{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T08:40:02Z","timestamp":1780389602575,"version":"3.54.1"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.ejogrb.2016.03.021","type":"journal-article","created":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T13:17:09Z","timestamp":1458825429000},"page":"1-6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Risk factors for residual disease after cervical conization in patients with cervical intraepithelial neoplasia grades 2 and 3 and positive surgical margins"],"prefix":"10.1016","volume":"201","author":[{"given":"Ali","family":"Ayhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan Aykut","family":"Tuncer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihan Haberal","family":"Reyhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"Kuscu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polat","family":"Dursun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2016.03.021_bib0110","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/LGT.0b013e318287d329","article-title":"2012 ASCCP Consensus Guidelines Conference. 2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursors","volume":"17","author":"Massad","year":"2013","journal-title":"J Low Genit Tract Dis"},{"key":"10.1016\/j.ejogrb.2016.03.021_bib0115","series-title":"Guidelines for the NHS Cervical Screening Programme","author":"Colposcopy and Programme Management","year":"2004"},{"key":"10.1016\/j.ejogrb.2016.03.021_bib0120","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S1470-2045(07)70283-8","article-title":"Incomplete excision of cervical intraepithelial neoplasia and risk of treatment failure: a meta-analysis","volume":"8","author":"Ghaem-Maghami","year":"2007","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ejogrb.2016.03.021_bib0125","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ejogrb.2012.06.026","article-title":"Risk factors for cervical intraepithelial neoplasia recurrence after conization: a 10-year study","volume":"165","author":"Serati","year":"2012","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"Suppl. 2","key":"10.1016\/j.ejogrb.2016.03.021_bib0130","first-page":"S100","article-title":"Cancer of the cervix uteri","volume":"119","author":"Wiebe","year":"2012","journal-title":"Int J Gynaecol Obstet"},{"issue":"Suppl. 7","key":"10.1016\/j.ejogrb.2016.03.021_bib0135","doi-asserted-by":"crossref","first-page":"vii27","DOI":"10.1093\/annonc\/mds268","article-title":"Cervical cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"23","author":"Colombo","year":"2012","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ejogrb.2016.03.021_bib0140","series-title":"NCCN clinical practice guidelines in oncology: cervical cancer. Version 1.2015","author":"NCCN","year":"2014"},{"key":"10.1016\/j.ejogrb.2016.03.021_bib0145","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/j.1471-0528.2011.03252.x","article-title":"The thickness and volume of LLETZ specimens can predict the relative risk of pregnancy-related morbidity","volume":"119","author":"Khalid","year":"2012","journal-title":"BJOG"},{"key":"10.1016\/j.ejogrb.2016.03.021_bib0150","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0140-6736(06)68181-6","article-title":"Obstetric outcomes after conservative treatment for intraepithelial or early invasive cervical lesions: systematic review and meta-analysis","volume":"367","author":"Kyrgiou","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.ejogrb.2016.03.021_bib0155","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ejogrb.2015.02.033","article-title":"The risk of preterm birth of treated versus untreated cervical intraepithelial neoplasia (CIN): a systematic review and meta-analysis","volume":"188","author":"Danhof","year":"2015","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ejogrb.2016.03.021_bib0160","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.bpobgyn.2011.04.007","article-title":"Management options for cervical intraepithelial neoplasia","volume":"25","author":"Petry","year":"2011","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.ejogrb.2016.03.021_bib0165","first-page":"3097","article-title":"Large loop excision of the transformation zone for treating cervical intraepithelial neoplasia: a 12-year experience","volume":"21","author":"Paraskevaidis","year":"2001","journal-title":"Anticancer Res"},{"key":"10.1016\/j.ejogrb.2016.03.021_bib0170","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ijgo.2009.05.027","article-title":"Factors associated with positive margins in patients with cervical intraepithelial neoplasia grade 3 and postconization management","volume":"107","author":"Lu","year":"2009","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.ejogrb.2016.03.021_bib0175","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0002-9378(95)90253-8","article-title":"Predictive factors from cold knife conization for residual cervical intraepithelial neoplasia in subsequent hysterectomy","volume":"173","author":"Moore","year":"1995","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2016.03.021_bib0180","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1006\/gyno.2000.5949","article-title":"Predictive factors for residual disease in subsequent hysterectomy following conization for CIN III","volume":"79","author":"Lu","year":"2000","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2016.03.021_bib0185","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ijgo.2008.11.015","article-title":"Repeat LEEP conization in patients with cervical intraepithelial neoplasia grade 3 and positive ectocervical margins","volume":"105","author":"Ayhan","year":"2009","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.ejogrb.2016.03.021_bib0190","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.ygyno.2007.11.009","article-title":"The association of pre-conization high-risk HPV load and the persistence of HPV infection and persistence\/recurrence of cervical intraepithelial neoplasia after conization","volume":"108","author":"Park","year":"2008","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2016.03.021_bib0195","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ygyno.2013.11.019","article-title":"Predictors of residual carcinoma or carcinoma-in-situ at hysterectomy following cervical conization with positive margins","volume":"132","author":"Diaz","year":"2014","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2016.03.021_bib0200","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.ygyno.2006.12.036","article-title":"Pathologic risk factors for predicting residual disease in subsequent hysterectomy following LEEP conization","volume":"105","author":"Kim","year":"2007","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2016.03.021_bib0205","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/LGT.0000000000000079","article-title":"Is there any predictor for residual disease after cervical conization with positive surgical margins for HSIL or microinvasive cervical cancer?","volume":"19","author":"Tasci","year":"2015","journal-title":"J Low Genit Tract Dis"},{"key":"10.1016\/j.ejogrb.2016.03.021_bib0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/LGT.0b013e31825afd5b","article-title":"Human papillomavirus type 16 causes larger colposcopic lesions than other HPV types in patients with grade 3 cervical intraepithelial neoplasia","volume":"17","author":"Nam","year":"2013","journal-title":"J Low Genit Tract Dis"}],"container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211516301117?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211516301117?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:35:31Z","timestamp":1759556131000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211516301117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":21,"alternative-id":["S0301211516301117"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2016.03.021","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk factors for residual disease after cervical conization in patients with cervical intraepithelial neoplasia grades 2 and 3 and positive surgical margins","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2016.03.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}