{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:31:55Z","timestamp":1792809115909,"version":"4.5.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.ejogrb.2014.10.036","type":"journal-article","created":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T14:48:58Z","timestamp":1414680538000},"page":"188-192","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"special_numbering":"C","title":["Dienogest in women with persistent endometriosis-related pelvic pain during norethisterone acetate treatment"],"prefix":"10.1016","volume":"183","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1790-1185","authenticated-orcid":false,"given":"Matteo","family":"Morotti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fausta","family":"Sozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentino","family":"Remorgida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Luigi","family":"Venturini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Ferrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2014.10.036_bib0005","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1093\/humrep\/det050","article-title":"Consensus on current management of endometriosis","volume":"28","author":"Johnson","year":"2013","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0010","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1093\/humrep\/dep231","article-title":"Medical treatment for rectovaginal endometriosis: what is the evidence","volume":"24","author":"Vercellini","year":"2009","journal-title":"Hum Reprod"},{"issue":"3","key":"10.1016\/j.ejogrb.2014.10.036_bib0015","first-page":"CD002122","article-title":"Progestagens and anti-progestagens for pain associated with endometriosis","author":"Brown","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0020","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1093\/humrep\/det457","article-title":"ESHRE guideline: management of women with endometriosis","volume":"29","author":"Dunselman","year":"2014","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0025","first-page":"24","article-title":"Effect of norethindrone acetate in the treatment of symptomatic endometriosis","volume":"43","author":"Muneyyirci-Delale","year":"1998","journal-title":"Int J Fertil Womens Med"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0030","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.fertnstert.2005.03.083","article-title":"Treatment of symptomatic rectovaginal endometriosis with an estrogen\u2013progestogen combination versus low-dose norethindrone acetate","volume":"84","author":"Vercellini","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0035","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1093\/humrep\/dep302","article-title":"Letrozole combined with norethisterone acetate compared with norethisterone acetate alone in the treatment of pain symptoms caused by endometriosis","volume":"24","author":"Ferrero","year":"2009","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0040","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1093\/humrep\/dep361","article-title":"Norethisterone acetate in the treatment of colorectal endometriosis: a pilot study","volume":"25","author":"Ferrero","year":"2010","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0045","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ejogrb.2013.11.030","article-title":"Norethisterone acetate versus norethisterone acetate combined with letrozole for the treatment of ovarian endometriotic cysts: a patient preference study","volume":"174","author":"Ferrero","year":"2014","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0050","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1517\/14656566.2014.943734","article-title":"Dienogest in the treatment of endometriosis","volume":"15","author":"Bizzarri","year":"2014","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0055","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.fertnstert.2007.12.080","article-title":"Dienogest is as effective as intranasal buserelin acetate for the relief of pain symptoms associated with endometriosis-a randomized, double-blind, multicenter, controlled trial","volume":"91","author":"Harada","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0060","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ijgo.2009.08.020","article-title":"A dose-ranging study to determine the efficacy and safety of 1, 2, and 4mg of dienogest daily for endometriosis","volume":"108","author":"K\u00f6hler","year":"2010","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0065","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1093\/humrep\/dep469","article-title":"Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24-week, randomized, multicentre, open-label trial","volume":"25","author":"Strowitzki","year":"2010","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0070","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ejogrb.2010.04.002","article-title":"Dienogest in the treatment of endometriosis-associated pelvic pain: a 12-week, randomized, double-blind, placebo-controlled study","volume":"151","author":"Strowitzki","year":"2010","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0075","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ejogrb.2011.03.012","article-title":"Maintenance therapy with dienogest following gonadotropin-releasing hormone agonist treatment for endometriosis-associated pelvic pain","volume":"157","author":"Kitawaki","year":"2011","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0080","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00404-011-1941-7","article-title":"Reduced pelvic pain in women with endometriosis: efficacy of long-term dienogest treatment","volume":"285","author":"Petraglia","year":"2012","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0085","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ijgo.2012.01.009","article-title":"Detailed analysis of a randomized, multicenter, comparative trial of dienogest versus leuprolide acetate in endometriosis","volume":"117","author":"Strowitzki","year":"2012","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0090","doi-asserted-by":"crossref","first-page":"717","DOI":"10.3109\/09513590.2010.533800","article-title":"Dienogest, a new conservative strategy for extragenital endometriosis: a pilot study","volume":"27","author":"Harada","year":"2011","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0095","doi-asserted-by":"crossref","first-page":"726","DOI":"10.3109\/09513590.2014.926882","article-title":"Efficacy of dienogest in the treatment of symptomatic adenomyosis: a pilot study","volume":"30","author":"Hirata","year":"2014","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0100","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1093\/humrep\/del231","article-title":"Measuring quality of life in women with endometriosis: tests of data quality, score reliability, response rate and scaling assumptions of the Endometriosis Health Profile Questionnaire","volume":"21","author":"Jones","year":"2006","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0105","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/009262300278597","article-title":"The Female Sexual Function Index (FSFI): a multidimensional self-report instrument for the assessment of female sexual function","volume":"26","author":"Rosen","year":"2000","journal-title":"J Sex Marital Ther"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0110","first-page":"179","article-title":"Transvaginal ultrasonography with water-contrast in the rectum in the diagnosis of bowel endometriosis","volume":"62","author":"Morotti","year":"2010","journal-title":"Minerva Ginecol"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0115","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/uog.8971","article-title":"Multidetector computerized tomography enteroclysis vs. rectal water contrast transvaginal ultrasonography in determining the presence and extent of bowel endometriosis","volume":"37","author":"Ferrero","year":"2011","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0120","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ejogrb.2014.05.016","article-title":"Progestogen-only contraceptive pill compared with combined oral contraceptive in the treatment of pain symptoms caused by endometriosis in patients with migraine without aura","volume":"179","author":"Morotti","year":"2014","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0125","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.fertnstert.2011.11.005","article-title":"Dienogest inhibits aromatase and cyclooxygenase-2 expression and prostaglandin E(2) production in human endometriotic stromal cells in spheroid culture","volume":"97","author":"Yamanaka","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0130","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.fertnstert.2007.03.042","article-title":"Dienogest inhibits BrdU uptake with G0\/G1 arrest in cultured endometriotic stromal cells","volume":"89","author":"Fu","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0135","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0002-9378(88)80106-6","article-title":"Reduction of the intraperitoneal inflammation associated with endometriosis by treatment with medroxyprogesterone acetate","volume":"159","author":"Haney","year":"1988","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0140","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.fertnstert.2013.10.038","article-title":"Dienogest inhibits nerve growth factor expression induced by tumor necrosis factor-\u03b1 or interleukin-1\u03b2","volume":"101","author":"Mita","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0145","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ejogrb.2014.03.019","article-title":"Dienogest improves human leucocyte antigen-DR underexpression and reduces tumour necrosis factor-\u03b1 production in peritoneal fluid cells from women with endometriosis","volume":"177","author":"Maeda","year":"2014","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0150","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/humupd\/dmu021","article-title":"Peripheral changes in endometriosis-associated pain","volume":"20","author":"Morotti","year":"2014","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0155","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1093\/humupd\/dmu025","article-title":"Central changes associated with chronic pelvic pain and endometriosis","volume":"20","author":"Brawn","year":"2014","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0160","doi-asserted-by":"crossref","first-page":"644","DOI":"10.3109\/09513590.2014.911279","article-title":"Dienogest reduces proliferation, aromatase expression and angiogenesis, and increases apoptosis in human endometriosis","volume":"30","author":"Miyashita","year":"2014","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.ejogrb.2014.10.036_bib0165","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/humupd\/dmt010","article-title":"Endometriosis: hormone regulation and clinical consequences of chemotaxis and apoptosis","volume":"19","author":"Reis","year":"2013","journal-title":"Hum Reprod Update"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211514005600?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211514005600?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:34:27Z","timestamp":1759556067000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211514005600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":33,"alternative-id":["S0301211514005600"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2014.10.036","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dienogest in women with persistent endometriosis-related pelvic pain during norethisterone acetate treatment","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2014.10.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}