{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:43:31Z","timestamp":1790844211737,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1016\/j.ejogrb.2011.03.026","type":"journal-article","created":{"date-parts":[[2011,5,8]],"date-time":"2011-05-08T14:04:48Z","timestamp":1304863488000},"page":"175-179","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Association of genetic variants in the two isoforms of 5\u03b1-reductase, SRD5A1 and SRD5A2, in lean patients with polycystic ovary syndrome"],"prefix":"10.1016","volume":"157","author":[{"given":"M.","family":"Graupp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Wehr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Schweighofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.R.","family":"Pieber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Obermayer-Pietsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.ejogrb.2011.03.026_bib0005","first-page":"3078","article-title":"Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study","volume":"83","author":"Knochenhauer","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"10.1016\/j.ejogrb.2011.03.026_bib0010","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.1210\/jcem.84.11.6148","article-title":"A survey of the polycystic ovary syndrome in the Greek island of Lesbos: hormonal and metabolic profile","volume":"84","author":"Diamanti-Kandarakis","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.ejogrb.2011.03.026_bib0015","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1046\/j.1365-2265.1999.00886.x","article-title":"Polycystic ovaries and associated clinical and biochemical features in young women","volume":"51","author":"Michelmore","year":"1999","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"7","key":"10.1016\/j.ejogrb.2011.03.026_bib0020","first-page":"2434","article-title":"A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain","volume":"85","author":"Asuncion","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.ejogrb.2011.03.026_bib0025","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1210\/jc.2003-032046","article-title":"The prevalence and features of the polycystic ovary syndrome in an unselected population","volume":"89","author":"Azziz","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.ejogrb.2011.03.026_bib0030","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","year":"2004","journal-title":"Fertil Steril"},{"issue":"5","key":"10.1016\/j.ejogrb.2011.03.026_bib0035","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3109\/09513599609012823","article-title":"Genetic and non-genetic theories on the etiology of polycystic ovary syndrome","volume":"10","author":"Jahanfar","year":"1996","journal-title":"Gynecol Endocrinol"},{"issue":"6","key":"10.1016\/j.ejogrb.2011.03.026_bib0040","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/humupd\/dmi025","article-title":"Genetics of polycystic ovary syndrome: searching for the way out of the labyrinth","volume":"11","author":"Diamanti-Kandarakis","year":"2005","journal-title":"Hum Reprod Update"},{"issue":"6","key":"10.1016\/j.ejogrb.2011.03.026_bib0045","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S1472-6483(10)61114-5","article-title":"Genetics of polycystic ovarian syndrome","volume":"10","author":"Fratantonio","year":"2005","journal-title":"Reprod Biomed Online"},{"issue":"2","key":"10.1016\/j.ejogrb.2011.03.026_bib0050","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0015-0282(03)00735-0","article-title":"Androgen excess is the key element in polycystic ovary syndrome","volume":"80","author":"Azziz","year":"2003","journal-title":"Fertil Steril"},{"issue":"1","key":"10.1016\/j.ejogrb.2011.03.026_bib0055","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1210\/jcem-62-1-16","article-title":"Histopathological effects of exogenously administered testosterone in 19 female to male transsexuals","volume":"62","author":"Futterweit","year":"1986","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.ejogrb.2011.03.026_bib0060","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1093\/humrep\/deg115","article-title":"Ultrasound examination of polycystic ovaries: is it worth counting the follicles?","volume":"18","author":"Jonard","year":"2003","journal-title":"Hum Reprod"},{"issue":"3","key":"10.1016\/j.ejogrb.2011.03.026_bib0065","first-page":"185","article-title":"The association between polymorphisms in the CYP17 and 5alpha-reductase (SRD5A2) genes and serum androgen concentrations in men","volume":"10","author":"Allen","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"10","key":"10.1016\/j.ejogrb.2011.03.026_bib0070","first-page":"1077","article-title":"Polymorphic markers in the SRD5A2 gene and prostate cancer risk: a population-based case-control study","volume":"10","author":"Hsing","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"5","key":"10.1016\/j.ejogrb.2011.03.026_bib0075","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/00008571-200007000-00004","article-title":"Biochemical and pharmacogenetic dissection of human steroid 5 alpha-reductase type II","volume":"10","author":"Makridakis","year":"2000","journal-title":"Pharmacogenetics"},{"issue":"5","key":"10.1016\/j.ejogrb.2011.03.026_bib0080","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1210\/jcem.83.5.4951","article-title":"Obesity and gender influence cortisol secretion and metabolism in man","volume":"83","author":"Andrew","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"10.1016\/j.ejogrb.2011.03.026_bib0085","first-page":"2414","article-title":"5alpha-Reductase activity in women with polycystic ovary syndrome","volume":"84","author":"Jakimiuk","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.ejogrb.2011.03.026_bib0090","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1210\/jc.2002-021875","article-title":"Beyond adrenal and ovarian androgen generation: Increased peripheral 5 alpha-reductase activity in women with polycystic ovary syndrome","volume":"88","author":"Fassnacht","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"10.1016\/j.ejogrb.2011.03.026_bib0095","doi-asserted-by":"crossref","first-page":"5907","DOI":"10.1210\/jc.2003-030240","article-title":"Altered cortisol metabolism in polycystic ovary syndrome: insulin enhances 5alpha-reduction but not the elevated adrenal steroid production rates","volume":"88","author":"Tsilchorozidou","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.ejogrb.2011.03.026_bib0100","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1515\/JPEM.2000.13.3.253","article-title":"Increased 5alpha-reductase and normal 11beta-hydroxysteroid dehydrogenase metabolism of C19 and C21 steroids in a young population with polycystic ovarian syndrome","volume":"13","author":"Chin","year":"2000","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"7","key":"10.1016\/j.ejogrb.2011.03.026_bib0105","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1056\/NEJM199402173300703","article-title":"Hyperandrogenism in polycystic ovary syndrome Evidence of dysregulation of 11 beta-hydroxysteroid dehydrogenase","volume":"330","author":"Rodin","year":"1994","journal-title":"N Engl J Med"},{"issue":"10","key":"10.1016\/j.ejogrb.2011.03.026_bib0110","doi-asserted-by":"crossref","first-page":"4085","DOI":"10.1210\/jc.2006-0227","article-title":"Variants in the 5alpha-reductase type 1 and type 2 genes are associated with polycystic ovary syndrome and the severity of hirsutism in affected women","volume":"91","author":"Goodarzi","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.ejogrb.2011.03.026_bib0115","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1055\/s-2007-992919","article-title":"Looking for polycystic ovary syndrome genes: rational and best strategy","volume":"26","author":"Goodarzi","year":"2008","journal-title":"Semin Reprod Med"},{"issue":"7","key":"10.1016\/j.ejogrb.2011.03.026_bib0120","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/0002-9378(81)90746-8","article-title":"Hirsutism: implications, etiology, and management","volume":"140","author":"Hatch","year":"1981","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.ejogrb.2011.03.026_bib0125","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/01.OGX.0000109523.25076.E2","article-title":"Detecting insulin resistance in polycystic ovary syndrome: purposes and pitfalls","volume":"59","author":"Legro","year":"2004","journal-title":"Obstet Gynecol Surv"},{"issue":"5","key":"10.1016\/j.ejogrb.2011.03.026_bib0130","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1053\/meta.2002.31975","article-title":"Evaluation of assays available to measure free testosterone","volume":"51","author":"Morley","year":"2002","journal-title":"Metab Clin Exp"},{"issue":"9","key":"10.1016\/j.ejogrb.2011.03.026_bib0135","doi-asserted-by":"crossref","first-page":"3558","DOI":"10.1210\/jc.2009-0837","article-title":"Increased 5 alpha-reductase activity and adrenocortical drive in women with polycystic ovary syndrome","volume":"94","author":"Vassiliadi","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"issue":"8687","key":"10.1016\/j.ejogrb.2011.03.026_bib0140","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0140-6736(90)90664-Q","article-title":"5alpha-Reductase activity in polycystic ovary syndrome","volume":"335","author":"Stewart","year":"1990","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.ejogrb.2011.03.026_bib0145","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1590\/S0100-879X2003001000024","article-title":"The 5alpha-reductase type 1, but not type 2, gene is expressed in anagen hairs plucked from the vertex area of the scalp of hirsute women and normal individuals","volume":"36","author":"Oliveira","year":"2003","journal-title":"Braz J Med Biol Res"},{"issue":"3","key":"10.1016\/j.ejogrb.2011.03.026_bib0150","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1159\/000211412","article-title":"expression of steroidogenesis enzyme subtypes in the human pilosebaceous unit","volume":"9","author":"Courchay","year":"1996","journal-title":"Skin Pharmacol"},{"issue":"1","key":"10.1016\/j.ejogrb.2011.03.026_bib0155","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1034\/j.1600-0625.2002.110106.x","article-title":"Type-1 steroid 5 alpha-reductase is functionally active in the hair follicle as evidenced by new selective inhibitors of either type-1 or type-2 human steroid 5 alpha-reductase","volume":"11","author":"Gerst","year":"2002","journal-title":"Exp Dermatol"},{"issue":"1","key":"10.1016\/j.ejogrb.2011.03.026_bib0160","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.1365-2605.2005.00623.x","article-title":"Development of polycystic ovary syndrome: involvement of genetic and environmental factors","volume":"29","author":"Franks","year":"2006","journal-title":"Int J Androl"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211511001849?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211511001849?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:24:39Z","timestamp":1759555479000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211511001849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S0301211511001849"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2011.03.026","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of genetic variants in the two isoforms of 5\u03b1-reductase, SRD5A1 and SRD5A2, in lean patients with polycystic ovary syndrome","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2011.03.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}