{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T14:45:53Z","timestamp":1780325153063,"version":"3.54.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.ejogrb.2016.11.017","type":"journal-article","created":{"date-parts":[[2016,11,19]],"date-time":"2016-11-19T12:32:54Z","timestamp":1479558774000},"page":"41-45","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Chemotherapy-related leukopenia as a biomarker predicting survival outcomes in locally advanced cervical cancer"],"prefix":"10.1016","volume":"208","author":[{"given":"Giorgio","family":"Bogani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Sabatucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppa","family":"Maltese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Lecce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Signorelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Martinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Chiappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Indini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Leone Roberti Maggiore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Borghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Fuc\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Ditto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Raspagliesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenica","family":"Lorusso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2016.11.017_bib0005","unstructured":"U.S. Cancer Statistics Working Group. United States Cancer Statistics: 1999\u20132012 Incidence and Mortality Web-based Report. Atlanta: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention and National Cancer Institute; 2015. Available at: www.cdc.gov\/uscs. (Accessed on May 2, 2016)."},{"key":"10.1016\/j.ejogrb.2016.11.017_bib0010","doi-asserted-by":"crossref","first-page":"vii27","DOI":"10.1093\/annonc\/mds268","article-title":"Cervical cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"23","author":"Colombo","year":"2012","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ejogrb.2016.11.017_bib0015","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1200\/JCO.2002.20.4.966","article-title":"Phase III trial comparing radical radiotherapy with and without cisplatin chemotherapy in patients with advanced squamous cell cancer of the cervix","volume":"20","author":"Pearcey","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejogrb.2016.11.017_bib0020","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1056\/NEJM199904153401502","article-title":"Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer","volume":"340","author":"Rose","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejogrb.2016.11.017_bib0025","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0140-6736(97)02250-2","article-title":"Randomised study of radical surgery versus radiotherapy for stage IB-IIA cervical cancer","volume":"350","author":"Landoni","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.ejogrb.2016.11.017_bib0030","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ygyno.2015.05.042","article-title":"Phase II study of weekly paclitaxel\/carboplatin in combination with prophylactic G-CSF in the treatment of gynecologic cancers: a study in 108 patients by the Belgian Gynaecological Oncology Group","volume":"138","author":"Vergote","year":"2015","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2016.11.017_bib0035","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1200\/JCO.2002.20.1.179","article-title":"Neoadjuvant chemotherapy and radical surgery versus exclusive radiotherapy in locally advanced squamous cell cervical cancer: results from the italian multicenter randomized study","volume":"20","author":"Benedetti Panici","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejogrb.2016.11.017_bib0040","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.ygyno.2015.05.043","article-title":"Neoadjuvant chemotherapy followed by large cone resection as fertility-sparing therapy in stage IB cervical cancer","volume":"139","author":"Salihi","year":"2015","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2016.11.017_bib0045","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1586\/14737140.2016.1121108","article-title":"Immunotherapy and targeted therapy for cervical cancer: an update","volume":"16","author":"Menderes","year":"2016","journal-title":"Expert Rev Anticancer Ther"},{"key":"10.1016\/j.ejogrb.2016.11.017_bib0050","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.ejca.2005.03.032","article-title":"Clark GM for the Statistics Subcommittee of the NCI-EORTC Working Group on Cancer diagnostics Reporting recommendations for tumor MARKer prognostic studies (REMARK)","volume":"41","author":"McShane","year":"2005","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ejogrb.2016.11.017_bib0055","doi-asserted-by":"crossref","first-page":"S944","DOI":"10.1245\/s10434-015-4799-2","article-title":"When does neoadjuvant chemotherapy really avoid radiotherapy: clinical predictors of adjuvant radiotherapy in cervical cancer","volume":"22","author":"Papadia","year":"2015","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejogrb.2016.11.017_bib0060","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.ejso.2015.03.228","article-title":"How often parametrial involvement leads to post-operative adjuvant treatment in locally advanced cervical cancer after neoadjuvant chemotherapy and type C radical hysterectomy","volume":"41","author":"Martinelli","year":"2015","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.ejogrb.2016.11.017_bib0065","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.ygyno.2009.07.027","article-title":"Classification of radical hysterectomy","volume":"115","author":"Querleu","year":"2009","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2016.11.017_bib0070","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)","volume":"45","author":"Eisenhauer","year":"2009","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ejogrb.2016.11.017_bib0075","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.1200\/JCO.2005.04.172","volume":"23","author":"Buda","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejogrb.2016.11.017_bib0080","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1097\/IGC.0000000000000515","article-title":"Long-term clinical benefits of neoadjuvant chemotherapy in women with locally advanced cervical cancer: validity of pathological response as surrogate endpoint of survival","volume":"25","author":"Buda","year":"2015","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.ejogrb.2016.11.017_bib0085","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1093\/annonc\/mdn690","volume":"20","author":"Lissoni","year":"2009","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ejogrb.2016.11.017_bib0090","unstructured":"National Cancer Institute. Common Terminology Criteria for Adverse Events (CTCAE) version 4.03. Available at: http:\/\/evs.nci.nih.gov\/ftp1\/CTCAE\/CTCAE_4.03_2010-06-14_QuickReference_8.5x11.pdf (Accessed on May 2, 2016)."},{"issue":"1","key":"10.1016\/j.ejogrb.2016.11.017_bib0095","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000441226","article-title":"Long-term toxicity and quality of life in patients treated for locally advanced cervical cancer","volume":"90","author":"Gargiulo","year":"2016","journal-title":"Oncology"},{"key":"10.1016\/j.ejogrb.2016.11.017_bib0100","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3892\/mco.2014.324","article-title":"Candidate biomarkers for cervical cancer treatment: potential for clinical practice (review)","volume":"2","author":"Iida","year":"2014","journal-title":"Mol Clin Oncol"},{"key":"10.1016\/j.ejogrb.2016.11.017_bib0105","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.ejca.2014.11.017","article-title":"Carboplatin and pegylated liposomal doxorubicin versus carboplatin and paclitaxel in very platinum-sensitive ovarian cancer patients: results from a subset analysis of the CALYPSO phase III trial","volume":"51","author":"Mahner","year":"2015","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ejogrb.2016.11.017_bib0110","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/bjc.2015.200","article-title":"Preoperative neutrophil:lymphocyte and platelet:lymphocyte ratios predict endometrial cancer survival","volume":"113","author":"Cummings","year":"2015","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ejogrb.2016.11.017_bib0115","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1097\/IGC.0000000000000219","article-title":"Preoperative neutrophil-lymphocyte ratio before platelet-lymphocyte ratio predicts clinical outcome in patients with cervical cancer treated with initial radical surgery","volume":"24","author":"Zhang","year":"2014","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.ejogrb.2016.11.017_bib0120","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.3892\/ol.2015.2884","article-title":"Link between chronic inflammation and human papillomavirus-induced carcinogenesis (review)","volume":"9","author":"Fernandes","year":"2015","journal-title":"Oncol Lett"},{"key":"10.1016\/j.ejogrb.2016.11.017_bib0125","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ygyno.2015.11.013","article-title":"Lymphopenia and its association with survival in patients with locally advanced cervical cancer","volume":"140","author":"Wu","year":"2016","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2016.11.017_bib0130","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1093\/annonc\/mdv546","article-title":"Pre-treatment lymphocytopaenia is an adverse prognostic biomarker in muscle-invasive and advanced bladder cancer","volume":"27","author":"Joseph","year":"2016","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ejogrb.2016.11.017_bib0135","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/SLA.0b013e31825b35d5","article-title":"Effects of allogeneic red blood cell transfusions on clinical outcomes in patients undergoing colorectal cancersurgery: a systematic review and meta-analysis","volume":"256","author":"Acheson","year":"2012","journal-title":"Ann Surg"},{"key":"10.1016\/j.ejogrb.2016.11.017_bib0140","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.eururo.2013.01.004","article-title":"The impact of perioperative blood transfusion on cancer recurrence and survival following radical cystectomy","volume":"63","author":"Linder","year":"2013","journal-title":"Eur Urol"},{"issue":"February","key":"10.1016\/j.ejogrb.2016.11.017_bib0145","article-title":"TGF-\u03b2: duality of function between tumor prevention and carcinogenesis","volume":"106","author":"Principe","year":"2014","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ejogrb.2016.11.017_bib0150","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1517\/14728222.2014.980235","article-title":"The PD-1\/PD-L1 pathway: biological background and clinical relevance of an emerging treatment target in immunotherapy","volume":"19","author":"Muenst","year":"2015","journal-title":"Expert Opin Ther Targets"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211516310296?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211516310296?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:37:56Z","timestamp":1759556276000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211516310296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":30,"alternative-id":["S0301211516310296"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2016.11.017","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chemotherapy-related leukopenia as a biomarker predicting survival outcomes in locally advanced cervical cancer","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2016.11.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}