{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:38:21Z","timestamp":1792517901150,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.ejogrb.2021.02.003","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T20:13:51Z","timestamp":1612642431000},"page":"53-59","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Effects of fetal involvement of inadvertent radioactive iodine therapy for the treatment of thyroid diseases during an unsuspected pregnancy"],"prefix":"10.1016","volume":"259","author":[{"given":"Shigeo","family":"Iijima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2021.02.003_bib0005","series-title":"Thyroid cancer\u2014advances in diagnosis and therapy","first-page":"229","article-title":"Radiation dosimetry in thyroid cancer patients","author":"Be\u015fli","year":"2016"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0010","first-page":"146","article-title":"Inadvertent 131I therapy for hyperthyroidism in the first trimester of pregnancy","volume":"17","author":"Stoffer","year":"1976","journal-title":"J Nucl Med"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0015","first-page":"560","article-title":"The effects of radioactive iodine on maternal and fetal thyroid function during pregnancy","volume":"104","author":"Russell","year":"1957","journal-title":"Surg Gynecol Obstet"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0020","first-page":"506","article-title":"Congenital cretinism associated with I-131 therapy of the mother","volume":"98","author":"Ray","year":"1959","journal-title":"AMA Am J Dis Child"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0025","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/S0002-9378(15)33452-9","article-title":"Fetal effects of radioactive iodine therapy in a pregnant woman with thyroid cancer","volume":"81","author":"Hamill","year":"1961","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0030","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0022-3476(63)80080-3","article-title":"Congenital hypothyroidism in infant following maternal I-131 therapy with a review of hazards of environmental radioisotope contamination","volume":"62","author":"Fisher","year":"1963","journal-title":"J Pediatr"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0035","first-page":"247","article-title":"Cretinism associated with maternal sodium iodide I 131 therapy during pregnancy","volume":"122","author":"Green","year":"1971","journal-title":"Am J Dis Child"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0040","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1159\/000240659","article-title":"Congenital athyroidism in the newborn infant from intra-uterine radioiodine action","volume":"24","author":"Exss","year":"1974","journal-title":"Biol Neonate"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0045","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1001\/archotol.1974.00780030381010","article-title":"Congenital radioactive iodine-induced stridor and hypothyroidism","volume":"99","author":"Jafek","year":"1974","journal-title":"Arch Otolaryngol"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0050","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0022-3476(81)80980-8","article-title":"Combined hypothyroidism and hypoparathyroidism in an infant after maternal 131I administration","volume":"99","author":"Richards","year":"1981","journal-title":"J Pediatr"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0055","first-page":"408","article-title":"Radioiodine therapy during an unknown remained pregnancy and radiation exposure of the fetus. A case report","volume":"170","author":"Arndt","year":"1994","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0060","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1046\/j.1365-2265.1998.00423.x","article-title":"Radioiodine treatment in unsuspected pregnancy","volume":"48","author":"Evans","year":"1998","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0065","first-page":"357","article-title":"Radioiodine treatment of hyperthyroidism in a pregnant woman","volume":"39","author":"Berg","year":"1998","journal-title":"J Nucl Med"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0070","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/02841860701558807","article-title":"Consequences of inadvertent radioactive treatment of Graves\u2019 disease and thyroid cancer in undiagnosed pregnancy. Can we rely on routine pregnancy testing?","volume":"47","author":"Berg","year":"2008","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0075","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/jcu.20737","article-title":"Prenatal diagnosis of fetal hypothyroidism after maternal radioactive iodine exposure during pregnancy","volume":"38","author":"Basbug","year":"2010","journal-title":"J Clin Ultrasound"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0080","doi-asserted-by":"crossref","DOI":"10.1186\/1687-9856-2010-858359","article-title":"I-131 treatment of Graves\u2019 disease in an unsuspected first trimester pregnancy; the potential for adverse effects on the fetus and a review of the current guidelines for pregnancy screening","volume":"2010","author":"Tran","year":"2010","journal-title":"Int J Pediatr Endocrinol"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0085","doi-asserted-by":"crossref","first-page":"111","DOI":"10.4274\/jcrpe.553","article-title":"Congenital hypothyroidism due to maternal radioactive iodine exposure during pregnancy","volume":"4","author":"Kurto\u011flu","year":"2012","journal-title":"J Clin Res Pediatr Endocrinol"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0090","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1111\/jog.12482","article-title":"Case of radioactive iodine exposure during pregnancy","volume":"40","author":"Sadakata","year":"2014","journal-title":"J Obstet Gynaecol Res"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0095","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1097\/RLU.0000000000001376","article-title":"No adverse effects after radioiodine treatment at 3 weeks of pregnancy","volume":"41","author":"Radacic-Aumiler","year":"2016","journal-title":"Clin Nucl Med"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0100","doi-asserted-by":"crossref","first-page":"120","DOI":"10.4274\/eamr.galenos.2018.04875","article-title":"Calculation of embryo\/fetus dose in pregnant thyroid patients who have accidentally received radioiodine","volume":"35","author":"Demir","year":"2019","journal-title":"Eur Arch Med Res"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0105","first-page":"57","article-title":"Radiation effects in the embryo and fetus. ICRP Publication 103","volume":"37","author":"International Commission on Radiological Protection","year":"2007","journal-title":"Ann ICRP"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0110","first-page":"1","article-title":"Pregnancy and medical radiation. ICRP Publication 84","volume":"30","author":"International Commission on Radiological Protection","year":"2000","journal-title":"Ann ICRP"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0115","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1741-4520.2002.tb00848.x","article-title":"Radiological protection for diagnostic examination of pregnant women","volume":"42","author":"Kusama","year":"2002","journal-title":"Congenit Anom (Kyoto)"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0120","first-page":"271","article-title":"Dealing with pregnancy in radiology: a thin line between science, social and regulatory aspects","volume":"92","author":"Buls","year":"2009","journal-title":"JBR-BTR"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0125","series-title":"Nelson textbook of pediatrics","first-page":"2914","article-title":"Hypothyroidism","author":"Wassner","year":"2019"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0130","series-title":"UNSCEAR 2001 Report. United Nations Scientific Committee on the Effects of Atomic Radiation, 2001 Report to the General Assembly, With Scientific Annex","first-page":"57","article-title":"Hereditary effects of radiation","author":"UNSCEAR","year":"2001"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0135","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0889-8545(05)70006-1","article-title":"Radiation therapy during pregnancy","volume":"25","author":"Mayr","year":"1998","journal-title":"Obstet Gynecol Clin North Am"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0140","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/095530098141555","article-title":"Radiation-related brain damage and growth retardation among the prenatally exposed atomic bomb survivors","volume":"74","author":"Otake","year":"1998","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0145","series-title":"Radiation and pregnancy: a fact sheet for clinicians","author":"Centers for Disease Control and Prevention","year":"2019"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0150","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1089\/thy.1999.9.721","article-title":"Radioiodine and pregnancy","volume":"9","author":"Gorman","year":"1999","journal-title":"Thyroid"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0155","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/0002-9378(70)90439-4","article-title":"Irradiation and radiocontamination during pregnancy","volume":"108","author":"Sternberg","year":"1970","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0160","series-title":"Proceedings of the Fifth International Radiopharmaceutical Dosimetry Symposium","first-page":"179","article-title":"Radiation absorbed dose to the human fetal thyroid","author":"Watson","year":"1992"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0165","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1097\/00004032-199711000-00003","article-title":"Radiation absorbed dose to the embryo\/fetus from radiopharmaceuticals","volume":"73","author":"Russell","year":"1997","journal-title":"Health Phys"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0170","series-title":"Age-related factors in radionuclide metabolism and dosimetry","first-page":"327","article-title":"Assessment of fetal activity concentration and fetal dose for selected radionuclides based on animal and human data","author":"Roedler","year":"1987"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0175","series-title":"Age-related factors in radionuclide metabolism and dosimetry","first-page":"249","article-title":"A review of age dependent radioiodine dosimetry","author":"Johnson","year":"1987"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0180","first-page":"150","article-title":"Exposure with I-131 during pregnancy: significance for mother and child","volume":"24","author":"Ogris","year":"1997","journal-title":"Acta Med Austriaca"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0185","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1097\/00004032-200006000-00008","article-title":"Effects of time of administration and dietary iodine levels on potassium iodide (KI) blockade of thyroid irradiation by 131I from radioactive fallout","volume":"78","author":"Zanzonico","year":"2000","journal-title":"Health Phys"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0190","series-title":"Practice guideline for the performance of therapy with unsealed radiopharmaceutical sources","author":"ACR","year":"2005"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0195","first-page":"220","article-title":"Pregnancy testing before high-dose radioiodine treatment: a case report","volume":"27","author":"Bohuslavizki","year":"1999","journal-title":"J Nucl Med Technol"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0200","series-title":"IAEA radiation protection of patients (RPOP)","author":"Radiation protection of pregnant women in nuclear medicine","year":"2010"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0205","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0301-2115(00)00346-8","article-title":"Prenatal diagnosis and early in utero management of fetal dyshormonogenetic goiter","volume":"94","author":"Perrotin","year":"2001","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0210","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1046\/j.1469-0705.2002.00717.x","article-title":"Intrauterine diagnosis and management of congenital goitrous hypothyroidism","volume":"19","author":"Agrawal","year":"2002","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0215","first-page":"1797","article-title":"Iodine-131 in breast milk following therapy for thyroid carcinoma","volume":"35","author":"Robinson","year":"1994","journal-title":"J Nucl Med"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0220","doi-asserted-by":"crossref","first-page":"e796","DOI":"10.1542\/peds.2013-1985","article-title":"Committee on Drugs. The transfer of drugs and therapeutics into human breast milk: an update on selected topics","volume":"132","author":"Sachs","year":"2013","journal-title":"Pediatrics"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0225","first-page":"64","article-title":"Breastfeeding. ICRP publication 94","volume":"34","author":"International Commission on Radiological Protection","year":"2004","journal-title":"Ann ICRP"},{"key":"10.1016\/j.ejogrb.2021.02.003_bib0230","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1007\/s00259-008-0883-1","article-title":"Guidelines for radioiodine therapy of differentiated thyroid cancer","volume":"35","author":"Luster","year":"2008","journal-title":"Eur J Nucl Med Mol Imaging"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211521000725?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211521000725?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:50:45Z","timestamp":1759557045000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211521000725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":46,"alternative-id":["S0301211521000725"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2021.02.003","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of fetal involvement of inadvertent radioactive iodine therapy for the treatment of thyroid diseases during an unsuspected pregnancy","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2021.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}