{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:27:30Z","timestamp":1783020450900,"version":"3.54.6"},"reference-count":20,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1016\/j.ejogrb.2011.06.025","type":"journal-article","created":{"date-parts":[[2011,7,8]],"date-time":"2011-07-08T21:07:07Z","timestamp":1310159227000},"page":"176-179","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Levonorgestrel intra-uterine system as a treatment option for complex endometrial hyperplasia"],"prefix":"10.1016","volume":"159","author":[{"given":"Zeina J.","family":"Haoula","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate F.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin C.","family":"Powell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2011.06.025_bib0005","series-title":"WHO International histological classification of tumours","article-title":"Histological typing of female genital tract tumours","author":"Scully","year":"1994"},{"key":"10.1016\/j.ejogrb.2011.06.025_bib0010","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/1097-0142(19850715)56:2<403::AID-CNCR2820560233>3.0.CO;2-X","article-title":"A long term study of untreated hyperplasias in 170 patients","volume":"56","author":"Kurman","year":"1985","journal-title":"Cancer"},{"issue":"2","key":"10.1016\/j.ejogrb.2011.06.025_bib0015","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/humrep\/14.2.479","article-title":"Regression of endometrial hyperplasia after treatment with the gonadotrophin \u2013 releasing hormone analogue Triptorelin: a prospective study","volume":"14","author":"Grmbizis","year":"1999","journal-title":"Hum Reprod"},{"issue":"3","key":"10.1016\/j.ejogrb.2011.06.025_bib0020","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.ygyno.2003.07.002","article-title":"Nuclear morphometric changes and therapy monitoring in patients with endometrial hyperplasia: a study comparing effects of intrauterine levonorgestrel and systemic medroxyprogesterone","volume":"91","author":"Vereide","year":"2003","journal-title":"Gynecol Oncol"},{"issue":"6","key":"10.1016\/j.ejogrb.2011.06.025_bib0025","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1365-2265.1982.tb01625.x","article-title":"Tissue concentrations of levonorgestrel in women using a levonorgestrel-releasing IUD","volume":"17","author":"Nilsson","year":"1982","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.ejogrb.2011.06.025_bib0030","unstructured":"Mirena. Summary of product characteristics, UK. Schering Health Care Ltd; February 2001."},{"key":"10.1016\/j.ejogrb.2011.06.025_bib0035","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1471-0528.2002.01167.x","article-title":"Intrauterine 10 microg and 20 microg levonorgestrel systems in postmenopausal women receiving oral oestrogen replacement therapy: clinical, endometrial and metabolic response","volume":"109","author":"Raudaskoski","year":"2002","journal-title":"BJOG"},{"key":"10.1016\/j.ejogrb.2011.06.025_bib0040","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/01.AOG.0000195269.76793.bb","article-title":"Use of the levonorgestrel-releasing intrauterine system and breast cancer","volume":"107","author":"Tjalma","year":"2006","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2011.06.025_bib0045","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.maturitas.2006.12.004","article-title":"Management of patients with non-atypical and atypical endometrial hyperplasia with a levonorgestrel-releasing intrauterine system: long-term follow-up","volume":"57","author":"Wildemeersch","year":"2007","journal-title":"Maturitas"},{"key":"10.1016\/j.ejogrb.2011.06.025_bib0050","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejogrb.2005.10.029","article-title":"Noncontraceptive uses of levonorgestrel-releasing hormone system (LNG-IUS) \u2013 a systematic enquiry and overview","volume":"125","author":"Varma","year":"2006","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ejogrb.2011.06.025_bib0055","first-page":"137","article-title":"Treatment of endometrial hyperplasia with levonorgestrel releasing intrauterine devices","volume":"18","author":"Perino","year":"1987","journal-title":"Acta Eur Fertil"},{"key":"10.1016\/j.ejogrb.2011.06.025_bib0060","first-page":"284","article-title":"Levo-norgestrel-nova- T and precancerous lesions of the endometrium","volume":"9","author":"Scarselli","year":"1988","journal-title":"Eur J Gynaecol Oncol"},{"key":"10.1016\/j.ejogrb.2011.06.025_bib0065","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ygyno.2005.10.030","article-title":"Effect of levonorgestrel IUD and oral medroxyprogesterone acetate on glandular and stromal progesterone receptors (PRA and PRB), and estrogen receptors (ER-alpha and ER-beta) in human endometrial hyperplasia","volume":"101","author":"Vereide","year":"2006","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2011.06.025_bib0070","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1067\/mob.2003.346","article-title":"Treatment of nonatypical and atypical endometrial hyperplasia with a levonorgestrel-releasing intrauterine system","volume":"188","author":"Wildemeersch","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2011.06.025_bib0075","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ejogrb.2008.02.022","article-title":"The effectiveness of a levonorgestrel-releasing intrauterine system (LNG-IUS) in the treatment of endometrial hyperplasia \u2013 a long-term follow-up study","volume":"139","author":"Varma","year":"2008","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ejogrb.2011.06.025_bib0080","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1093\/humrep\/15.suppl_3.162","article-title":"Morphological and functional changes in human endometrium following intrauterine levonorgestrel delivery","volume":"3","author":"Jones","year":"2000","journal-title":"Hum Reprod Suppl"},{"issue":"126","key":"10.1016\/j.ejogrb.2011.06.025_bib0085","article-title":"The biologic significance of cytologic atypia in progestogen-treated endometrial hyperplasia","volume":"160.","author":"Ferenczy","year":"1989","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2011.06.025_bib0090","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1097\/gme.0b013e3181659837","article-title":"Treatment of endometrial hyperplasia without atypia in peri- and postmenopausal women with a levonorgestrel intrauterine device","volume":"15","author":"Haimovich","year":"2008","journal-title":"Menopause"},{"key":"10.1016\/j.ejogrb.2011.06.025_bib0095","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ygyno.2008.06.014","article-title":"Treatment results of endometrial hyperplasia after prospective D-score classification: a follow-up study comparing effect of LNG-IUD and oral progestins versus observation only","volume":"111","author":"Orbo","year":"2008","journal-title":"Gynecol Oncol"},{"issue":"547.","key":"10.1016\/j.ejogrb.2011.06.025_bib0100","first-page":"e1","article-title":"Oral progestogens vs levonorgestrel-releasing intrauterine system for endometrial hyperplasia: a systematic review and metaanalysis","volume":"203","author":"Gallos","year":"2010","journal-title":"Am J Obstet Gynecol"}],"container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211511003836?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211511003836?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:26:23Z","timestamp":1759555583000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211511003836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S0301211511003836"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2011.06.025","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Levonorgestrel intra-uterine system as a treatment option for complex endometrial hyperplasia","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2011.06.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}