{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:15:44Z","timestamp":1790813744625,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T00:00:00Z","timestamp":1658534400000},"content-version":"am","delay-in-days":325,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.ejogrb.2021.06.042","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T11:24:32Z","timestamp":1624965872000},"page":"173-177","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Changes in S100B and troponin levels in a fetal sheep model of worsening acidosis"],"prefix":"10.1016","volume":"264","author":[{"given":"Yasmine","family":"Hamoud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean David","family":"Pekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Drumez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Lacan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Maboudou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"De Jonckheere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Storme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Houfflin-Debarge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dyuti","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2105-9784","authenticated-orcid":false,"given":"Charles","family":"Garabedian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Ghesqui\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ejogrb.2021.06.042_b0005","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ajog.2019.07.032","article-title":"The physiology of intrapartum fetal compromise at term","volume":"222","author":"Turner","year":"2020","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.ejogrb.2021.06.042_b0010","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jogoh.2016.11.005","article-title":"Understanding fetal physiology and second line monitoring during labor","volume":"46","author":"Garabedian","year":"2017","journal-title":"J Gynecol Obstet Hum Reprod"},{"issue":"23","key":"10.1016\/j.ejogrb.2021.06.042_b0015","doi-asserted-by":"crossref","first-page":"5611","DOI":"10.1113\/JP274937","article-title":"The peripheral chemoreflex: indefatigable guardian of fetal physiological adaptation to labour","volume":"596","author":"Lear","year":"2018","journal-title":"J Physiol"},{"issue":"9","key":"10.1016\/j.ejogrb.2021.06.042_b0020","first-page":"1523","article-title":"S100B - a potential biomarker for early detection of neonatal brain damage following asphyxia","volume":"25","author":"Beharier","year":"2012","journal-title":"J Matern-Fetal Neonatal Med Off J Eur Assoc Perinat Med Fed Asia Ocean Perinat Soc Int Soc Perinat Obstet"},{"issue":"4","key":"10.1016\/j.ejogrb.2021.06.042_b0025","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1651-2227.2011.02539.x","article-title":"Cardiac biomarkers in neonatal hypoxic ischaemia","volume":"101","author":"Sweetman","year":"1992","journal-title":"Acta Paediatr Oslo Nor"},{"issue":"105","key":"10.1016\/j.ejogrb.2021.06.042_b0030","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.earlhumdev.2016.12.005","article-title":"The potentials and limitations of neuro-biomarkers as predictors of outcome in neonates with birth asphyxia","volume":"1","author":"Satriano","year":"2017","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.ejogrb.2021.06.042_b0035","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/978-1-4939-9030-6_44","article-title":"The Ca2+-binding S100B protein: an important diagnostic and prognostic neurobiomarker in pediatric laboratory medicine","volume":"1929","author":"Gazzolo","year":"2019","journal-title":"Methods Mol Biol Clifton NJ"},{"key":"10.1016\/j.ejogrb.2021.06.042_b0040","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.earlhumdev.2017.07.015","article-title":"Protein S100B in umbilical cord blood as a potential biomarker of hypoxic-ischemic encephalopathy in asphyxiated newborns","volume":"112","author":"Zaigham","year":"2017","journal-title":"Early Hum Dev"},{"issue":"6","key":"10.1016\/j.ejogrb.2021.06.042_b0045","first-page":"791","article-title":"Biochemical and clinical predictors of hypoxic-ischemic encephalopathy after perinatal asphyxia","volume":"31","author":"Jones","year":"2018","journal-title":"J Matern-Fetal Neonatal Med Off J Eur Assoc Perinat Med Fed Asia Ocean Perinat Soc Int Soc Perinat Obstet"},{"issue":"2","key":"10.1016\/j.ejogrb.2021.06.042_b0050","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1651-2227.2007.00104.x","article-title":"Is serum troponin T a useful marker of myocardial damage in newborn infants with perinatal asphyxia?","volume":"96","author":"Costa","year":"2007","journal-title":"Acta Paediatr Oslo Nor"},{"issue":"3","key":"10.1016\/j.ejogrb.2021.06.042_b0055","doi-asserted-by":"crossref","first-page":"273.e1","DOI":"10.1016\/j.ajog.2008.10.009","article-title":"Biochemical tissue-specific injury markers of the heart and brain in postpartum cord blood","volume":"200","author":"Kocylowski","year":"2009","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.ejogrb.2021.06.042_b0060","doi-asserted-by":"crossref","first-page":"e0190463","DOI":"10.1371\/journal.pone.0190463","article-title":"Correlation of a new index reflecting the fluctuation of parasympathetic tone and fetal acidosis in an experimental study in a sheep model","volume":"13","author":"Garabedian","year":"2018","journal-title":"PLoS ONE"},{"issue":"4","key":"10.1016\/j.ejogrb.2021.06.042_b0065","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/aogs.13515","article-title":"Parasympathetic nervous system response to acidosis: evaluation in an experimental fetal sheep model","volume":"98","author":"Ghesqui\u00e8re","year":"2019","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.ejogrb.2021.06.042_b0070","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ejogrb.2020.01.018","article-title":"Autonomic response to fetal acidosis using an experimental sheep model","volume":"246","author":"Vanspranghels","year":"2020","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ejogrb.2021.06.042_b0075","doi-asserted-by":"crossref","unstructured":"Prout AP, Frasch MG, Veldhuizen RAW, Hammond R, Ross MG, Richardson BS., Systemic and cerebral inflammatory response to umbilical cord occlusions with worsening acidosis in the ovine fetus. Am J Obstet Gynecol. 2010 Jan, 202(1), 82.e1-9.","DOI":"10.1016\/j.ajog.2009.08.020"},{"issue":"1","key":"10.1016\/j.ejogrb.2021.06.042_b0080","doi-asserted-by":"crossref","DOI":"10.1186\/s12887-018-1232-6","article-title":"LyTONEPAL Writing Group. LyTONEPAL: long term outcome of neonatal hypoxic encephalopathy in the era of neuroprotective treatment with hypothermia: a French population-based cohort","volume":"18","author":"Debillon","year":"2018","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.ejogrb.2021.06.042_b0085","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.cca.2015.08.021","article-title":"Neonatal hypoxic ischemic encephalopathy-related biomarkers in serum and cerebrospinal fluid","volume":"450","author":"Lv","year":"2015","journal-title":"Clin Chim Acta Int J Clin Chem"},{"issue":"2","key":"10.1016\/j.ejogrb.2021.06.042_b0090","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1203\/01.PDR.0000169999.66157.C0","article-title":"Acute hypoxia increases S100\u03b2 Protein in association with blood flow redistribution away from peripheral circulations in fetal sheep","volume":"58","author":"Giussani","year":"2005","journal-title":"Pediatr Res"},{"issue":"4","key":"10.1016\/j.ejogrb.2021.06.042_b0095","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1203\/00006450-200104000-00011","article-title":"Early biochemical indicators of hypoxic-ischemic encephalopathy after birth asphyxia","volume":"49","author":"Nagdyman","year":"2001","journal-title":"Pediatr Res"},{"issue":"8","key":"10.1016\/j.ejogrb.2021.06.042_b0100","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1177\/1933719109335801","article-title":"Increased maternal\/fetal blood S100B levels following systemic endotoxin administration and periventricular white matter injury in preterm fetal sheep","volume":"16","author":"Garnier","year":"2009","journal-title":"Reprod Sci Thousand Oaks Calif"},{"issue":"3","key":"10.1016\/j.ejogrb.2021.06.042_b0105","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ajog.2016.05.046","article-title":"Decelerations, tachycardia, and decreased variability: have we overlooked the significance of longitudinal fetal heart rate changes for detecting intrapartum fetal hypoxia?","volume":"215","author":"Vintzileos","year":"2016","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.ejogrb.2021.06.042_b0110","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1113\/JP271099","article-title":"The fetal brain sparing response to hypoxia: physiological mechanisms","volume":"594","author":"Giussani","year":"2016","journal-title":"J Physiol"},{"issue":"3","key":"10.1016\/j.ejogrb.2021.06.042_b0115","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.clp.2016.04.006","article-title":"Cardiovascular alterations and multiorgan dysfunction after birth asphyxia","volume":"43","author":"Polglase","year":"2016","journal-title":"Clin Perinatol"},{"issue":"3","key":"10.1016\/j.ejogrb.2021.06.042_b0120","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3390\/brainsci9030049","article-title":"Haemodynamic instability and brain injury in neonates exposed to hypoxia-ischaemia","volume":"9","author":"Badurdeen","year":"2019","journal-title":"Brain Sci [Internet]."},{"issue":"7","key":"10.1016\/j.ejogrb.2021.06.042_b0125","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1177\/1933719115623640","article-title":"Brain injury and inflammatory response to umbilical cord occlusions is limited with worsening acidosis in the near-term ovine fetus","volume":"23","author":"Xu","year":"2016","journal-title":"Reprod Sci Thousand Oaks Calif"},{"issue":"1","key":"10.1016\/j.ejogrb.2021.06.042_b0130","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1203\/00006450-199701000-00015","article-title":"Brief repeated umbilical cord occlusions cause sustained cytotoxic cerebral edema and focal infarcts in near-term fetal lambs","volume":"41","author":"De Haan","year":"1997","journal-title":"Pediatr Res"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211521003274?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211521003274?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:53:55Z","timestamp":1759557235000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211521003274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":26,"alternative-id":["S0301211521003274"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2021.06.042","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Changes in S100B and troponin levels in a fetal sheep model of worsening acidosis","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2021.06.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}