{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T22:26:24Z","timestamp":1782253584713,"version":"3.54.5"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.ejogrb.2017.01.009","type":"journal-article","created":{"date-parts":[[2017,1,7]],"date-time":"2017-01-07T21:02:11Z","timestamp":1483822931000},"page":"275-280","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["Diagnostic performance of dual-staining cytology for cervical cancer screening: A systematic literature review"],"prefix":"10.1016","volume":"210","author":[{"given":"Wiebren A.A.","family":"Tjalma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ejogrb.2017.01.009_bib0005","first-page":"211","article-title":"The ideal cervical cancer screening recommendation for Belgium, an industrialized country in Europe","volume":"35","author":"Tjalma","year":"2014","journal-title":"Eur J Gynaecol Oncol"},{"key":"10.1016\/j.ejogrb.2017.01.009_bib0010","article-title":"ANOVA model for network meta-analysis of diagnostic test accuracy data","volume":"20","author":"Nyaga","year":"2016","journal-title":"Stat Methods Med Res Sep"},{"issue":"7","key":"10.1016\/j.ejogrb.2017.01.009_bib0015","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"key":"10.1016\/j.ejogrb.2017.01.009_bib0020","doi-asserted-by":"crossref","first-page":"889","DOI":"10.7326\/0003-4819-149-12-200812160-00008","article-title":"Systematic reviews of diagnostic test accuracy","volume":"149","author":"Leeflang","year":"2008","journal-title":"Ann Intern Med (Ann Intern Med)"},{"issue":"3","key":"10.1016\/j.ejogrb.2017.01.009_bib0025","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/cncy.20140","article-title":"p16\/ki-67 dual-stain cytology in the triage of ASCUS and LSIL Papanicolaou cytology: results from the European equivocal or mildly abnormal Papanicolaou cytology study","volume":"119","author":"Schmidt","year":"2011","journal-title":"Cancer Cytopathol"},{"issue":"10","key":"10.1016\/j.ejogrb.2017.01.009_bib0030","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.jclinepi.2005.02.022","article-title":"Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews","volume":"58","author":"Reitsma","year":"2005","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.ejogrb.2017.01.009_bib0035","unstructured":"R Development Core Team RF for SC. R: a Language and Environment for statistical computing. 2008."},{"issue":"20","key":"10.1016\/j.ejogrb.2017.01.009_bib0040","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1093\/jnci\/djt235","article-title":"Screening for cervical cancer precursors with p16\/Ki-67 dual-stained cytology: results of the PALMS study","volume":"105","author":"Ikenberg","year":"2013","journal-title":"J Natl Cancer Inst"},{"issue":"3","key":"10.1016\/j.ejogrb.2017.01.009_bib0045","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.ygyno.2011.02.033","article-title":"Triaging Pap cytology negative, HPV positive cervical cancer screening results with p16\/Ki-67 Dual-stained cytology","volume":"121","author":"Petry","year":"2011","journal-title":"Gynecol Oncol"},{"issue":"3","key":"10.1016\/j.ejogrb.2017.01.009_bib0050","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/cncy.21366","article-title":"Usefulness of p16\/Ki67 immunostaining in the triage of women referred to colposcopy","volume":"122","author":"Ordi","year":"2014","journal-title":"Cancer Cytopathol"},{"issue":"5","key":"10.1016\/j.ejogrb.2017.01.009_bib0055","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s00428-013-1483-4","article-title":"Dual immunostaining of cervical cytology specimens with atypical squamous cells for p16\/Ki-67 does not exclude the existence of a high-grade squamous intraepithelial lesion","volume":"463","author":"Koo","year":"2013","journal-title":"Virchows Arch"},{"issue":"2","key":"10.1016\/j.ejogrb.2017.01.009_bib0060","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ygyno.2012.05.004","article-title":"p16\/Ki-67 dual staining in cervico-vaginal cytology: correlation with histology, Human Papillomavirus detection and genotyping in women undergoing colposcopy","volume":"126","author":"Don\u00e0","year":"2012","journal-title":"Gynecol Oncol"},{"issue":"15","key":"10.1016\/j.ejogrb.2017.01.009_bib0065","doi-asserted-by":"crossref","first-page":"4154","DOI":"10.1158\/1078-0432.CCR-12-0270","article-title":"Performance of p16\/Ki-67 immunostaining to detect cervical cancer precursors in a colposcopy referral population","volume":"18","author":"Wentzensen","year":"2012","journal-title":"Clin Cancer Res"},{"issue":"6","key":"10.1016\/j.ejogrb.2017.01.009_bib0070","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1038\/bjc.2014.34","article-title":"Triaging borderline\/mild dyskaryotic Pap cytology with p16\/Ki-67 dual-stained cytology testing: cross-sectional and longitudinal outcome study","volume":"110","author":"Uijterwaal","year":"2014","journal-title":"Br J Cancer"},{"issue":"12","key":"10.1016\/j.ejogrb.2017.01.009_bib0075","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.7150\/ijms.6526","article-title":"Immunostaining of p16(INK4a)\/Ki-67 and L1 capsid protein on liquid-based cytology specimens obtained from ASC-H and LSIL-H cases","volume":"10","author":"Byun","year":"2013","journal-title":"Int J Med Sci"},{"issue":"7","key":"10.1016\/j.ejogrb.2017.01.009_bib0080","doi-asserted-by":"crossref","DOI":"10.1002\/dc.22900","article-title":"CINtec\u00ae plus dual immunostain: a triage tool for cervical pap smears with atypical squamous cells of undetermined significance and low grade squamous","volume":"41","author":"Loghavi","year":"2013","journal-title":"Diagn Cytopathol"},{"issue":"4","key":"10.1016\/j.ejogrb.2017.01.009_bib0085","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00292-012-1613-9","article-title":"Immunocytochemistry of p16INK4a and Ki-67 as adjunctive method for routine gynecological cytology of mild and moderate dysplasia","volume":"34","author":"Ziemke","year":"2012","journal-title":"Pathologe"},{"issue":"3","key":"10.1016\/j.ejogrb.2017.01.009_bib0090","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/cncy.21233","article-title":"Evaluation of p16(INK4a)\/Ki-67 dual stain in comparison with an mRNA human papillomavirus test on liquid-based cytology samples with low-grade squamous intraepithelial lesion","volume":"121","author":"Waldstr\u00f8m","year":"2013","journal-title":"Cancer Cytopathol"},{"issue":"3","key":"10.1016\/j.ejogrb.2017.01.009_bib0095","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ygyno.2012.11.030","article-title":"Implementing specificity of HPV-DNA primary screening in a successful organised cervical cancer prevention programme","volume":"128","author":"Zappacosta","year":"2013","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejogrb.2017.01.009_bib0100","doi-asserted-by":"crossref","first-page":"453606","DOI":"10.1155\/2013\/453606","article-title":"Chromogenic in situ hybridization and p16\/Ki67 dual staining on formalin-fixed paraffin-embedded cervical specimens: correlation with HPV-DNA test, E6\/E7 mRNA test, and potential clinical applications","volume":"2013","author":"Zappacosta","year":"2013","journal-title":"Biomed Res Int"},{"issue":"1","key":"10.1016\/j.ejogrb.2017.01.009_bib0105","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/cncy.20188","article-title":"Immunocytochemical colocalization of P16(INK4a) and Ki-67 predicts CIN2\/3 and AIS\/adenocarcinoma","volume":"120","author":"Singh","year":"2012","journal-title":"Cancer Cytopathol"},{"issue":"1","key":"10.1016\/j.ejogrb.2017.01.009_bib0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/LGT.0b013e31828aeb39","article-title":"Improved abnormal pap smear triage using cervical cancer biomarkers","volume":"18","author":"Killeen","year":"2014","journal-title":"J Low Genit Tract Dis"},{"issue":"8","key":"10.1016\/j.ejogrb.2017.01.009_bib0115","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1200\/JCO.2014.59.0331","article-title":"There are two prophylactic human papillomavirus vaccines against cancer, and they are different","volume":"33","author":"Tjalma","year":"2015","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejogrb.2017.01.009_bib0120","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1016\/S0959-8049(02)00462-8","article-title":"New markers for cervical dysplasia to visualise the genomic chaos created by aberrant oncogenic papillomavirus infections","volume":"38","author":"von Knebel Doeberitz","year":"2002","journal-title":"Eur Cancer"},{"key":"10.1016\/j.ejogrb.2017.01.009_bib0125","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1158\/1055-9965.EPI-08-0306","article-title":"Human papillomavirus mRNA and p16 detection as biomarkers for the improved diagnosis of cervical neoplasia","volume":"17","author":"Cuschieri","year":"2008","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.ejogrb.2017.01.009_bib0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejogrb.2017.01.010","article-title":"The impact on women\u2019s health and the cervical cancer screening budget when the screening is based on primary HPV screening with dual stain cytology triage","author":"Tjalma","year":"2017","journal-title":"Eur J Obstet Gynecol"}],"container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030121151730009X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030121151730009X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T15:00:17Z","timestamp":1779807617000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030121151730009X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":26,"alternative-id":["S030121151730009X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2017.01.009","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diagnostic performance of dual-staining cytology for cervical cancer screening: A systematic literature review","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2017.01.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}