{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:57:03Z","timestamp":1777388223216,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.ejogrb.2012.10.006","type":"journal-article","created":{"date-parts":[[2012,10,24]],"date-time":"2012-10-24T13:45:30Z","timestamp":1351086330000},"page":"178-184","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Effects of melatonin on ovarian follicles"],"prefix":"10.1016","volume":"166","author":[{"given":"Carla Cristina","family":"Maganhin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Fernando Portugal","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Santos","family":"Sim\u00f5es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Martins","family":"Oliveira-Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"de Jesus Sim\u00f5es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmund Chada","family":"Baracat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Jos\u00e9 Maria","family":"Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2012.10.006_bib0005","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1126\/science.273.5271.67","article-title":"Menopause: the aging of multiple pacemakers","volume":"273","author":"Wise","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/07420520500180439","article-title":"Circadian phase in adults of contrasting ages","volume":"22","author":"Kripke","year":"2005","journal-title":"Chronobiology International"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0015","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1080\/07420520500263193","article-title":"Effect of menopause on melatonin and alertness rhythms investigated in constant routine conditions","volume":"22","author":"Walters","year":"2005","journal-title":"Chronobiology International"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0020","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.yfrne.2004.08.001","article-title":"Human pineal physiology and functional significance of melatonin","volume":"25","author":"Macchi","year":"2004","journal-title":"Frontiers in Neuroendocrinology"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0025","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.smrv.2004.08.001","article-title":"The basic physiology and pathophysiology of melatonin","volume":"9","author":"Claustrat","year":"2005","journal-title":"Sleep Medicine Reviews"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0030","first-page":"159","article-title":"Neuroendocrine changes characteristic of sexual maturation","volume":"21","author":"Sizonenko","year":"1986","journal-title":"Journal of Neural Transmission Supplementum"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0035","doi-asserted-by":"crossref","first-page":"4789","DOI":"10.1210\/jcem.86.10.7912","article-title":"Direct action of melatonin in human granulosa-luteal cells","volume":"86","author":"Woo","year":"2001","journal-title":"The Journal of Clinical Endocrinology Metabolism"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0040","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1080\/gye.17.2.115.123","article-title":"Pinealectomy changes rat ovarian interstitial cell morphology and decreases progesterone receptor expression","volume":"17","author":"Soares","year":"2003","journal-title":"Gynecological Endocrinology"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0045","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000084897","article-title":"17-Beta-estradiol modulates hMT1 melatonin receptor function","volume":"81","author":"Masana","year":"2005","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0050","first-page":"189","article-title":"Evaluation of the implantation in pinealectomized and\/or submitted to the constant illumination rats","volume":"22","author":"Teixeira","year":"2004","journal-title":"International Journal of Morphology"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0055","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.fertnstert.2007.03.050","article-title":"Effects of melatonin on the endometrial morphology and embryo implantation in rats","volume":"89","author":"Dair","year":"2008","journal-title":"Fertility and Sterility"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0060","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.fertnstert.2010.04.042","article-title":"Effects of melatonin on histomorphology and on the expression of steroid receptors, VEGF, and PCNA in ovaries of pinealectomized female rats","volume":"95","author":"Romeu","year":"2011","journal-title":"Fertility and Sterility"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0065","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s11055-006-0086-9","article-title":"The behavior of rats in response to changes in the light regime and administration of melatonin","volume":"36","author":"Pertsov","year":"2006","journal-title":"Neuroscience and Behavioral Physiology"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0070","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1590\/S0102-86502009000400013","article-title":"Rat pinealectomy:a modified direct visual approach","volume":"24","author":"Maganhin","year":"2009","journal-title":"Acta Cirurgica Brasileira"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0075","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1177\/000456328802500319","article-title":"Radioimmunoassay for 6-sulphatoxymelatonin in urine using an iodinated tracer","volume":"25","author":"Aldhous","year":"1988","journal-title":"Annals of Clinical Biochemistry"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0080","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurements with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0085","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/jso.2930180411","article-title":"Steroid receptor in a group of Brazilian breast cancer patients","volume":"18","author":"Brentani","year":"1981","journal-title":"Journal of Surgical Oncology"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0090","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1093\/clinchem\/24.7.1170","article-title":"Simplified Scatchard plot assay for progesterone receptor in breast cancer: comparison with single-point and multipoint assay","volume":"24","author":"Johnson","year":"1978","journal-title":"Clinical Chemistry"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0095","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3109\/07853899808999391","article-title":"Melatonin and human reproduction","volume":"30","author":"Reiter","year":"1998","journal-title":"Annals of Medicine"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0100","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.fertnstert.2008.05.016","article-title":"Melatonin and the ovary: physiological and pathophysiological implications","volume":"92","author":"Tamura","year":"2009","journal-title":"Fertility and Sterility"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0105","first-page":"4","article-title":"The role of steroids in follicular growth","volume":"10","author":"Drummond","year":"2006","journal-title":"Reproductive Biology Endocrinology"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0110","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0303-7207(94)90278-X","article-title":"Follicular oestrogen synthesis: the \u201ctwo-cell, two-gonadotrophin\u201d model revisited","volume":"100","author":"Hillier","year":"1994","journal-title":"Molecular and Cellular Endocrinology"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0115","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/1477-7827-9-108","article-title":"Melatonin reduces LH, 17 beta-estradiol and induces differential regulation of sex steroid receptors in reproductive tissues during rat ovulation","volume":"9","author":"Chuffa","year":"2011","journal-title":"Reprodutive Biology Endocrinology"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0120","doi-asserted-by":"crossref","first-page":"e31393","DOI":"10.1371\/journal.pone.0031393","article-title":"Disparate impact of butyroyloxymethyl diethylphosphate (AN-7), a histone deacetylase inhibitor, and doxorubicin in mice bearing a mammary tumor","volume":"7","author":"Tarasenko","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0125","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1016\/j.biocel.2006.12.005","article-title":"c-kit-a hematopoietic cell essential receptor tyrosine kinase","volume":"39","author":"Edling","year":"2007","journal-title":"The International Journal of Biochemistry and Cell Biology"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0130","doi-asserted-by":"crossref","first-page":"8085","DOI":"10.1158\/0008-5472.CAN-05-0471","article-title":"Amplification and overexpression of the Kit gene is associated with progression in the seminoma subtype of testicular germ cell tumors of adolescents and adults","volume":"65","author":"McIntyre","year":"2005","journal-title":"Cancer Research"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0135","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nature07427","article-title":"Generation of a prostate from a single adult stem cell","volume":"456","author":"Leong","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0140","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1530\/ror.0.0050143","article-title":"Roles of kit and kit ligand in ovarian function","volume":"5","author":"Driancourt","year":"2000","journal-title":"Reviews of Reproduction"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0145","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1006\/dbio.1993.1114","article-title":"The expression pattern of the c-kit ligand in gonads of mice supports a role for the c-kit receptor in oocyte growth and in proliferation of spermatogonia","volume":"157","author":"Manova","year":"1993","journal-title":"Developmental Biology"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0150","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1006\/dbio.1994.1020","article-title":"The ligand of the c-kit receptor promotes oocyte growth","volume":"161","author":"Packer","year":"1994","journal-title":"Developmental Biology"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0155","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.1210\/endo.140.9.6994","article-title":"Kit-ligand\/stem cell factor induces primordial follicle development and initiates folliculogenesis","volume":"140","author":"Parrott","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0160","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/mrd.20142","article-title":"Anti-apoptotic action of stem cell factor on oocytes in primordial follicles and its signal transduction","volume":"70","author":"Jin","year":"2005","journal-title":"Molecular Reproduction and Development"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0165","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0015-0282(16)56890-3","article-title":"Follicular fluid contents of hyaluronic acid, follicle-stimulating hormone and steroids relative to success of in vitro fertilization of human oocyte","volume":"62","author":"Suchanek","year":"1994","journal-title":"Fertility and Sterility"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0170","doi-asserted-by":"crossref","first-page":"167","DOI":"10.4196\/kjpp.2012.16.3.167","article-title":"Generation of CD2(+)CD8(+) NK cells from c-kit(+) bone marrow cells in porcine","volume":"16","author":"Lim","year":"2012","journal-title":"Korean Journal of Physiology and Pharmacology"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0175","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.1210\/en.2004-1444","article-title":"Fetal programming:prenatal testosterone treatment causes intrauterine growth retardation, reduces ovarian reserve and increases ovarian follicular recruitment","volume":"146","author":"Steckler","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0180","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1172\/JCI2081","article-title":"Androgens stimulate early stages of follicular growth in the primate ovary","volume":"101","author":"Vendola","year":"1998","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0185","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1210\/jcem-49-6-851","article-title":"The microenvironment of the human antral follicle: interrelationships among the steroid levels in antral fluid, the population of granulosa cells, and status of the oocyte in vivo and in vitro","volume":"49","author":"McNatty","year":"1979","journal-title":"The Journal of Clinical Endocrinology Metabolism"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0190","first-page":"1227","article-title":"Characteristics of human follicular fluid associated with successful conception after in vitro fertilization","volume":"77","author":"Andersen","year":"1993","journal-title":"The Journal of Clinical Endocrinology Metabolism"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0195","doi-asserted-by":"crossref","first-page":"3819","DOI":"10.1210\/endo.138.9.5368","article-title":"Direct actions of kit ligand on theca cell growth and differentiation during follicle development","volume":"138","author":"Parrott","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0200","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1530\/REP-10-0094","article-title":"Theca \u2013 the forgotten cell of the ovarian follicle","volume":"140","author":"Young","year":"2010","journal-title":"Reproduction"},{"key":"10.1016\/j.ejogrb.2012.10.006_bib0205","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0015-0282(01)01747-2","article-title":"Hepatocyte growth factor and stem cell involvement in paracrine interplays of theca and granulose cells in the human ovary","volume":"75","author":"Ito","year":"2001","journal-title":"Fertility and sterility"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211512004575?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211512004575?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:27:31Z","timestamp":1759555651000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211512004575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0301211512004575"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2012.10.006","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of melatonin on ovarian follicles","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2012.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}