{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:29:05Z","timestamp":1790692145944,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.ejogrb.2012.04.014","type":"journal-article","created":{"date-parts":[[2012,5,11]],"date-time":"2012-05-11T00:49:59Z","timestamp":1336697399000},"page":"185-189","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Sibutramine administration decreases serum anti-M\u00fcllerian hormone (AMH) levels in women with polycystic ovary syndrome"],"prefix":"10.1016","volume":"163","author":[{"given":"Christos","family":"Vosnakis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neoklis A.","family":"Georgopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia K.","family":"Armeni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efstathios","family":"Papadakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos D.","family":"Roupas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilias","family":"Katsikis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Panidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2012.04.014_bib0005","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1056\/NEJMra041536","article-title":"Polycystic ovary syndrome","volume":"352","author":"Ehrmann","year":"2005","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.ejogrb.2012.04.014_bib0010","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1210\/jcem-72-1-83","article-title":"A direct effect of hyperinsulinemia on serum sex hormone-binding globulin levels in obese women with the polycystic ovary syndrome","volume":"72","author":"Nestler","year":"1991","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.ejogrb.2012.04.014_bib0015","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1210\/jcem-61-3-564","article-title":"Fat tissue: a steroid reservoir and site of steroid metabolism","volume":"61","author":"Deslypere","year":"1985","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.ejogrb.2012.04.014_bib0020","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1210\/jc.2002-020815","article-title":"Dietary composition in restoring reproductive and metabolic physiology in overweight women with polycystic ovary syndrome","volume":"88","author":"Moran","year":"2003","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.ejogrb.2012.04.014_bib0025","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/sj.ijo.0803777","article-title":"Effect of hypocaloric diet plus sibutramine treatment on hormonal and metabolic features in overweight and obese women with polycystic ovary syndrome: a randomized, 24-week study","volume":"32","author":"Florakis","year":"2008","journal-title":"International Journal of Obesity (London)"},{"key":"10.1016\/j.ejogrb.2012.04.014_bib0030","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1210\/endo.143.3.8691","article-title":"Anti-M\u00fcllerian hormone inhibits initiation of primordial follicle growth in the mouse ovary","volume":"143","author":"Durlinger","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejogrb.2012.04.014_bib0035","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.1210\/endo.142.11.8486","article-title":"Anti-M\u00fcllerian hormone attenuates the effects of FSH on follicle development in the mouse ovary","volume":"142","author":"Durlinger","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejogrb.2012.04.014_bib0040","doi-asserted-by":"crossref","first-page":"E238","DOI":"10.1152\/ajpendo.90684.2008","article-title":"Anti-M\u00fcllerian hormone levels reflect the severity of PCOS, but are negatively influenced by obesity: relationship with increased Luteinizing Hormone levels","volume":"296","author":"Piouka","year":"2009","journal-title":"American Journal of Physiology \u2013 Endocrinology and Metabolism"},{"key":"10.1016\/j.ejogrb.2012.04.014_bib0045","doi-asserted-by":"crossref","first-page":"5957","DOI":"10.1210\/jc.2003-030727","article-title":"Elevated serum level of antim\u00fcllerian hormone in patients with polycystic ovary syndrome: relationship to the ovarian follicle excess and the follicular arrest","volume":"88","author":"Pigny","year":"2003","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.ejogrb.2012.04.014_bib0050","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1210\/jc.2005-2076","article-title":"Serum antim\u00fcllerian hormone as a surrogate for antral follicle count for definition of the polycystic ovary syndrome","volume":"91","author":"Pigny","year":"2006","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.ejogrb.2012.04.014_bib0055","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.fertnstert.2005.02.052","article-title":"Serum m\u00fcllerian inhibiting substance levels in adolescent girls with normal menstrual cycles or with polycystic ovary syndrome","volume":"84","author":"Siow","year":"2005","journal-title":"Fertility and Sterility"},{"key":"10.1016\/j.ejogrb.2012.04.014_bib0060","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.fertnstert.2005.02.017","article-title":"Serum luteinizing hormone levels are markedly increased and significantly correlated with delta 4-androstenedione levels in lean women with polycystic ovary syndrome","volume":"84","author":"Panidis","year":"2005","journal-title":"Fertility and Sterility"},{"key":"10.1016\/j.ejogrb.2012.04.014_bib0065","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.fertnstert.2007.04.043","article-title":"Obesity, weight loss, and the polycystic ovary syndrome: effect of treatment with diet and orlistat for 24 weeks on insulin resistance and androgen levels","volume":"89","author":"Panidis","year":"2008","journal-title":"Fertility and Sterility"},{"key":"10.1016\/j.ejogrb.2012.04.014_bib0070","doi-asserted-by":"crossref","first-page":"587","DOI":"10.3109\/09513590.2010.507283","article-title":"The impact of oral contraceptives and metformin on AMH serum levels in women with polycystic ovary syndrome (PCOS) and biochemical hyperandrogenemia","volume":"27","author":"Panidis","year":"2011","journal-title":"Gynecological Endocrinology"},{"key":"10.1016\/j.ejogrb.2012.04.014_bib0075","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","year":"2004","journal-title":"Fertility and Sterility"},{"key":"10.1016\/j.ejogrb.2012.04.014_bib0080","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.mehy.2011.07.005","article-title":"Serum anti-M\u00fcllerian hormone (AMH) levels are differentially modulated by both serum gonadotropins and not only by serum follicle stimulating hormone (FSH) levels","volume":"77","author":"Panidis","year":"2011","journal-title":"Medical Hypotheses"},{"key":"10.1016\/j.ejogrb.2012.04.014_bib0085","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/sj.bjp.0702067","article-title":"A comparison of the effects on central 5-HT function of sibutraminehydrochloride and other weight-modifying agents","volume":"125","author":"Heal","year":"1998","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.ejogrb.2012.04.014_bib0090","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1210\/endo.131.6.1446632","article-title":"Neuropeptide Y potentiates luteinizing hormone (LH)-releasing hormone-induced LH secretion only under conditions leading to preovulatory LH surges","volume":"131","author":"Bauer-Dantoin","year":"1992","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejogrb.2012.04.014_bib0095","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1210\/endo.132.1.8380374","article-title":"Neuropeptide Y administered chronically into the lateral ventricle profoundly inhibits both the gonadotropic and the somatotropic axis in intact adult female rats","volume":"132","author":"Catzeflis","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejogrb.2012.04.014_bib0100","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1080\/1028415031000094264","article-title":"Sibutramine decreases body weight gain and increases energy expenditure in obese Zucker rats without changes in NPY and orexins","volume":"6","author":"Casado","year":"2003","journal-title":"Nature Neuroscience"},{"key":"10.1016\/j.ejogrb.2012.04.014_bib0105","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/BF03033262","article-title":"Effects of sibutramine on the central dopaminergic system in rodents","volume":"3","author":"Nakagawa","year":"2001","journal-title":"Neurotoxicity Research"},{"key":"10.1016\/j.ejogrb.2012.04.014_bib0110","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1210\/jcem-73-3-549","article-title":"Inhibition of endogenous catecholamine synthesis augments early follicular phase luteinizing hormone secretion","volume":"73","author":"Plosker","year":"1991","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.ejogrb.2012.04.014_bib0115","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/BF02245152","article-title":"A comparison of the effects of sibutramine hydrochloride, bupropion and methamphetamine on dopaminergic function: evidence that dopamine is not a pharmacological target for sibutramine","volume":"107","author":"Heal","year":"1992","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.ejogrb.2012.04.014_bib0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/rep.1.00529","article-title":"Anti-M\u00fcllerian hormone: a new marker of ovarian function","volume":"131","author":"Visser","year":"2006","journal-title":"Reproduction"},{"key":"10.1016\/j.ejogrb.2012.04.014_bib0125","doi-asserted-by":"crossref","first-page":"4951","DOI":"10.1210\/endo.136.11.7588229","article-title":"Anti-M\u00fcllerian hormone and anti-M\u00fcllerian hormone type II receptor messenger ribonucleic acid expression in rat ovaries during postnatal development, the estrous cycle and gonadotropin-induced follicle growth","volume":"136","author":"Baarends","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejogrb.2012.04.014_bib0130","doi-asserted-by":"crossref","first-page":"10990","DOI":"10.1073\/pnas.95.18.10990","article-title":"Oocytes are a source of catecholamines in the primate ovary: evidence for a cell\u2013cell regulatory loop","volume":"95","author":"Mayerhofe","year":"1998","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.ejogrb.2012.04.014_bib0135","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1254\/jphs.09135FP","article-title":"Modulation of noradrenergic neurotransmission in isolated rat radial artery","volume":"111","author":"Mart\u00ednez","year":"2009","journal-title":"Journal of Pharmacological Sciences"},{"key":"10.1016\/j.ejogrb.2012.04.014_bib0140","doi-asserted-by":"crossref","first-page":"e4579","DOI":"10.1371\/journal.pone.0004579","article-title":"Localisation and function of the endocannabinoid system in the human ovary","volume":"4","author":"El-Talatini","year":"2009","journal-title":"PLoS ONE"}],"container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211512001893?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211512001893?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:26:42Z","timestamp":1759555602000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211512001893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0301211512001893"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2012.04.014","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sibutramine administration decreases serum anti-M\u00fcllerian hormone (AMH) levels in women with polycystic ovary syndrome","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2012.04.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}