{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T12:16:39Z","timestamp":1770725799774,"version":"3.49.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.ejogrb.2018.04.037","type":"journal-article","created":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T14:45:35Z","timestamp":1525099535000},"page":"189-193","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Association between early \u03b2hCG kinetics, blastocyst morphology and pregnancy outcome in a single-blastocyst transfer program"],"prefix":"10.1016","volume":"225","author":[{"given":"Jean-Maxime","family":"Girard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathilde","family":"Simorre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Leperlier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9290-7579","authenticated-orcid":false,"given":"Arnaud","family":"Reignier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6440-2928","authenticated-orcid":false,"given":"Tiphaine","family":"Lefebvre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Barri\u00e8re","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7243-7709","authenticated-orcid":false,"given":"Thomas","family":"Fr\u00e9our","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2018.04.037_bib0005","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1007\/s10815-016-0744-y","article-title":"Serum hCG-\u03b2 levels of postovulatory day 12 and 14 with the sequential application of hCG-\u03b2 fold change significantly increased predictability of pregnancy outcome after IVF-ET cycle","volume":"33","author":"Sung","year":"2016","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.ejogrb.2018.04.037_bib0010","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ejogrb.2005.12.023","article-title":"Optimizing hCG cut-off values: a single determination on day 14 or 15 is sufficient for a reliable prediction of pregnancy outcome","volume":"127","author":"Lambers","year":"2006","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ejogrb.2018.04.037_bib0015","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1093\/humrep\/dei389","article-title":"Defining the rise of serum HCG in viable pregnancies achieved through use of IVF","volume":"21","author":"Chung","year":"2006","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ejogrb.2018.04.037_bib0020","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.3109\/00016340903322743","article-title":"Predictive value of early serum beta-hCG levels after single blastocyst transfer","volume":"88","author":"Ochsenk\u00fchn","year":"2009","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ejogrb.2018.04.037_bib0025","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1016\/j.fertnstert.2015.02.028","article-title":"Predictive value of maternal serum human chorionic gonadotropin levels in pregnancies achieved by in vitro fertilization with single cleavage and single blastocyst embryo transfers","volume":"103","author":"Oron","year":"2015","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2018.04.037_bib0030","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.rbmo.2013.07.006","article-title":"Association between blastocyst morphology and outcome of single-blastocyst transfer","volume":"27","author":"Van den Abbeel","year":"2013","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.ejogrb.2018.04.037_bib0035","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1093\/humrep\/der325","article-title":"Trophectoderm morphology: an important parameter for predicting live birth after single blastocyst transfer","volume":"26","author":"Ahlstr\u00f6m","year":"2011","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ejogrb.2018.04.037_bib0040","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.rbmo.2017.05.011","article-title":"Predictive value of serum HCG concentrations in pregnancies achieved after single fresh or vitrified-warmed blastocyst transfer","volume":"35","author":"Oron","year":"2017","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.ejogrb.2018.04.037_bib0045","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/S0015-0282(99)00311-8","article-title":"Blastocyst culture and transfer: analysis of results and parameters affecting outcome in two in vitro fertilization programs","volume":"72","author":"Schoolcraft","year":"1999","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2018.04.037_bib0050","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0002-9378(87)80349-6","article-title":"Observations on the log human chorionic gonadotropin-time relationship in early pregnancy and its practical implications","volume":"157","author":"Kadar","year":"1987","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2018.04.037_bib0055","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1479-828X.1984.tb01491.x","article-title":"Monitoring early production of chorionic gonadotrophin (HCG) following in vitro fertilization and embryo transfer","volume":"24","author":"Hay","year":"1984","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"10.1016\/j.ejogrb.2018.04.037_bib0060","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.fertnstert.2006.04.048","article-title":"The rate at which serum total \u03b2-subunit human chorionic gonadotropin increases after embryo transfer is a predictor of the viability of pregnancy and an identifier of determinants of pregnancy","volume":"86","author":"Stone","year":"2006","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2018.04.037_bib0065","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/s10815-014-0273-5","article-title":"Maternal age and initial \u03b2-hCG levels predict pregnancy outcome after single vitrified-warmed blastocyst transfer","volume":"31","author":"UenoS","year":"2014","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.ejogrb.2018.04.037_bib0070","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.rbmo.2016.04.014","article-title":"Higher \u03b2-HCG concentrations and higher birthweights ensue from single vitrified embryo transfers","volume":"33","author":"Keane","year":"2016","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.ejogrb.2018.04.037_bib0075","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S1001-7844(07)60026-1","article-title":"Serum beta-hCG of 11 days after embryo transfer to predict pregnancy outcome","volume":"18","author":"Huang","year":"2007","journal-title":"J Reprod Contracept"},{"key":"10.1016\/j.ejogrb.2018.04.037_bib0080","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/S0015-0282(01)02840-0","article-title":"Human chorionic gonadotropin levels after blastocyst transfer are highly predictive of pregnancy outcome","volume":"76","author":"Papageorgiou","year":"2001","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2018.04.037_bib0085","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.fertnstert.2011.09.042","article-title":"Prognostic value of beta-human chorionic gonadotropin is dependent on day of embryo transfer during in vitro fertilization","volume":"96","author":"Kathiresan","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2018.04.037_bib0090","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0015-0282(99)00512-9","article-title":"Human chorionic gonadotropin as a predictor of outcome in assisted reproductive technology pregnancies","volume":"73","author":"Homan","year":"2000","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2018.04.037_bib0095","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/S0015-0282(02)03278-8","article-title":"Serum human chorionic gonadotropin measurements may predict pregnancy outcome and multiple gestation after in vitro fertilization","volume":"78","author":"Urbancsek","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2018.04.037_bib0100","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.rbmo.2012.05.015","article-title":"Serum HCG measured in the peri-implantation period predicts IVF cycle outcomes","volume":"25","author":"Shapiro","year":"2012","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.ejogrb.2018.04.037_bib0105","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1093\/humrep\/17.7.1901","article-title":"Serum HCG 12 days after embryo transfer in predicting pregnancy outcome","volume":"17","author":"Poikkeus","year":"2002","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ejogrb.2018.04.037_bib0110","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.fertnstert.2011.05.071","article-title":"Serum beta human chorionic gonadotropin levels can inform outcome counseling after in vitro fertilization","volume":"96","author":"Lawler","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2018.04.037_bib0115","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.fertnstert.2015.07.1133","article-title":"Successful treatment algorithm for evaluation of early pregnancy after in vitro fertilization","volume":"104","author":"Cookingham","year":"2015","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2018.04.037_bib0120","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.fertnstert.2016.08.009","article-title":"Ratio between inner cell mass diameter and blastocyst diameter is correlated with successful pregnancy outcomes of single blastocyst transfers","volume":"106","author":"Almagor","year":"2016","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2018.04.037_bib0125","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.fertnstert.2016.11.012","article-title":"Morphologic grading of euploid blastocysts influences implantation and ongoing pregnancy rates","volume":"107","author":"Irani","year":"2017","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2018.04.037_bib0130","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1093\/humrep\/det366","article-title":"Inter- and intra-observer variability of time-lapse annotations","volume":"28","author":"Sundvall","year":"2013","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ejogrb.2018.04.037_bib0135","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.fertnstert.2016.11.014","article-title":"Examining the efficacy of six published time-lapse imaging embryo selection algorithms to predict implantation to demonstrate the need for the development of specific, in-house morphokinetic selection algorithms","volume":"107","author":"Barrie","year":"2017","journal-title":"Fertil Steril"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211518302112?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211518302112?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T16:52:37Z","timestamp":1770655957000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211518302112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":27,"alternative-id":["S0301211518302112"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2018.04.037","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between early \u03b2hCG kinetics, blastocyst morphology and pregnancy outcome in a single-blastocyst transfer program","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2018.04.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}