{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:30:23Z","timestamp":1765546223306,"version":"build-2065373602"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.ejogrb.2017.09.022","type":"journal-article","created":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T19:16:21Z","timestamp":1506107781000},"page":"113-118","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Association of Single Nucleotide Polymorphism -2548 G\/A (rs12112075) of leptin gene with endometrial cancer and uterine leiomyomas"],"prefix":"10.1016","volume":"218","author":[{"given":"Jan","family":"Bie\u0144kiewicz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Romanowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Malinowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beata","family":"Smolarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"January\u2013February (10)","key":"10.1016\/j.ejogrb.2017.09.022_bib0005","first-page":"10","article-title":"Cancer statistics, 2012","volume":"62","author":"Siegel","year":"2012","journal-title":"CA Cancer J Clin"},{"issue":"April (4)","key":"10.1016\/j.ejogrb.2017.09.022_bib0010","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2217\/epi.12.13","article-title":"Epigenetics and genetics in endometrial cancer: new carcinogenic mechanisms and relationship with clinical practice","volume":"2","author":"Banno","year":"2012","journal-title":"Epigenomics"},{"issue":"August (9484)","key":"10.1016\/j.ejogrb.2017.09.022_bib0015","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0140-6736(05)67063-8","article-title":"Endometrial cancer","volume":"366","author":"Amant","year":"2005","journal-title":"Lancet"},{"issue":"August (9945)","key":"10.1016\/j.ejogrb.2017.09.022_bib0020","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0140-6736(14)60892-8","article-title":"Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5\u00b724 million UK adults","volume":"384","author":"Bhaskaran","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.ejogrb.2017.09.022_bib0025","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/164_2015_6","article-title":"Adipokines and the endocrine role of adipose tissues","volume":"233","author":"Giralt","year":"2016","journal-title":"Handb Exp Pharmacol"},{"issue":"October (10)","key":"10.1016\/j.ejogrb.2017.09.022_bib0030","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nri1937","article-title":"Adipocytokines: mediators linking adipose tissue, inflammation and immunity","volume":"6","author":"Tilg","year":"2006","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"10.1016\/j.ejogrb.2017.09.022_bib0035","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1159\/000366352","article-title":"High leptin level is an independent risk factor of endometrial cancer: a meta-analysis","volume":"34","author":"Wang","year":"2014","journal-title":"Cell Physiol Biochem"},{"issue":"October (8)","key":"10.1016\/j.ejogrb.2017.09.022_bib0040","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1002\/ijc.29561","article-title":"Circulating adiponectin, leptin and adiponectin-leptin ratio and endometrial cancer risk: evidence from a meta-analysis of epidemiologic studies","volume":"137","author":"Gong","year":"2015","journal-title":"Int J Cancer"},{"issue":"October (4)","key":"10.1016\/j.ejogrb.2017.09.022_bib0045","doi-asserted-by":"crossref","first-page":"336","DOI":"10.3802\/jgo.2013.24.4.336","article-title":"Serum leptin, adiponectin and endometrial cancer risk in Chinese women","volume":"24","author":"Ma","year":"2013","journal-title":"J Gynecol Oncol"},{"issue":"February","key":"10.1016\/j.ejogrb.2017.09.022_bib0050","doi-asserted-by":"crossref","first-page":"10494","DOI":"10.1038\/ncomms10494","article-title":"Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels","volume":"7","author":"Kilpel\u00e4inen","year":"2016","journal-title":"Nat Commun"},{"issue":"June","key":"10.1016\/j.ejogrb.2017.09.022_bib0055","first-page":"2015","article-title":"Fibroids (uterine myomatosis, leiomyomas)","author":"Lethaby","year":"2015","journal-title":"BMJ Clin Evid"},{"issue":"January\u2013March (1)","key":"10.1016\/j.ejogrb.2017.09.022_bib0060","first-page":"22","article-title":"Uterine leiomyomas: an ENIGMA","volume":"7","author":"Geethamala","year":"2016","journal-title":"J Midlife Health"},{"issue":"June (3)","key":"10.1016\/j.ejogrb.2017.09.022_bib0065","first-page":"274","article-title":"Leiomyomas and genomics","volume":"68","author":"Siristatidis","year":"2016","journal-title":"Minerva Ginecol"},{"issue":"March (1)","key":"10.1016\/j.ejogrb.2017.09.022_bib0070","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S1028-4559(08)60103-5","article-title":"Serum leptin levels in women with uterine leiomyomas","volume":"46","author":"Dingiloglu","year":"2007","journal-title":"Taiwan J Obstet Gynecol"},{"issue":"February (2)","key":"10.1016\/j.ejogrb.2017.09.022_bib0075","first-page":"173","article-title":"Decreased serum leptin levels in women with uterine leiomyomas","volume":"82","author":"Chan","year":"2003","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"May (Pt 3)","key":"10.1016\/j.ejogrb.2017.09.022_bib0080","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1046\/j.1469-1809.1999.6330227.x","article-title":"Sequence variants in the 5' flanking region of the leptin gene are associated with obesity in women","volume":"63","author":"Li","year":"1999","journal-title":"Ann Hum Genet"},{"issue":"September (Pt 5)","key":"10.1016\/j.ejogrb.2017.09.022_bib0085","first-page":"391","article-title":"Association of the G-2548A polymorphism in the 5' region of the LEP gene with overweight","volume":"64","author":"Mamm\u00e8s","year":"2000","journal-title":"Ann Hum Genet"},{"issue":"May (7\u20138)","key":"10.1016\/j.ejogrb.2017.09.022_bib0090","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.clinbiochem.2008.11.001","article-title":"Association of G-2548A LEP polymorphism with plasma leptin levels in Tunisian obese patients","volume":"42","author":"Ben Ali","year":"2009","journal-title":"Clin Biochem"},{"issue":"8","key":"10.1016\/j.ejogrb.2017.09.022_bib0095","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s10654-006-9045-6","article-title":"Effect of genetic variation in the leptin gene promoter and the leptin receptor gene on obesity risk in a population-based case-control study in Spain","volume":"21","author":"Portol\u00e9s","year":"2006","journal-title":"Eur J Epidemiol"},{"issue":"October (4)","key":"10.1016\/j.ejogrb.2017.09.022_bib0100","first-page":"1035","article-title":"LEPR p. Q223R, beta3-AR p. W64R and LEP c.-2548G>A gene variants in obese Brazilian subjects","volume":"6","author":"Duarte","year":"2007","journal-title":"Genet Mol Res"},{"issue":"July (4)","key":"10.1016\/j.ejogrb.2017.09.022_bib0105","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1469-1809.2010.00586.x","article-title":"Influence of the leptin G-2548A polymorphism on leptin levels and anthropometric measurements in healthy Spanish adolescents","volume":"74","author":"Riestra","year":"2010","journal-title":"Ann Hum Genet"},{"key":"10.1016\/j.ejogrb.2017.09.022_bib0110","unstructured":"http:\/\/www.biobank.uni.lodz.pl\/index.php?lang=en."},{"issue":"January (1)","key":"10.1016\/j.ejogrb.2017.09.022_bib0115","first-page":"448","article-title":"Genetic association between leptin-2548G\/A polymorphism and risk of cancer: a meta analysis","volume":"8","author":"Liu","year":"2015","journal-title":"Int J Clin Exp Med"},{"issue":"5","key":"10.1016\/j.ejogrb.2017.09.022_bib0120","first-page":"223","article-title":"Leptin -2548\u2009g\/A polymorphism in endometrial cancer","volume":"22","author":"Chovanec","year":"2009","journal-title":"Klin Onkol"},{"issue":"2","key":"10.1016\/j.ejogrb.2017.09.022_bib0125","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1159\/000363392","article-title":"Association of leptin gene-2548 G\/A polymorphism with obesity: a meta-analysis","volume":"64","author":"Zhang","year":"2014","journal-title":"Ann Nutr Metab"},{"issue":"December (12)","key":"10.1016\/j.ejogrb.2017.09.022_bib0130","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1002\/ijc.23887","article-title":"Leptin regulation of proangiogenic molecules in benign and cancerous endometrial cells","volume":"123","author":"Carino","year":"2008","journal-title":"Int J Cancer"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211517304578?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211517304578?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:40:01Z","timestamp":1759556401000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211517304578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":26,"alternative-id":["S0301211517304578"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2017.09.022","relation":{},"ISSN":["0301-2115"],"issn-type":[{"type":"print","value":"0301-2115"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of Single Nucleotide Polymorphism -2548 G\/A (rs12112075) of leptin gene with endometrial cancer and uterine leiomyomas","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2017.09.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}