{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:26:53Z","timestamp":1765546013435,"version":"build-2065373602"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.ejogrb.2015.03.016","type":"journal-article","created":{"date-parts":[[2015,3,28]],"date-time":"2015-03-28T13:51:45Z","timestamp":1427550705000},"page":"13-18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Comparing outcomes and costs between contingent and combined first-trimester screening strategies for Down's syndrome"],"prefix":"10.1016","volume":"189","author":[{"given":"I.","family":"Mart\u00edn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.J.","family":"Gibert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Aulesa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Alsina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Casals","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Bau\u00e7a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2015.03.016_bib0135","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/uog.14636","article-title":"Procedure-related risk of miscarriage following amniocentesis and chorionic villus sampling: a systematic review and meta-analysis","volume":"45","author":"Akolekar","year":"2015","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2015.03.016_bib0140","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0140-6736(97)02174-0","article-title":"Presence of fetal DNA in maternal plasma and serum","volume":"350","author":"Lo","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.ejogrb.2015.03.016_bib0145","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.tig.2012.10.013","article-title":"Recent advances in the prenatal interrogation of the human fetal genome","volume":"29","author":"Hui","year":"2013","journal-title":"Trends Genet"},{"key":"10.1016\/j.ejogrb.2015.03.016_bib0150","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1038\/nm.2829","article-title":"From prenatal genomic diagnosis to fetal personalized medicine: progress and challenges","volume":"18","author":"Bianchi","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.ejogrb.2015.03.016_bib0155","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/01.AOG.0000263470.89007.e3","article-title":"First- and second-trimester evaluation of risk for down syndrome","volume":"110","author":"Ball","year":"2007","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2015.03.016_bib0160","first-page":"56","article-title":"First and second trimester antenatal screening for Down's syndrome: the results of the Serum, Urine and Ultrasound Screening Study (SURUSS)","volume":"10","author":"Wald","year":"2003","journal-title":"J Med Screen"},{"key":"10.1016\/j.ejogrb.2015.03.016_bib0165","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1002\/pd.1498","article-title":"Sequential and contingent prenatal screening for Down syndrome","volume":"26","author":"Wald","year":"2006","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ejogrb.2015.03.016_bib0170","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.cll.2010.04.007","article-title":"Cost-effectiveness of Down syndrome screening paradigms","volume":"30","author":"Caughey","year":"2010","journal-title":"Clin Lab Med"},{"year":"2007","series-title":"Descripci\u00f3n del estado de situaci\u00f3n del cribado prenatal de las cromosomopat\u00edas fetales m\u00e1s frecuentes \u2013 principalmente S\u00edndrome de Down \u2013 en el Estado espa\u00f1ol y propuestas de mejora en la pr\u00e1ctica cl\u00ednica habitual","author":"Estrada","key":"10.1016\/j.ejogrb.2015.03.016_bib0175"},{"key":"10.1016\/j.ejogrb.2015.03.016_bib0180","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.cll.2010.04.012","article-title":"Monitoring quality control of nuchal translucency","volume":"30","author":"Cuckle","year":"2010","journal-title":"Clin Lab Med"},{"year":"2008","series-title":"Barcelona: Programa de diagn\u00f3stico prenatal de anomal\u00edas cong\u00e9nitas fetales de Catalu\u00f1a","author":"CatSalut. Instrucci\u00f3n 07\/2008","key":"10.1016\/j.ejogrb.2015.03.016_bib0185"},{"key":"10.1016\/j.ejogrb.2015.03.016_bib0190","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1053\/j.semperi.2005.05.004","article-title":"Down syndrome screening in the first and\/or second trimester: model predicted performance using meta-analysis parameters","volume":"29","author":"Cuckle","year":"2005","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.ejogrb.2015.03.016_bib0195","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1002\/pd.974","article-title":"Contingent screening for Down syndrome is an efficient alternative to non-disclosure sequential screening","volume":"24","author":"Wright","year":"2004","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ejogrb.2015.03.016_bib0200","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/pd.1215","article-title":"Practical strategies in contingent sequential screening for Down syndrome","volume":"25","author":"Benn","year":"2005","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ejogrb.2015.03.016_bib0205","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/pd.1913","article-title":"Contingent screening for Down syndrome \u2013 results from the FaSTER trial","volume":"28","author":"Cuckle","year":"2008","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ejogrb.2015.03.016_bib0210","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1002\/pd.2836","article-title":"Comparison of combined, stepwise sequential, contingent, and integrated screening in 7292 high-risk pregnant woman","volume":"31","author":"Guanciali-Franchi","year":"2011","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ejogrb.2015.03.016_bib0215","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1097\/GIM.0b013e3181ad5246","article-title":"Technical standards and guidelines: prenatal screening for Down syndrome that includes first-trimester biochemistry and\/or ultrasound measurements","volume":"11","author":"Palomaki","year":"2009","journal-title":"Genet Med"},{"key":"10.1016\/j.ejogrb.2015.03.016_bib0220","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/pd.2488","article-title":"The NTplus method of screening for Down syndrome: achieving the 2010 targets?","volume":"30","author":"Habayeb","year":"2010","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ejogrb.2015.03.016_bib0225","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/pd.4139","article-title":"Position statement from the Aneuploidy Screening Committee on behalf of the Board of the International Society for Prenatal Diagnosis","volume":"33","author":"Benn","year":"2013","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ejogrb.2015.03.016_bib0230","doi-asserted-by":"crossref","first-page":"b138","DOI":"10.1136\/bmj.b138","article-title":"Comparison of different strategies in prenatal screening for Down's syndrome: cost effectiveness analysis of computer simulation","volume":"338","author":"Gekas","year":"2009","journal-title":"Br Med J"},{"key":"10.1016\/j.ejogrb.2015.03.016_bib0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2010.09.017","article-title":"Cost-effectiveness and accuracy of prenatal Down syndrome screening strategies: should the combined test continue to be widely used?","volume":"204","author":"Gekas","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2015.03.016_bib0240","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ajog.2012.08.033","article-title":"Noninvasive prenatal testing for fetal trisomies in a routinely screened first-trimester population","volume":"207","author":"Nicolaides","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2015.03.016_bib0245","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1093\/humupd\/dmt001","article-title":"Non-invasive detection of fetal trisomy 21: systematic review and report of quality and outcomes of diagnostic accuracy studies performed between 1997 and 2012","volume":"19","author":"Mersy","year":"2013","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.ejogrb.2015.03.016_bib0250","doi-asserted-by":"crossref","first-page":"e93559","DOI":"10.1371\/journal.pone.0093559","article-title":"Model-based analysis of costs and outcomes of non invasive prenatal testing for Down's syndrome using free fetal DNA in the UK National Health Service","volume":"9","author":"Morris","year":"2014","journal-title":"PLOS ONE"},{"key":"10.1016\/j.ejogrb.2015.03.016_bib0255","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/1471-0528.12579","article-title":"Non-invasive prenatal testing for trisomy 21: a cross-sectional survey of service user\u2019 views and likely uptake","volume":"121","author":"Lewis","year":"2014","journal-title":"BJOG"},{"key":"10.1016\/j.ejogrb.2015.03.016_bib0260","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/1471-2393-14-229","article-title":"Evaluation of non-invasive prenatal testing (NIPT) for aneuploidy in an NHS setting: a reliable accurate prenatal non-invasive diagnosis (RAPID) protocol","volume":"14","author":"Hill","year":"2014","journal-title":"BMC Pregnancy Childbirth"}],"container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211515000962?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211515000962?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:33:49Z","timestamp":1759556029000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211515000962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":26,"alternative-id":["S0301211515000962"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2015.03.016","relation":{},"ISSN":["0301-2115"],"issn-type":[{"type":"print","value":"0301-2115"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparing outcomes and costs between contingent and combined first-trimester screening strategies for Down's syndrome","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2015.03.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}