{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:46:16Z","timestamp":1782927976781,"version":"3.54.5"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T00:00:00Z","timestamp":1397606400000},"content-version":"vor","delay-in-days":501,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"Fundo de Incentivo a Pesquisa (FIPE) do Grupo de Pesquisa e P\u00f3s-Gradua\u00e7\u00e3o (GPPG) do Hospital de Cl\u00ednicas de Porto Alegre"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.ejogrb.2012.08.016","type":"journal-article","created":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T13:02:54Z","timestamp":1346504574000},"page":"342-346","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Minimal cold knife conization height for high-grade cervical squamous intraepithelial lesion treatment"],"prefix":"10.1016","volume":"165","author":[{"given":"L\u00facia Maria","family":"Kliemann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiri","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00edlia","family":"Reinheimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldemar A.","family":"Rivoire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edison","family":"Capp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"dos Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2012.08.016_bib0005","doi-asserted-by":"crossref","first-page":"301680","DOI":"10.5402\/2011\/301680","article-title":"Management of precancerous lesions of the uterine cervix according to demographic data","volume":"2011","author":"Modinou","year":"2011","journal-title":"ISRN Obstetrics and Gynecology"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0010","series-title":"SEER Cancer Statistics review, 1975\u20132008","author":"Howlader","year":"2010"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0015","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1016\/S0140-6736(03)13778-6","article-title":"Cervical cancer","volume":"361","author":"Waggoner","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0020","series-title":"Estimativa 2010: incid\u00eancia de c\u00e2ncer no Brasil","author":"INCA","year":"2009"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0025","series-title":"NHS cervical screening programme","author":"Patnick","year":"2010"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0185","unstructured":"INCA. Monitoramento das a\u00e7\u00f5es de controle do c\u00e2ncer do colo e de mama. Rio de Janeiro: Ministerio da Sa\u00fade, Instituto Nacional de C\u00e2ncer, Available at https:\/\/docs.google.com\/viewer?a=v&q=cache:WpYFEEjMjrUJ:www1.inca.gov.br\/inca\/Arquivos\/inform.deteccaoprecoce.pdf+&hl=pt-BR&gl=br&pid=bl&srcid=ADGEESi7feZkNP2tmqUAf7Wtaa65EKw0lZi5MsQ7HDiVhSk3Bu_PzyIcFJifzOuYnAXl2TGByxlftZNN8naH4xcl53Ccl53LfA6AifdSL0QedXuz0l7RXiX8RZqiluC8nyC54aiWrzOP&sig=AHIEtbRJGVjIFffArBmf080zKBjt2HfnYQ. 2010; 1:1-6."},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0035","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1111\/IGC.0b013e3181f16c5f","article-title":"A global review of age-specific and overall prevalence of cervical lesions","volume":"20","author":"Ting","year":"2010","journal-title":"International Journal of Gynecological Cancer"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0040","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ajog.2007.07.047","article-title":"2006 consensus guidelines for the management of women with abnormal cervical cancer screening tests","volume":"197","author":"Wright","year":"2007","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0045","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.ygyno.2008.11.022","article-title":"Routine follow-up intervals in patients with high-grade squamous intraepithelial lesions (HSIL) and free excision margins can safely be increased in the first two years after large loop excision of the transformation zone (LLETZ)","volume":"113","author":"Eijsink","year":"2009","journal-title":"Gynecologic Oncology"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0050","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/j.1447-0756.2007.00628.x","article-title":"Cervical intraepithelial neoplasia II\u2013III with endocervical cone margin involvement after cervical loop conization: is there any predictor for residual disease?","volume":"33","author":"Kietpeerakool","year":"2007","journal-title":"Journal of Obstetrics and Gynaecology Research"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0055","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3760\/cma.j.issn.0366-6999.2009.04.002","article-title":"Predictors and clinical significance of the positive cone margin in cervical intraepithelial neoplasia III patients","volume":"122","author":"Sun","year":"2009","journal-title":"Chinese Medical Journal (English)"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0060","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1136\/jcp.53.3.191","article-title":"Completeness of excision and follow up cytology in patients treated with loop excision biopsy","volume":"53","author":"Zaitoun","year":"2000","journal-title":"Journal of Clinical Pathology"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0065","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1093\/annonc\/mdp257","article-title":"Surgery and radiotherapy in the treatment of cutaneous melanoma","volume":"20","author":"Testori","year":"2009","journal-title":"Annals of Oncology"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0070","doi-asserted-by":"crossref","first-page":"R91","DOI":"10.1186\/bcr2770","article-title":"Optical breast cancer margin assessment: an observational study of the effects of tissue heterogeneity on optical contrast","volume":"12","author":"Kennedy","year":"2010","journal-title":"Breast Cancer Research"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0075","doi-asserted-by":"crossref","first-page":"3811","DOI":"10.1245\/s10434-011-1778-0","article-title":"Prognostic value of pathological resection margin distance in squamous cell cancer of the vulva","volume":"18","author":"Woelber","year":"2011","journal-title":"Annals of Surgical Oncology"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0080","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1006\/gyno.1999.5697","article-title":"Positive margins after conization and risk of persistent lesion","volume":"76","author":"Narducci","year":"2000","journal-title":"Gynecologic Oncology"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0085","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1006\/gyno.1997.4817","article-title":"Outcomes after cervical cold knife conization with complete and incomplete excision of abnormal epithelium: a review of 699 cases","volume":"67","author":"Mohamed-Noor","year":"1997","journal-title":"Gynecologic Oncology"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0090","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.ejso.2010.08.135","article-title":"Predictors of recurrence in high-grade cervical lesions and a plan of management","volume":"36","author":"Leguevaque","year":"2010","journal-title":"European Journal of Surgical Oncology"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0095","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0002-9378(99)70200-0","article-title":"Cold-knife conization versus conization by the loop electrosurgical excision procedure: a randomized, prospective study","volume":"180","author":"Duggan","year":"1999","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0100","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ijgo.2009.04.011","article-title":"Three-step versus see-and-treat approach in women with high-grade squamous intraepithelial lesions in a low-resource country","volume":"106","author":"Li","year":"2009","journal-title":"International Journal of Gynaecology and Obstetrics"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0105","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.ygyno.2011.05.012","article-title":"Clinical, colposcopic and pathological characteristics of cervical and vaginal high-grade lesions negative for HPV by hybrid capture 2","volume":"122","author":"Del Pino","year":"2011","journal-title":"Gynecologic Oncology"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0110","first-page":"105","article-title":"Management of histologic abnormalities of the cervix","volume":"73","author":"Spitzer","year":"2006","journal-title":"American Family Physician"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0115","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ijgo.2009.05.027","article-title":"Factors associated with positive margins in patients with cervical intraepithelial neoplasia grade 3 and postconization management","volume":"107","author":"Chen","year":"2009","journal-title":"International Journal of Gynecology and Obstetrics"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0120","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1006\/gyno.1993.1168","article-title":"A comparison between loop diathermy conization and cold-knife conization for management of cervical dysplasia associated with unsatisfactory colposcopy","volume":"50","author":"Oyesanya","year":"1993","journal-title":"Gynecologic Oncology"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0125","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1089\/jwh.1.1999.8.469","article-title":"Papanicolaou smear: can we make a good test better? Technical and interpretive challenges for the practitioner","volume":"8","author":"Eltabbakh","year":"1999","journal-title":"Journal of Women's Health and Gender-Based Medicine"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0130","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1097\/00006254-200008000-00025","article-title":"Margin status and excision of cervical intraepithelial neoplasia: a review","volume":"55","author":"Jakus","year":"2000","journal-title":"Obstetrical and Gynecological Survey"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0135","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s00404-009-1298-3","article-title":"Residual and recurrent disease rates following LEEP treatment in high-grade cervical intraepithelial lesions","volume":"282","author":"Baloglu","year":"2010","journal-title":"Archives of Gynecology and Obstetrics"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0140","series-title":"Rotinas em ginecologia","author":"Freitas","year":"2011"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0145","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3802\/jgo.2011.22.1.25","article-title":"The safety of conization in the management of adenocarcinoma in situ of the uterine cervix","volume":"22","author":"Kim","year":"2011","journal-title":"Journal of Gynecologic Oncology"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0150","first-page":"637","article-title":"Positive margin prevalence and risk factors with cervical specimens obtained from loop electrosurgical excision procedures and cold knife conization","volume":"10","author":"Panna","year":"2009","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0155","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1006\/gyno.1994.1189","article-title":"A randomized prospective study comparing three techniques of conization: cold knife, laser, and LEEP","volume":"54","author":"Mathevet","year":"1994","journal-title":"Gynecologic Oncology"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0160","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ygyno.2005.10.001","article-title":"Diagnostic and therapeutic laser conization for cervical intraepithelial neoplasia","volume":"101","author":"Ueda","year":"2006","journal-title":"Gynecologic Oncology"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0165","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0029-7844(96)00331-6","article-title":"Risk of cervical stenosis after large loop excision or laser conization","volume":"88","author":"Baldauf","year":"1996","journal-title":"Obstetrics and Gynecology"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0170","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1006\/gyno.1994.1308","article-title":"Cold-knife conization versus loop excision: histopathologic and clinical results of a randomized trial","volume":"55","author":"Girardi","year":"1994","journal-title":"Gynecologic Oncology"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0175","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ijgo.2010.10.015","article-title":"Pregnancy outcome in patients treated with cervical conization for cervical intraepithelial neoplasia","volume":"112","author":"Andia","year":"2011","journal-title":"International Journal of Gynaecology and Obstetrics"},{"key":"10.1016\/j.ejogrb.2012.08.016_bib0180","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s12253-009-9148-y","article-title":"Minimally invasive therapy of cervical intraepithelial neoplasia for fertility preservation","volume":"15","author":"Milinovic","year":"2009","journal-title":"Pathology Oncology Research"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211512003752?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211512003752?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T16:58:52Z","timestamp":1782925132000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211512003752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0301211512003752"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2012.08.016","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Minimal cold knife conization height for high-grade cervical squamous intraepithelial lesion treatment","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2012.08.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}