{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:49:36Z","timestamp":1763599776109,"version":"build-2065373602"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.ejogrb.2014.05.033","type":"journal-article","created":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T15:30:09Z","timestamp":1401723009000},"page":"175-180","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Cut-off value of initial serum \u03b2-hCG level predicting a successful MTX therapy in tubal ectopic pregnancy: a retrospective cohort study"],"prefix":"10.1016","volume":"179","author":[{"given":"S.","family":"Helmy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Bader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Pablik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Tiringer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Pils","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Laml","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"K\u00f6lbl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4748-2994","authenticated-orcid":false,"given":"M.","family":"Koch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"year":"2007","series-title":"Gyn\u00e4kologie und Geburtshilfe","author":"Reiche","key":"10.1016\/j.ejogrb.2014.05.033_bib0005"},{"key":"10.1016\/j.ejogrb.2014.05.033_bib0010","series-title":"Gynecology","article-title":"Management of common problems obstetrics","author":"Murphy Goodwin","year":"2010"},{"issue":"2","key":"10.1016\/j.ejogrb.2014.05.033_bib0015","first-page":"1","article-title":"Pregnancy-related mortality surveillance\u2013United States, 1991\u20131999","volume":"52","author":"Chang","year":"2003","journal-title":"MMWR Surveill Summ"},{"issue":"4","key":"10.1016\/j.ejogrb.2014.05.033_bib0020","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00404-008-0731-3","article-title":"Tubal ectopic pregnancy: diagnosis and management","volume":"279","author":"Nama","year":"2009","journal-title":"Arch Gynecol Obstet"},{"year":"2004","series-title":"The management of tubal pregnancy, in guideline no. 21","author":"Kelly","key":"10.1016\/j.ejogrb.2014.05.033_bib0025"},{"year":"2004","series-title":"Why mothers die in the 6th report of the confidential enquiries into maternal deaths in the United Kingdom","key":"10.1016\/j.ejogrb.2014.05.033_bib0030"},{"key":"10.1016\/j.ejogrb.2014.05.033_bib0035","doi-asserted-by":"crossref","DOI":"10.1007\/s00404-013-2879-8","article-title":"Role of initial and day 4 human chorionic gonadotropin levels in predicting the outcome of single-dose methotrexate treatment in women with tubal ectopic pregnancy","author":"Ustunyurt","year":"2013","journal-title":"Arch Gynecol Obstet"},{"issue":"2","key":"10.1016\/j.ejogrb.2014.05.033_bib0040","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ijgo.2011.09.023","article-title":"The optimal cutoff serum level of human chorionic gonadotropin for efficacy of methotrexate treatment in women with extrauterine pregnancy","volume":"116","author":"Sagiv","year":"2012","journal-title":"Int J Gynaecol Obstet"},{"issue":"1","key":"10.1016\/j.ejogrb.2014.05.033_bib0045","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/humrep\/des373","article-title":"Methotrexate or expectant management in women with an ectopic pregnancy or pregnancy of unknown location and low serum hCG concentrations? A randomized comparison","volume":"28","author":"van Mello","year":"2013","journal-title":"Hum Reprod"},{"issue":"4","key":"10.1016\/j.ejogrb.2014.05.033_bib0050","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3109\/01443615.2011.560301","article-title":"Comparison of single-dose and two-dose methotrexate protocols for the treatment of unruptured ectopic pregnancy","volume":"31","author":"Gungorduk","year":"2011","journal-title":"J Obstet Gynaecol"},{"key":"10.1016\/j.ejogrb.2014.05.033_bib0055","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.3109\/00016340903188912","article-title":"Success and spontaneous pregnancy rates following systemic methotrexate versus laparoscopic surgery for tubal pregnancies a randomized trial","volume":"88","author":"Krag Moeller","year":"2009","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ejogrb.2014.05.033_bib0060","first-page":"269425","article-title":"The importance of gestational sac size of ectopic pregnancy in response to single-dose methotrexate","author":"Kimiaei","year":"2013","journal-title":"ISRN Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.ejogrb.2014.05.033_bib0065","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ejogrb.2005.09.006","article-title":"A new predictive scoring system including shock index for unruptured tubal pregnancy patients","volume":"126","author":"Kahyaoglu","year":"2006","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ejogrb.2014.05.033_bib0070","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1093\/humrep\/17.10.2585","article-title":"The ultrasonographic appearance of tubal pregnancy in patients treated with methotrexate","volume":"17","author":"Gamzu","year":"2002","journal-title":"Hum Reprod"},{"issue":"8","key":"10.1016\/j.ejogrb.2014.05.033_bib0075","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1503\/cmaj.050222","article-title":"Diagnosis and treatment of ectopic pregnancy","volume":"173","author":"Murray","year":"2005","journal-title":"CMAJ"},{"issue":"4","key":"10.1016\/j.ejogrb.2014.05.033_bib0080","first-page":"590","article-title":"Management of separation pain after single-dose methotrexate therapy for ectopic pregnancy","volume":"93","author":"Lipscomb","year":"1999","journal-title":"Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.ejogrb.2014.05.033_bib0085","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S0015-0282(00)01547-8","article-title":"Predictors of treatment failure for ectopic pregnancy treated with single-dose methotrexate","volume":"74","author":"Tawfiq","year":"2000","journal-title":"Fertil Steril"},{"issue":"3","key":"10.1016\/j.ejogrb.2014.05.033_bib0090","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.fertnstert.2006.10.007","article-title":"Establishing a human chorionic gonadotropin cutoff to guide methotrexate treatment of ectopic pregnancy: a systematic review","volume":"87","author":"Menon","year":"2007","journal-title":"Fertil Steril"},{"issue":"2","key":"10.1016\/j.ejogrb.2014.05.033_bib0095","first-page":"204","article-title":"An economic evaluation of single dose systemic methotrexate and laparoscopic surgery for the treatment of unruptured ectopic pregnancy","volume":"108","author":"Sowter","year":"2001","journal-title":"BJOG"},{"issue":"4","key":"10.1016\/j.ejogrb.2014.05.033_bib0100","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0002-9378(99)70330-3","article-title":"Treatment of tubal pregnancy in the netherlands an economic comparison of systemic methotrexate administration and laparoscopic salpingostomy","volume":"181","author":"Mol","year":"1999","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"10.1016\/j.ejogrb.2014.05.033_bib0105","first-page":"778","article-title":"The medical management of ectopic pregnancy: a meta-analysis comparing \u201csingle dose\u201d and \u201cmultidose\u201d regimens","volume":"101","author":"Barnhart","year":"2003","journal-title":"Obstet Gynecol"},{"issue":"26","key":"10.1016\/j.ejogrb.2014.05.033_bib0110","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1056\/NEJM199912233412604","article-title":"Predictors of success of methotrexate treatment in women with tubal ectopic pregnancies","volume":"341","author":"Lipscomb","year":"1999","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.ejogrb.2014.05.033_bib0115","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1016\/S0002-9378(96)70219-3","article-title":"Single-dose methotrexate for the treatment of ectopic pregnancy: Northwestern Memorial Hospital three-year experience","volume":"174","author":"Stika","year":"1996","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"10.1016\/j.ejogrb.2014.05.033_bib0120","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/uog.1061","article-title":"Expectant management of tubal ectopic pregnancy prediction of successful outcome using decision tree analysis","volume":"23","author":"Elson","year":"2004","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"7","key":"10.1016\/j.ejogrb.2014.05.033_bib0125","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1002\/uog.5186","article-title":"Fertility outcomes following expectant management of tubal ectopic pregnancy","volume":"30","author":"Helmy","year":"2007","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"6","key":"10.1016\/j.ejogrb.2014.05.033_bib0130","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1002\/uog.6380","article-title":"Use of serum progesterone measurements to reduce need for follow-up in women with pregnancies of unknown location","volume":"33","author":"Day","year":"2009","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"18","key":"10.1016\/j.ejogrb.2014.05.033_bib0135","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1056\/NEJM200011023431807","article-title":"Nonsurgical treatment of ectopic pregnancy","volume":"343","author":"Lipscomb","year":"2000","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.ejogrb.2014.05.033_bib0140","first-page":"754","article-title":"Single-dose methotrexate for treatment of ectopic pregnancy","volume":"77","author":"Stovall","year":"1991","journal-title":"Obstet Gynecol"},{"issue":"6 Pt 1","key":"10.1016\/j.ejogrb.2014.05.033_bib0145","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1016\/0002-9378(93)90687-E","article-title":"Single-dose methotrexate: an expanded clinical trial","volume":"168","author":"Stovall","year":"1993","journal-title":"Am J Obstet Gynecol"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030121151400308X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030121151400308X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:32:39Z","timestamp":1759555959000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030121151400308X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":29,"alternative-id":["S030121151400308X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2014.05.033","relation":{},"ISSN":["0301-2115"],"issn-type":[{"type":"print","value":"0301-2115"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cut-off value of initial serum \u03b2-hCG level predicting a successful MTX therapy in tubal ectopic pregnancy: a retrospective cohort study","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2014.05.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}