{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:46:17Z","timestamp":1782927977698,"version":"3.54.5"},"reference-count":37,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T00:00:00Z","timestamp":1397606400000},"content-version":"vor","delay-in-days":501,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003810","name":"Hospital de Cl\u00ednicas de Porto Alegre","doi-asserted-by":"publisher","award":["FIPE-HCPA 340\/2004"],"award-info":[{"award-number":["FIPE-HCPA 340\/2004"]}],"id":[{"id":"10.13039\/501100003810","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["1289\/05"],"award-info":[{"award-number":["1289\/05"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["INCT 573747\/2008-3"],"award-info":[{"award-number":["INCT 573747\/2008-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.ejogrb.2012.07.024","type":"journal-article","created":{"date-parts":[[2012,8,15]],"date-time":"2012-08-15T01:32:14Z","timestamp":1344994334000},"page":"302-306","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fat mass and obesity-associated gene polymorphisms do not affect metabolic response to hormone therapy in healthy postmenopausal women"],"prefix":"10.1016","volume":"165","author":[{"given":"Ramon B.","family":"Ramos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gislaine K.","family":"Casanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poli M.","family":"Spritzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2012.07.024_bib0005","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0008-6363(01)00466-7","article-title":"Estrogen replacement therapy, atherosclerosis, and vascular function","volume":"53","author":"Mikkola","year":"2002","journal-title":"Cardiovascular Research"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0010","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1093\/aje\/kwp043","article-title":"Lipid changes during the menopause transition in relation to age and weight: the study of women's health across the nation","volume":"169","author":"Derby","year":"2009","journal-title":"American Journal of Epidemiology"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0015","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1053\/meta.2001.24931","article-title":"Abdominal fat distribution in pre- and postmenopausal women: the impact of physical activity, age, and menopausal status","volume":"50","author":"Kanaley","year":"2001","journal-title":"Metabolism: Clinical and Experimental"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0020","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1001\/jama.280.7.605","article-title":"Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen\/Progestin Replacement Study (Hers) Research Group","volume":"280","author":"Hulley","year":"1998","journal-title":"JAMA: The Journal of the American Medical Association"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0025","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1001\/jama.288.8.980","article-title":"Inflammatory biomarkers, hormone replacement therapy, and incident coronary heart disease: prospective analysis from the Women's Health Initiative observational study","volume":"288","author":"Pradhan","year":"2002","journal-title":"JAMA: The Journal of the American Medical Association"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0030","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.amjmed.2010.09.021","article-title":"Timing and duration of menopausal hormone treatment may affect cardiovascular outcomes","volume":"124","author":"Harman","year":"2011","journal-title":"American Journal of Medicine"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0035","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1038\/oby.2008.408","article-title":"FTO polymorphisms are associated with obesity but not diabetes risk in postmenopausal women","volume":"16","author":"Song","year":"2008","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0040","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.fertnstert.2011.07.1148","article-title":"Variations in the fat mass and obesity-associated (FTO) gene are related to glucose levels and higher lipid accumulation product in postmenopausal women from southern Brazil","volume":"96","author":"Ramos","year":"2011","journal-title":"Fertility and Sterility"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0045","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1530\/EJE-10-1039","article-title":"Lipid accumulation product: a powerful marker of metabolic syndrome in healthy population","volume":"164","author":"Taverna","year":"2011","journal-title":"European Journal of Endocrinology\/European Federation of Endocrine Societies"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0050","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1471-2261-5-26","article-title":"The \u201clipid accumulation product\u201d performs better than the body mass index for recognizing cardiovascular risk: a population-based comparison","volume":"5","author":"Kahn","year":"2005","journal-title":"BMC Cardiovascular Disorders"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0055","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.fertnstert.2008.06.049","article-title":"Effects of nonoral estradiol\u2013micronized progesterone or low-dose oral estradiol\u2013drospirenone therapy on metabolic variables and markers of endothelial function in early postmenopause","volume":"92","author":"Casanova","year":"2009","journal-title":"Fertility and Sterility"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0060","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.metabol.2007.03.006","article-title":"Estimation of truncal adiposity using waist circumference or the sum of trunk skinfolds: a pilot study for insulin resistance screening in hirsute patients with or without polycystic ovary syndrome","volume":"56","author":"Toscani","year":"2007","journal-title":"Metabolism: Clinical and Experimental"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0065","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1001\/jama.289.19.2560","article-title":"The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report","volume":"289","author":"Chobanian","year":"2003","journal-title":"JAMA: The Journal of the American Medical Association"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0070","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clinical Chemistry"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0075","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","article-title":"A simple salting out procedure for extracting DNA from human nucleated cells","volume":"16","author":"Miller","year":"1988","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0080","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/genetics\/117.2.331","article-title":"Gametic disequilibrium measures: proceed with caution","volume":"117","author":"Hedrick","year":"1987","journal-title":"Genetics"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0085","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1093\/genetics\/120.3.849","article-title":"On measures of gametic disequilibrium","volume":"120","author":"Lewontin","year":"1988","journal-title":"Genetics"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0090","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1086\/319501","article-title":"A new statistical method for haplotype reconstruction from population data","volume":"68","author":"Stephens","year":"2001","journal-title":"American Journal of Human Genetics"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0095","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1056\/NEJMoa071513","article-title":"Estrogen therapy and coronary-artery calcification","volume":"356","author":"Manson","year":"2007","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0100","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1001\/jama.297.13.1465","article-title":"Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause","volume":"297","author":"Rossouw","year":"2007","journal-title":"JAMA: The Journal of the American Medical Association"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0105","article-title":"Bayesian meta-analysis of hormone therapy and mortality in younger postmenopausal women","volume":"122","author":"Salpeter","year":"2009","journal-title":"American Journal of Medicine"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0110","article-title":"Oestrogen and progestogen hormone replacement therapy for peri-menopausal and post-menopausal women: weight and body fat distribution","author":"Norman","year":"2000","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0115","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1097\/01.GME.0000153888.94399.AF","article-title":"Effects of transdermal and oral postmenopausal hormone therapy on vascular function: a randomized, placebo-controlled study in healthy postmenopausal women","volume":"12","author":"Hemelaar","year":"2005","journal-title":"Menopause"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0120","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1111\/j.1463-1326.2005.00545.x","article-title":"Meta-analysis: effect of hormone-replacement therapy on components of the metabolic syndrome in postmenopausal women","volume":"8","author":"Salpeter","year":"2006","journal-title":"Diabetes, Obesity and Metabolism"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0125","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1126\/science.1141634","article-title":"A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity","volume":"316","author":"Frayling","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0130","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1007\/s10038-008-0283-1","article-title":"Variations in the FTO gene are associated with severe obesity in the Japanese","volume":"53","author":"Hotta","year":"2008","journal-title":"Journal of Human Genetics"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0135","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1038\/oby.2011.42","article-title":"The lipid accumulation product is associated with increased mortality in normal weight postmenopausal women","volume":"19","author":"Wehr","year":"2011","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0140","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/1476-511X-9-100","article-title":"Predictive performances of lipid accumulation product vs. adiposity measures for cardiovascular diseases and all-cause mortality, 8.6-year follow-up: Tehran lipid and glucose study","volume":"9","author":"Bozorgmanesh","year":"2010","journal-title":"Lipids in Health and Disease"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0145","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.maturitas.2011.09.012","article-title":"Lipid accumulation product (LAP) is related to androgenicity and cardiovascular risk factors in postmenopausal women","volume":"70","author":"Maturana","year":"2011","journal-title":"Maturitas"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0150","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1126\/science.1151710","article-title":"The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase","volume":"318","author":"Gerken","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0155","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1741-7015-9-71","article-title":"FTO gene polymorphisms and obesity risk: a meta-analysis","volume":"9","author":"Peng","year":"2011","journal-title":"BMC Medicine"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0160","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0895-3988(10)60001-3","article-title":"FTO polymorphisms are associated with obesity but not with diabetes in East Asian populations: a meta-analysis","volume":"22","author":"Xi","year":"2009","journal-title":"Biomedical and Environmental Sciences"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0165","doi-asserted-by":"crossref","first-page":"e1001116","DOI":"10.1371\/journal.pmed.1001116","article-title":"Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children","volume":"8","author":"Kilpelainen","year":"2011","journal-title":"PLoS Medicine"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0170","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1210\/jc.2008-1592","article-title":"Increased recovery rates of phosphocreatine and inorganic phosphate after isometric contraction in oxidative muscle fibers and elevated hepatic insulin resistance in homozygous carriers of the A-allele of FTO rs9939609","volume":"94","author":"Grunnet","year":"2009","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0175","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1210\/jc.2008-1199","article-title":"FTO genotype is associated with body mass index after the age of seven years but not with energy intake or leisure-time physical activity","volume":"94","author":"Hakanen","year":"2009","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0180","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/oby.2009.311","article-title":"FTO genotype and the weight loss benefits of moderate intensity exercise","volume":"18","author":"Mitchell","year":"2010","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.ejogrb.2012.07.024_bib0185","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.ahj.2010.08.002","article-title":"The fat-mass and obesity-associated (FTO) gene, physical activity, and risk of incident cardiovascular events in white women","volume":"160","author":"Ahmad","year":"2010","journal-title":"American Heart Journal"}],"container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211512003430?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211512003430?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T16:59:11Z","timestamp":1782925151000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211512003430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0301211512003430"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2012.07.024","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fat mass and obesity-associated gene polymorphisms do not affect metabolic response to hormone therapy in healthy postmenopausal women","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2012.07.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}