{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:34:23Z","timestamp":1792809263892,"version":"4.5.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.ejogrb.2012.08.023","type":"journal-article","created":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T16:45:15Z","timestamp":1347036315000},"page":"76-80","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Antiproliferative and apoptotic effects of norethisterone on endometriotic stromal cells in vitro"],"prefix":"10.1016","volume":"166","author":[{"given":"Toshiyuki","family":"Minami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Kosugi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izumi","family":"Suganuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoruko","family":"Yamanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izumi","family":"Kusuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Oyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo","family":"Kitawaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2012.08.023_bib0005","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(04)17403-5","article-title":"Endometriosis","volume":"364","author":"Giudice","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.ejogrb.2012.08.023_bib0010","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1056\/NEJMra0804690","volume":"360","author":"Bulun","year":"2009","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.ejogrb.2012.08.023_bib0015","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1080\/09513590802549858","article-title":"Chronic pelvic pain in women: etiology, pathogenesis and diagnostic approach","volume":"25","author":"Vercellini","year":"2009","journal-title":"Gynecological Endocrinology"},{"key":"10.1016\/j.ejogrb.2012.08.023_bib0020","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJM200107263450407","article-title":"Treatment of endometriosis","volume":"345","author":"Olive","year":"2001","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.ejogrb.2012.08.023_bib0025","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/humupd\/dmi049","article-title":"Advances in the management of endometriosis: an update for clinicians","volume":"12","author":"Crosignani","year":"2006","journal-title":"Human Reproduction Update"},{"key":"10.1016\/j.ejogrb.2012.08.023_bib0030","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/j.fertnstert.2007.05.052","article-title":"Maintenance therapy involving a tapering dose of danazol or mid\/low doses of oral contraceptive after gonadotropin-releasing hormone agonist treatment for endometriosis-associated pelvic pain","volume":"89","author":"Kitawaki","year":"2008","journal-title":"Fertility and Sterility"},{"key":"10.1016\/j.ejogrb.2012.08.023_bib0035","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ejogrb.2011.03.012","article-title":"Maintenance therapy with dienogest following gonadotropin-releasing hormone agonist treatment for endometriosis-associated pelvic pain","volume":"157","author":"Kitawaki","year":"2011","journal-title":"European Journal of Obstetrics, Gynecology, and Reproductive Biology"},{"key":"10.1016\/j.ejogrb.2012.08.023_bib0040","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jmig.2008.09.582","article-title":"Postoperative long-term maintenance therapy with oral contraceptives after gonadotropin-releasing hormone analog treatment in women with ovarian endometrioma","volume":"16","author":"Park","year":"2009","journal-title":"Journal of Minimally Invasive Gynecology"},{"key":"10.1016\/j.ejogrb.2012.08.023_bib0045","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1749-6632.1997.tb48524.x","article-title":"The endometrial approach in contraception","volume":"828","author":"Levy","year":"1997","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.ejogrb.2012.08.023_bib0050","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/S0015-0282(02)03099-6","article-title":"Oral contraceptives suppress cell proliferation and enhance apoptosis of eutopic endometrial tissue from patients with endometriosis","volume":"77","author":"Meresman","year":"2002","journal-title":"Fertility and Sterility"},{"key":"10.1016\/j.ejogrb.2012.08.023_bib0055","first-page":"207","article-title":"Norethindrone \u2013 a review of therapeutic applications","volume":"40","author":"Taitel","year":"1995","journal-title":"International Journal of Fertility and Menopausal Studies"},{"key":"10.1016\/j.ejogrb.2012.08.023_bib0060","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2147\/CIA.S1663","article-title":"HT update: spotlight on estradiol\/norethindrone acetate combination therapy","volume":"3","author":"Casey","year":"2008","journal-title":"Clinical and Interventional Aging"},{"key":"10.1016\/j.ejogrb.2012.08.023_bib0065","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/j.fertnstert.2007.08.051","article-title":"Low-dose oral contraceptive pill for dysmenorrhea associated with endometriosis: a placebo-controlled, double-blind, randomized trial","volume":"90","author":"Harada","year":"2008","journal-title":"Fertility and Sterility"},{"key":"10.1016\/j.ejogrb.2012.08.023_bib0070","doi-asserted-by":"crossref","first-page":"F578","DOI":"10.1152\/ajprenal.00455.2005","article-title":"Caspases and calpain are independent mediators of cisplatin-induced endothelial cell necrosis","volume":"291","author":"Dursun","year":"2006","journal-title":"American Journal of Physiology. Renal Physiology"},{"key":"10.1016\/j.ejogrb.2012.08.023_bib0075","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0015-0282(16)55199-1","article-title":"Direct effects of medroxyprogesterone acetate, danazol, and leuprolide acetate on endometrial stromal cell proliferation in vitro","volume":"58","author":"Surrey","year":"1992","journal-title":"Fertility and Sterility"},{"key":"10.1016\/j.ejogrb.2012.08.023_bib0080","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/molehr\/7.4.341","article-title":"The inhibitory effect of dienogest, a synthetic steroid, on the growth of human endometrial stromal cells in vitro","volume":"7","author":"Okada","year":"2001","journal-title":"Molecular Human Reproduction"},{"key":"10.1016\/j.ejogrb.2012.08.023_bib0085","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.fertnstert.2007.03.042","article-title":"Dienogest inhibits BrdU uptake with G0\/G1 arrest in cultured endometriotic stromal cells","volume":"89","author":"Fu","year":"2008","journal-title":"Fertility and Sterility"},{"key":"10.1016\/j.ejogrb.2012.08.023_bib0090","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.fertnstert.2007.12.080","article-title":"Dienogest is as effective as intranasal buserelin acetate for the relief of pain symptoms associated with endometriosis \u2013 a randomized, double-blind, multicenter, controlled trial","volume":"91","author":"Harada","year":"2009","journal-title":"Fertility and Sterility"},{"key":"10.1016\/j.ejogrb.2012.08.023_bib0095","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/0010-7824(89)90130-3","article-title":"Bioequivalence of two oral contraceptive drugs containing norethindrone and ethinyl estradiol","volume":"40","author":"Saperstein","year":"1989","journal-title":"Contraception"},{"key":"10.1016\/j.ejogrb.2012.08.023_bib0100","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1095\/biolreprod57.6.1360","article-title":"Regulation of progesterone receptor messenger ribonucleic acid by progestin in human endometrial stromal cells","volume":"57","author":"Tseng","year":"1997","journal-title":"Biology of Reproduction"},{"key":"10.1016\/j.ejogrb.2012.08.023_bib0105","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1055\/s-2001-15111","article-title":"Regulation of estrogen receptor \u03b1 and progesterone receptor (isoform A and B) expression in cultured human endometrial cells","volume":"109","author":"Prange-Kiel","year":"2001","journal-title":"Experimental and Clinical Endocrinology and Diabetes"},{"key":"10.1016\/j.ejogrb.2012.08.023_bib0110","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1159\/000235871","article-title":"Apoptosis in endometriosis","volume":"68","author":"Agic","year":"2009","journal-title":"Gynecologic and Obstetric Investigation"},{"key":"10.1016\/j.ejogrb.2012.08.023_bib0115","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/molehr\/gah133","article-title":"Endometriotic cells are resistant to interferon-\u03b3-induced cell growth inhibition and apoptosis: a possible mechanism involved in the pathogenesis of endometriosis","volume":"11","author":"Nishida","year":"2005","journal-title":"Molecular Human Reproduction"},{"key":"10.1016\/j.ejogrb.2012.08.023_bib0120","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1093\/humrep\/dei372","article-title":"Drug-induced apoptosis was markedly attenuated in endometriotic stromal cells","volume":"21","author":"Izawa","year":"2006","journal-title":"Human Reproduction"},{"key":"10.1016\/j.ejogrb.2012.08.023_bib0125","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.steroids.2011.03.001","article-title":"Molecular mechanisms of steroid receptor-mediated actions by synthetic progestins used in HRT and contraception","volume":"76","author":"Africander","year":"2011","journal-title":"Steroids"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211512004010?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211512004010?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:27:42Z","timestamp":1759555662000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211512004010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0301211512004010"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2012.08.023","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antiproliferative and apoptotic effects of norethisterone on endometriotic stromal cells in vitro","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2012.08.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}