{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:00:14Z","timestamp":1791342014894,"version":"4.3.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.ejogrb.2015.12.019","type":"journal-article","created":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T12:45:12Z","timestamp":1451479512000},"page":"1-6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["First trimester pregnancy-associated plasma protein-A and birth weight"],"prefix":"10.1016","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8485-1977","authenticated-orcid":false,"given":"Rebecca J.","family":"Baer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre J.","family":"Lyell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Norton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Currier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura L.","family":"Jelliffe-Pawlowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"June (2)","key":"10.1016\/j.ejogrb.2015.12.019_bib0155","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/00003081-200606000-00008","article-title":"Perinatal outcome and later implications of intrauterine growth restriction","volume":"49","author":"Pallotto","year":"2006","journal-title":"Clin Obstet Gynecol"},{"issue":"June (3)","key":"10.1016\/j.ejogrb.2015.12.019_bib0160","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.beem.2008.01.014","article-title":"Effects of being born small for gestational age on long-term intellectual performance","volume":"22","author":"Lundgren","year":"2008","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.ejogrb.2015.12.019_bib0165","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1159\/000271911","article-title":"Brain development, intelligence and cognitive outcome in children born small for gestational age","volume":"73","author":"de Bie","year":"2010","journal-title":"Horm Res Paediatr"},{"issue":"September (9)","key":"10.1016\/j.ejogrb.2015.12.019_bib0170","first-page":"717","article-title":"Intrauterine growth restriction \u2013 diagnosis and management","volume":"34","author":"Sheridan","year":"2005","journal-title":"Aust Fam Phys"},{"issue":"March (1)","key":"10.1016\/j.ejogrb.2015.12.019_bib0175","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0301-2115(97)00242-X","article-title":"Fetal macrosomia: risk factors and outcome. A study of the outcome concerning 100 cases >4500g","volume":"77","author":"Berard","year":"1998","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"June (2)","key":"10.1016\/j.ejogrb.2015.12.019_bib0180","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ejogrb.2012.03.005","article-title":"Prediction and prevention of the macrosomic fetus","volume":"162","author":"Walsh","year":"2012","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"November (11)","key":"10.1016\/j.ejogrb.2015.12.019_bib0185","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1002\/pd.3961","article-title":"Integrated and first trimester prenatal screening in California: program implementation and patient choice for follow-up services","volume":"32","author":"Currier","year":"2012","journal-title":"Prenat Diagn"},{"issue":"October (4)","key":"10.1016\/j.ejogrb.2015.12.019_bib0190","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1016\/j.ajog.2004.06.052","article-title":"First-trimester maternal serum PAPP-A and free-beta subunit human chorionic gonadotropin concentrations and nuchal translucency are associated with obstetric complications: a population-based screening study (the FASTER Trial)","volume":"191","author":"Dugoff","year":"2004","journal-title":"Am J Obstet Gynecol"},{"issue":"June (6)","key":"10.1016\/j.ejogrb.2015.12.019_bib0195","first-page":"492","article-title":"Association of early-preterm birth with abnormal levels of routinely collected first- and second-trimester biomarkers","volume":"208","author":"Jelliffe-Pawlowski","year":"2013","journal-title":"Am J Obstet Gynecol"},{"issue":"June (7)","key":"10.1016\/j.ejogrb.2015.12.019_bib0200","first-page":"703","article-title":"Early-onset severe preeclampsia by first trimester pregnancy-associated plasma protein A and total human chorionic gonadotropin","volume":"32","author":"Jelliffe-Pawlowski","year":"2015","journal-title":"Am J Perinatol"},{"issue":"May (5)","key":"10.1016\/j.ejogrb.2015.12.019_bib0205","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.1016\/j.ajog.2007.12.026","article-title":"First-trimester pregnancy-associated plasma protein A and subsequent abnormalities of fetal growth","volume":"198","author":"Peterson","year":"2008","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.ejogrb.2015.12.019_bib0210","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000324318","article-title":"Placental volume at 11\u201313 weeks\u2019 gestation in the prediction of birth weight percentile","volume":"30","author":"Plasencia","year":"2011","journal-title":"Fetal Diagn Ther"},{"issue":"March (2)","key":"10.1016\/j.ejogrb.2015.12.019_bib0215","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1515\/jpm-2013-0249","article-title":"Correlation of neonatal weight with maternal serum levels of pregnancy-associated plasma protein-A during the first trimester of pregnancy: a retrospective study","volume":"43","author":"Giudice","year":"2015","journal-title":"J Perinat Med"},{"issue":"February (2)","key":"10.1016\/j.ejogrb.2015.12.019_bib0220","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/pd.4277","article-title":"Elevated first trimester PAPP\u2013a is associated with increased risk of placenta accreta","volume":"34","author":"Desai","year":"2014","journal-title":"Prenat Diagn"},{"issue":"December (Suppl. 2)","key":"10.1016\/j.ejogrb.2015.12.019_bib0225","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/humrep\/14.suppl_2.90","article-title":"Role of the IGF system in trophoblast invasion and pre-eclampsia","volume":"14","author":"Irwin","year":"1999","journal-title":"Hum Reprod"},{"issue":"December (12)","key":"10.1016\/j.ejogrb.2015.12.019_bib0230","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.7863\/jum.2009.28.12.1615","article-title":"First-trimester placental volume and vascularization measured by 3-dimensional power Doppler sonography in pregnancies with low serum pregnancy-associated plasma protein a levels","volume":"28","author":"Rizzo","year":"2009","journal-title":"J Ultrasound Med"},{"issue":"December (12)","key":"10.1016\/j.ejogrb.2015.12.019_bib0235","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.placenta.2011.10.005","article-title":"The secretion of PAPP-A, ADAM12, and PP13 correlates with the size of the placenta for the first month of pregnancy","volume":"32","author":"Sahraravand","year":"2011","journal-title":"Placenta"},{"issue":"September (9)","key":"10.1016\/j.ejogrb.2015.12.019_bib0240","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1002\/pd.2802","article-title":"Detection rate of quadruple-marker screening determined by clinical follow-up and registry data in the statewide California program, July 2007 to February 2009","volume":"31","author":"Kazerouni","year":"2011","journal-title":"Prenat Diagn"},{"issue":"July (1)","key":"10.1016\/j.ejogrb.2015.12.019_bib0245","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/AOG.0b013e3181a9479e","article-title":"Triple-marker prenatal screening program for chromosomal defects","volume":"114","author":"Kazerouni","year":"2009","journal-title":"Obstet Gynecol"},{"issue":"February (2)","key":"10.1016\/j.ejogrb.2015.12.019_bib0250","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0029-7844(95)00386-X","article-title":"A United States national reference for fetal growth","volume":"87","author":"Alexander","year":"1996","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2015.12.019_bib0255","series-title":"International Classification of Diseases: ICD-9-CM 2008 Physician","author":"American Medical Association","year":"2008"},{"issue":"September (8)","key":"10.1016\/j.ejogrb.2015.12.019_bib0260","first-page":"665","article-title":"First-trimester prediction of birth weight","volume":"30","author":"Boucoiran","year":"2013","journal-title":"Am J Perinatol"},{"issue":"January (1)","key":"10.1016\/j.ejogrb.2015.12.019_bib0265","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.fertnstert.2007.02.024","article-title":"Association between birth weight and first-trimester free beta-human chorionic gonadotropin and pregnancy-associated plasma protein A","volume":"89","author":"Canini","year":"2008","journal-title":"Fertil Steril"},{"issue":"September (9)","key":"10.1016\/j.ejogrb.2015.12.019_bib0270","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.3109\/00016349.2010.505639","article-title":"Biology of pregnancy-associated plasma protein-A in relation to prenatal diagnostics: an overview","volume":"89","author":"Kirkegaard","year":"2010","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"March (6)","key":"10.1016\/j.ejogrb.2015.12.019_bib0275","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1073\/pnas.96.6.3149","article-title":"The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A","volume":"96","author":"Lawrence","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"May (5)","key":"10.1016\/j.ejogrb.2015.12.019_bib0280","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1210\/jcem.87.5.8448","article-title":"Identification and regulation of the IGFBP-4 protease and its physiological inhibitor in human trophoblasts and endometrial stroma: evidence for paracrine regulation of IGF-II bioavailability in the placental bed during human implantation","volume":"87","author":"Giudice","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"issue":"August (8)","key":"10.1016\/j.ejogrb.2015.12.019_bib0285","doi-asserted-by":"crossref","first-page":"E1429","DOI":"10.1210\/jc.2011-2511","article-title":"Significance of IGFBP-4 in the development of fetal growth restriction","volume":"97","author":"Qiu","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"October (10)","key":"10.1016\/j.ejogrb.2015.12.019_bib0290","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/S1701-2163(16)32973-5","article-title":"Obstetrical complications associated with abnormal maternal serum markers analytes","volume":"30","author":"Gagnon","year":"2008","journal-title":"J Obstet Gynaecol Can"},{"issue":"September (9)","key":"10.1016\/j.ejogrb.2015.12.019_bib0295","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/pd.4141","article-title":"Association between first-trimester maternal serum pregnancy-associated plasma protein-A and obstetric complications","volume":"33","author":"D\u2019Antonio","year":"2013","journal-title":"Prenat Diagn"},{"issue":"January (1)","key":"10.1016\/j.ejogrb.2015.12.019_bib0300","doi-asserted-by":"crossref","first-page":"F62","DOI":"10.1136\/adc.2005.082297","article-title":"Management of fetal growth restriction","volume":"92","author":"Alberry","year":"2007","journal-title":"Arch Dis Child Fetal Neonatal Ed"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030121151500487X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030121151500487X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:34:57Z","timestamp":1759556097000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030121151500487X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":30,"alternative-id":["S030121151500487X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2015.12.019","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"First trimester pregnancy-associated plasma protein-A and birth weight","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2015.12.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}