{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T08:25:37Z","timestamp":1783412737717,"version":"3.54.6"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Health and Medical Research Fund, Hong Kong","award":["11121661"],"award-info":[{"award-number":["11121661"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.ejogrb.2018.11.017","type":"journal-article","created":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T12:00:49Z","timestamp":1542974449000},"page":"97-100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["The effect of rupture of membranes and labour on the risk of hepatitis B vertical transmission: Prospective multicentre observational study"],"prefix":"10.1016","volume":"232","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1207-6494","authenticated-orcid":false,"given":"Ka Wang","family":"Cheung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7435-8169","authenticated-orcid":false,"given":"Mimi Tin Yan","family":"Seto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po Lam","family":"So","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annisa Shui Lam","family":"Mak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai Lam","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita Sik Yau","family":"Kan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin Peng","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest Hung Yu","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2018.11.017_bib0005","unstructured":"World Health Organization. Hepatitis B Fact Sheet. July 2017. http:\/\/www.who.int\/mediacentre\/factsheets\/fs204\/en\/. accessed April 1, 2018."},{"key":"10.1016\/j.ejogrb.2018.11.017_bib0010","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1098\/rspb.1993.0102","article-title":"The influence of age on the development of the hepatitis B carrier state","volume":"253","author":"Edmunds","year":"1993","journal-title":"Proc R Soc Biol Sci"},{"key":"10.1016\/j.ejogrb.2018.11.017_bib0015","doi-asserted-by":"crossref","first-page":"e1135","DOI":"10.1542\/peds.2012-1262","article-title":"Cost-effectiveness of augmenting universal hepatitis B vaccination with immunoglobin treatment","volume":"131","author":"Chen","year":"2013","journal-title":"Pediatrics"},{"key":"10.1016\/j.ejogrb.2018.11.017_bib0020","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1111\/j.1365-2893.2011.01492.x","article-title":"Virologic factors associated with failure to passive-active immunoprophylaxis in infants born to HBsAg-positive mothers","volume":"19","author":"Zou","year":"2012","journal-title":"J Viral Hepat"},{"key":"10.1016\/j.ejogrb.2018.11.017_bib0025","doi-asserted-by":"crossref","first-page":"711","DOI":"10.2169\/internalmedicine.54.3514","article-title":"Factors associated with mother-to-child transmission of hepatitis B virus despite immunoprophylaxis","volume":"54","author":"Liu","year":"2015","journal-title":"Intern Med"},{"key":"10.1016\/j.ejogrb.2018.11.017_bib0030","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jhep.2013.02.015","article-title":"Mother-to-infant transmission of hepatitis B virus infection: significance of maternal viral load and strategies for intervention","volume":"59","author":"Wen","year":"2013","journal-title":"J Hepatol"},{"key":"10.1016\/j.ejogrb.2018.11.017_bib0035","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1007\/s00431-014-2305-7","article-title":"A study of immunoprophylaxis failure and risk factors of hepatitis B virus mother-to-infant transmission","volume":"173","author":"Zhang","year":"2014","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.ejogrb.2018.11.017_bib0040","doi-asserted-by":"crossref","first-page":"e1141","DOI":"10.1542\/peds.2014-3213","article-title":"Outcomes of infants born to women infected with hepatitis B","volume":"135","author":"Schillie","year":"2015","journal-title":"Pediatrics"},{"key":"10.1016\/j.ejogrb.2018.11.017_bib0045","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.cgh.2017.07.013","article-title":"Immunoprophylaxis failure of infants born to hepatitis B carrier mothers following routine vaccination","volume":"16","author":"Cheung","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.ejogrb.2018.11.017_bib0050","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1001\/jama.285.16.2083","article-title":"Lamivudine\u2013zidovudine combination for prevention of maternal\u2013infant transmission of HIV-1","volume":"285","author":"Mandelbrot","year":"2001","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.ejogrb.2018.11.017_bib0055","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1016\/S0140-6736(07)61908-4","article-title":"Genital herpes","volume":"370","author":"Gupta","year":"2007","journal-title":"Lancet"},{"issue":"15","key":"10.1016\/j.ejogrb.2018.11.017_bib0060","first-page":"1","article-title":"British HIV Association guidelines for the management of HIV infection in pregnant women 2012 (2014 interim review)","author":"de Ruiter","year":"2014","journal-title":"HIV Med"},{"issue":"26","key":"10.1016\/j.ejogrb.2018.11.017_bib0065","first-page":"763","article-title":"UK national guideline for the management of anogenital herpes","volume":"2015","author":"Patel","year":"2014","journal-title":"Int J Std Aids"},{"key":"10.1016\/j.ejogrb.2018.11.017_bib0070","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1186\/s12884-017-1487-1","article-title":"Cesarean section to prevent mother-to-child transmission of hepatitis B virus in China: a meta-analysis","volume":"17","author":"Yang","year":"2017","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.ejogrb.2018.11.017_bib0075","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/hep.28156","article-title":"AASLD guidelines for treatment of chronic hepatitis B","volume":"63","author":"Terrault","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.ejogrb.2018.11.017_bib0080","first-page":"18","article-title":"Clinical Practice Guidelines on the management of hepatitis B virus infection","volume":"2017","author":"European Association for the Study of the Liver. EASL","year":"2017","journal-title":"J Hepatol"},{"key":"10.1016\/j.ejogrb.2018.11.017_bib0085","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/00002030-200102160-00009","article-title":"Duration of ruptured membranes and vertical transmission of HIV-1: a meta-analysis from 15 prospective cohort studies","volume":"15","author":"International Perinatal HIV Group","year":"2001","journal-title":"AIDS"},{"issue":"482","key":"10.1016\/j.ejogrb.2018.11.017_bib0090","first-page":"e1","article-title":"Duration of membrane rupture and risk of perinatal transmission of HIV-1 in the era of combination antiretroviral therapy","volume":"207","author":"Cotter","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2018.11.017_bib0095","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1111\/1471-0528.13442","article-title":"Duration of ruptured membranes and mother-to-child HIV transmission: a prospective population-based surveillance study","volume":"123","author":"Peters","year":"2016","journal-title":"BJOG"},{"key":"10.1016\/j.ejogrb.2018.11.017_bib0100","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1056\/NEJMoa1708131","article-title":"Tenofovir versus placebo to prevent perinatal transmission of hepatitis B","volume":"378","author":"Jourdain","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejogrb.2018.11.017_bib0105","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ejogrb.2013.02.001","article-title":"Towards complete eradication of hepatitis B infection from perinatal transmission: review of the mechanisms of in utero infection and the use of antiviral treatment during pregnancy","volume":"169","author":"Cheung","year":"2013","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ejogrb.2018.11.017_bib0110","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1128\/CVI.00168-10","article-title":"Does hepatitis B virus prenatal transmission result in postnatal immunoprophylaxis failure?","volume":"17","author":"Zhu","year":"2010","journal-title":"Clin Vacc Immunol"},{"key":"10.1016\/j.ejogrb.2018.11.017_bib0115","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1111\/j.1365-2893.2011.01492.x","article-title":"Virologic factors associated with failure to passive-active immunoprophylaxis in infants born to HBsAg-positive mothers","volume":"19","author":"Zou","year":"2012","journal-title":"J Viral Hepat"},{"key":"10.1016\/j.ejogrb.2018.11.017_bib0120","doi-asserted-by":"crossref","first-page":"e2001","DOI":"10.1097\/MD.0000000000002001","article-title":"Kinetic changes of Viremia and viral antigens of hepatitis B virus during and after pregnancy","volume":"94","author":"Liu","year":"2015","journal-title":"Med (Baltim)"},{"key":"10.1016\/j.ejogrb.2018.11.017_bib0125","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s00431-006-0327-5","article-title":"Factors associated with immunoprophylaxis failure against vertical transmission of hepatitis B virus","volume":"166","author":"Song","year":"2007","journal-title":"Eur J Pediatr"}],"container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211518310996?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211518310996?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:43:35Z","timestamp":1759556615000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211518310996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":25,"alternative-id":["S0301211518310996"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2018.11.017","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of rupture of membranes and labour on the risk of hepatitis B vertical transmission: Prospective multicentre observational study","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2018.11.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}