{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T01:51:31Z","timestamp":1782179491154,"version":"3.54.5"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.ejogrb.2020.04.012","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T21:29:51Z","timestamp":1588195791000},"page":"155-161","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Chemotherapy for breast cancer during pregnancy induces vascular alterations and impaired development of placental villi: A preliminary histopathological study"],"prefix":"10.1016","volume":"250","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8194-3232","authenticated-orcid":false,"given":"Alessandro","family":"Del Gobbo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Scarfone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8227-8740","authenticated-orcid":false,"given":"Fedro Alessandro","family":"Peccatori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Villa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wally","family":"Ossola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Ercoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvano","family":"Bosari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Ferrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca Laura","family":"Boggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Grossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulvia Milena","family":"Cribi\u00f9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl. 6","key":"10.1016\/j.ejogrb.2020.04.012_bib0005","article-title":"Cancer, pregnancy and fertility: ESMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"24","author":"Peccatori","year":"2013","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ejogrb.2020.04.012_bib0010","doi-asserted-by":"crossref","first-page":"9815","DOI":"10.1016\/S0140-6736(11)61092-1","article-title":"Breast cancer in pregnancy","volume":"379","author":"Amant","year":"2012","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.ejogrb.2020.04.012_bib0015","article-title":"Breast cancer in pregnancy: a literature review","volume":"138","author":"Woo","year":"2003","journal-title":"Arch Surg (Chic III 1960)"},{"key":"10.1016\/j.ejogrb.2020.04.012_bib0020","first-page":"4","article-title":"Breast cancer and pregnancy","volume":"32","author":"Leslie","year":"2005","journal-title":"Obstet Gynecol Clin North Am"},{"key":"10.1016\/j.ejogrb.2020.04.012_bib0025","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1471-0528.2012.03475.x","article-title":"Incidence and outcomes of pregnancy-associated cancer in Australia, 1994\u20132008: a population-based linkage study","volume":"119","author":"Lee","year":"2012","journal-title":"BJOG"},{"key":"10.1016\/j.ejogrb.2020.04.012_bib0030","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/AOG.0b013e3182a057a2","article-title":"Incidence of pregnancy-associated cancer in Denmark, 1977\u20132006","volume":"122","author":"Eibye","year":"2013","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2020.04.012_bib0035","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/IGC.0000000000000904","article-title":"Frequency of pregnancy related cancer: a population based linkage study in Lombardy, Italy","volume":"27","author":"Parazzini","year":"2017","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.ejogrb.2020.04.012_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1701-2163(16)35138-6","article-title":"Delayed child-bearing","volume":"34","author":"Johnson","year":"2012","journal-title":"J Obstet Gynaecol Can"},{"key":"10.1016\/j.ejogrb.2020.04.012_bib0045","first-page":"3","article-title":"Increasing incidence of pregnancy-associated breast cancer in Sweden","volume":"114","author":"TM-L","year":"2009","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2020.04.012_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10549-012-2031-7","article-title":"Breast cancer incidence trends in European women aged 20-39 years at diagnosis","volume":"134","author":"Merlo","year":"2012","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.ejogrb.2020.04.012_bib0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2350\/08-03-0435.1","article-title":"Effects of chemotherapy during pregnancy on the placenta","volume":"12","author":"Abellar","year":"2009","journal-title":"Pediatr Dev Pathol"},{"key":"10.1016\/j.ejogrb.2020.04.012_bib0060","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S1470-2045(12)70261-9","article-title":"Treatment of breast cancer during pregnancy: an observational study","volume":"13","author":"Loibl","year":"2012","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ejogrb.2020.04.012_bib0065","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ogc.2013.05.006","article-title":"Breast cancer in pregnancy","volume":"40","author":"Krishna","year":"2013","journal-title":"Obstet Gynecol Clin North Am"},{"key":"10.1016\/j.ejogrb.2020.04.012_bib0070","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ctrv.2012.06.004","article-title":"Prognosis of pregnancy-associated breast cancer: a meta-analysis of 30 studies","volume":"38","author":"Azim","year":"2012","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.ejogrb.2020.04.012_bib0075","first-page":"5","article-title":"The biological features and prognosis of breast cancer diagnosed during pregnancy: a case-control study","volume":"51","author":"Azim","year":"2012","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ejogrb.2020.04.012_bib0080","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1200\/JCO.2012.45.6335","article-title":"Prognosis of women with primary breast cancer diagnosed during pregnancy: results from an international collaborative study","volume":"31","author":"Amant","year":"2013","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejogrb.2020.04.012_bib0085","first-page":"1","article-title":"Breast cancer during pregnancy: maternal and fetal outcomes","volume":"16","author":"Cardonick","year":"2010","journal-title":"Cancer J Sudbury Mass"},{"key":"10.1016\/j.ejogrb.2020.04.012_bib0090","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1470-2045(11)70363-1","article-title":"Long-term cognitive and cardiac outcomes after prenatal exposure to chemotherapy in children aged 18 months or older: an observational study","volume":"13","author":"Amant","year":"2012","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ejogrb.2020.04.012_bib0095","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1056\/NEJMoa1508913","article-title":"Pediatric outcome after maternal Cancer Diagnosed during pregnancy","volume":"373","author":"Amant","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejogrb.2020.04.012_bib0100","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1200\/JCO.2009.23.2801","article-title":"Cancer during pregnancy: an analysis of 215 patients emphasizing the obstetrical and the neonatal outcomes","volume":"28","author":"Van Calsteren","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ejogrb.2020.04.012_bib0105","article-title":"Macroscopic examination of the fresh placenta. Statistical analysis of 1,200 cases. Comparison with maternal and neonatal pathology","volume":"3","author":"Nessmann-Emmanuelli","year":"1976","journal-title":"J Gynecol Obstet Biol Reprod"},{"key":"10.1016\/j.ejogrb.2020.04.012_bib0110","doi-asserted-by":"crossref","DOI":"10.1007\/s11095-016-2028-8","article-title":"Placental ABC transporters: biological impact and pharmaceutical significance","volume":"33","author":"Joshi","year":"2016","journal-title":"Pharm Res"},{"key":"10.1016\/j.ejogrb.2020.04.012_bib0115","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3109\/00016349.2010.512070","article-title":"Pharmacokinetics of chemotherapeutic agents in pregnancy: a preclinical and clinical study","volume":"89","author":"Van Calsteren","year":"2010","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ejogrb.2020.04.012_bib0120","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1470-2045(18)30059-7","article-title":"Oncological management and obstetric and neonatal outcomes for women diagnosed with cancer during pregnancy: a 20-year international cohort study of 1170 patients","volume":"19","author":"de Haan","year":"2018","journal-title":"Lancet Oncol"},{"issue":"7","key":"10.1016\/j.ejogrb.2020.04.012_bib0125","doi-asserted-by":"crossref","first-page":"698","DOI":"10.5858\/arpa.2015-0225-CC","article-title":"Sampling and definitions of placental lesions: Amsterdam placental workshop group consensus statement","volume":"140","author":"Khong","year":"2016","journal-title":"Arch Pathol Lab Med"},{"issue":"6D","key":"10.1016\/j.ejogrb.2020.04.012_bib0130","first-page":"5225","article-title":"Chemotherapy with epirubicin and paclitaxel for breast cancer during pregnancy: case report and review of the literature","volume":"23","author":"Gadducci","year":"2003","journal-title":"Anticancer Res"},{"issue":"10","key":"10.1016\/j.ejogrb.2020.04.012_bib0135","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.3109\/00016349.2010.512070","article-title":"Pharmacokinetics of chemotherapeutic agents in pregnancy: a preclinical and clinical study","volume":"89","author":"Van Calsteren","year":"2010","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ejogrb.2020.04.012_bib0140","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.placenta.2018.03.002","article-title":"Genetic and microscopic assessment of the human chemotherapy-exposed placenta reveals possible pathways contributive to fetal growth restriction","volume":"64","author":"Verheecke","year":"2018","journal-title":"Placenta"}],"container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211520301809?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211520301809?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:48:11Z","timestamp":1759556891000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211520301809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":28,"alternative-id":["S0301211520301809"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2020.04.012","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chemotherapy for breast cancer during pregnancy induces vascular alterations and impaired development of placental villi: A preliminary histopathological study","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2020.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}