{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T09:04:25Z","timestamp":1781859865664,"version":"3.54.5"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["843002804"],"award-info":[{"award-number":["843002804"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.ejogrb.2020.10.058","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T12:30:04Z","timestamp":1603888204000},"page":"63-69","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["A multi-centre, randomized, non-inferiority trial to compare ulipristal with standard surgical treatment in women with symptomatic uterine fibroids: Protocol of the MYOMEX-2 trial"],"prefix":"10.1016","volume":"256","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0847-2566","authenticated-orcid":false,"given":"Mei-An","family":"Middelkoop","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A.F.","family":"Huirne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijke C. Jansen","family":"van der Weide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith E.","family":"Bosmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter J.K.","family":"Hehenkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9252","key":"10.1016\/j.ejogrb.2020.10.058_bib0005","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0140-6736(00)03622-9","article-title":"Uterine fibroids","volume":"357","author":"Stewart","year":"2001","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.ejogrb.2020.10.058_bib0010","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/aji.12127","article-title":"Cytokine patterns differ seasonally between women with and without uterine leiomyomata","volume":"70","author":"Wegienka","year":"2013","journal-title":"Am J Reprod Immunol."},{"issue":"1","key":"10.1016\/j.ejogrb.2020.10.058_bib0015","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1067\/mob.2003.99","article-title":"High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence","volume":"188","author":"Baird","year":"2003","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.ejogrb.2020.10.058_bib0020","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1093\/humupd\/dmt042","article-title":"The role of angiogenic factors in fibroid pathogenesis: potential implications for future therapy","volume":"20","author":"Tal","year":"2014","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.ejogrb.2020.10.058_bib0025","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.bpobgyn.2015.11.017","article-title":"Pregnancy outcome and uterine fibroids","volume":"34","author":"Parazzini","year":"2016","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"6","key":"10.1016\/j.ejogrb.2020.10.058_bib0030","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/humupd\/dmw023","article-title":"Uterine fibroid management: from the present to the future","volume":"22","author":"Donnez","year":"2016","journal-title":"Hum Reprod Update"},{"issue":"4","key":"10.1016\/j.ejogrb.2020.10.058_bib0035","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/ajcp\/94.4.435","article-title":"The frequency of uterine leiomyomas","volume":"94","author":"Cramer","year":"1990","journal-title":"Am J Clin Pathol"},{"issue":"5","key":"10.1016\/j.ejogrb.2020.10.058_bib0040","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1056\/NEJMoa1103182","article-title":"Ulipristal acetate versus placebo for fibroid treatment before surgery","volume":"366","author":"Donnez","year":"2012","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.ejogrb.2020.10.058_bib0045","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1056\/NEJMoa1103180","article-title":"Ulipristal acetate versus leuprolide acetate for uterine fibroids","volume":"366","author":"Donnez","year":"2012","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.ejogrb.2020.10.058_bib0050","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/modpathol.2008.19","article-title":"The spectrum of endometrial pathology induced by progesterone receptor modulators","volume":"21","author":"Mutter","year":"2008","journal-title":"Mod Pathol"},{"issue":"1","key":"10.1016\/j.ejogrb.2020.10.058_bib0055","first-page":"48","article-title":"Long-term intermittent pharmacological therapy of uterine fibroids - a possibility to avoid hysterectomy and its negative consequences","volume":"15","author":"Olejek","year":"2016","journal-title":"Prz Menopauzalny"},{"issue":"10","key":"10.1016\/j.ejogrb.2020.10.058_bib0060","doi-asserted-by":"crossref","first-page":"683","DOI":"10.3109\/09513590.2014.950647","article-title":"Selective progesterone receptor modulators: a class with multiple actions and applications in reproductive endocrinology, and gynecology","volume":"30","author":"Bouchard","year":"2014","journal-title":"Gynecol Endocrinol"},{"issue":"3","key":"10.1016\/j.ejogrb.2020.10.058_bib0065","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1210\/er.2005-0001","article-title":"Selective progesterone receptor modulator development and use in the treatment of leiomyomata and endometriosis","volume":"26","author":"Chwalisz","year":"2005","journal-title":"Endocr Rev"},{"issue":"6","key":"10.1016\/j.ejogrb.2020.10.058_bib0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2014.02.008","article-title":"Long-term treatment of uterine fibroids with ulipristal acetate\u22c6","volume":"101","author":"Donnez","year":"2014","journal-title":"Fertil Steril"},{"issue":"7","key":"10.1016\/j.ejogrb.2020.10.058_bib0075","doi-asserted-by":"crossref","DOI":"10.1038\/ajg.2014.131","article-title":"ACG Clinical Guideline: the diagnosis and management of idiosyncratic drug-induced liver injury","volume":"109","author":"Chalasani","year":"2014","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.ejogrb.2020.10.058_bib0080","series-title":"PRAC recommends new measures to minimise risk of rare but serious liver injury with Esmya for fibroids","author":"PRAC","year":"2018"},{"key":"10.1016\/j.ejogrb.2020.10.058_bib0085","series-title":"Assessment report on provisional measures","author":"PRAC","year":"2018"},{"key":"10.1016\/j.ejogrb.2020.10.058_bib0090","series-title":"Esmya: new measures to minimise risk of rare but serious liver injury","author":"PRAC","year":"2018"},{"key":"10.1016\/j.ejogrb.2020.10.058_bib0095","series-title":"Suspension of ulipristal acetate for uterine fibroids during ongoing EMA review of liver injury risk","author":"Agency EM","year":"2020"},{"issue":"4","key":"10.1016\/j.ejogrb.2020.10.058_bib0100","doi-asserted-by":"crossref","first-page":"519","DOI":"10.4293\/108680812X13462882736736","article-title":"Costs and outcomes of abdominal, vaginal, laparoscopic and robotic hysterectomies","volume":"16","author":"Wright","year":"2012","journal-title":"JSLS"},{"issue":"2 Pt 1","key":"10.1016\/j.ejogrb.2020.10.058_bib0105","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/AOG.0b013e318299a6cf","article-title":"Nationwide trends in the performance of inpatient hysterectomy in the United States","volume":"122","author":"Wright","year":"2013","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2020.10.058_bib0110","article-title":"The past, present, and future of selective progesterone receptor modulators in the management of uterine fibroids","author":"Singh","year":"2017","journal-title":"Am J Obstet Gynecol"},{"issue":"346","key":"10.1016\/j.ejogrb.2020.10.058_bib0115","doi-asserted-by":"crossref","first-page":"e7586","DOI":"10.1136\/bmj.e7586","article-title":"SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials","author":"Chan","year":"2013","journal-title":"BMJ"},{"key":"10.1016\/j.ejogrb.2020.10.058_bib0120","author":"Nederland"},{"key":"10.1016\/j.ejogrb.2020.10.058_bib0125","series-title":"Richtlijn voor het uitvoeren van economische evaluaties in de gezondheidszorg","year":"2016"},{"key":"10.1016\/j.ejogrb.2020.10.058_bib0130","series-title":"Kostenhandleiding: Methodologie van kostenonderzoek en referentieprijzen voor economische evaluaties in de gezondheidszorg","author":"Hakkaart-Van Roijen LVdL","year":"2016"},{"issue":"3","key":"10.1016\/j.ejogrb.2020.10.058_bib0135","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/ndt\/gfv456","article-title":"Recommendations for the use of tolvaptan in autosomal dominant polycystic kidney disease: a position statement on behalf of the ERA-EDTA Working Groups on inherited kidney disorders and European renal best practice","volume":"31","author":"Gansevoort","year":"2016","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.ejogrb.2020.10.058_bib0140","series-title":"Guidance for industry drug-induced liver injury: premarketing clinical evaluation","author":"FDA","year":"2009"},{"issue":"3","key":"10.1016\/j.ejogrb.2020.10.058_bib0145","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1007\/s00270-011-0228-5","article-title":"Uterine artery embolization versus myomectomy: impact on quality of life--results of the FUME (Fibroids of the Uterus: myomectomy versus Embolization) Trial","volume":"35","author":"Manyonda","year":"2012","journal-title":"Cardiovasc Intervent Radiol"},{"issue":"3","key":"10.1016\/j.ejogrb.2020.10.058_bib0150","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1097\/AOG.0b013e3181ed36b3","article-title":"Outcomes from leiomyoma therapies: comparison with normal controls","volume":"116","author":"Spies","year":"2010","journal-title":"Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.ejogrb.2020.10.058_bib0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2015.09.032","article-title":"Long-term medical management of uterine fibroids with ulipristal acetate","volume":"105","author":"Donnez","year":"2016","journal-title":"Fertil Steril"},{"issue":"2","key":"10.1016\/j.ejogrb.2020.10.058_bib0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2014.10.038","article-title":"Efficacy and safety of repeated use of ulipristal acetate in uterine fibroids","volume":"103","author":"Donnez","year":"2015","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2020.10.058_bib0165","series-title":"Afkwapwaarden klinische chemie Erasmus MC","year":"2015"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211520306965?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211520306965?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:49:15Z","timestamp":1759556955000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211520306965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":33,"alternative-id":["S0301211520306965"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2020.10.058","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A multi-centre, randomized, non-inferiority trial to compare ulipristal with standard surgical treatment in women with symptomatic uterine fibroids: Protocol of the MYOMEX-2 trial","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2020.10.058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}