{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T09:30:40Z","timestamp":1783071040332,"version":"3.54.6"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.ejogrb.2019.10.021","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T11:36:51Z","timestamp":1571744211000},"page":"93-96","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Angiogenic profiling in HELLP syndrome cases with or without hypertension and proteinuria"],"prefix":"10.1016","volume":"243","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9839-4105","authenticated-orcid":false,"given":"Fabienne","family":"Trottmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Baumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Amylidi-Mohr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Surbek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"Risch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Mosimann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Raio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"09","key":"10.1016\/j.ejogrb.2019.10.021_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejogrb.2013.05.005","article-title":"Global and regional estimates of preeclampsia and eclampsia: a systematic review","volume":"170","author":"Abalos","year":"2013","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ejogrb.2019.10.021_bib0010","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.preghy.2014.02.001","article-title":"The classification, diagnosis and management of the hypertensive disorders of pregnancy: a revised statement from the ISSHP","volume":"4","author":"Tranquilli","year":"2014","journal-title":"Pregnancy Hypertens"},{"key":"10.1016\/j.ejogrb.2019.10.021_bib0015","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0002-9378(16)32330-4","article-title":"Syndrome of hemolysis, elevated liver enzymes, and low platelet count. A severe consequence of hypertension in pregnancy","volume":"142","author":"Weinstein","year":"1982","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2019.10.021_bib0020","first-page":"97","article-title":"The definition of severe and early-onset preeclampsia. Statements from the International Society for the Study of Hypertension in Pregnancy","volume":"3","author":"Tranquilli","year":"2012","journal-title":"Pregnancy Hypertens"},{"issue":"05","key":"10.1016\/j.ejogrb.2019.10.021_bib0025","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.preghy.2018.05.004","article-title":"The hypertensive disorders of pregnancy: ISSHP classification, diagnosis & management recommendations for international practice","volume":"13","author":"Brown","year":"2018","journal-title":"Pregnancy Hypertens"},{"key":"10.1016\/j.ejogrb.2019.10.021_bib0030","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1097\/01.AOG.0000126245.35811.2a","article-title":"Diagnosis, controversies, and management of the syndrome of hemolysis, elevated liver enzymes, and low platelet count","volume":"103","author":"Sibai","year":"2004","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2019.10.021_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/0002-9378(93)90043-I","article-title":"Maternal morbidity and mortality in 442 pregnancies with hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome)","volume":"169","author":"Sibai","year":"1993","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2019.10.021_bib0040","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2393-9-8","article-title":"The HELLP syndrome: Clinical issues and management. A review","volume":"9","author":"Haram","year":"2009","journal-title":"BMC Pregnancy Childbirth"},{"issue":"08","key":"10.1016\/j.ejogrb.2019.10.021_bib0045","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/AOG.0b013e31829ca9a7","article-title":"The role of growth trajectories in classifying fetal growth restriction","volume":"122","author":"Barker","year":"2013","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2019.10.021_bib0050","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/ajh\/hpx024","article-title":"Total and fetal circulating cell-free DNA, angiogenic,and antiangiogenic factors in preeclampsia and HELLP syndrome","volume":"30","author":"Mu\u00f1oz-Hern\u00e1ndez","year":"2017","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.ejogrb.2019.10.021_bib0055","first-page":"202","article-title":"An automated method for the determination of the sFlt-1\/PIGF ratio in the assessment of preeclampsia","volume":"02","author":"Verlohren","year":"2010","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2019.10.021_bib0060","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1161\/HYPERTENSIONAHA.113.01787","article-title":"New gestational phase\u2013specific cutoff values for the use of the soluble fms-like Tyrosine Kinase-1\/Placental growth factor ratio as a diagnostic test for preeclampsia","volume":"63","author":"Verlohren","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.ejogrb.2019.10.021_bib0065","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa1414838","article-title":"Predictive value of the sFlt-1:PlGF ratio in women with suspected preeclampsia","volume":"374","author":"Zeisler","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejogrb.2019.10.021_bib0070","article-title":"The sFlt-1\/PlGF Ratio: ruling out pre-eclampsia for up to 4 weeks and the value of retesting","volume":"07","author":"Zeisler","year":"2018","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"4 (suppl)","key":"10.1016\/j.ejogrb.2019.10.021_bib0075","first-page":"9","article-title":"Preeclampsia, biomarkers, syncytiotrophoblast stress, and placental capacity","volume":"213","author":"Redman","year":"2015","journal-title":"Am J Obstet Gynecol"},{"issue":"11","key":"10.1016\/j.ejogrb.2019.10.021_bib0080","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.placenta.2016.09.012","article-title":"The placental component and obstetric outcome in severe preeclampsia with and without HELLP syndrome","volume":"44","author":"Weiner","year":"2016","journal-title":"Placenta"},{"key":"10.1016\/j.ejogrb.2019.10.021_bib0085","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1365-2141.2012.09167.x","article-title":"Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies","volume":"158","author":"Scully","year":"2012","journal-title":"Br J Haematol"},{"key":"10.1016\/j.ejogrb.2019.10.021_bib0090","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.preghy.2018.02.007","article-title":"Thrombotic microangiopathies of pregnancy: differential diagnosis","volume":"12","author":"Gupta","year":"2018","journal-title":"Pregnancy Hypertens"}],"container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211519304774?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211519304774?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:46:33Z","timestamp":1759556793000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211519304774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":18,"alternative-id":["S0301211519304774"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2019.10.021","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Angiogenic profiling in HELLP syndrome cases with or without hypertension and proteinuria","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2019.10.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}