{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T01:16:36Z","timestamp":1771550196825,"version":"3.50.1"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.ejogrb.2017.02.007","type":"journal-article","created":{"date-parts":[[2017,2,9]],"date-time":"2017-02-09T05:02:48Z","timestamp":1486616568000},"page":"103-107","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["The role of HCG increment in the 48 h prior to methotrexate treatment as a predictor for treatment success"],"prefix":"10.1016","volume":"211","author":[{"given":"Aviad","family":"Cohen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benny","family":"Almog","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoni","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Bibi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eli","family":"Rimon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ishai","family":"Levin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ejogrb.2017.02.007_bib0005","first-page":"1","article-title":"Pregnancy-related mortality surveillance \u2013 United States, 1991\u20131999","volume":"52","author":"Chang","year":"2003","journal-title":"Morbid Mortal Wkly Rep Surveill Summ"},{"issue":"11","key":"10.1016\/j.ejogrb.2017.02.007_bib0010","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1093\/oxfordjournals.aje.a009747","article-title":"Estimates of the annual number of clinically recognized pregnancies in the United States, 1981\u20131991","volume":"149","author":"Saraiya","year":"1999","journal-title":"Am J Epidemiol"},{"issue":"4","key":"10.1016\/j.ejogrb.2017.02.007_bib0015","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1097\/AOG.0b013e3182113c10","article-title":"Trends in ectopic pregnancy mortality in the United States: 1980\u20132007","volume":"117","author":"Creanga","year":"2011","journal-title":"Obstet Gynecol"},{"issue":"9080","key":"10.1016\/j.ejogrb.2017.02.007_bib0020","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/S0140-6736(97)05487-1","article-title":"Randomised trial of systemic methotrexate versus laparoscopic salpingostomy in tubal pregnancy","volume":"350","author":"Hajenius","year":"1997","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.ejogrb.2017.02.007_bib0025","first-page":"754","article-title":"Single-dose methotrexate for treatment of ectopic pregnancy","volume":"77","author":"Stovall","year":"1991","journal-title":"Obstet Gynecol"},{"issue":"26","key":"10.1016\/j.ejogrb.2017.02.007_bib0030","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1056\/NEJM199912233412604","article-title":"Predictors of success of methotrexate treatment in women with tubal ectopic pregnancies","volume":"341","author":"Lipscomb","year":"1999","journal-title":"N Eng J Med"},{"issue":"2","key":"10.1016\/j.ejogrb.2017.02.007_bib0035","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ajog.2014.03.043","article-title":"Methotrexate success rates in progressing ectopic pregnancies: a reappraisal","volume":"211","author":"Cohen","year":"2014","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.ejogrb.2017.02.007_bib0040","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.fertnstert.2006.10.007","article-title":"Establishing a human chorionic gonadotropin cutoff to guide methotrexate treatment of ectopic pregnancy: a systematic review","volume":"87","author":"Menon","year":"2007","journal-title":"Fertil Steril"},{"issue":"3","key":"10.1016\/j.ejogrb.2017.02.007_bib0045","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.fertnstert.2010.10.014","article-title":"Watchful waiting in ectopic pregnancies: a balance between reduced success rates and less methotrexate","volume":"95","author":"Levin","year":"2011","journal-title":"Fertil Steril"},{"issue":"5","key":"10.1016\/j.ejogrb.2017.02.007_bib0050","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.fertnstert.2012.09.040","article-title":"Ectopic pregnancy: how the diagnostic and therapeutic management has changed","volume":"98","author":"van Mello","year":"2012","journal-title":"Fertil Steril"},{"issue":"3","key":"10.1016\/j.ejogrb.2017.02.007_bib0055","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.fertnstert.2013.06.013","article-title":"Practice Committee of American Society for M. Reproductive Medical treatment of ectopic pregnancy: a committee opinion","volume":"100","year":"2013","journal-title":"Fertil Steril"},{"issue":"3","key":"10.1016\/j.ejogrb.2017.02.007_bib0060","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/AOG.0b013e3181d0c328","article-title":"Trends in the diagnosis and treatment of ectopic pregnancy in the United States","volume":"115","author":"Hoover","year":"2010","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2017.02.007_bib0065","series-title":"Ectopic pregnancy: a clinical casebook","year":"2015"},{"issue":"3","key":"10.1016\/j.ejogrb.2017.02.007_bib0070","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1093\/humrep\/del433","article-title":"A validation of the most commonly used protocol to predict the success of single-dose methotrexate in the treatment of ectopic pregnancy","volume":"22","author":"Kirk","year":"2007","journal-title":"Hum Reprod"},{"issue":"3","key":"10.1016\/j.ejogrb.2017.02.007_bib0075","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1055\/s-2006-934097","article-title":"Do serum beta-human chorionic gonadotropin levels on day 4 following methotrexate treatment of patients with ectopic pregnancy predict successful single-dose therapy?","volume":"23","author":"Gabbur","year":"2006","journal-title":"Am J Perinatol"},{"issue":"6","key":"10.1016\/j.ejogrb.2017.02.007_bib0080","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.ajog.2010.03.022","article-title":"Are early human chorionic gonadotropin levels after methotrexate therapy a predictor of response in ectopic pregnancy?","volume":"202","author":"Nguyen","year":"2010","journal-title":"Am J Obstet Gynecol"},{"issue":"13","key":"10.1016\/j.ejogrb.2017.02.007_bib0085","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1111\/j.1471-0528.2011.03133.x","article-title":"Decline in betahCG levels between days 0 and 4 after a single dose of methotrexate for ectopic pregnancy predicts treatment success: a retrospective cohort study","volume":"118","author":"Skubisz","year":"2011","journal-title":"BJOG"},{"issue":"2","key":"10.1016\/j.ejogrb.2017.02.007_bib0090","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.fertnstert.2006.11.138","article-title":"Prognostic value of human chorionic gonadotropin changes after methotrexate injection for ectopic pregnancy","volume":"88","author":"Agostini","year":"2007","journal-title":"Fertil Steril"},{"issue":"3","key":"10.1016\/j.ejogrb.2017.02.007_bib0095","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1097\/01.AOG.0000198635.25135.e7","article-title":"Human chorionic gonadotropin profile for women with ectopic pregnancy","volume":"107","author":"Silva","year":"2006","journal-title":"Obstet Gynecol"},{"issue":"9","key":"10.1016\/j.ejogrb.2017.02.007_bib0100","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1093\/humrep\/del170","article-title":"Predictive factors of trophoblastic invasion into the ampullary region of the tubal wall in ectopic pregnancy","volume":"21","author":"Cabar","year":"2006","journal-title":"Hum Reprod"},{"issue":"4","key":"10.1016\/j.ejogrb.2017.02.007_bib0105","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/S0015-0282(02)04922-1","article-title":"Human chorionic gonadotropin level as a predictor of trophoblastic infiltration into the tubal wall in ectopic pregnancy: a blinded study","volume":"79","author":"Natale","year":"2003","journal-title":"Fertil Steril"},{"issue":"2","key":"10.1016\/j.ejogrb.2017.02.007_bib0110","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/humrep\/12.2.383","article-title":"Proliferative cell activity in correlation to human chorionic gonadotrophin release of trophoblast tissue of tubal pregnancy","volume":"12","author":"Kiss","year":"1997","journal-title":"Hum Reprod"},{"issue":"5","key":"10.1016\/j.ejogrb.2017.02.007_bib0115","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.fertnstert.2004.03.066","article-title":"Characterizing ectopic pregnancies that rupture despite treatment with methotrexate","volume":"82","author":"Dudley","year":"2004","journal-title":"Fertil Steril"},{"issue":"4","key":"10.1016\/j.ejogrb.2017.02.007_bib0120","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00404-008-0589-4","article-title":"Increment in beta-hCG in the 48-h period prior to treatment: a new variable predictive of therapeutic success in the treatment of ectopic pregnancy with methotrexate","volume":"278","author":"da Costa Soares","year":"2008","journal-title":"Arch Gynecol Obstet"}],"container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211517300799?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211517300799?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:39:15Z","timestamp":1759556355000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211517300799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":24,"alternative-id":["S0301211517300799"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2017.02.007","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of HCG increment in the 48h prior to methotrexate treatment as a predictor for treatment success","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2017.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}