{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:56:10Z","timestamp":1790978170308,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1016\/j.ejogrb.2011.04.010","type":"journal-article","created":{"date-parts":[[2011,6,19]],"date-time":"2011-06-19T10:27:42Z","timestamp":1308479262000},"page":"9-16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"title":["Prevention of pre-eclampsia with low-dose aspirin or vitamins C and E in women at high or low risk: a systematic review with meta-analysis"],"prefix":"10.1016","volume":"158","author":[{"given":"A. Cristina","family":"Rossi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick M.","family":"Mullin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ejogrb.2011.04.010_bib0005","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/S0002-9378(98)70439-9","article-title":"The preterm prediction study: risk factors for indicated preterm births. Maternal\u2013fetal medicine units network of the national institute of child health and human development","volume":"178","author":"Meis","year":"1998","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.ejogrb.2011.04.010_bib0010","first-page":"122","article-title":"Preeclampsia: a review of the role of prostaglandins","volume":"71","author":"Friedman","year":"1988","journal-title":"Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.ejogrb.2011.04.010_bib0015","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0002-9378(85)80223-4","article-title":"Preeclampsia: an imbalance in placental prostacyclin and thromboxane production","volume":"152","author":"Walsh","year":"1985","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"10.1016\/j.ejogrb.2011.04.010_bib0020","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1056\/NEJM198908103210604","article-title":"Effect of low-dose aspirin on fetal and maternal generation of thromboxane by platelets in women at risk for pregnancy-induced hypertension","volume":"321","author":"Benigni","year":"1989","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.ejogrb.2011.04.010_bib0025","first-page":"551","article-title":"Low-dose aspirin in pregnancy","volume":"74","author":"Sibai","year":"1989","journal-title":"Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.ejogrb.2011.04.010_bib0030","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1055\/s-2007-1016254","article-title":"Oxidative stress and altered endothelial cell function in preeclampsia","volume":"16","author":"Davidge","year":"1998","journal-title":"Semin Reprod Endocrinol"},{"issue":"2","key":"10.1016\/j.ejogrb.2011.04.010_bib0035","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1203\/00006450-198802000-00001","article-title":"Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production","volume":"23","author":"Saugstad","year":"1988","journal-title":"Pediatr Res"},{"issue":"2","key":"10.1016\/j.ejogrb.2011.04.010_bib0040","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/00001703-200104000-00009","article-title":"Update on oxygen radical disease in neonatology","volume":"13","author":"Saugstad","year":"2001","journal-title":"Curr Opin Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.ejogrb.2011.04.010_bib0045","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/01.ogx.0000256787.04807.da","article-title":"Combined vitamin C and E supplementation during pregnancy for preeclampsia prevention: a systematic review","volume":"62","author":"Polyzos","year":"2007","journal-title":"Obstet Gynecol Surv"},{"issue":"9575","key":"10.1016\/j.ejogrb.2011.04.010_bib0050","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/S0140-6736(07)60712-0","article-title":"Antiplatelet agents for prevention of pre-eclampsia: a meta-analysis of individual patient data","volume":"369","author":"Askie","year":"2007","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.ejogrb.2011.04.010_bib0055","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3109\/10641950802629667","article-title":"A meta-analysis on the efficacy and safety of combined vitamin C and E supplementation in preeclamptic women","volume":"28","author":"Rahimi","year":"2009","journal-title":"Hypertens Pregnancy"},{"issue":"4","key":"10.1016\/j.ejogrb.2011.04.010_bib0060","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/0002-9378(88)90090-7","article-title":"The classification and definition of the hypertensive disorders of pregnancy","volume":"158","author":"Davey","year":"1988","journal-title":"Am J Obstet Gynecol"},{"issue":"9193","key":"10.1016\/j.ejogrb.2011.04.010_bib0065","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1016\/S0140-6736(99)04149-5","article-title":"Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Quality of reporting of meta-analyses","volume":"354","author":"Moher","year":"1999","journal-title":"Lancet"},{"issue":"7568","key":"10.1016\/j.ejogrb.2011.04.010_bib0070","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1136\/bmj.333.7568.597","article-title":"The case of the misleading funnel plot","volume":"333","author":"Lau","year":"2006","journal-title":"BMJ"},{"issue":"7414","key":"10.1016\/j.ejogrb.2011.04.010_bib0075","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.ejogrb.2011.04.010_bib0080","doi-asserted-by":"crossref","unstructured":"CLASP: a randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women. CLASP (Collaborative Low-dose Aspirin Study in Pregnancy) Collaborative Group. Lancet 1994;343(8898):619\u201329.","DOI":"10.1016\/S0140-6736(94)92633-6"},{"key":"10.1016\/j.ejogrb.2011.04.010_bib0085","doi-asserted-by":"crossref","unstructured":"ECPPA: randomised trial of low dose aspirin for the prevention of maternal and fetal complications in high risk pregnant women. ECPPA (Estudo Colaborativo para Prevencao da Pre-eclampsia com Aspirina) Collaborative Group. Br J Obstet Gynaecol 1996;103(1):39\u201347.","DOI":"10.1111\/j.1471-0528.1996.tb09513.x"},{"issue":"2","key":"10.1016\/j.ejogrb.2011.04.010_bib0090","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0020-7292(97)00257-9","article-title":"A randomized controlled trial of low-dose aspirin in women at risk from pre-eclampsia","volume":"60","author":"Byaruhanga","year":"1998","journal-title":"Int J Gynaecol Obstet"},{"issue":"3","key":"10.1016\/j.ejogrb.2011.04.010_bib0095","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/uog.218","article-title":"Randomized controlled trial using low-dose aspirin in the prevention of pre-eclampsia in women with abnormal uterine artery Doppler at 23 weeks\u2019 gestation","volume":"22","author":"Yu","year":"2003","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.ejogrb.2011.04.010_bib0100","first-page":"161","article-title":"Low dose acetylsalicylic acid in prevention of pregnancy-induced hypertension and intrauterine growth retardation in women with bilateral uterine artery notches","volume":"109","author":"Vainio","year":"2002","journal-title":"BJOG"},{"issue":"5","key":"10.1016\/j.ejogrb.2011.04.010_bib0105","first-page":"826","article-title":"Usefulness of aspirin therapy in high-risk pregnant women with abnormal uterine artery Doppler ultrasound at 14\u201316 weeks pregnancy: randomized controlled clinical trial","volume":"46","author":"Ebrashy","year":"2005","journal-title":"Croat Med J"},{"issue":"1","key":"10.1016\/j.ejogrb.2011.04.010_bib0110","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/0029-7844(95)00340-1","article-title":"A randomized controlled trial of aspirin in patients with abnormal uterine artery blood flow","volume":"87","author":"Morris","year":"1996","journal-title":"Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.ejogrb.2011.04.010_bib0115","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1471-0528.1998.tb10088.x","article-title":"Barbados low dose aspirin study in pregnancy (BLASP): a randomised trial for the prevention of pre-eclampsia and its complications","volume":"105","author":"Rotchell","year":"1998","journal-title":"Br J Obstet Gynaecol"},{"issue":"5","key":"10.1016\/j.ejogrb.2011.04.010_bib0120","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1046\/j.1471-0528.2003.t01-1-02097.x","article-title":"Randomised comparison of uterine artery Doppler and aspirin (100mg) with placebo in nulliparous women: the Essai Regional Aspirine Mere-Enfant study (Part 2)","volume":"110","author":"Subtil","year":"2003","journal-title":"BJOG"},{"issue":"17","key":"10.1016\/j.ejogrb.2011.04.010_bib0125","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1056\/NEJM199310213291701","article-title":"Prevention of preeclampsia with low-dose aspirin in healthy, nulliparous pregnant women. The national institute of child health and human development network of maternal\u2013fetal medicine units","volume":"329","author":"Sibai","year":"1993","journal-title":"N Engl J Med"},{"issue":"9517","key":"10.1016\/j.ejogrb.2011.04.010_bib0130","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/S0140-6736(06)68433-X","article-title":"Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial","volume":"367","author":"Poston","year":"2006","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.ejogrb.2011.04.010_bib0135","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.ajog.2004.09.005","article-title":"Vitamin C and E supplementation in women at high risk for preeclampsia: a double-blind, placebo-controlled trial","volume":"192","author":"Beazley","year":"2005","journal-title":"Am J Obstet Gynecol"},{"issue":"9181","key":"10.1016\/j.ejogrb.2011.04.010_bib0140","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/S0140-6736(99)80010-5","article-title":"Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial","volume":"354","author":"Chappell","year":"1999","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.ejogrb.2011.04.010_bib0145","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1097\/01.AOG.0000289576.43441.1f","article-title":"Antioxidant therapy to prevent preeclampsia: a randomized controlled trial","volume":"110","author":"Spinnato","year":"2007","journal-title":"Obstet Gynecol"},{"issue":"17","key":"10.1016\/j.ejogrb.2011.04.010_bib0150","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1056\/NEJMoa054186","article-title":"Vitamins C and E and the risks of preeclampsia and perinatal complications","volume":"354","author":"Rumbold","year":"2006","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.ejogrb.2011.04.010_bib0155","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0301-2115(00)00243-8","article-title":"Vitamin E and C in preeclampsia","volume":"93","author":"Kharb","year":"2000","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"5","key":"10.1016\/j.ejogrb.2011.04.010_bib0160","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/aje\/kwj218","article-title":"Periconceptional multivitamin use reduces the risk of preeclampsia","volume":"164","author":"Bodnar","year":"2006","journal-title":"Am J Epidemiol"},{"issue":"1","key":"10.1016\/j.ejogrb.2011.04.010_bib0165","doi-asserted-by":"crossref","first-page":"45 e1-7","DOI":"10.1016\/j.ajog.2007.06.067","article-title":"Folic acid supplementation in early second trimester and the risk of preeclampsia","volume":"198","author":"Wen","year":"2008","journal-title":"Am J Obstet Gynecol"},{"issue":"2 Pt 1","key":"10.1016\/j.ejogrb.2011.04.010_bib0170","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1097\/AOG.0b013e3181e9322a","article-title":"Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy: a meta-analysis","volume":"116","author":"Bujold","year":"2010","journal-title":"Obstet Gynecol"}],"container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211511002260?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211511002260?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:24:17Z","timestamp":1783337057000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211511002260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0301211511002260"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2011.04.010","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prevention of pre-eclampsia with low-dose aspirin or vitamins C and E in women at high or low risk: a systematic review with meta-analysis","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2011.04.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ireland Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}