{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:27:09Z","timestamp":1793287629931,"version":"4.5.0"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National Centre for Child Health and Development 24-3","id":[{"id":"https:\/\/ror.org\/03fvwxc59","id-type":"ROR","asserted-by":"crossref"}]},{"name":"JSPS KAKENHI","award":["JP17K11219"],"award-info":[{"award-number":["JP17K11219"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.ejogrb.2020.10.050","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T12:58:32Z","timestamp":1603803512000},"page":"75-81","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Retrospective details of false-positive and false-negative results in non-invasive prenatal testing for fetal trisomies 21, 18 and 13"],"prefix":"10.1016","volume":"256","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9003-1289","authenticated-orcid":false,"given":"Nobuhiro","family":"Suzumori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Sekizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Samura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3099-4619","authenticated-orcid":false,"given":"Aiko","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina","family":"Akaishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruka","family":"Hamanoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiki","family":"Hirahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8997-464X","authenticated-orcid":false,"given":"Hideaki","family":"Sawai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyonori","family":"Miura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Masuzaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Setsuko","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimasa","family":"Kamei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Namba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Murotsuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Tairaku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyo","family":"Kasai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyotake","family":"Ichizuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinori","family":"Ida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Miharu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Hasuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayuko","family":"Ichikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunichiro","family":"Izumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiko","family":"Kuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Yotsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuki","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahoko","family":"Shirato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuko","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9387-1849","authenticated-orcid":false,"given":"Haruhiko","family":"Sago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2020.10.050_bib0005","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1097\/AOG.0b013e31824fb482","article-title":"Maternal blood is source to accurately diagnose fetal aneuploidy (MELISSA) Study Group. Genome-wide fetal aneuploidy detection by maternal plasma DNA sequencing","volume":"119","author":"Bianchi","year":"2012","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2020.10.050_bib0010","first-page":"1","article-title":"Nationwide demonstration project of next-generation sequencing of cell-free DNA in maternal plasma in Japan: 1-year experience","volume":"35","author":"Sago","year":"2015","journal-title":"J Prenat Diagn Ther"},{"key":"10.1016\/j.ejogrb.2020.10.050_bib0015","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1111\/jog.13373","article-title":"Current status of noninvasive prenatal testing in Japan","volume":"43","author":"Samura","year":"2017","journal-title":"J Obstet Gynecol Res"},{"key":"10.1016\/j.ejogrb.2020.10.050_bib0020","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1038\/jhg.2016.96","article-title":"A survey on awareness of genetic counseling for non-invasive prenatal testing: the first year experience in Japan","volume":"61","author":"Yotsumoto","year":"2016","journal-title":"J Hum Genet"},{"key":"10.1016\/j.ejogrb.2020.10.050_bib0025","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/jhg.2016.25","article-title":"Fetal cell-free DNA fraction in maternal plasma is affected by fetal trisomy","volume":"61","author":"Suzumori","year":"2016","journal-title":"J Hum Genet"},{"key":"10.1016\/j.ejogrb.2020.10.050_bib0030","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/pd.5408","article-title":"Classification of factors involved in nonreportable results of noninvasive prenatal testing (NIPT) and prediction of success rate of second NIPT","volume":"39","author":"Suzumori","year":"2019","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ejogrb.2020.10.050_bib0035","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1056\/NEJMra1705345","article-title":"Sequencing of circulating cell-free DNA during pregnancy","volume":"379","author":"Bianchi","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejogrb.2020.10.050_bib0040","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13039-018-0397-x","article-title":"Analysis of the accuracy of Z-scores of non-invasive prenatal testing for fetal trisomies 13, 18, and 21 that employs the ion proton semiconductor sequencing platform","volume":"11","author":"Tian","year":"2018","journal-title":"Mol Cytogenet"},{"key":"10.1016\/j.ejogrb.2020.10.050_bib0045","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/pd.5014","article-title":"Contribution of maternal copy number variations to false-positive fetal trisomies detected by noninvasive prenatal testing","volume":"37","author":"Zhou","year":"2017","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ejogrb.2020.10.050_bib0050","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/pd.4783","article-title":"Incidental detection of familial APP duplication: an unusual reason for a false positive NIPT result of trisomy 21","volume":"36","author":"Meschino","year":"2016","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ejogrb.2020.10.050_bib0055","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1126\/science.6867735","article-title":"Chromosomal mosaicism confined to the placenta in human conceptions","volume":"221","author":"Kalousek","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.ejogrb.2020.10.050_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmg.2018.08.014","article-title":"Molecular genetic analysis reveals atypical confined placental mosaicism with a small supernumerary marker chromosome derived from chromosome 18: a clinical report of discordant results from three prenatal tests","volume":"62","author":"Sato","year":"2019","journal-title":"Eur J Med Genet"},{"key":"10.1016\/j.ejogrb.2020.10.050_bib0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0146794","article-title":"False negative NIPT results: risk figures for chromosomes 13, 18 and 21 based on chorionic villi results in 5967 cases and literature review","volume":"11","author":"Van Opstal","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ejogrb.2020.10.050_bib0070","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/uog.13277","article-title":"Non-invasive prenatal testing for fetal chromosomal abnormalities by low-coverage whole-genome sequencing of maternal plasma DNA: review of 1982 consecutive cases in a single center","volume":"43","author":"Lau","year":"2014","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2020.10.050_bib0075","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1097\/AOG.0000000000002728","article-title":"Factors associated with informative redraw after an initial no result in noninvasive prenatal testing","volume":"132","author":"Benn","year":"2018","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2020.10.050_bib0080","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/s10038-018-0453-8","article-title":"Maternal age-specific risk for trisomy 21 based on the clinical performance of NIPT and empirically derived NIPT age-specific positive and negative predictive values in Japan","volume":"63","author":"Yamada","year":"2018","journal-title":"J Hum Genet"},{"key":"10.1016\/j.ejogrb.2020.10.050_bib0085","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/pd.5049","article-title":"Discordant non-invasive testing (NIPT) \u2013 a systematic review","volume":"37","author":"Hartwig","year":"2017","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ejogrb.2020.10.050_bib0090","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/pd.4837","article-title":"Noninvasive prenatal testing (NIPT) in twin pregnancies with treatment of assisted reproductive techniques (ART) in a single center","volume":"36","author":"Tan","year":"2016","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ejogrb.2020.10.050_bib0095","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1111\/jog.13744","article-title":"Performance and outcomes of noninvasive prenatal testing for twin pregnancies in Japan","volume":"44","author":"Takeda","year":"2018","journal-title":"J Obstet Gynecol Res"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211520306886?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211520306886?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:49:21Z","timestamp":1759556961000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211520306886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":19,"alternative-id":["S0301211520306886"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2020.10.050","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Retrospective details of false-positive and false-negative results in non-invasive prenatal testing for fetal trisomies 21, 18 and 13","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2020.10.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}