{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T01:16:15Z","timestamp":1771982175451,"version":"3.50.1"},"reference-count":14,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.ejogrb.2015.06.007","type":"journal-article","created":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T00:40:15Z","timestamp":1434501615000},"page":"1-5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Randomized comparison of health-related quality of life in women with ectopic pregnancy or pregnancy of unknown location treated with systemic methotrexate or expectant management"],"prefix":"10.1016","volume":"192","author":[{"given":"Norah M.","family":"van Mello","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Femke","family":"Mol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra J.","family":"Hajenius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem M.","family":"Ankum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben Willem","family":"Mol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fulco","family":"van der Veen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madelon","family":"van Wely","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2015.06.007_bib0075","series-title":"The management of tubal pregnancies. Greentop guideline no. 21","author":"Royal College of Obstetricians and Gynaecologists","year":"2010"},{"key":"10.1016\/j.ejogrb.2015.06.007_bib0080","first-page":"CD000324","article-title":"Interventions for tubal ectopic pregnancy","author":"Hajenius","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"10.1016\/j.ejogrb.2015.06.007_bib0085","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/humrep\/des373","article-title":"Methotrexate or expectant management in women with an ectopic pregnancy or pregnancy of unknown location and low serum hCG concentrations? A randomized comparison","volume":"28","author":"Van Mello","year":"2013","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ejogrb.2015.06.007_bib0090","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/qjmed\/92.10.551","article-title":"The effects of methotrexate on pregnancy, fertility and lactation","volume":"92","author":"Lloyd","year":"1999","journal-title":"QJM"},{"key":"10.1016\/j.ejogrb.2015.06.007_bib0095","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1016\/j.fertnstert.2005.11.055","article-title":"Comparison of success rates in the medical management of ectopic pregnancy with single-dose and multiple-dose administration of methotrexate: a prospective, randomized clinical trial","volume":"85","author":"Alleyassin","year":"2006","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2015.06.007_bib0100","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1016\/j.ajog.2004.12.061","article-title":"Comparison of multidose and single-dose methotrexate protocols for the treatment of ectopic pregnancy","volume":"192","author":"Lipscomb","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2015.06.007_bib0105","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/S0895-4356(98)00097-3","article-title":"Translation, validation, and norming of the Dutch language version of the SF-36 Health Survey in community and chronic disease populations","volume":"51","author":"Aaronson","year":"1998","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.ejogrb.2015.06.007_bib0110","series-title":"Measuring the quality of life of cancer patients with the Rotterdam Symptom Checklist (RSCL): a manual","author":"De Haes","year":"2012"},{"key":"10.1016\/j.ejogrb.2015.06.007_bib0115","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1017\/S0033291796004382","article-title":"A validation study of the Hospital Anxiety and Depression Scale (HADS) in different groups of Dutch subjects","volume":"27","author":"Spinhoven","year":"1997","journal-title":"Psychol Med"},{"key":"10.1016\/j.ejogrb.2015.06.007_bib0120","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/BF00635621","article-title":"Statistical analysis of longitudinal quality of life data with missing measurements","volume":"1","author":"Zwinderman","year":"1992","journal-title":"Qual Life Res"},{"key":"10.1016\/j.ejogrb.2015.06.007_bib0125","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1477-7525-7-57","article-title":"Investigating the missing data mechanism in quality of life outcomes: a comparison of approaches","volume":"7","author":"Fielding","year":"2009","journal-title":"Health Qual Life Outcomes"},{"key":"10.1016\/j.ejogrb.2015.06.007_bib0130","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0015-0282(98)00212-X","article-title":"Systemic methotrexate therapy versus laparoscopic salpingostomy in patients with tubal pregnancy. Part I. Impact on patients\u2019 health-related quality of life","volume":"70","author":"Nieuwkerk","year":"1998","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2015.06.007_bib0135","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1002\/nur.21486","article-title":"Effects of progressive muscle relaxation training on anxiety and quality of life of inpatients with ectopic pregnancy receiving methotrexate treatment","volume":"35","author":"Pan","year":"2012","journal-title":"Res Nurs Health"},{"issue":"4","key":"10.1016\/j.ejogrb.2015.06.007_bib0140","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s00404-014-3513-0","article-title":"Effectiveness of expectant management versus methotrexate in tubal ectopic pregnancy: a double-blind randomized trial","volume":"291","author":"Silva","year":"2015","journal-title":"Arch Gynecol Obstet"}],"container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211515001906?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211515001906?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:34:29Z","timestamp":1759556069000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211515001906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":14,"alternative-id":["S0301211515001906"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2015.06.007","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Randomized comparison of health-related quality of life in women with ectopic pregnancy or pregnancy of unknown location treated with systemic methotrexate or expectant management","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2015.06.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}