{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:29:18Z","timestamp":1759624158505,"version":"build-2065373602"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.ejogrb.2017.01.023","type":"journal-article","created":{"date-parts":[[2017,1,19]],"date-time":"2017-01-19T14:16:57Z","timestamp":1484835417000},"page":"15-20","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Anal study in immunocompetent women with human papillomavirus related lower genital tract pathology"],"prefix":"10.1016","volume":"211","author":[{"given":"Concepci\u00f3n","family":"Donaire","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos","family":"Reillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan C.","family":"Mart\u00ednez-Escoriza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A.","family":"L\u00f3pez-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.ejogrb.2017.01.023_bib0005","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1002\/ijc.24215","article-title":"Human papillomavirus type distribution in anal cancer and anal intraepithelial lesions","volume":"124","author":"Hoots","year":"2009","journal-title":"Int J Cancer"},{"issue":"11 Pt. 1","key":"10.1016\/j.ejogrb.2017.01.023_bib0010","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1158\/1055-9965.EPI-05-0460","article-title":"Anal human papillomavirus infection in women and its relationship with cervical infection","volume":"14","author":"Hernandez","year":"2005","journal-title":"Cancer Epidemiol Biomark Prev"},{"issue":"6","key":"10.1016\/j.ejogrb.2017.01.023_bib0015","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.canep.2013.09.015","article-title":"Squamous anal cancer: patient characteristics and HPV type distribution","volume":"37","author":"Ouhoummane","year":"2013","journal-title":"Cancer Epidemiol"},{"issue":"1","key":"10.1016\/j.ejogrb.2017.01.023_bib0020","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/cncy.20126","article-title":"Anal cancer and cervical cancer screening: key differences","volume":"119","author":"Darragh","year":"2011","journal-title":"Cancer Cytopathol"},{"issue":"1","key":"10.1016\/j.ejogrb.2017.01.023_bib0025","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ogc.2009.02.003","article-title":"The epidemiology of anal human papillomavirus and related neoplasia","volume":"36","author":"Palefsky","year":"2009","journal-title":"Obstet Gynecol Clin North Am"},{"issue":"2 Pt. 1","key":"10.1016\/j.ejogrb.2017.01.023_bib0030","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1097\/AOG.0000000000000370","article-title":"Concurrent anal human papillomavirus and abnormal anal cytology in women with known cervical dysplasia","volume":"124","author":"Lamme","year":"2014","journal-title":"Obstet Gynecol"},{"issue":"4","key":"10.1016\/j.ejogrb.2017.01.023_bib0035","first-page":"1","article-title":"Anal dysplasia screening: an evidence-based analysis","volume":"7","year":"2007","journal-title":"Ont Health Technol Assess Ser"},{"issue":"2","key":"10.1016\/j.ejogrb.2017.01.023_bib0040","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/cncr.20364","article-title":"Anal cancer incidence and survival: the surveillance, epidemiology, and end results experience, 1973\u20132000","volume":"101","author":"Johnson","year":"2004","journal-title":"Cancer"},{"article-title":"Overview in a single PDF","year":"2014","series-title":"SEER. Cancer Statistics Reviews (CSR) 1975\u20132011","key":"10.1016\/j.ejogrb.2017.01.023_bib0045"},{"issue":"9","key":"10.1016\/j.ejogrb.2017.01.023_bib0050","first-page":"837","article-title":"Risk factors for anal cancer: results of a population-based case\u2013control study","volume":"14","author":"Tseng","year":"2003","journal-title":"Cancer Causes Control"},{"issue":"2","key":"10.1016\/j.ejogrb.2017.01.023_bib0055","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/cncr.20365","article-title":"Human papillomavirus, smoking, and sexual practices in the etiology of anal cancer","volume":"101","author":"Daling","year":"2004","journal-title":"Cancer"},{"issue":"7","key":"10.1016\/j.ejogrb.2017.01.023_bib0060","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1093\/infdis\/jis458","article-title":"Prevalence of and risk factors for anal human papillomavirus infection among young healthy women in Costa Rica","volume":"206","author":"Castro","year":"2012","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ejogrb.2017.01.023_bib0065","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1186\/1471-2407-12-398","article-title":"HPV infection, anal intra-epithelial neoplasia (AIN) and anal cancer: current issues","volume":"12","author":"Stanley","year":"2012","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ejogrb.2017.01.023_bib0070","first-page":"1","article-title":"Anal patients in renal transplant patients","volume":"16","author":"Patel","year":"2005","journal-title":"Int J Colorectal Dis"},{"issue":"Suppl. 5","key":"10.1016\/j.ejogrb.2017.01.023_bib0075","doi-asserted-by":"crossref","first-page":"F24","DOI":"10.1016\/j.vaccine.2012.05.089","article-title":"Updating the natural history of human papillomavirus and anogenital cancers","volume":"30","author":"Moscicki","year":"2012","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.ejogrb.2017.01.023_bib0080","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.ygyno.2009.05.006","article-title":"Presumed previous human papillomavirus (HPV) related gynecological cancer in women diagnosed with anal cancer in the province of Ontario","volume":"114","author":"Jimenez","year":"2009","journal-title":"Gynecol Oncol"},{"issue":"4","key":"10.1016\/j.ejogrb.2017.01.023_bib0085","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/00001648-200007000-00016","article-title":"Second primary cancer after in situ and invasive cervical cancer","volume":"11","author":"Hemminki","year":"2000","journal-title":"Epidemiology"},{"issue":"4","key":"10.1016\/j.ejogrb.2017.01.023_bib0090","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S1470-2045(07)70043-8","article-title":"Risk of anogenital cancer after diagnosis of cervical intraepithelial neoplasia: a prospective population-based study","volume":"8","author":"Edgren","year":"2007","journal-title":"Lancet Oncol"},{"issue":"3","key":"10.1016\/j.ejogrb.2017.01.023_bib0095","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1097\/AOG.0b013e31820bfb16","article-title":"Risk of anal cancer in a cohort with human papillomavirus-related gynecologic neoplasm","volume":"117","author":"Saleem","year":"2011","journal-title":"Obstet Gynecol"},{"issue":"8666","key":"10.1016\/j.ejogrb.2017.01.023_bib0100","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S0140-6736(89)90830-1","article-title":"Anal and cervical intraepithelial neoplasia: possible parallel","volume":"2","author":"Scholefield","year":"1989","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.ejogrb.2017.01.023_bib0105","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.ygyno.2009.05.008","article-title":"Anal human papillomavirus infection and abnormal anal cytology in women with genital neoplasia","volume":"114","author":"Park","year":"2009","journal-title":"Gynecol Oncol"},{"issue":"3","key":"10.1016\/j.ejogrb.2017.01.023_bib0110","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1097\/AOG.0b013e3181ea1834","article-title":"Anal intraepithelial neoplasia in women with genital intraepithelial neoplasia","volume":"116","author":"Santoso","year":"2010","journal-title":"Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.ejogrb.2017.01.023_bib0115","doi-asserted-by":"crossref","first-page":"115e1-5","DOI":"10.1016\/j.ajog.2011.03.011","article-title":"Association between genital intraepithelial lesions and anal squamous intraepithelial lesions in HIV-negative women","volume":"205","author":"Jacyntho","year":"2011","journal-title":"Am J Obstet Gynecol"},{"issue":"8830","key":"10.1016\/j.ejogrb.2017.01.023_bib0120","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/0140-6736(92)92961-E","article-title":"Anal intraepithelial neoplasia: part of a multifocal disease process","volume":"340","author":"Scholefield","year":"1992","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.ejogrb.2017.01.023_bib0125","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jcv.2013.11.004","article-title":"The relationship between the cervical and anal HPV infection in women with cervical intraepithelial neoplasia","volume":"59","author":"Sehnal","year":"2014","journal-title":"J Clin Virol"},{"issue":"9","key":"10.1016\/j.ejogrb.2017.01.023_bib0130","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1038\/bjc.2015.89","article-title":"Lifestyle and reproductive risk factors associated with anal cancer in women aged over 50 years","volume":"112","author":"Coffey","year":"2015","journal-title":"Br J Cancer"},{"issue":"9","key":"10.1016\/j.ejogrb.2017.01.023_bib0135","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1086\/344057","article-title":"Natural history and clinical management of anal human papillomavirus disease in men and women infected with human immunodeficiency virus","volume":"35","author":"Chin-Hong","year":"2002","journal-title":"Clin Infect Dis"},{"issue":"12","key":"10.1016\/j.ejogrb.2017.01.023_bib0140","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1086\/588145","article-title":"Prevalence of and risk factors for anal human papillomavirus infection in heterosexual men","volume":"197","author":"Nyitray","year":"2008","journal-title":"J Infect Dis"},{"issue":"2","key":"10.1016\/j.ejogrb.2017.01.023_bib0145","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s11904-008-0013-5","article-title":"Human papillomavirus and anal neoplasia","volume":"5","author":"Palefsky","year":"2008","journal-title":"Curr HIV\/AIDS Rep"},{"issue":"2","key":"10.1016\/j.ejogrb.2017.01.023_bib0150","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1086\/505219","article-title":"Screening HIV-infected individuals for anal cancer precursor lesions: a systematic review","volume":"43","author":"Chiao","year":"2006","journal-title":"Clin Infect Dis"},{"issue":"7","key":"10.1016\/j.ejogrb.2017.01.023_bib0155","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1086\/529207","article-title":"Acquisition of anal human papillomavirus (HPV) infection in women: the Hawaii HPV Cohort study","volume":"197","author":"Goodman","year":"2008","journal-title":"J Infect Dis"},{"issue":"6 Suppl. 16","key":"10.1016\/j.ejogrb.2017.01.023_bib0160","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1053\/sonc.2002.37263","article-title":"Role of angiogenesis in tumor growth and metastasis","volume":"29","author":"Folkman","year":"2002","journal-title":"Semin Oncol"},{"issue":"5","key":"10.1016\/j.ejogrb.2017.01.023_bib0165","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/dc.23050","article-title":"A six-year experience with anal cytology in women with HPV in the lower genital tract: utility, limitations, and clinical correlation","volume":"42","author":"Cardinal","year":"2013","journal-title":"Diagn Cytopathol"},{"issue":"2","key":"10.1016\/j.ejogrb.2017.01.023_bib0170","first-page":"173","article-title":"Risk factors for abnormal anal cytology in young heterosexual women","volume":"8","author":"Moscicki","year":"1999","journal-title":"Cancer Epidemiol Biomark Prev"},{"issue":"3","key":"10.1016\/j.ejogrb.2017.01.023_bib0175","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.ygyno.2011.05.033","article-title":"Human papillomavirus DNA and mRNA positivity of the anal canal in women with lower genital tract HPV lesions: predictors and clinical implications","volume":"122","author":"Valari","year":"2011","journal-title":"Gynecol Oncol"},{"issue":"2 Pt. 1","key":"10.1016\/j.ejogrb.2017.01.023_bib0180","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1097\/AOG.0000000000000370","article-title":"Concurrent anal human papillomavirus and abnormal anal cytology in women with known cervical dysplasia","volume":"124","author":"Lamme","year":"2014","journal-title":"Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.ejogrb.2017.01.023_bib0185","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1086\/318071","article-title":"Prevalence and risk factors for anal human papillomavirus infection in human immunodeficiency virus (HIV)-positive and high-risk HIV-negative women","volume":"183","author":"Palefsky","year":"2001","journal-title":"J Infect Dis"},{"issue":"3","key":"10.1016\/j.ejogrb.2017.01.023_bib0190","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ajog.2015.03.034","article-title":"Prevalence of anal human papillomavirus infection and anal HPV-related disorders in women: a systematic review","volume":"213","author":"Stier","year":"2015","journal-title":"Am J Obstet Gynecol"},{"issue":"9","key":"10.1016\/j.ejogrb.2017.01.023_bib0195","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1086\/651620","article-title":"Sequential acquisition of human papillomavirus (HPV) infection of the anus and cervix: the Hawaii HPV Cohort Study","volume":"201","author":"Goodman","year":"2010","journal-title":"J Infect Dis"},{"issue":"16","key":"10.1016\/j.ejogrb.2017.01.023_bib0200","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1056\/NEJM198710153171601","article-title":"Sexual practices, sexually transmitted diseases, and the incidence of anal cancer","volume":"317","author":"Daling","year":"1987","journal-title":"N Engl J Med"},{"issue":"11","key":"10.1016\/j.ejogrb.2017.01.023_bib0205","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1093\/jnci\/93.11.843","article-title":"Prevalence and risk factors for anal squamous intraepithelial lesions in women","volume":"93","author":"Holly","year":"2001","journal-title":"J Natl Cancer Inst"},{"issue":"8508","key":"10.1016\/j.ejogrb.2017.01.023_bib0210","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0140-6736(86)90168-6","article-title":"Association between anorectal dysplasia, human papillomavirus, and human immunodeficiency virus infection in homosexual men","volume":"2","author":"Frazer","year":"1986","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.ejogrb.2017.01.023_bib0215","first-page":"21","article-title":"Anal human papillomavirus infection: a comparative study of cytology, colposcopy and DNA hybridisation as methods of detection","volume":"67","author":"Sonnex","year":"1991","journal-title":"Genitourin Med"},{"issue":"6","key":"10.1016\/j.ejogrb.2017.01.023_bib0220","first-page":"378","article-title":"Cytological screening to detect subclinical anal human papillomavirus (HPV) infection in homosexual men attending genitourinary medicine clinic","volume":"64","author":"Haye","year":"1988","journal-title":"Genitourin Med"},{"issue":"9","key":"10.1016\/j.ejogrb.2017.01.023_bib0225","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1002\/bjs.4994","article-title":"Malignant transformation of high-grade anal intraepithelial neoplasia","volume":"92","author":"Scholefield","year":"2005","journal-title":"Br J Surg"},{"issue":"8","key":"10.1016\/j.ejogrb.2017.01.023_bib0230","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1158\/0008-5472.CAN-09-4179","article-title":"A population-based prospective study of carcinogenic human papillomavirus variant lineages, viral persistence, and cervical neoplasia","volume":"70","author":"Schiffman","year":"2010","journal-title":"Cancer Res"},{"issue":"Suppl. 3","key":"10.1016\/j.ejogrb.2017.01.023_bib0235","article-title":"Chapter 6: Epidemiology and transmission dynamics of genital HPV infection","volume":"24","author":"Burchell","year":"2006","journal-title":"Vaccine"},{"issue":"6","key":"10.1016\/j.ejogrb.2017.01.023_bib0240","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/ijc.27828","article-title":"Patterns of persistent genital human papillomavirus infection among women worldwide: a literature review and meta-analysis","volume":"133","author":"Rositch","year":"2013","journal-title":"Int J Cancer"},{"issue":"4","key":"10.1016\/j.ejogrb.2017.01.023_bib0245","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/(SICI)1096-9896(199612)180:4<378::AID-PATH697>3.0.CO;2-H","article-title":"Properties of HPV-positive and HPV-negative anal carcinomas","volume":"180","author":"Williams","year":"1996","journal-title":"J Pathol"},{"issue":"4","key":"10.1016\/j.ejogrb.2017.01.023_bib0250","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/ijc.21193","article-title":"The role of diet and nutrition in cervical carcinogenesis: a review of recent evidence","volume":"117","author":"Garcia-Closas","year":"2005","journal-title":"Int J Cancer"},{"issue":"4","key":"10.1016\/j.ejogrb.2017.01.023_bib0255","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1001\/jama.1992.03480040076034","article-title":"Folate deficiency and cervical dysplasia","volume":"267","author":"Butterworth","year":"1992","journal-title":"JAMA"},{"issue":"7","key":"10.1016\/j.ejogrb.2017.01.023_bib0260","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1093\/jn\/131.7.2040","article-title":"Low serum and red blood cell folate are moderately, but nonsignificantly associated with increased risk of invasive cervical cancer in U.S. women","volume":"131","author":"Weinstein","year":"2001","journal-title":"J Nutr"},{"issue":"7","key":"10.1016\/j.ejogrb.2017.01.023_bib0265","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1158\/1940-6207.CAPR-08-0175","article-title":"Lower risk of cervical intraepithelial neoplasia in women with high plasma folate and sufficient vitamin B12 in the post-folic acid fortification era","volume":"2","author":"Piyathilake","year":"2009","journal-title":"Cancer Prev Res (Phila)"},{"issue":"2","key":"10.1016\/j.ejogrb.2017.01.023_bib0270","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0022-3476(98)70445-7","article-title":"The natural history of human papillomavirus infection as measured by repeated DNA testing in adolescent and young women","volume":"132","author":"Moscicki","year":"1998","journal-title":"J Pediatr"}],"container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211517300234?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211517300234?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:38:20Z","timestamp":1759556300000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211517300234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":54,"alternative-id":["S0301211517300234"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2017.01.023","relation":{},"ISSN":["0301-2115"],"issn-type":[{"type":"print","value":"0301-2115"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anal study in immunocompetent women with human papillomavirus related lower genital tract pathology","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2017.01.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}