{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T17:32:21Z","timestamp":1782754341274,"version":"3.54.5"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.ejogrb.2020.06.042","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T11:35:21Z","timestamp":1592912121000},"page":"218-224","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Efficacy of hyoscine butyl-bromide in shortening the active phase of labor: Systematic review and meta-analysis of randomized trials"],"prefix":"10.1016","volume":"252","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3676-7716","authenticated-orcid":false,"given":"Gaetano","family":"Riemma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"La Verde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2994-1093","authenticated-orcid":false,"given":"Antonio","family":"Schiattarella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Cobellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"De Franciscis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Colacurci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maddalena","family":"Morlando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ejogrb.2020.06.042_bib0005","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/aogs.13039","article-title":"Duration of the active phase of labor in spontaneous and induced labors","volume":"96","author":"Ostborg","year":"2017","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"14","key":"10.1016\/j.ejogrb.2020.06.042_bib0010","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.3109\/14767058.2014.964677","article-title":"Factors affecting uterine electrical activity during the active phase of labor prior to rupture of membranes","volume":"28","author":"Hiersch","year":"2015","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"8","key":"10.1016\/j.ejogrb.2020.06.042_bib0015","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.3109\/00016349.2010.499446","article-title":"Identification of latent phase factors associated with active labor duration in low-risk nulliparous women with spontaneous contractions","volume":"89","author":"Dencker","year":"2010","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"4","key":"10.1016\/j.ejogrb.2020.06.042_bib0020","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1080\/00016340902811001","article-title":"Incidence and outcomes of dystocia in the active phase of labor in term nulliparous women with spontaneous labor onset","volume":"88","author":"Kjaergaard","year":"2009","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"3","key":"10.1016\/j.ejogrb.2020.06.042_bib0025","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1523-536X.1989.tb00879.x","article-title":"Active management of labor: results in Dublin, Houston, London, New Brunswick, Singapore, and Valparaiso","volume":"16","author":"Boylan","year":"1989","journal-title":"Birth"},{"issue":"2","key":"10.1016\/j.ejogrb.2020.06.042_bib0030","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0889-8545(05)70075-9","article-title":"Active management of labor","volume":"26","author":"Socol","year":"1999","journal-title":"Obstet Gynecol Clin North Am"},{"issue":"4","key":"10.1016\/j.ejogrb.2020.06.042_bib0035","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1136\/ewjm.172.4.240","article-title":"Active management of labor: a cost analysis of a randomized controlled trial","volume":"172","author":"Rogers","year":"2000","journal-title":"West J Med"},{"issue":"3","key":"10.1016\/j.ejogrb.2020.06.042_bib0040","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0002-9378(97)70152-2","article-title":"Active management of labor: does it make a difference?","volume":"177","author":"Rogers","year":"1997","journal-title":"Am J Obstet Gynecol"},{"issue":"7","key":"10.1016\/j.ejogrb.2020.06.042_bib0045","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1056\/NEJM199202133260705","article-title":"A controlled trial of a program for the active management of labor","volume":"326","author":"Lopez-Zeno","year":"1992","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.ejogrb.2020.06.042_bib0050","article-title":"Antispasmodics for labour","author":"Rohwer","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"issue":"12","key":"10.1016\/j.ejogrb.2020.06.042_bib0055","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1111\/j.1471-0528.2007.01497.x","article-title":"The effect of hyoscine butylbromide on the first stage of labour in term pregnancies","volume":"114","author":"Samuels","year":"2007","journal-title":"BJOG"},{"issue":"9","key":"10.1016\/j.ejogrb.2020.06.042_bib0060","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.2165\/00003495-200767090-00007","article-title":"Hyoscine butylbromide: a review of its use in the treatment of abdominal cramping and pain","volume":"67","author":"Tytgat","year":"2007","journal-title":"Drugs"},{"issue":"10","key":"10.1016\/j.ejogrb.2020.06.042_bib0065","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.jclinepi.2009.06.005","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"62","author":"Moher","year":"2009","journal-title":"J Clin Epidemiol"},{"issue":"2","key":"10.1016\/j.ejogrb.2020.06.042_bib0070","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1479-828X.2005.00359.x","article-title":"Efficacy of hyoscine-N-butyl bromide (Buscopan) suppositories as a cervical spasmolytic agent in labour","volume":"45","author":"Sirohiwal","year":"2005","journal-title":"Aust N Z J Obstet Gynaecol"},{"issue":"5","key":"10.1016\/j.ejogrb.2020.06.042_bib0075","doi-asserted-by":"crossref","first-page":"179","DOI":"10.4103\/0019-5359.40982","article-title":"Role of hyoscine N-butyl bromide (HBB, buscopan) as labor analgesic","volume":"62","author":"Aggarwal","year":"2008","journal-title":"Indian J Med Sci"},{"issue":"6","key":"10.1016\/j.ejogrb.2020.06.042_bib0080","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.tjog.2017.10.003","article-title":"Effect of hyoscine butyl-bromide on the duration of active phase of labor: a randomized-controlled trial","volume":"56","author":"Imaralu","year":"2017","journal-title":"Taiwan J Obstet Gynecol"},{"issue":"9","key":"10.1016\/j.ejogrb.2020.06.042_bib0085","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.3109\/14767058.2014.942628","article-title":"Effect of intravenous hyoscine-N-butyl bromide on active phase of labor progress: a randomized double blind placebo controlled trial","volume":"28","author":"Kirim","year":"2015","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"22","key":"10.1016\/j.ejogrb.2020.06.042_bib0090","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1080\/14767058.2017.1359828","article-title":"The effect of hyoscine butylbromide on the duration and progress of labor in primigravidae: a randomized controlled trial","volume":"31","author":"Maged","year":"2018","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"2","key":"10.1016\/j.ejogrb.2020.06.042_bib0095","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3325\/cmj.2011.52.159","article-title":"Effect of hyoscine-N-butyl bromide rectal suppository on labor progress in primigravid women: randomized double-blind placebo-controlled clinical trial","volume":"52","author":"Makvandi","year":"2011","journal-title":"Croat Med J"},{"key":"10.1016\/j.ejogrb.2020.06.042_bib0100","doi-asserted-by":"crossref","first-page":"495","DOI":"10.2147\/TCRM.S16415","article-title":"The effect of hyoscine butylbromide in shortening the first stage of labor: a double blind, randomized, controlled, clinical trial","volume":"7","author":"Qahtani","year":"2011","journal-title":"Ther Clin Risk Manag"},{"issue":"66","key":"10.1016\/j.ejogrb.2020.06.042_bib0105","first-page":"30","article-title":"Effect of hyoscine butylbromide on cervical dilation during labor","volume":"17","author":"Trevi\u00f1o-Salinas","year":"2015","journal-title":"Med Univ"},{"issue":"9","key":"10.1016\/j.ejogrb.2020.06.042_bib0110","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3923\/pjbs.2013.443.445","article-title":"Hyoscine-N-butylbromide versus atropine as labour accelerant and analgesic: a randomized clinical trial","volume":"16","author":"Fardiazar","year":"2013","journal-title":"Pak J Biol Sci"},{"issue":"5","key":"10.1016\/j.ejogrb.2020.06.042_bib0115","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1097\/MPG.0b013e3182483e8f","article-title":"Amino acid-based formula as a rescue strategy in feeding very-low-birth-weight infants with intrauterine growth restriction","volume":"54","author":"Raimondi","year":"2012","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"4","key":"10.1016\/j.ejogrb.2020.06.042_bib0120","first-page":"e52","article-title":"Committee on obstetric practice American academy of pediatrics - Committee on fetus and newborn. Committee opinion No. 644","volume":"126","year":"2015","journal-title":"The Apgar Score. Obstet Gynecol."},{"issue":"23","key":"10.1016\/j.ejogrb.2020.06.042_bib0125","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.3109\/14767058.2016.1148134","article-title":"Analgesic effects of acetaminophen, diclofenac and hyoscine N-butylbromide in second trimester pregnancy termination: a prospective randomized study","author":"Velipasaoglu","year":"2016","journal-title":"J Matern Fetal Neonatal Med"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211520304176?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211520304176?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:50:13Z","timestamp":1759557013000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211520304176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":25,"alternative-id":["S0301211520304176"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2020.06.042","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of hyoscine butyl-bromide in shortening the active phase of labor: Systematic review and meta-analysis of randomized trials","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2020.06.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}