{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T13:27:11Z","timestamp":1770730031380,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.ejogrb.2018.04.031","type":"journal-article","created":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T22:33:08Z","timestamp":1524609188000},"page":"221-227","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Serum betatrophin\/angiopoietin-like protein 8 (ANGPTL8) levels in pregnancies affected by hyperemesis gravidarum"],"prefix":"10.1016","volume":"225","author":[{"given":"Burcu","family":"Timur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serap F\u0131rt\u0131na","family":"Tuncer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serkan","family":"Bodur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakan","family":"Timur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5739-5689","authenticated-orcid":false,"given":"Aytekin","family":"Tokmak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Funda","family":"Gucel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Metin","family":"Altay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2018.04.031_bib0005","doi-asserted-by":"crossref","first-page":"d3606","DOI":"10.1136\/bmj.d3606","article-title":"Management of nausea and vomiting in pregnancy","volume":"342","author":"Jarvis","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0010","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1172\/JCI109108","article-title":"Insulin binding to monocytes and insulin action in human obesity, starvation, and refeeding","volume":"62","author":"DeFronzo","year":"1978","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0015","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/1056-8727(94)00077-8","article-title":"Starvation diet and very-low-calorie diets may induce insulin resistance and overt diabetes mellitus","volume":"10","author":"Koffler","year":"1996","journal-title":"J Diabet Complicat"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0020","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/ajcn\/47.2.239","article-title":"Glucagon secretion in anorexia nervosa","volume":"47","author":"Kumai","year":"1988","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0025","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/0002-9378(90)91306-W","article-title":"Insulin sensitivity and B-cell responsiveness to glucose during late pregnancy in lean and moderately obese women with normal glucose tolerance or mild gestational diabetes","volume":"162","author":"Buchanan","year":"1990","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0030","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ijgo.2015.06.061","article-title":"Effect of hyperemesis gravidarum on gestational diabetes mellitus screening","volume":"132","author":"Ohara","year":"2016","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0035","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.bbrc.2012.07.038","article-title":"Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels","volume":"424","author":"Zhang","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0040","doi-asserted-by":"crossref","first-page":"E334","DOI":"10.1152\/ajpendo.00084.2012","article-title":"Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism","volume":"303","author":"Ren","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0045","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/ijc.20363","article-title":"Identification of genes differentially expressed in human hepatocellular carcinoma by a modified suppression subtractive hybridization method","volume":"112","author":"Dong","year":"2004","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0050","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s12933-014-0133-8","article-title":"A dual role of lipasin (betatrophin) in lipid metabolism and glucose homeostasis: consensus and controversy","volume":"13","author":"Zhang","year":"2014","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0055","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.cell.2013.04.008","article-title":"Betatrophin: a hormone that controls pancreatic beta cell proliferation","volume":"153","author":"Yi","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0060","doi-asserted-by":"crossref","first-page":"E2510","DOI":"10.1210\/jc.2013-4349","article-title":"Circulating angiopoietin like protein 8 is independently associated with fasting plasma glucose and type 2 diabetes mellitus","volume":"99","author":"Ebert","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0065","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1507\/endocrj.EJ14-0525","article-title":"Circulating betatrophin is elevated in patients with type 1 and type 2 diabetes","volume":"62","author":"Yamada","year":"2015","journal-title":"Endocr J"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0070","doi-asserted-by":"crossref","first-page":"652","DOI":"10.3109\/09513590.2015.1056142","article-title":"Evaluation of circulating betatrophin levels in gestational diabetes mellitus","volume":"31","author":"Erol","year":"2015","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/EJE-14-0815","article-title":"Betatrophin levels are increased in women with gestational diabetes mellitus compared to healthy pregnant controls","volume":"173","author":"Ebert","year":"2015","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0080","doi-asserted-by":"crossref","first-page":"e136701","DOI":"10.1371\/journal.pone.0136701","article-title":"Circulating betatrophin is strongly increased in pregnancy and gestational diabetes mellitus","volume":"10","author":"Trebotic","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0085","doi-asserted-by":"crossref","first-page":"e131171","DOI":"10.1371\/journal.pone.0131171","article-title":"Increased maternal and cord blood betatrophin in gestational diabetes","volume":"10","author":"Wawrusiewicz-Kurylonek","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0090","first-page":"1070","article-title":"Changes and clinical significance of Betatrophin level in plasma and cord blood in pregnant women with gestational diabetes mellitus","volume":"7","author":"Wang","year":"2016","journal-title":"Hainan Med J"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0095","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1055\/s-0036-1584566","article-title":"Betatrophin levels were increased in pregnant women with or without gestational diabetes mellitus and associated with beta cell function","volume":"38","author":"Huang","year":"2016","journal-title":"Rev Bras Ginecol Obstet"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0100","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1080\/14767058.2016.1192118","article-title":"WISP1 is a novel adipokine linked to metabolic parameters in gestational diabetes mellitus","volume":"30","author":"Sahin","year":"2017","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0105","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.diabet.2016.07.029","article-title":"Levels of betatrophin decrease during pregnancy despite increased insulin resistance, beta-cell function and triglyceride levels","volume":"42","author":"Zielinska","year":"2016","journal-title":"Diabetes Metab"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0110","doi-asserted-by":"crossref","first-page":"16109","DOI":"10.1073\/pnas.1315292110","article-title":"Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis","volume":"110","author":"Wang","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0115","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.cell.2014.09.027","article-title":"ANGPTL8\/betatrophin does not control pancreatic beta cell expansion","volume":"159","author":"Gusarova","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0120","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.2337\/db13-1435","article-title":"Elevated mouse hepatic betatrophin expression does not increase human beta-cell replication in the transplant setting","volume":"63","author":"Jiao","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0125","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.cmet.2014.11.016","article-title":"Betatrophin-promises fading and lessons learned","volume":"20","author":"Kaestner","year":"2014","journal-title":"Cell Metab"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0130","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.2337\/db14-0009","article-title":"Betatrophin versus bitter-trophin and the elephant in the room: time for a new normal in beta-cell regeneration research","volume":"63","author":"Stewart","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0135","first-page":"1584","article-title":"Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans","volume":"80","author":"Zhou","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0140","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.clnu.2005.08.008","article-title":"Effects of acute starvation on insulin resistance in obese patients with and without type 2 diabetesmellitus","volume":"24","author":"Duska","year":"2005","journal-title":"Clin Nutr"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0145","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0168-8227(89)90047-8","article-title":"Effects of very-low-calorie diet weight reduction on glucose tolerance, insulin secretion, and insulin resistance in obese non-insulin-dependent diabetics","volume":"7","author":"Fukuda","year":"1989","journal-title":"Diabetes Res Clin Pract"},{"issue":"Suppl. 1","key":"10.1016\/j.ejogrb.2018.04.031_bib0150","first-page":"11","article-title":"Glucose phosphorylating activities in the islets of Langerhans of the rat. Effect of fasting","volume":"16","author":"Bedoya","year":"1984","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0155","doi-asserted-by":"crossref","first-page":"E1188","DOI":"10.1210\/JC.2015-1595","article-title":"Circulating betatrophin levels are increased in anorexia and decreased in morbidly obese women","volume":"100","author":"Barja-Fern\u00e1ndez","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0160","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1007\/s00125-014-3208-x","article-title":"Circulating betatrophin correlates with atherogenic lipid profiles but not with glucose and insulin levels in insulin-resistant individuals","volume":"57","author":"Fenzl","year":"2014","journal-title":"Diabetologia"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0165","doi-asserted-by":"crossref","first-page":"19751","DOI":"10.1073\/pnas.1217552109","article-title":"Atypical angiopoietin-like protein that regulates angptl3","volume":"109","author":"Quagliarini","year":"2012","journal-title":"PNAS"},{"issue":"April (4)","key":"10.1016\/j.ejogrb.2018.04.031_bib0170","doi-asserted-by":"crossref","first-page":"150272","DOI":"10.1098\/rsob.150272","article-title":"The ANGPTL3-4-8 model, a molecular mechanism for triglyceride trafficking","volume":"6","author":"Zhang","year":"2016","journal-title":"Open Biol"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0175","first-page":"QC12","article-title":"Evaluation of lipid profile in second and third trimester of pregnancy","volume":"10","author":"Pusukuru","year":"2016","journal-title":"J Clin Diagn Res"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0180","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.metabol.2015.06.015","article-title":"Influence of thyroid dysfunction on serum levels of angiopoietin-like protein 6","volume":"64","author":"Lim","year":"2015","journal-title":"Metabolism"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0185","doi-asserted-by":"crossref","first-page":"11553","DOI":"10.1074\/jbc.M512554200","article-title":"The lipoprotein lipase inhibitor ANGPTL3 is negatively regulated by thyroid hormone","volume":"281","author":"Fugier","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ejogrb.2018.04.031_bib0190","doi-asserted-by":"crossref","first-page":"e0173197","DOI":"10.1371\/journal.pone.0173197","article-title":"Renal function is independently associated with circulating betatrophin","volume":"12","author":"Maurer","year":"2017","journal-title":"PLoS One"}],"container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211518302033?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211518302033?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T16:52:51Z","timestamp":1770655971000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211518302033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":38,"alternative-id":["S0301211518302033"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2018.04.031","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum betatrophin\/angiopoietin-like protein 8 (ANGPTL8) levels in pregnancies affected by hyperemesis gravidarum","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2018.04.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}