{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:32:23Z","timestamp":1789979543175,"version":"4.0.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.ejogrb.2015.09.022","type":"journal-article","created":{"date-parts":[[2015,10,19]],"date-time":"2015-10-19T17:25:00Z","timestamp":1445275500000},"page":"94-99","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Folic acid supplementation in early pregnancy and the risk of preeclampsia, small for gestational age offspring and preterm delivery"],"prefix":"10.1016","volume":"195","author":[{"given":"Marit P.","family":"Martinussen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Bracken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth W.","family":"Triche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geir W.","family":"Jacobsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari R.","family":"Risnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2015.09.022_bib0195","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1056\/NEJM199911113412006","article-title":"Medical progress: neural tube defects","volume":"341","author":"Botto","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0200","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1469-8749.2011.04216.x","article-title":"Brain development of very preterm and very low-birthweight children in childhood and adolescence: a meta-analysis","volume":"54","author":"de Kieviet","year":"2012","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0205","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.pbiomolbio.2010.12.005","article-title":"Pathways linking the early environment to long-term health and lifespan","volume":"106","author":"Barnes","year":"2011","journal-title":"Prog Biophys Mol Biol"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0210","doi-asserted-by":"crossref","first-page":"S115","DOI":"10.1079\/BJN2000303","article-title":"Importance of folate in human nutrition","volume":"85","author":"Krishnaswamy","year":"2001","journal-title":"Br J Nutr"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0215","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/00000441-200602000-00011","article-title":"Effects of riboflavin and folic acid supplementation on plasma homocysteine levels in healthy subjects","volume":"331","author":"Chuang","year":"2006","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0220","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1146\/annurev.med.49.1.31","article-title":"Homocysteine and cardiovascular disease","volume":"49","author":"Refsum","year":"1998","journal-title":"Annu Rev Med"},{"issue":"4","key":"10.1016\/j.ejogrb.2015.09.022_bib0225","first-page":"739","article-title":"Asthma symptoms, severity, and drug therapy: a prospective study of effects on 2205 pregnancies","volume":"102","author":"Bracken","year":"2003","journal-title":"Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.ejogrb.2015.09.022_bib0230","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1093\/aje\/kwq400","article-title":"Antibiotic exposure by 6 months and asthma and allergy at 6 years: Findings in a cohort of 1,401 US children","volume":"173","author":"Risnes","year":"2011","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0235","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1093\/aje\/kwf220","article-title":"Association of maternal caffeine consumption with decrements in fetal growth","volume":"157","author":"Bracken","year":"2003","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0240","series-title":"Centers for Disease Control and Prevention, National Center for Health Statistics. 1999 natality detail file, issued June","author":"CDC","year":"2001"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0245","unstructured":"NIH Publication No. 00-3029, Originally Printed 1990, revised 2000. (http:\/\/www.nhlbi.nih.gov\/guidelines\/archives\/hbp_preg\/hbp_preg_archive.pdf)."},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0250","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1093\/aje\/kwp052","article-title":"Association of periconseptual multivitamin use with reduced risk of preeclampsia among normal-weight women in the Danish national birth cohort","volume":"169","author":"Catov","year":"2009","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0255","doi-asserted-by":"crossref","first-page":"957S","DOI":"10.3945\/jn.112.173021","article-title":"Dietary supplement use and smoking are important correlates of biomarkers of water-soluble vitamin status after adjusting for sociodemographic and lifestyle variables in a representative sample of US adults","volume":"143","author":"Pfeiffer","year":"2013","journal-title":"J Nutr"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0260","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/mnfr.201200116","article-title":"Use of folic acid supplements in early pregnancy in relation to maternal plasma levels in week 18 of pregnancy","volume":"57","author":"Roth","year":"2013","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0265","first-page":"555","article-title":"Red cell or serum folate: what to do in clinical practice?","volume":"51","author":"Farell","year":"2013","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0270","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/aje\/kwj218","article-title":"Periconceptional multivitamin use reduces the risk of preeclampsia","volume":"164","author":"Bodnar","year":"2006","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0275","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1093\/aje\/kwf129","article-title":"Risk of gestational hypertension in relation to folic acid supplementation during pregnancy","volume":"156","author":"Hernandez-Dias","year":"2002","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0280","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/AOG.0b013e31829b2f7c","article-title":"Absence of association between serum folate and preeclampsia in women exposed to food fortification","volume":"122","author":"Theriault","year":"2013","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0285","doi-asserted-by":"crossref","first-page":"45e1","DOI":"10.1016\/j.ajog.2007.06.067","article-title":"Folic acid supplementation in early second trimester and the risk of preeclampsia","volume":"198","author":"Wen","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0290","first-page":"294312","article-title":"Effect of folic acid supplementation in pregnancy on preeclampsia: the folic acid clinical trail study","volume":"2013","author":"Wen","year":"2013","journal-title":"J Pregn"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0295","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1373\/clinchem.2007.097469","article-title":"Effect of homocysteine concentration in early pregnancy on gestational hypertensive disorders and other pregnancy outcomes","volume":"54","author":"Dodds","year":"2008","journal-title":"Clin Chem"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0300","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1447-0756.2010.01317.x","article-title":"Homocysteine, folic acid and vitamin B12 levels in maternal and umbilical cord plasma and homocysteine levels in placenta in pregnant women with pre-eclampsia","volume":"37","author":"Acilmis","year":"2011","journal-title":"J Obstet Gynaecol Res"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0305","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1093\/ajcn\/71.4.962","article-title":"Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland homeocysteine study","volume":"71","author":"Vollset","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0310","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1373\/clinchem.2004.032904","article-title":"Maternal homocysteine before conception and throughout pregnancy predicts fetal homocysteine and birth weight","volume":"50","author":"Murphy","year":"2004","journal-title":"Clin Chem"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0315","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1093\/ajcn\/76.3.614","article-title":"The pregnancy-related decrease in fasting plasma homocysteine is not explained by folic acid supplementation, hemodilution, or a decrease in albumin in a longitudinal study","volume":"76","author":"Murphy","year":"2002","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0320","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3945\/ajcn.112.057489","article-title":"Impact of continuing folic acid after the first trimester of pregnancy: findings of a randomized trial of folic acid supplementation in the second and third trimesters","volume":"98","author":"McNulty","year":"2013","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0325","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.tem.2010.05.002","article-title":"Pre-eclampsia: connecting angiogeneic and metabolic pathways","volume":"21","author":"Shenoy","year":"2010","journal-title":"Trends Endocrinol Metabol"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0330","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1177\/003335490411900210","article-title":"Occurrence of low birthweight and preterm delivery among California infants before and after compulsory food fortification with folic acid","volume":"119","author":"Shaw","year":"2004","journal-title":"Pub Health Rep"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0335","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1740-8709.2011.00364.x","article-title":"Folate, Vitamin B12, Vitamin B6 and homeocysteine: impact on pregnancy outcome","volume":"9","author":"Furness","year":"2013","journal-title":"Mat Child Nutr"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0340","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00394-011-0261-9","article-title":"Influence of maternal cigarette smoking during pregnancy on neonatal serum folate levels","volume":"51","author":"Oncel","year":"2012","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0345","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.3945\/jn.111.142976","article-title":"Folic acid supplements modify the adverse effects of maternal smoking on fetal growth and neonatal complications","volume":"141","author":"Bakker","year":"2011","journal-title":"J Nutr"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0350","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.mrfmmm.2005.04.015","article-title":"The impact of plasma folate levels of mothers and newborns on intrauterine growth retardation and birth weight","volume":"591","author":"Sram","year":"2005","journal-title":"Mutat Res"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0355","doi-asserted-by":"crossref","first-page":"572","DOI":"10.3945\/jn.109.118158","article-title":"Infant birth size is not associated with maternal intake and status of folate during the second trimester in Norwegian pregnant women","volume":"140","author":"Nilsen","year":"2010","journal-title":"J Nutr"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0360","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1542\/peds.108.3.624","article-title":"Determinants of cobalamin status in newborns","volume":"108","author":"Bj\u00f8rke Monsen","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0365","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/1471-2393-13-160","article-title":"Folic acid supplementation, dietary folate intake during pregnancy and risk for spontaneous preterm delivery: a prospective observational cohort study","volume":"13","author":"Siegnpil","year":"2013","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0370","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1365-3016.2005.00633.x","article-title":"Folic acid supplements in pregnancy and birth outcome: re-analyses of a large randomized controlled trial and update of Cochrane review","volume":"19","author":"Charles","year":"2005","journal-title":"Paediatr Perinat Epidemiol"},{"key":"10.1016\/j.ejogrb.2015.09.022_bib0375","article-title":"Folic acid supplementation during pregnancy for maternal health and pregnancy outcomes","author":"Lassi","year":"2013","journal-title":"The Cochrane Library"},{"issue":"March (3)","key":"10.1016\/j.ejogrb.2015.09.022_bib0380","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/ajcn\/77.3.687","article-title":"Effect of the methylenetetrahydrofolate reductase 677C-->T mutation on the relations among folate intake and plasma folate and homocysteine concentrations in a general population sample","volume":"77","author":"de Bree","year":"2003","journal-title":"Am J Clin Nutr"}],"container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211515003279?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211515003279?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:35:37Z","timestamp":1759556137000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211515003279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":38,"alternative-id":["S0301211515003279"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2015.09.022","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Folic acid supplementation in early pregnancy and the risk of preeclampsia, small for gestational age offspring and preterm delivery","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2015.09.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}