{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:20:01Z","timestamp":1792678801095,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.ejogrb.2012.07.027","type":"journal-article","created":{"date-parts":[[2012,8,15]],"date-time":"2012-08-15T01:30:17Z","timestamp":1344994217000},"page":"141-155","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"title":["Systematic review and meta-analysis of middle cerebral artery Doppler to predict perinatal wellbeing"],"prefix":"10.1016","volume":"165","author":[{"given":"R.K.","family":"Morris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Say","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.C.","family":"Robson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Kleijnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.S.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2012.07.027_bib0005","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1542\/peds.99.4.585","article-title":"Workshop summary: fetal growth: its regulation and disorders","volume":"99","author":"Hay","year":"1997","journal-title":"Pediatrics"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0010","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1056\/NEJM199904223401603","article-title":"Birth weight in relation to morbidity and mortality among newborn infants","volume":"340","author":"McIntire","year":"1999","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0015","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/j.1471-0528.1989.tb03317.x","article-title":"Fetal growth and achievement and neurodevelopmental disability","volume":"96","author":"Taylor","year":"1989","journal-title":"British Journal of Obstetrics and Gynaecology"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0020","doi-asserted-by":"crossref","first-page":"279","DOI":"10.7326\/0003-4819-130-4_Part_1-199902160-00005","article-title":"Birthweight and the risk for type 2 diabetes mellitus in adult women","volume":"130","author":"Rich-Edwards","year":"1999","journal-title":"Annals of Internal Medicine"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0025","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1651-2227.2004.tb00236.x","article-title":"The developmental origins of chronic adult disease","volume":"93","author":"Barker","year":"2004","journal-title":"Acta Paediatrica. Supplementum"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0030","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0002-9378(74)90587-0","article-title":"Cardiovascular responses to hypoxemia and acidemia in fetal lambs","volume":"120","author":"Cohn","year":"1974","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0035","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/0002-9378(79)90739-7","article-title":"Redistribution of cardiac output and oxygen delivery in the hypoxemic fetal lamb","volume":"135","author":"Sheldon","year":"1979","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0040","first-page":"613","article-title":"Cerebral and umbilical blood flow velocity waveforms in normal and growth retarded pregnancies","volume":"69","author":"Wladimiroff","year":"1987","journal-title":"Obstetrics and Gynecology"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0045","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/S0002-9378(11)90620-6","article-title":"Middle cerebral artery flow velocity waveforms in normal and small for gestational age fetuses","volume":"166","author":"Mari","year":"1992","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0050","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1046\/j.1469-0705.1996.07010010.x","article-title":"Demonstration of fetal coronary blood flow by color-coded and pulsed wave Doppler sonography: a possible indicator of severe compromise and impending demise in intrauterine growth retardation","volume":"7","author":"Gembruch","year":"1996","journal-title":"Ultrasound in Obstetrics and Gynecology"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0055","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1046\/j.1469-0705.1996.08020082.x","article-title":"Adrenal artery velocity waveforms in the appropriate and small-for-gestational-age fetus","volume":"8","author":"Mari","year":"1996","journal-title":"Ultrasound in Obstetrics and Gynecology"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0060","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0378-3782(96)01777-X","article-title":"Middle cerebral artery velocimetry as a predictor of hypoxemia in fetuses with increased resistance to blood flow in the umbilical artery","volume":"47","author":"Dubiel","year":"1997","journal-title":"Early Human Development"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0065","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0301-2115(98)00167-5","article-title":"Umbilical and middle cerebral artery Doppler indices in patients with preeclampsia","volume":"82","author":"Ozeren","year":"1999","journal-title":"European Journal of Obstetrics, Gynecology, and Reproductive Biology"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0070","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1046\/j.1469-0705.2000.00079.x","article-title":"Fetal cerebral blood flow redistribution in late gestation: identification of compromise in small fetuses with normal umbilical artery Doppler","volume":"15","author":"Hershkovitz","year":"2000","journal-title":"Ultrasound in Obstetrics and Gynecology"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0075","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/uog.1114","article-title":"Lack of normalization of middle cerebral artery flow velocity prior to fetal death before the 30th week of gestation: a report of three cases","volume":"24","author":"Fieni","year":"2004","journal-title":"Ultrasound in Obstetrics and Gynecology"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0080","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/uog.7738","article-title":"Longitudinal changes in uterine, umbilical and fetal cerebral Doppler indices in late-onset small for gestational age fetuses","volume":"37","author":"Oros","year":"2011","journal-title":"Ultrasound in Obstetrics and Gynecology"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0085","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1046\/j.1469-0705.2002.00652.x","article-title":"Uterine and fetal cerebral Doppler predict the outcome of third-trimester small-for-gestational age fetuses with normal umbilical artery Doppler","volume":"19","author":"Severi","year":"2002","journal-title":"Ultrasound in Obstetrics and Gynecology"},{"issue":"2","key":"10.1016\/j.ejogrb.2012.07.027_bib0090","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD005548","article-title":"Antiplatelet agents for preventing pre-eclampsia and its complications","author":"Duley","year":"2007","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0095","unstructured":"Coomarasamy A, Frisk N, Gee H, Robson S. The investigation and management of the small for gestational age fetus. Guideline No. 31 November 2002. London: RCOG; 2003."},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0100","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1471-2393-7-3","article-title":"The value of predicting restriction of fetal growth and compromise of its wellbeing: systematic quantitative overviews (meta-analysis) of test accuracy literature","volume":"7","author":"Morris","year":"2007","journal-title":"BMC Pregnancy and Childbirth"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0105","unstructured":"Cochrane Methods Working Group on Systematic Reviews of Screening and Diagnostic Tests: Recommended methods; 1996."},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0110","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1136\/bmj.323.7305.157","article-title":"Systematic reviews in health care: systematic reviews of diagnostic and screening tests","volume":"323","author":"Deeks","year":"2001","journal-title":"British Medical Journal"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0115","doi-asserted-by":"crossref","first-page":"667","DOI":"10.7326\/0003-4819-120-8-199404150-00008","article-title":"Guidelines for meta-analyses evaluating diagnostic tests","volume":"120","author":"Irwig","year":"1994","journal-title":"Annals of Internal Medicine"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0120","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0301-2115(00)00463-2","article-title":"Systematic reviews to evaluate diagnostic tests","volume":"95","author":"Khan","year":"2001","journal-title":"European Journal of Obstetrics, Gynecology, and Reproductive Biology"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0125","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1471-2288-3-25","article-title":"The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews","volume":"3","author":"Whiting","year":"2003","journal-title":"BMC Medical Research Methodology"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0130","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1471-2288-6-9","article-title":"Evaluation of QUADAS, a tool for the quality assessment of diagnostic accuracy studies","volume":"6","author":"Whiting","year":"2006","journal-title":"BMC Medical Research Methodology"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0135","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1136\/bmj.326.7379.41","article-title":"Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative","volume":"326","author":"Bossuyt","year":"2003","journal-title":"British Medical Journal"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0140","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/jama.282.11.1061","article-title":"Empirical evidence of design-related bias in studies of diagnostic tests","volume":"282","author":"Lijmer","year":"1999","journal-title":"Journal of the American Medical Association"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0145","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1503\/cmaj.050090","article-title":"Evidence of bias and variation in diagnostic accuracy studies","volume":"174","author":"Rutjes","year":"2006","journal-title":"Canadian Medical Association Journal"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta8250","article-title":"Development and validation of methods for assessing the quality of diagnostic accuracy studies","volume":"8","author":"Whiting","year":"2004","journal-title":"Health Technology Assessment"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0155","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1472-6963-2-4","article-title":"Reporting of measures of accuracy in systematic reviews of diagnostic literature","volume":"2","author":"Honest","year":"2002","journal-title":"BMC Health Services Research"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0160","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1001\/jama.1994.03510330081039","article-title":"Users\u2019 guides to the medical literature, III. How to use an article about a diagnostic test. B. What are the results and will they help me in caring for my patients? The Evidence-Based Medicine Working Group","volume":"271","author":"Jaeschke","year":"1994","journal-title":"Journal of the American Medical Association"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0165","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.jclinepi.2005.02.022","article-title":"Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews","volume":"58","author":"Reitsma","year":"2005","journal-title":"Journal of Clinical Epidemiology"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0170","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1002\/sim.4780122405","article-title":"A bivariate approach to meta-analysis","volume":"12","author":"Van Houwelingen","year":"1993","journal-title":"Statistics in Medicine"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0175","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/sim.1040","article-title":"Advanced methods in meta-analysis: multivariate approach and meta-regression","volume":"21","author":"Van Houwelingen","year":"2002","journal-title":"Statistics in Medicine"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0180","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1471-2288-6-31","article-title":"Meta-Disc: a software for meta-analysis of test accuracy data","volume":"6","author":"Zamora","year":"2006","journal-title":"BMC Medical Research Methodology"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0185","unstructured":"Metandi: Stata module for meta-analysis of diagnostic accuracy. 2008."},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0190","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","article-title":"Meta-analysis of observational studies in epidemiology: a proposal for reporting, Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group","volume":"283","author":"Stroup","year":"2000","journal-title":"Journal of the American Medical Association"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0195","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/sim.2992","article-title":"We should not pool diagnostic likelihood ratios in systematic reviews","volume":"27","author":"Zwinderman","year":"2007","journal-title":"Statistics in Medicine"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0200","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1471-2288-5-19","article-title":"No role for quality scores in systematic reviews of diagnostic accuracy studies","volume":"5","author":"Whiting","year":"2005","journal-title":"BMC Medical Research Methodology"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0205","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/uog.3953","article-title":"Middle cerebral artery peak systolic velocity: a new Doppler parameter in the assessment of growth-restricted fetuses","volume":"29","author":"Mari","year":"2007","journal-title":"Ultrasound in Obstetrics and Gynecology"},{"key":"10.1016\/j.ejogrb.2012.07.027_bib0210","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1136\/bmj.329.7458.168","article-title":"Diagnostic tests: likelihood ratios","volume":"329","author":"Deeks","year":"2004","journal-title":"British Medical Journal"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211512003466?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211512003466?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:01:45Z","timestamp":1782925305000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211512003466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0301211512003466"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2012.07.027","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systematic review and meta-analysis of middle cerebral artery Doppler to predict perinatal wellbeing","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2012.07.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ireland Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}