{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:32:18Z","timestamp":1787956338858,"version":"build-2784847793"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.ejogrb.2018.08.008","type":"journal-article","created":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T12:25:57Z","timestamp":1533558357000},"page":"45-56","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Efficacy of vaginal therapies alternative to vaginal estrogens on sexual function and orgasm of menopausal women: A systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.1016","volume":"229","author":[{"given":"Eleni","family":"Pitsouni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Themos","family":"Grigoriadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Douskos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Kyriakidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew E.","family":"Falagas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavros","family":"Athanasiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2018.08.008_bib0005","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.maturitas.2016.09.013","article-title":"Female sexual dysfunction (FSD): prevalence and impact on quality of life (QoL)","volume":"94","author":"Nappi","year":"2016","journal-title":"Maturitas"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0010","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jsxm.2015.12.019","article-title":"Definitions of Sexual Dysfunctions in women and men: a consensus statement from the fourth international consultation on sexual medicine 2015","volume":"13","author":"Mc Cabe","year":"2016","journal-title":"J Sex Med"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0015","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1111\/j.1743-6109.2011.02395.x","article-title":"Questionnaires for assessment of female sexual dysfunction: a review and proposal for a standardized screener","volume":"8","author":"Giraldi","year":"2011","journal-title":"J Sex Med"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0020","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jsxm.2015.12.015","article-title":"Risk factors for sexual dysfunction amng women and men: a consensus statement from the fourth international consultation on sexual medicine 2015","volume":"13","author":"McCabe","year":"2016","journal-title":"J Sex Med"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0025","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1097\/gme.0b013e31815a5168","article-title":"Vulvovaginal atrophy is strongly associated with female sexual dysfunction among sexually active postmenopausal women","volume":"15","author":"Levine","year":"2008","journal-title":"Menopause"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0030","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1097\/GME.0000000000000329","volume":"21","author":"Portman","year":"2014","journal-title":"Menopause"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0035","first-page":"281","article-title":"Sexual dysfunction in women: a practical approach","volume":"92","author":"Faubion","year":"2015","journal-title":"Am Fam Phys"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0040","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3109\/13697137.2010.522875","article-title":"Recommendations for the management of postmenopausal vaginal atrophy","volume":"13","author":"Sturdee","year":"2010","journal-title":"Climacteric"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0045","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1097\/gme.0b013e3181a95581","article-title":"Efficacy and tolerability of local estrogen therapy for urogenital atrophy","volume":"17","author":"Archer","year":"2010","journal-title":"Menopause"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0050","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1097\/GME.0b013e3182a122c2","article-title":"Management of symptomatic vulvovaginal atrophy: 2013 statement of the North American Menopause Society","volume":"20","author":"Position Statement","year":"2013","journal-title":"Menopause"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0055","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jsxm.2015.11.015","article-title":"Role of estrogens and estrogen-like compounds in female sexual function and dysfunction","volume":"13","author":"Santoro","year":"2016","journal-title":"J Sex Med"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0060","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.ajog.2016.07.045","article-title":"Genitourinary syndrome of menopause: an overview of clinical manifestations, pathophysiology, etiology, evaluation and management","volume":"215","author":"Gandhi","year":"2016","journal-title":"AJOG"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0065","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1089\/jwh.2010.2151","article-title":"Identifying and treating sexual dysfunction in postmenopausal women: the role of estrogen","volume":"20","author":"Simon","year":"2011","journal-title":"J Womens Health (Larcmt)"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0070","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4137\/CMRH.S14498","article-title":"Management of vaginal atrophy: implications from the REVIVE survey","volume":"8","author":"Wysocki","year":"2014","journal-title":"Clin Med Insights Reprod Health"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0075","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1097\/GME.0000000000000428","article-title":"VVA Prasterone Group. Treatment of pain at sexual activity (dyspareunia) with intravaginal dehydroepiandrosterone (prasterone)","volume":"22","author":"Archer","year":"2015","journal-title":"Menopause"},{"issue":"262","key":"10.1016\/j.ejogrb.2018.08.008_bib0080","article-title":"Use of phytoestrogens and effects perceived by postmenopausal women: result of a questionnaire-based survey","volume":"14","author":"Girardi","year":"2014","journal-title":"BMC Complement Altern Med"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0085","unstructured":"http:\/\/handbook.cochrane.org\/chapter_8\/8_5_the_cochrane_collaborations_tool_for_assessing_risk_of_bias.htm (Accessed on 31 May 2017)."},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0090","unstructured":"http:\/\/handbook.cochrane.org\/chapter_9\/9_5_2_identifying_and_measuring_heterogeneity.htm (Accessed on 31 May 2017)."},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0095","article-title":"Ranomized, double-blind, placebo-controlled trial for evaluating the efficacy of fractional CO2 laser compared with topical estriol in the treatment of vaginal atrophy in postmenopausal women","author":"Cruz","year":"2017","journal-title":"Menopause"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0100","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1111\/jsm.12125","article-title":"Evaluation of the efficacy and safety of hyaluronic acid vaginal gel to ease vaginal dryness: a multicenter, randomized, controlled, open-label, parallel-group, clinical trial","volume":"10","author":"Chen","year":"2013","journal-title":"J Sex Med"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0105","first-page":"321","article-title":"Role of high molecular weight hyaluronic acid in postmenopausal vaginal discomfort","volume":"6","author":"Grimaldi","year":"2012","journal-title":"Minerv Ginecol"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0110","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s00404-010-1382-8","article-title":"The comparison of hyaluronic acid vaginal tablets with estradiol vaginal tablets in the treatment of atrophic vaginitis: a randomized controlled trial","volume":"283","author":"Ekin","year":"2011","journal-title":"Arch Gynacol Obstet"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0115","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1007\/s00404-010-1545-7","article-title":"The effect of vaginally administered genistein in comparison with hyaluronic acid on atrophic epithelium in postmenopause","volume":"283","author":"Le Donne","year":"2011","journal-title":"Arch Gynecol"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0120","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1080\/13697137.2016.1258396","article-title":"Can polyacrilic acid treat sexual dysfunction in women with breast cancer receiving tamoxifen?","volume":"20","author":"Juliato","year":"2017","journal-title":"Climacteric"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0125","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1111\/jsm.12473","article-title":"Efficacy of vaginally applied estrogen, testosterone, or polyacrylic acid on sexual function in postmenaopausal women: a randomized controlled trial","volume":"11","author":"Fernandes","year":"2014","journal-title":"J Sex Med"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0130","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1097\/AOG.0b013e3182118790","article-title":"Vaginal Ph-Balanced Gel for the Control of Atrophic Vaginitis Among Breast Cancer Survivors. A Randomized Controlled Trial","volume":"117","author":"Lee","year":"2011","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0135","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1200\/JCO.1997.15.3.969","article-title":"Phase III randomized double-blind study to evaluate the efficacy of polycarbophil-based vaginal moisturizer in women with breast Cancer","volume":"15","author":"Loprinzi","year":"1997","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0140","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0378-5122(95)00955-8","article-title":"Replens versus dienostrol cream in the symptomatic treatment of vaginal atrophy in postmenopausal women","volume":"23","author":"Bygdeman","year":"1996","journal-title":"Maturitas"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0145","doi-asserted-by":"crossref","DOI":"10.1080\/13697137.2017.1335703","article-title":"Monurelle Biogel vaginal gel in the treatment of vaginal dryness in postmenopausal women","author":"Nappi","year":"2017","journal-title":"Climacteric"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0150","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10549-016-3865-1","article-title":"Randomized, double-blind, crossover trial comparing a silicone versus water-based lubricant for sexual discomfort after breast cancer","volume":"158","author":"Hickey","year":"2016","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0155","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.19082\/3184","article-title":"Comparison between vaginal royal jelly and vaginal estrogen effects on quality of life and vaginal atrophy in postmenopausal women: a clinical trial study","volume":"8","author":"Seyyedi","year":"2016","journal-title":"Electron Phys"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0160","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1111\/j.1743-6109.2009.01667.x","article-title":"A comparative study of the effects of local estrogen with or without local testosterone on vulvovaginal and sexual dysfunction in postmenopausal women","volume":"7","author":"Raghunandan","year":"2010","journal-title":"J Sex Med"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0165","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/GME.0000000000000742","article-title":"Comparison of Pueraria mirifica gel and conjugated equine estrogen cream effects on vaginal health in postmeopausal women","volume":"24","author":"Suwanvesh","year":"2016","journal-title":"Menopause"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0170","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.maturitas.2015.11.005","article-title":"Effect of Foeniculum vulgare (fennel) vaginal cream on vaginal atrophy in postmenopausal women: a double-blind randomized placebo-controlled trial","volume":"84","author":"Yaralizadeh","year":"2016","journal-title":"Maturitas"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0175","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.maturitas.2014.04.007","article-title":"Effects of Glycine max (L.) Merr.sOy isoflavone vaginal gel on epithelium morphology and estrogen receptor expression in postmenopausal women: a 12-week, randomized, double-blind, placebo-controlled trial","volume":"78","author":"SMRR","year":"2014","journal-title":"Maturitas"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0180","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.maturitas.2012.11.012","article-title":"Effective treatment of vaginal atrophy with isoflavone vaginal gel","volume":"74","author":"Lima","year":"2013","journal-title":"Maturitas"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0185","doi-asserted-by":"crossref","first-page":"652","DOI":"10.3109\/09513590.2011.650764","article-title":"Comparison of vaginal gel isoflavones versus no topical treatment in vaginal dystrophy: results of a preliminary prospective study","volume":"28","author":"Tedeschi","year":"2012","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0190","doi-asserted-by":"crossref","first-page":"3394","DOI":"10.1200\/JCO.2014.60.7366","article-title":"A practical solution for dyspareunia in breast Cancer survivors: a randomized controlled trial","volume":"33","author":"Goetsch","year":"2015","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0195","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/GME.0000000000000571","article-title":"VVA Prasterone Research Group. Efficacy of intravaginal dehydroapiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause","volume":"23","author":"Labrie","year":"2016","journal-title":"Menopause"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0200","doi-asserted-by":"crossref","first-page":"590","DOI":"10.3109\/13697137.2014.992012","article-title":"VVA Prasterone Research Group. Decreased efficacy of twice-weekly intravaginal dehydroepiandrosterone on vulvovaginal atrophy","volume":"18","author":"Bouchard","year":"2015","journal-title":"Climacteric"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0205","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1111\/jsm.13045","article-title":"Members of the VVA prasterone research group. Effect of intravaginal prasterone on sexual dysfunction in postmenopausal women with vulvovaginal atrophy","volume":"12","author":"Labrie","year":"2015","journal-title":"J Sex Med"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0210","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1111\/jsm.12517","article-title":"Lack of influence of dyspareunia on the beneficial effect of intravaginal prasterone (dehydroapiandrosterone, DHEA) on sexual dysfunction in postmenopausal women","volume":"11","author":"Labrie","year":"2014","journal-title":"J Sex Med"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0215","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3109\/13697137.2010.535226","article-title":"Intrvaginal dehydroepiandrosterone (prasterone), a highly efficient treatment of dyspareunia","volume":"14","author":"Labrie","year":"2011","journal-title":"Climacteric"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0220","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1097\/gme.0b013e31819e85c6","article-title":"Effect of intravaginal dehydroepiandrosterone (Prasterone) on libido and sexual dysfunction in postmenopausal women","volume":"16","author":"Labrie","year":"2009","journal-title":"Menopause"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0225","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1097\/gme.0b013e31819e8e2d","article-title":"Intravaginal dehydroepiandrosterone (Prasterone), a physiological and highly efficient treatment of vaginal atrophy","volume":"16","author":"Labrie","year":"2009","journal-title":"Menopause"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0230","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1001\/jamaoncol.2016.3904","article-title":"Vaginal Testosterone Cream vs Estradiol Vaginal Ring for Vaginal Dryness or decreased Libido in Women Receiving Aromatase Inhibitors for Early-Stage Breast Cancer A Randomized Clinical Trial","volume":"3","author":"Melisko","year":"2017","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0235","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1258\/mi.2011.011030","article-title":"Topical oxytocin reverses vaginal atrophy in postmenopausal women: a double-blind randomized pilot study","volume":"17","author":"Jonasson","year":"2011","journal-title":"Menopause Int"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0240","series-title":"Draft Guidance for Industry: estrogen and estrogen\/progestin drug products to treat vasomotor symptoms and vulvar and vaginal atrophy symptoms-Recommendations for Clinical Evaluation","author":"US Food and Drug Administration","year":"2003"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0245","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/gme.0b013e3181eeb774","article-title":"Dyspareunia is associated with decreased frequency of intercourse in the menopausal transition","volume":"18","author":"Thomas","year":"2011","journal-title":"Menopause"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0250","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1016\/j.jsxm.2016.09.002","article-title":"TX-004HR improves sexual function as measured by the female sexual function index in postmenopausal women with vulvar and vaginal atrophy: the REJOICE trial","volume":"13","year":"2016","journal-title":"J Sex Med"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0255","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1097\/01.gme.0000227401.98933.0b","article-title":"A randomized comparative study of the effects of oral and topical estrogen therapy on the vascularization and sexual function in hysterectomized postmenopausal women","volume":"13","author":"Long","year":"2006","journal-title":"Menopause"},{"issue":"Suppl (4)","key":"10.1016\/j.ejogrb.2018.08.008_bib0260","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1016\/S0015-0282(02)03001-7","article-title":"Hormones, mood, sexuality and the menopausal transition","volume":"77","author":"Dennerstein","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0265","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/01.gme.0000172596.76272.06","article-title":"Hypoactive sexual desire disorder in postmenopausal women: US results from the Women\u2019s International Study of Health and Sexuality (WISHeS)","volume":"13","author":"Leiblum","year":"2006","journal-title":"Menopause"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0270","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1743-6109.2006.00215.x","article-title":"Hypoactive sexual desire disorder in menopausal women: a survey of western European women","volume":"3","author":"Dennerstein","year":"2006","journal-title":"J Sex Med"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0275","first-page":"445","article-title":"Perceptions of dyspareunia in postmenopausal women with vulvar and vaginal atrophy: findings from the REVIVE survey","volume":"10","author":"Freedman","year":"2014","journal-title":"Women\u2019s Health"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0280","first-page":"342","article-title":"Dynamic quadripolar radiofrequency treatment of vaginal laxity\/menopausal vulvo-vaginal atrophy: 12-month efficacy and safety","volume":"69","author":"Vicariotto","year":"2017","journal-title":"Minerva Ginecol"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0285","first-page":"149","article-title":"Transutaneous tempereature controlled radiofrequency (TTCRF) for the treatemnt of menopausal Vaginal\/Genitourinary symptoms","volume":"XXIX","author":"Leibaschoff","year":"2016","journal-title":"Surg Technol Int"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0290","first-page":"225","article-title":"Technological evolution in the radiofrequency treatment of vaginal laxity and menopuasl vulvo-vaginal atrophy and other genitourinary symptoms: first experience with a novel dynamic quadripolar device","volume":"68","year":"2016","journal-title":"Minerva Ginecol"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0295","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.maturitas.2017.07.007","article-title":"CO2-laser for the genitourinary syndrome of menopause. How many laser sessions?","volume":"104","author":"Athanasiou","year":"2017","journal-title":"Maturitas"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0300","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1097\/GME.0000000000000700","article-title":"An assessment of the safety and efficacy of a fractional CO2 laser system for the treatment of vulvovaginal atrophy","volume":"23","author":"Sokol","year":"2016","journal-title":"Menopause"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0305","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.maturitas.2016.09.012","article-title":"Microablative fractional CO2-Laser and the genitourinary syndrome of menopause: an observational study","volume":"94","author":"Pitsouni","year":"2016","journal-title":"Maturitas"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0310","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3109\/13697137.2014.975197","article-title":"Sexual function after fractional microablative CO2 laser in women with vulvovaginal atrophy","volume":"18","author":"Salvatore","year":"2015","journal-title":"Climacteric"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0315","article-title":"Microablative fractional CO2 laser improves dyspareunia related to vulvovaginal atrophy: a pilot study","author":"Salvatore","year":"2014","journal-title":"J Endom Pelv Pain Disord"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0320","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.maturitas.2017.06.029","article-title":"Laser therapy for the genitourinary syndrome of menopause. A systematic review and meta-analysis","volume":"103","author":"Pitsouni","year":"2017","journal-title":"Maturitas"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.sxmr.2017.07.003","article-title":"Sexual function in women suffering from genitourinary syndrome of menopause treated with fractionated CO2 laser","author":"Salvatore","year":"2017","journal-title":"Sex Med Rev"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0330","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jsxm.2016.11.322","article-title":"Effect of single-treatment, surface-cooled radiofrequency therapy on vaginal laxity and female sexual function: the VIVEVE I randomized controlled trial","volume":"14","author":"Krychman","year":"2017","journal-title":"J Sex Med"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0335","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/lsm.22537","article-title":"Transcutaneous temperature controlled radiofrequency for orgasmic dysfunction","volume":"48","author":"Alinsod","year":"2016","journal-title":"Lasers Surg Med"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0340","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1089\/jwh.2012.4123","article-title":"Laxity of the vaginal introitus after childbirth: nonsurgical outpatient procedure for vaginal tissue restoration and improved sexual satisfaction using low-energy radiofrequency thermal therapy","volume":"22","author":"Sekiguchi","year":"2013","journal-title":"J Womens Health (Larchmt)"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0345","article-title":"Dehydroepiandosterone for women in the peri- or postmenopausal phase","volume":"1","author":"Scheffers","year":"2015","journal-title":"Cochrane Dtabase Syst Rev"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0350","doi-asserted-by":"crossref","DOI":"10.1080\/13697137.2017.1279141","article-title":"The effects of dehydroepiandrosterone on sexual function: a systematic review","author":"Peixoto","year":"2017","journal-title":"Climacteric"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0355","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jsbmb.2014.09.003","article-title":"Dehydroepiandrosterone intra vaginal administration for the management of postmenopausal vulvovaginal atrophy","volume":"145","author":"Archer","year":"2015","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0360","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/smrj.53","article-title":"Testosterone therpay for female sexual dysfunction","volume":"3","author":"Khera","year":"2015","journal-title":"Sex Med Rev"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0365","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2147\/IJWH.S116212","article-title":"Has testosterone passed the test in premenopausal women with low libido? A systematic review","volume":"8","author":"Reed","year":"2016","journal-title":"Int J Womens Health"},{"key":"10.1016\/j.ejogrb.2018.08.008_bib0370","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1177\/2042018810379588","article-title":"Testosterone therapy for reduced libido in women","volume":"1","author":"Basson","year":"2010","journal-title":"Ther Adv Endocrinol Metab"}],"container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211518303671?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211518303671?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:42:19Z","timestamp":1759556539000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211518303671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":74,"alternative-id":["S0301211518303671"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2018.08.008","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.733809176.793582598","asserted-by":"object"}]},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of vaginal therapies alternative to vaginal estrogens on sexual function and orgasm of menopausal women: A systematic review and meta-analysis of randomized controlled trials","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2018.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}