{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:33:52Z","timestamp":1792784032284,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"University of Essen"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.ejogrb.2017.03.001","type":"journal-article","created":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T17:31:17Z","timestamp":1490203877000},"page":"150-154","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Follistatin during pregnancy and its potential role as an ovarian suppressing agent"],"prefix":"10.1016","volume":"212","author":[{"given":"Angela","family":"K\u00f6ninger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00f6rge","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Damaske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cahit","family":"Birdir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Enekwe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Kimmig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Strowitzki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Gellhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ejogrb.2017.03.001_bib0005","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1210\/mend.12.1.0053","article-title":"Overexpression of mouse follistatin causes reproductive defects in transgenic mice","volume":"12","author":"Guo","year":"1998","journal-title":"Mol Endocrinol"},{"issue":"5","key":"10.1016\/j.ejogrb.2017.03.001_bib0010","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1530\/REP-07-0208","article-title":"Follistatin serum concentrations during full-term labor in women\u2014significant differences between spontaneous and induced labor","volume":"134","author":"Rae","year":"2007","journal-title":"Reproduction"},{"issue":"23","key":"10.1016\/j.ejogrb.2017.03.001_bib0015","doi-asserted-by":"crossref","first-page":"8282","DOI":"10.1073\/pnas.84.23.8282","article-title":"Isolation and partial characterization of follistatin: a single-chain Mr 35,000 monomeric protein that inhibits the release of follicle-stimulating hormone","volume":"84","author":"Ueno","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"10.1016\/j.ejogrb.2017.03.001_bib0020","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1210\/endo-128-6-3313","article-title":"Follistatin binds to both activin and inhibin through the common subunit","volume":"128","author":"Shimonaka","year":"1991","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.ejogrb.2017.03.001_bib0025","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1210\/endo.131.5.1425435","article-title":"Interaction between activin and follicle-stimulating hormone-suppressing protein\/follistatin in the regulation of basal inhibin production by cultured rat granulosa cells","volume":"131","author":"Xiao","year":"1992","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.ejogrb.2017.03.001_bib0030","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1095\/biolreprod48.1.15","article-title":"An update on the roles of inhibin, activin, and follistatin as local regulators of folliculogenesis","volume":"48","author":"Findlay","year":"1993","journal-title":"Biol Reprod"},{"issue":"21","key":"10.1016\/j.ejogrb.2017.03.001_bib0035","doi-asserted-by":"crossref","first-page":"15579","DOI":"10.1016\/S0021-9258(18)82296-7","article-title":"Molecular heterogeneity of follistatin, an activin-binding protein. Higher affinity of the carboxyl-terminal truncated forms for heparan sulfate proteoglycans on the ovarian granulosa cell","volume":"268","author":"Sugino","year":"1993","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.ejogrb.2017.03.001_bib0040","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/0006-291X(87)90430-X","article-title":"The isolation of polypeptides with FSH suppressing activity from bovine follicular fluid which are structurally different to inhibin","volume":"149","author":"Robertson","year":"1987","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"10.1016\/j.ejogrb.2017.03.001_bib0045","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1507\/endocrj.43.375","article-title":"Immunohistochemical localization of activin A and follistatin in human tissues","volume":"43","author":"Wada","year":"1996","journal-title":"Endocr J"},{"issue":"7","key":"10.1016\/j.ejogrb.2017.03.001_bib0050","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/BF03347022","article-title":"Human placenta and fetal membranes express follistatin-related gene mRNA and protein","volume":"26","author":"Ciarmela","year":"2003","journal-title":"J Endocrinol Invest"},{"issue":"1","key":"10.1016\/j.ejogrb.2017.03.001_bib0055","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1677\/joe.0.1630099","article-title":"Concentrations of activin A, inhibin A, and follistatin in human amnion, choriodecidual and placental tissues at term and preterm","volume":"163","author":"Keelan","year":"1999","journal-title":"J Endocrinol"},{"key":"10.1016\/j.ejogrb.2017.03.001_bib0060","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1477-7827-11-60","article-title":"Anti-Mullerian-hormone levels during pregnancy and postpartum","volume":"11","author":"K\u00f6ninger","year":"2013","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.ejogrb.2017.03.001_bib0065","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s12958-015-0082-4","article-title":"Anti-Mullerian-hormone during pregnancy and peripartum using the new Beckman Coulter AMH Gen II Assay","volume":"13","author":"K\u00f6ninger","year":"2015","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.ejogrb.2017.03.001_bib0070","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/1477-7827-9-98","article-title":"Anti-Mullerian hormone levels decline under hormonal suppression: a prospective analysis in fertile women after delivery","volume":"9","author":"Weghofer","year":"2011","journal-title":"Reprod Biol Endocrinol"},{"issue":"7","key":"10.1016\/j.ejogrb.2017.03.001_bib0075","doi-asserted-by":"crossref","first-page":"e22024","DOI":"10.1371\/journal.pone.0022024","article-title":"A validated model of serum anti-mullerian hormone from conception to menopause","volume":"6","author":"Kelsey","year":"2011","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.ejogrb.2017.03.001_bib0080","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/humrep\/deg042","article-title":"Serum anti-Mullerian hormone is more strongly related to ovarian follicular status than serum inhibin B, estradiol, FSH and LH on day 3","volume":"18","author":"Fanchin","year":"2003","journal-title":"Hum Reprod"},{"issue":"2","key":"10.1016\/j.ejogrb.2017.03.001_bib0085","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0015-0282(01)02993-4","article-title":"Antimullerian hormone serum levels: a putative marker for ovarian aging","volume":"77","author":"de Vet","year":"2002","journal-title":"Fertil Steril"},{"issue":"5","key":"10.1016\/j.ejogrb.2017.03.001_bib0090","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1530\/rep.0.1240601","article-title":"Regulation of ovarian function: the role of anti-Mullerian hormone","volume":"124","author":"Durlinger","year":"2002","journal-title":"Reproduction"},{"issue":"2","key":"10.1016\/j.ejogrb.2017.03.001_bib0095","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/molehr\/gah015","article-title":"Anti-Mullerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment","volume":"10","author":"Weenen","year":"2004","journal-title":"Mol Hum Reprod"},{"issue":"11","key":"10.1016\/j.ejogrb.2017.03.001_bib0100","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.1210\/endo.142.11.8486","article-title":"Anti-Mullerian hormone attenuates the effects of FSH on follicle development in the mouse ovary","volume":"142","author":"Durlinger","year":"2001","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.ejogrb.2017.03.001_bib0105","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1530\/rep.1.01074","article-title":"TGF-beta superfamily members and ovarian follicle development","volume":"132","author":"Knight","year":"2006","journal-title":"Reproduction"},{"key":"10.1016\/j.ejogrb.2017.03.001_bib0110","series-title":"R: a language and environment for statistical computing","author":"R Core Team","year":"2014"},{"issue":"2","key":"10.1016\/j.ejogrb.2017.03.001_bib0115","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/cen.12715","article-title":"Longitudinal analysis of maternal serum Follistatin concentration in normal pregnancy and preeclampsia","volume":"83","author":"Garc\u00e9s","year":"2015","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"10","key":"10.1016\/j.ejogrb.2017.03.001_bib0120","first-page":"1337","article-title":"Synergistic effects of inhibins and mullerian-inhibiting substance on testicular tumorigenesis","volume":"9","author":"Matzuk","year":"1995","journal-title":"Mol Endocrinol"},{"issue":"1","key":"10.1016\/j.ejogrb.2017.03.001_bib0125","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0006-291X(87)91614-7","article-title":"Follistatin specifically inhibits pituitary follicle stimulating hormone release in vitro","volume":"149","author":"Ying","year":"1987","journal-title":"Biochem Biophys Res Commun"},{"issue":"4944","key":"10.1016\/j.ejogrb.2017.03.001_bib0130","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1126\/science.2106159","article-title":"Activin-binding protein from rat ovary is follistatin","volume":"247","author":"Nakamura","year":"1990","journal-title":"Science"},{"issue":"6402","key":"10.1016\/j.ejogrb.2017.03.001_bib0135","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/360313a0","article-title":"Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice","volume":"360","author":"Matzuk","year":"1992","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.ejogrb.2017.03.001_bib0140","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/hep.510240212","article-title":"Intravenous administration of follistatin: delivery to the liver and effect on liver regeneration after partial hepatectomy","volume":"24","author":"Kogure","year":"1996","journal-title":"Hepatology"},{"issue":"1\u20133","key":"10.1016\/j.ejogrb.2017.03.001_bib0145","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.anireprosci.2008.08.022","article-title":"Changes in concentrations of follistatin in maternal plasma and foetal fluids during pregnancy and parturition in sheep","volume":"114","author":"Xia","year":"2009","journal-title":"Anim Reprod Sci"},{"issue":"2","key":"10.1016\/j.ejogrb.2017.03.001_bib0150","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1124\/jpet.113.211169","article-title":"Follistatin: a novel therapeutic for the improvement of muscle regeneration","volume":"349","author":"Yaden","year":"2014","journal-title":"J Pharmacol Exp Ther"},{"issue":"8","key":"10.1016\/j.ejogrb.2017.03.001_bib0155","doi-asserted-by":"crossref","first-page":"e789","DOI":"10.1371\/journal.pone.0000789","article-title":"Quadrupling muscle mass in mice by targeting TGF-beta signaling pathways","volume":"2","author":"Lee","year":"2007","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.ejogrb.2017.03.001_bib0160","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/0021-9681(87)90113-5","article-title":"Factors influencing the age at natural menopause","volume":"40","author":"Stanford","year":"1987","journal-title":"J Chronic Dis"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211517301045?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211517301045?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:39:34Z","timestamp":1759556374000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211517301045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":32,"alternative-id":["S0301211517301045"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2017.03.001","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Follistatin during pregnancy and its potential role as an ovarian suppressing agent","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2017.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}