{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T07:58:04Z","timestamp":1759564684966,"version":"build-2065373602"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.ejogrb.2016.01.007","type":"journal-article","created":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T12:13:00Z","timestamp":1452514380000},"page":"94-99","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["MicroRNA-92 expression may be associated with reduced estrogen receptor \u03b21 mRNA levels in cervical portion of uterosacral ligaments in women with pelvic organ prolapse"],"prefix":"10.1016","volume":"198","author":[{"given":"Ke","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Xiu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hu","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2016.01.007_bib0195","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/S0140-6736(07)60462-0","article-title":"Pelvic organ prolapse","volume":"369","author":"Jelovsek","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0200","first-page":"1111","article-title":"Pelvic organ prolapse","volume":"81","author":"Kuncharapu","year":"2010","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0205","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1007\/s00192-012-1704-4","article-title":"A systematic review of clinical studies on hereditary factors in pelvic organ prolapse","volume":"23","author":"Lince","year":"2012","journal-title":"Int Urogynecol J"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0210","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1111\/j.1464-410X.2011.10385.x","article-title":"Pelvic floor disorders: linking genetic risk factors to biochemical changes","volume":"108","author":"Campeau","year":"2011","journal-title":"BJU Int"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0215","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/jcmm.12448","article-title":"MicroRNA-30d and microRNA-181a regulate HOXA11 expression in the uterosacral ligaments and are overexpressed in pelvic organ prolapse","volume":"19","author":"Jeon","year":"2015","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0220","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.mcna.2008.04.004","article-title":"Urinary incontinence and pelvic organ prolapse: diagnosis and treatment for the primary care physician","volume":"92","author":"Abed","year":"2008","journal-title":"Med Clin North Am"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0225","doi-asserted-by":"crossref","first-page":"521","DOI":"10.5603\/FHC.2011.0073","article-title":"Expression of estrogen receptors in the pelvic floor of pre- and post-menopausal women presenting pelvic organ prolapse","volume":"49","author":"Zbucka-Kretowska","year":"2011","journal-title":"Folia Histochem Cytobiol"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0230","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1097\/01.AOG.0000175832.13266.bb","article-title":"Pelvic organ prolapse","volume":"106","author":"Weber","year":"2005","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0235","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1124\/mi.5.6.7","article-title":"Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting","volume":"5","author":"Hall","year":"2005","journal-title":"Mol Interv"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0240","doi-asserted-by":"crossref","first-page":"5228","DOI":"10.1158\/1078-0432.CCR-07-4528","article-title":"Nuclear and cytoplasmic expression of ERbeta1, ERbeta2, and ERbeta5 identifies distinct prognostic outcome for breast cancer patients","volume":"14","author":"Shaaban","year":"2008","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0245","doi-asserted-by":"crossref","first-page":"13162","DOI":"10.1073\/pnas.0605676103","article-title":"Estrogen receptor (ER)-beta isoforms: a key to understanding ER-beta signaling","volume":"103","author":"Leung","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0250","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00192-011-1615-9","article-title":"Relaxin and gonadal steroid receptors in uterosacral ligaments of women with and without pelvic organ prolapse","volume":"23","author":"Dietrich","year":"2012","journal-title":"Int Urogynecol J"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0255","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1097\/01.ju.0000061472.94183.26","article-title":"Anatomical correction of vaginal vault prolapse by uterosacral ligament fixation in women who also require a pubovaginal sling","volume":"169","author":"Amundsen","year":"2003","journal-title":"J Urol"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0260","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/molehr\/gam090","article-title":"Changes in transcription profile and cytoskeleton morphology in pelvic ligament fibroblasts in response to stretch: the effects of estradiol and levormeloxifene","volume":"14","author":"Ewies","year":"2008","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0265","first-page":"803","article-title":"Differential effects of estradiol and raloxifene on collagen biosynthesis in cultured human skin fibroblasts","volume":"12","author":"Surazynski","year":"2003","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0270","doi-asserted-by":"crossref","first-page":"4778","DOI":"10.1158\/0008-5472.CAN-09-4104","article-title":"Estrogen receptor {beta}1 expression is regulated by miR-92 in breast cancer","volume":"70","author":"Al-Nakhle","year":"2010","journal-title":"Cancer Res"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0275","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s10549-009-0413-2","article-title":"Estrogen receptor beta exerts growth-inhibitory effects on human mammary epithelial cells","volume":"120","author":"Treeck","year":"2010","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0280","doi-asserted-by":"crossref","first-page":"11207","DOI":"10.1158\/0008-5472.CAN-06-0017","article-title":"Estrogen receptor beta inhibits angiogenesis and growth of T47D breast cancer xenografts","volume":"66","author":"Hartman","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0285","doi-asserted-by":"crossref","first-page":"468","DOI":"10.3892\/ol.2013.1404","article-title":"MicroRNA-92 regulates cervical tumorigenesis and its expression is upregulated by human papillomavirus-16 E6 in cervical cancer cells","volume":"6","author":"Yu","year":"2013","journal-title":"Oncol Lett"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0290","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nrg2290","article-title":"Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?","volume":"9","author":"Filipowicz","year":"2008","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0295","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nrm2085","article-title":"Illuminating the silence: understanding the structure and function of small RNAs","volume":"8","author":"Rana","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0300","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1101\/gad.1861409","article-title":"miR-19 is a key oncogenic component of mir-17-92","volume":"23","author":"Olive","year":"2009","journal-title":"Genes Dev"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0305","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ejogrb.2013.11.024","article-title":"Relationship between the expressions of mitofusin-2 and procollagen in uterosacral ligament fibroblasts of postmenopausal patients with pelvic organ prolapse","volume":"174","author":"Chen","year":"2014","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0310","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1136\/jcp.51.7.506","article-title":"The EnVision++ system: a new immunohistochemical method for diagnostics and research. Critical comparison with the APAAP, ChemMate, CSA, LABC, and SABC techniques","volume":"51","author":"Sabattini","year":"1998","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0315","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00418-004-0645-5","article-title":"Immunohistochemical localization of hTERT protein in human tissues","volume":"121","author":"Yan","year":"2004","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0320","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1111\/j.1349-7006.2011.02081.x","article-title":"miR-92 is a key oncogenic component of the miR-17-92 cluster in colon cancer","volume":"102","author":"Tsuchida","year":"2011","journal-title":"Cancer Sci"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0325","doi-asserted-by":"crossref","first-page":"e2557","DOI":"10.1371\/journal.pone.0002557","article-title":"Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth","volume":"3","author":"Wang","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0330","doi-asserted-by":"crossref","first-page":"11013","DOI":"10.1007\/s13277-014-2342-x","article-title":"MicroRNA-92 promotes gastric cancer cell proliferation and invasion through targeting FXR","volume":"35","author":"Duan","year":"2014","journal-title":"Tumour Biol"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0335","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/S0959-8049(03)00239-9","article-title":"Oestrogen receptor beta (ERbeta) is abundantly expressed in normal colonic mucosa, but declines in colon adenocarcinoma paralleling the tumour's dedifferentiation","volume":"39","author":"Konstantinopoulos","year":"2003","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0340","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/path.1077","article-title":"Evaluation of seven oestrogen receptor beta antibodies for immunohistochemistry, western blotting, and flow cytometry in human breast tissue","volume":"197","author":"Skliris","year":"2002","journal-title":"J Pathol"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0345","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1007\/s00192-005-0045-y","article-title":"Increased expression of matrix metalloproteinase 2 in uterosacral ligaments is associated with pelvic organ prolapse","volume":"17","author":"Gabriel","year":"2006","journal-title":"Int Urogynecol J Pelvic Floor Dysfunct"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0350","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s00192-003-1042-7","article-title":"Expression of estrogen receptor-alpha and -beta in anterior vaginal walls of genuine stress incontinent women","volume":"14","author":"Fu","year":"2003","journal-title":"Int Urogynecol J Pelvic Floor Dysfunct"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0355","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1080\/00016340701444764","article-title":"Connective tissue alterations in women with pelvic organ prolapse and urinary incontinence","volume":"86","author":"Suzme","year":"2007","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0360","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1097\/01.gco.0000242958.25244.ff","article-title":"Remodeling of vaginal connective tissue in patients with prolapse","volume":"18","author":"Alperin","year":"2006","journal-title":"Curr Opin Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0365","first-page":"1050","article-title":"HOXA11 is critical for development and maintenance of uterosacral ligaments and deficient in pelvic prolapse","volume":"118","author":"Connell","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0370","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/s00192-012-1703-5","article-title":"Increased microRNA-221\/222 and decreased estrogen receptor alpha in the cervical portion of the uterosacral ligaments from women with pelvic organ prolapse","volume":"23","author":"Shi","year":"2012","journal-title":"Int Urogynecol J"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0375","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/PPO.0b013e318250c001","article-title":"Causes and consequences of microRNA dysregulation","volume":"18","author":"Iorio","year":"2012","journal-title":"Cancer J"},{"key":"10.1016\/j.ejogrb.2016.01.007_bib0380","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"}],"container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211516000099?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211516000099?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:36:04Z","timestamp":1759556164000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211516000099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":38,"alternative-id":["S0301211516000099"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2016.01.007","relation":{},"ISSN":["0301-2115"],"issn-type":[{"type":"print","value":"0301-2115"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MicroRNA-92 expression may be associated with reduced estrogen receptor \u03b21 mRNA levels in cervical portion of uterosacral ligaments in women with pelvic organ prolapse","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2016.01.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}