{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:19:42Z","timestamp":1777645182310,"version":"3.51.4"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.ejogrb.2019.04.008","type":"journal-article","created":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T13:18:01Z","timestamp":1554815881000},"page":"28-32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Management of caesarean scar pregnancy with high dose intravenous methotrexate infusion therapy: 10-year experience at a single tertiary centre"],"prefix":"10.1016","volume":"237","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8958-0731","authenticated-orcid":false,"given":"Keisuke","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise","family":"Coghill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Ballard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renuka","family":"Sekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9428-650X","authenticated-orcid":false,"given":"Akwasi","family":"Amoako","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akram","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Baartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2019.04.008_bib0005","first-page":"e15","article-title":"On behalf of the Royal College of Obstetricians and Gynaecologists Diagnosis and management of ectopic pregnancy","volume":"123","author":"Elson","year":"2016","journal-title":"BJOG"},{"key":"10.1016\/j.ejogrb.2019.04.008_bib0010","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ajog.2012.03.007","article-title":"Unforeseen consequences of the increasing rate of cesarean deliveries: early placenta accreta and cesarean scar pregnancy. A review","volume":"207","author":"Timor-Tritsch","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2019.04.008_bib0015","doi-asserted-by":"crossref","first-page":"601","DOI":"10.7863\/ultra.34.4.601","article-title":"Cesarean scar pregnancies: experience of 60 cases","volume":"34","author":"Timor-Tritsch","year":"2015","journal-title":"J Ultrasound Med"},{"key":"10.1016\/j.ejogrb.2019.04.008_bib0020","doi-asserted-by":"crossref","first-page":"595","DOI":"10.7863\/ultra.34.4.595","article-title":"Outcome of cesarean scar pregnancies diagnosed sonographically in the first trimester","volume":"34","author":"Michaels","year":"2015","journal-title":"J Ultrasound Med"},{"key":"10.1016\/j.ejogrb.2019.04.008_bib0025","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/uog.14775","article-title":"Natural history of early first-trimester pregnancies implanted in Cesarean scars","volume":"46","author":"Zosmer","year":"2015","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2019.04.008_bib0030","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.7863\/jum.2011.30.9.1179","article-title":"Fertility performance and obstetric outcomes among women with previous cesarean scar pregnancy","volume":"30","author":"Maymon","year":"2011","journal-title":"J Ultrasound Med"},{"key":"10.1016\/j.ejogrb.2019.04.008_bib0035","first-page":"253","article-title":"Non-tubal ectopic pregnancy","volume":"114","author":"Ngu","year":"2007","journal-title":"BJOG"},{"key":"10.1016\/j.ejogrb.2019.04.008_bib0040","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/uog.2644","article-title":"Primary evacuation therapy for cesarean scar pregnancy: three new cases and review","volume":"27","author":"Wang","year":"2006","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2019.04.008_bib0045","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1600-0412.2004.0033a.x","article-title":"Unsuccessful medical treatment of cesarean scar ectopic pregnancy with systemic methotrexate: a report of two cases","volume":"83","author":"Lam","year":"2004","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ejogrb.2019.04.008_bib0050","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.jmig.2017.02.020","article-title":"Cesarean scar pregnancy: a systematic review","volume":"24","author":"Gonzalez","year":"2017","journal-title":"J Minim Invasive Gynecol"},{"key":"10.1016\/j.ejogrb.2019.04.008_bib0055","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1479-828X.2006.00537.x","article-title":"A medical management of interstitial ectopic pregnancy. A 5 year clinical study","volume":"46","author":"Tang","year":"2006","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"10.1016\/j.ejogrb.2019.04.008_bib0060","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/ajo.12315","article-title":"Management of interstitial ectopic pregnancy with intravenous methotrexate: an extended study of a standardised regimen","volume":"55","author":"Tanaka","year":"2015","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"10.1016\/j.ejogrb.2019.04.008_bib0065","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S0015-0282(97)81930-9","article-title":"An ectopic pregnancy developing in a previous Caesarean section scar","volume":"67","author":"Goldin","year":"1997","journal-title":"Fertil Seril"},{"issue":"44","key":"10.1016\/j.ejogrb.2019.04.008_bib0070","first-page":"e1","article-title":"The diagnosis, treatment, and follow up of cesarean scar pregnancy","volume":"207","author":"Timor-Tritsch","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2019.04.008_bib0075","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/uog.56","article-title":"First-trimester diagnosis and management of pregnancies implanted into the lower uterine segment Cesarean section scar","volume":"21","author":"Jurkovic","year":"2003","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2019.04.008_bib0080","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1046\/j.0960-7692.2001.00569.x","article-title":"Ultrasound diagnosis of a pregnancy in a Cesarean section scar","volume":"18","author":"Seow","year":"2001","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2019.04.008_bib0085","doi-asserted-by":"crossref","first-page":"290","DOI":"10.3109\/01443615.2014.954101","article-title":"The efficacy of the systemic methotrexate treatment in caesarean scar ectopic pregnancy: a quantitative review of English literature","volume":"35","author":"Bodur","year":"2015","journal-title":"J Obstet Gynaecol"},{"key":"10.1016\/j.ejogrb.2019.04.008_bib0090","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.jmig.2017.05.019","article-title":"Cesarean scar pregnancies: a systematic review of treatment options","volume":"24","author":"Maheux-Lacroix","year":"2017","journal-title":"J Minim Invasive Gynecol"},{"key":"10.1016\/j.ejogrb.2019.04.008_bib0095","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1111\/j.1471-0528.2010.02578.x","article-title":"Uterine artery embolization combined with local methotrexate for treatment of caesarean scar pregnancy","volume":"117","author":"Yang","year":"2010","journal-title":"BJOG"},{"key":"10.1016\/j.ejogrb.2019.04.008_bib0100","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s00270-011-0097-y","article-title":"Uterine artery embolization combined with local methotrexate and systemic methotrexate for treatment of cesarean scar pregnancy with different ultrasonographic pattern","volume":"35","author":"Lian","year":"2012","journal-title":"Cardiovasc Intervent Radiol"},{"key":"10.1016\/j.ejogrb.2019.04.008_bib0105","first-page":"137","article-title":"Comparative efficacy and safety of local and systemic methotrexate injection in caesarean scar pregnancy","volume":"27","author":"Peng","year":"2015","journal-title":"Ther Clin Risk Manag"},{"key":"10.1016\/j.ejogrb.2019.04.008_bib0110","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1111\/jog.12414","article-title":"Successful medical treatment of cesarean scar ectopic pregnancyes with systemic multidose methotrexate: single-center experience","volume":"40","author":"Kutuk","year":"2014","journal-title":"J Obstet Gynaecol Res"},{"key":"10.1016\/j.ejogrb.2019.04.008_bib0115","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s00404-015-3881-0","article-title":"Therapeutic effects of uterine artery embolization (UAE) and methotrexate (MTX) conservative therapy used in treatment of cesarean scar pregnancy","volume":"293","author":"Yang","year":"2016","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.ejogrb.2019.04.008_bib0120","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1111\/j.1471-0528.1997.tb10956.x","article-title":"Successful methotrexate of a viable pregnancy within a thin uterine scar","volume":"104","author":"Donnez","year":"1997","journal-title":"BJOG"},{"key":"10.1016\/j.ejogrb.2019.04.008_bib0125","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.fertnstert.2015.12.130","article-title":"Cesarean scar pregnancy: a systemic review of treatment studies","volume":"105","author":"Birch Petersen","year":"2016","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2019.04.008_bib0130","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/uog.13282","article-title":"Cesarean scar pregnancy and early placenta accreta share common histology","volume":"43","author":"Timor-Tritsch","year":"2014","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2019.04.008_bib0135","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1046\/j.1469-0705.2000.00300-2.x","article-title":"Pregnancy in a cesarean scar","volume":"16","author":"Vial","year":"2000","journal-title":"Ultrasound Obstet Gynecol"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211519301630?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211519301630?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:44:42Z","timestamp":1759556682000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211519301630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":27,"alternative-id":["S0301211519301630"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2019.04.008","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Management of caesarean scar pregnancy with high dose intravenous methotrexate infusion therapy: 10-year experience at a single tertiary centre","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2019.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}