","key":"10.1016\/j.ejogrb.2010.10.009_bib0185","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/10641950701380958","article-title":"Anti-hypertensive drugs alter cytokine production from preeclamptic placentas and peripheral blood mononuclear cells","volume":"26","author":"Xu","year":"2007","journal-title":"Hypertens Pregnancy"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211510005038?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211510005038?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:23:25Z","timestamp":1759555405000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211510005038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["S0301211510005038"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2010.10.009","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal circulating osteoprotegerin and soluble RANKL in pre-eclamptic women","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2010.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}