{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:59:24Z","timestamp":1791939564705,"version":"4.3.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.ejogrb.2017.10.024","type":"journal-article","created":{"date-parts":[[2017,11,4]],"date-time":"2017-11-04T18:15:34Z","timestamp":1509819334000},"page":"122-131","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Prediction of miscarriage in women with viable intrauterine pregnancy\u2014A systematic review and diagnostic accuracy meta-analysis"],"prefix":"10.1016","volume":"220","author":[{"given":"Rekha N.","family":"Pillai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin C.","family":"Konje","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas G.","family":"Tincello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelam","family":"Potdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.ejogrb.2017.10.024_bib0005","first-page":"827","article-title":"Spontaneous fetal loss after demonstration of a live fetus in the first trimester","volume":"70","author":"Cashner","year":"1987","journal-title":"Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.ejogrb.2017.10.024_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-2007-999640","article-title":"Rate of spontaneous abortion after first trimester sonographic demonstration of fetal cardiac activity","volume":"5","author":"Siddiqi","year":"1988","journal-title":"Am J Perinatol"},{"issue":"1","key":"10.1016\/j.ejogrb.2017.10.024_bib0015","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ejogrb.2007.06.023","article-title":"Yolk sac size and embryonic heart rate as prognostic factors of first trimester pregnancy outcome","volume":"138","author":"Varelas","year":"2008","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"1","key":"10.1016\/j.ejogrb.2017.10.024_bib0020","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/ajo.12046","article-title":"A prediction model for viability at the end of the first trimester after a single early pregnancy evaluation","volume":"53","author":"Oates","year":"2013","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"10.1016\/j.ejogrb.2017.10.024_bib0025","doi-asserted-by":"crossref","first-page":"529","DOI":"10.7326\/0003-4819-155-8-201110180-00009","article-title":"QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies","volume":"155","author":"Whiting","year":"2011","journal-title":"Ann Intern Med"},{"issue":"2","key":"10.1016\/j.ejogrb.2017.10.024_bib0030","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/biostatistics\/kxl004","article-title":"A unification of models for meta-analysis of diagnostic accuracy studies","volume":"8","author":"Harbord","year":"2007","journal-title":"Biostatistics"},{"issue":"19","key":"10.1016\/j.ejogrb.2017.10.024_bib0035","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1002\/sim.942","article-title":"A hierarchical regression approach to meta-analysis of diagnostic test accuracy evaluations","volume":"20","author":"Rutter","year":"2001","journal-title":"Stat Med"},{"issue":"4","key":"10.1016\/j.ejogrb.2017.10.024_bib0040","doi-asserted-by":"crossref","first-page":"264","DOI":"10.7326\/0003-4819-151-4-200908180-00135","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"151","author":"Moher","year":"2009","journal-title":"Ann Intern Med"},{"issue":"3","key":"10.1016\/j.ejogrb.2017.10.024_bib0045","first-page":"330","article-title":"Heart rate as a predictor of first-trimester spontaneous abortion after ultrasound-proven viability","volume":"78","author":"Achiron","year":"1991","journal-title":"Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.ejogrb.2017.10.024_bib0050","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1447-0756.2008.00927.x","article-title":"The assessment of the gestational sac diameter, crown\u2013rump length, progesterone and fetal heart rate measurements at the 10th gestational week to predict the spontaneous abortion risk","volume":"35","author":"Altay","year":"2009","journal-title":"J Obstet Gynaecol Res"},{"issue":"7","key":"10.1016\/j.ejogrb.2017.10.024_bib0055","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1093\/humrep\/15.7.1629","article-title":"Is trophoblastic thickness at the embryonic implantation site a new sign of negative evolution in first trimester pregnancy?","volume":"15","author":"Bajo","year":"2000","journal-title":"Hum Reprod"},{"issue":"1","key":"10.1016\/j.ejogrb.2017.10.024_bib0060","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2214\/ajr.175.1.1750067","article-title":"Outcome of pregnancies with rapid embryonic heart rates in the early first trimester","volume":"175","author":"Doubilet","year":"2000","journal-title":"Am J Roentgenol"},{"issue":"1","key":"10.1016\/j.ejogrb.2017.10.024_bib0065","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3346\/jkms.1992.7.1.34","article-title":"Predictable ultrasonographic findings of early abortion","volume":"7","author":"Jun","year":"1992","journal-title":"J Korean Med Sci"},{"issue":"7","key":"10.1016\/j.ejogrb.2017.10.024_bib0070","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/jcu.21957","article-title":"Prediction of abortion using three-dimensional ultrasound volumetry of the gestational sac and the amniotic sac in threatened abortion","volume":"40","author":"Odeh","year":"2012","journal-title":"J Clin Ultrasound"},{"issue":"6","key":"10.1016\/j.ejogrb.2017.10.024_bib0075","first-page":"459","article-title":"Predicting first-trimester spontaneous abortion: ratio of mean sac diameter to crown-rump length compared to embryonic heart rate","volume":"39","author":"Tadmor","year":"1994","journal-title":"J Reprod Med"},{"issue":"10","key":"10.1016\/j.ejogrb.2017.10.024_bib0080","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1111\/j.1471-0528.2008.01833.x","article-title":"Evidence of early first-trimester growth restriction in pregnancies that subsequently end in miscarriage","volume":"115","author":"Mukri","year":"2008","journal-title":"BJOG"},{"key":"10.1016\/j.ejogrb.2017.10.024_bib0085","series-title":"Definitions and indicators in family planning maternal & child health and reproductive health used in the WHO regional office for Europe","author":"World Health Organization","year":"2000"},{"issue":"1","key":"10.1016\/j.ejogrb.2017.10.024_bib0090","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.fertnstert.2003.12.026","article-title":"Slow fetal heart rate may predict pregnancy outcome in first-trimester threatened abortion","volume":"82","author":"Chittacharoen","year":"2004","journal-title":"Fertil Steril"},{"issue":"6","key":"10.1016\/j.ejogrb.2017.10.024_bib0095","doi-asserted-by":"crossref","first-page":"622","DOI":"10.3109\/01443615.2010.489164","article-title":"Fetal loss in threatened abortion after demonstration of fetal cardiac activity in a low socioeconomic population","volume":"30","author":"Dede","year":"2010","journal-title":"J Obstet Gynaecol"},{"issue":"1","key":"10.1016\/j.ejogrb.2017.10.024_bib0100","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.mefs.2014.04.006","article-title":"Prediction of spontaneous miscarriage risk by the use of first trimester ultrasound measurements and maternal serum progesterone level at the 7th week of pregnancy","volume":"20","author":"El-Mekkawi","year":"2015","journal-title":"Middle East Fertil Soc J"},{"issue":"3","key":"10.1016\/j.ejogrb.2017.10.024_bib0105","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1046\/j.1469-0705.1996.07030165.x","article-title":"Sonography of pregnancies with first-trimester bleeding and a viable embryo: a study of prognostic indicators by logistic regression analysis","volume":"7","author":"Falco","year":"1996","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"10","key":"10.1016\/j.ejogrb.2017.10.024_bib0110","doi-asserted-by":"crossref","first-page":"561","DOI":"10.7863\/jum.1989.8.10.561","article-title":"First trimester bradycardia: a sign of impending fetal loss","volume":"8","author":"Laboda","year":"1989","journal-title":"J Ultrasound Med"},{"issue":"3","key":"10.1016\/j.ejogrb.2017.10.024_bib0115","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.mefs.2013.04.001","article-title":"Biochemical and ultrasonographic predictors of outcome in threatened abortion","volume":"18","author":"Maged","year":"2013","journal-title":"Middle East Fertil Soc J"},{"issue":"5","key":"10.1016\/j.ejogrb.2017.10.024_bib0120","first-page":"529","article-title":"Combined maternal serum inhibin A and embryonic\/fetal heart rate for the prediction of pregnancy outcome in a first-trimester threatened abortion","volume":"94","author":"Phupong","year":"2011","journal-title":"J Med Assoc Thai"},{"issue":"6","key":"10.1016\/j.ejogrb.2017.10.024_bib0125","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/S0029-7844(97)00096-3","article-title":"The predictive value of first-trimester embryonic heart rates in infertility patients","volume":"89","author":"Qasim","year":"1997","journal-title":"Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.ejogrb.2017.10.024_bib0130","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/(SICI)1097-0096(199801)26:1<33::AID-JCU7>3.0.CO;2-K","article-title":"Embryonic heart rate in early pregnancy","volume":"26","author":"Stefos","year":"1998","journal-title":"J Clin Ultrasound"},{"issue":"1","key":"10.1016\/j.ejogrb.2017.10.024_bib0135","first-page":"11","article-title":"Predictive value of earl embryonic cardiac activity for pregnancy outcome","volume":"165","author":"Merchiers","year":"1991","journal-title":"Obstet Gynecol"},{"issue":"10","key":"10.1016\/j.ejogrb.2017.10.024_bib0140","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1111\/jog.12082","article-title":"Can a smaller than expected crown\u2013rump length reliably predict the occurrence of subsequent miscarriage in a viable first trimester pregnancy?","volume":"39","author":"Abuelghar","year":"2013","journal-title":"J Obstet Gynaecol Res"},{"issue":"6","key":"10.1016\/j.ejogrb.2017.10.024_bib0145","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1046\/j.1469-0705.2001.00370.x","article-title":"The significance of crown-rump length measurement for predicting adverse pregnancy outcome of threatened abortion","volume":"17","author":"Reljic","year":"2001","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.ejogrb.2017.10.024_bib0150","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0015-0282(99)00486-0","article-title":"Uteroplacental circulation in patients with first-trimester threatened abortion","volume":"73","author":"Alc\u00e1zar","year":"2000","journal-title":"Fertil Steril"},{"issue":"2","key":"10.1016\/j.ejogrb.2017.10.024_bib0155","first-page":"231","article-title":"Long-term prognosis of pregnancies in women with intrauterine hematomas","volume":"74","author":"Borlum","year":"1989","journal-title":"Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.ejogrb.2017.10.024_bib0160","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/(SICI)1097-0096(199601)24:1<3::AID-JCU1>3.0.CO;2-N","article-title":"Transvaginal sonography of the yolk sac in normal and abnormal pregnancy","volume":"24","author":"Stampone","year":"1996","journal-title":"J Clin Ultrasound"},{"issue":"1","key":"10.1016\/j.ejogrb.2017.10.024_bib0165","doi-asserted-by":"crossref","first-page":"15","DOI":"10.11152\/mu.2014.2066.161.st1gt2","article-title":"Abnormal sonographic appearances of the yolk sac: which can be associated with adverse perinatal outcome?","volume":"16","author":"Tan","year":"2014","journal-title":"Med Ultrasonogr"},{"issue":"1","key":"10.1016\/j.ejogrb.2017.10.024_bib0170","doi-asserted-by":"crossref","first-page":"31","DOI":"10.7863\/jum.2011.30.1.31","article-title":"Irregular yolk sac shape: is it really associated with an increased risk of spontaneous abortion?","volume":"30","author":"Tan","year":"2011","journal-title":"J Ultrasound Med"},{"issue":"3","key":"10.1016\/j.ejogrb.2017.10.024_bib0175","first-page":"483","article-title":"Obstetric outcome after threatened miscarriage with and without a hematoma on ultrasound","volume":"102","author":"Johns","year":"2003","journal-title":"Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.ejogrb.2017.10.024_bib0180","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1471-0528.1990.tb01720.x","article-title":"Large intrauterine haematomata in threatened miscarriage: frequency and clinical consequences","volume":"97","author":"Pedersen","year":"1990","journal-title":"BJOG"},{"issue":"4","key":"10.1016\/j.ejogrb.2017.10.024_bib0185","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.bpobgyn.2009.01.011","article-title":"Dating and growth in the first trimester","volume":"23","author":"Bottomley","year":"2009","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"3","key":"10.1016\/j.ejogrb.2017.10.024_bib0190","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/01443610500060677","article-title":"The value of the secondary yolk sac in predicting pregnancy outcome","volume":"25","author":"Chama","year":"2005","journal-title":"J Obstet Gynaecol"}],"container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211517304955?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211517304955?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:41:51Z","timestamp":1759556511000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211517304955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":38,"alternative-id":["S0301211517304955"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2017.10.024","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prediction of miscarriage in women with viable intrauterine pregnancy\u2014A systematic review and diagnostic accuracy meta-analysis","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2017.10.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2017 Published by Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}