{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T08:44:38Z","timestamp":1775292278157,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.ejogrb.2021.09.012","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T11:08:03Z","timestamp":1631876883000},"page":"48-54","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Trauma and pregnancy: Is flow cytometry detection and quantification of fetal red blood cells useful?"],"prefix":"10.1016","volume":"266","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4875-1455","authenticated-orcid":false,"given":"Misgav","family":"Rottenstreich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reut","family":"Meir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2957-9090","authenticated-orcid":false,"given":"Itamar","family":"Glick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heli","family":"Alexandroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6917-6827","authenticated-orcid":false,"given":"Alon D.","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Broide","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sorina","family":"Grisaru-Granovsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hen Y.","family":"Sela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ejogrb.2021.09.012_b0005","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.suc.2007.12.006","article-title":"Trauma and surgical emergencies in the obstetric patient","volume":"88","author":"Hill","year":"2008","journal-title":"Surg Clin North Am."},{"issue":"12","key":"10.1016\/j.ejogrb.2021.09.012_b0010","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1089\/jwh.2013.4560","article-title":"Risk factors for maternal injuries in a population-based sample of pregnant women","volume":"23","author":"Harland","year":"2014","journal-title":"J Women\u2019s Heal."},{"issue":"1","key":"10.1016\/j.ejogrb.2021.09.012_b0015","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.amjsurg.2013.10.018","article-title":"The cost of injury: hospital charges for pregnant trauma patients, 1999 to 2003","volume":"208","author":"Periyanayagam","year":"2014","journal-title":"Am J Surg."},{"issue":"1","key":"10.1016\/j.ejogrb.2021.09.012_b0020","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/TA.0b013e31821cb600","article-title":"Minor trauma is an unrecognized contributor to poor fetal outcomes: a population-based study of 78,552 pregnancies","volume":"71","author":"Fischer","year":"2011","journal-title":"J Trauma Acute Care Surg."},{"issue":"1","key":"10.1016\/j.ejogrb.2021.09.012_b0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ajog.2013.01.021","article-title":"Trauma in pregnancy: an updated systematic review","volume":"209","author":"Mendez-Figueroa","year":"2013","journal-title":"Am J Obstet Gynecol."},{"issue":"3","key":"10.1016\/j.ejogrb.2021.09.012_b0030","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.jamcollsurg.2015.12.010","article-title":"Association between hospital trauma designation and maternal and neonatal outcomes after injury among pregnant women in Washington State","volume":"222","author":"Distelhorst","year":"2016","journal-title":"J Am Coll Surg."},{"issue":"6","key":"10.1016\/j.ejogrb.2021.09.012_b0035","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/aje\/kwi078","article-title":"Pregnancy outcomes following hospitalization for motor vehicle crashes in Washington State from 1989 to 2001","volume":"161","author":"Schiff","year":"2005","journal-title":"Am J Epidemiol."},{"key":"10.1016\/j.ejogrb.2021.09.012_b0040","article-title":"Baby on board: Trauma in pregnancy","author":"Fantus","year":"2020","journal-title":"American College Of Surgeons."},{"issue":"1","key":"10.1016\/j.ejogrb.2021.09.012_b0045","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1046\/j.1365-3148.2003.00416.x","article-title":"Quantification of feto-maternal haemorrhage (FMH) by flow cytometry: anti-fetal haemoglobin labelling potentially underestimates massive FMH in comparison to labelling with anti-D","volume":"13","author":"Kennedy","year":"2003","journal-title":"Transfus Med."},{"issue":"6","key":"10.1016\/j.ejogrb.2021.09.012_b0050","first-page":"285","article-title":"Multicenter clinical experience with flow cytometric method for fetomaternal hemorrhage detection","volume":"50","author":"Chen","year":"2002","journal-title":"Cytom J Int Soc Anal Cytol."},{"issue":"9","key":"10.1016\/j.ejogrb.2021.09.012_b0055","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1136\/jcp.43.9.728","article-title":"Assessment of fetal-maternal haemorrhage in mothers with hereditary persistence of fetal haemoglobin","volume":"43","author":"Patton","year":"1990","journal-title":"J Clin Pathol."},{"issue":"6","key":"10.1016\/j.ejogrb.2021.09.012_b0060","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1097\/01.moh.0000245687.09215.c4","article-title":"Detecting fetomaternal hemorrhage by flow cytometry","volume":"13","author":"Dziegiel","year":"2006","journal-title":"Curr Opin Hematol."},{"issue":"7","key":"10.1016\/j.ejogrb.2021.09.012_b0065","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1111\/j.1537-2995.2007.01271.x","article-title":"Identification and quantification of fetal red blood cells in maternal blood by a dual-color flow cytometric method: evaluation of the Fetal Cell Count kit","volume":"47","author":"Porra","year":"2007","journal-title":"Transfusion."},{"issue":"6","key":"10.1016\/j.ejogrb.2021.09.012_b0070","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1080\/15513815.2016.1209260","article-title":"Flow cytometry in detection of fetal red blood cells and maternal F cells to identify fetomaternal hemorrhage","volume":"35","author":"Farias","year":"2016","journal-title":"Fetal Pediatr Pathol."},{"issue":"2","key":"10.1016\/j.ejogrb.2021.09.012_b0075","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.ajog.2004.01.007","article-title":"Quantification of fetomaternal hemorrhage: a comparative study of the manual and automated microscopic Kleihauer-Betke tests and flow cytometry in clinical samples","volume":"191","author":"Pelikan","year":"2004","journal-title":"Am J Obstet Gynecol."},{"issue":"4","key":"10.1016\/j.ejogrb.2021.09.012_b0080","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1097\/01.AOG.0000141646.58884.09","article-title":"Persistent fetal hemoglobin in maternal circulation complicating the diagnosis of fetomaternal hemorrhage","volume":"105","author":"Kush","year":"2005","journal-title":"Obstet Gynecol."},{"issue":"1\u20132","key":"10.1016\/j.ejogrb.2021.09.012_b0085","first-page":"3","article-title":"Predicting adverse outcomes following trauma in pregnancy","volume":"57","author":"Trivedi","year":"2012","journal-title":"J Reprod Med."},{"issue":"11","key":"10.1016\/j.ejogrb.2021.09.012_b0090","first-page":"584","article-title":"Trauma and pregnancy: Is the Kleihauer-Betke test really useful?","volume":"45","author":"Girard","year":"2017","journal-title":"Gynecol Obstet Fertil Senol."},{"issue":"3","key":"10.1016\/j.ejogrb.2021.09.012_b0095","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/00005373-197403000-00001","article-title":"The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care","volume":"14","author":"BAKER","year":"1974","journal-title":"J Trauma."},{"issue":"1","key":"10.1016\/j.ejogrb.2021.09.012_b0100","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/00005373-198801000-00010","article-title":"The Injury Severity Score revisited","volume":"28","author":"Copes","year":"1988","journal-title":"J Trauma."},{"key":"10.1016\/j.ejogrb.2021.09.012_b0105","series-title":"ATLS\u00ae : Advanced Trauma Life Support Student Course Manual","author":"American College of Surgeons","year":"2018"},{"key":"10.1016\/j.ejogrb.2021.09.012_b0110","volume":"249","year":"1998","journal-title":"ACOG Educ Bull."},{"issue":"6","key":"10.1016\/j.ejogrb.2021.09.012_b0115","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1097\/AOG.0b013e31825af2f0","article-title":"127: Management of preterm labor","volume":"119","author":"ACOG practice bulletin no","year":"2012","journal-title":"Obstet Gynecol."},{"issue":"1","key":"10.1016\/j.ejogrb.2021.09.012_b0120","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ejogrb.2010.03.008","article-title":"Identification of feto-maternal haemorrhage around labour using flow cytometry immunophenotyping","volume":"151","author":"Uriel","year":"2010","journal-title":"Eur J Obstet Gynecol Reprod Biol."},{"key":"10.1016\/j.ejogrb.2021.09.012_b0125","series-title":"WHO Recommendation on Routes of Oxytocin Administration for the Prevention of Postpartum Haemorrhage after Vaginal Birth","author":"Organization","year":"2020"},{"issue":"1","key":"10.1016\/j.ejogrb.2021.09.012_b0130","doi-asserted-by":"crossref","first-page":"76.e1","DOI":"10.1016\/j.ajog.2015.02.023","article-title":"Prevention and management of postpartum hemorrhage: a comparison of 4 national guidelines","volume":"213","author":"Dahlke","year":"2015","journal-title":"Am J Obstet Gynecol."},{"issue":"5","key":"10.1016\/j.ejogrb.2021.09.012_b0135","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1600-0412.2011.01107.x","article-title":"Postpartum hemorrhage\u2013update on problems of definitions and diagnosis","volume":"90","author":"Rath","year":"2011","journal-title":"Acta Obstet Gynecol Scand."},{"issue":"3","key":"10.1016\/j.ejogrb.2021.09.012_b0140","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0368-2315(04)96443-5","article-title":"Usefulness of a collecting bag for the diagnosis of post-partum hemorrhage","volume":"33","author":"Tourn\u00e9","year":"2004","journal-title":"J Gynecol Obstet Biol Reprod (Paris)."},{"issue":"1","key":"10.1016\/j.ejogrb.2021.09.012_b0145","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.anclin.2012.10.002","article-title":"Management and outcomes of trauma during pregnancy","volume":"31","author":"Einav","year":"2013","journal-title":"Anesthesiol Clin."},{"issue":"1","key":"10.1016\/j.ejogrb.2021.09.012_b0150","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1586\/eog.10.68","article-title":"Injury in motor vehicle accidents during pregnancy: a pregnant issue","volume":"6","author":"Sela","year":"2011","journal-title":"Expert Rev Obstet Gynecol."},{"issue":"4","key":"10.1016\/j.ejogrb.2021.09.012_b0155","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1046\/j.1537-2995.1990.30490273444.x","article-title":"Fetomaternal hemorrhage: incidence, risk factors, time of occurrence, and clinical effects","volume":"30","author":"Sebring","year":"1990","journal-title":"Transfusion."},{"key":"10.1016\/j.ejogrb.2021.09.012_b0160","article-title":"Severe fetomaternal hemorrhage. A report of four cases","author":"Moya","year":"1987323243","journal-title":"J Reprod Med."},{"key":"10.1016\/j.ejogrb.2021.09.012_b0165","doi-asserted-by":"crossref","unstructured":"Kosasa TS, Ebesugawa I, Nakayama RT, Hale RW. Massive fetomaternal hemorrhage preceded by decreased fetal movement and a nonreactive fetal heart rate pattern. Obstet Gynecol. 1993;82(4 Pt 2 Suppl):711-714.","DOI":"10.1097\/00006250-199310020-00029"},{"issue":"2","key":"10.1016\/j.ejogrb.2021.09.012_b0170","first-page":"308","article-title":"Massive fetomaternal transplacental hemorrhage as a perinatology problem, role of AB0 fetomaternal compatibility-case studies","volume":"7","author":"Zizka","year":"2001","journal-title":"Med Sci Monit."},{"issue":"05","key":"10.1016\/j.ejogrb.2021.09.012_b0175","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1055\/s-2007-994142","article-title":"Massive fetomaternal hemorrhage","volume":"14","author":"Akanli","year":"1997","journal-title":"Am J Perinatol."},{"issue":"3","key":"10.1016\/j.ejogrb.2021.09.012_b0180","first-page":"323","article-title":"Massive fetomaternal hemorrhage: Manitoba experience","volume":"83","author":"de Almeida","year":"1994","journal-title":"Obstet Gynecol."},{"issue":"6","key":"10.1016\/j.ejogrb.2021.09.012_b0185","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/0002-9378(90)90913-R","article-title":"A prospective controlled study of outcome after trauma during pregnancy","volume":"162","author":"Pearlman","year":"1990","journal-title":"Am J Obstet Gynecol."},{"issue":"8","key":"10.1016\/j.ejogrb.2021.09.012_b0190","first-page":"621","article-title":"Clinical application of the Kleihauer-Betke test","volume":"38","author":"Dupre","year":"1993","journal-title":"J Reprod Med."},{"issue":"10","key":"10.1016\/j.ejogrb.2021.09.012_b0195","first-page":"717","article-title":"Trauma in pregnancy: assessment, management, and prevention","volume":"90","author":"Murphy","year":"2014","journal-title":"Am Fam Physician."},{"key":"10.1016\/j.ejogrb.2021.09.012_b0200","unstructured":"American College of Surgeons. Trauma in pregnancy and intimate partner violence Advanced Trauma Life Support Student Course Manual 9th ed. 2012 Chicago, Ill"},{"key":"10.1016\/j.ejogrb.2021.09.012_b0205","doi-asserted-by":"crossref","unstructured":"Dahmus MA, Sibai BM. Blunt abdominal trauma\u202f: Are there any predictive factors for abruptio placentae or maternal-fetal distress\u202f? Am J Obstet Gynecol. 169(4):1054-1059. doi:10.1016\/0002-9378(93)90053-L","DOI":"10.1016\/0002-9378(93)90053-L"},{"issue":"5","key":"10.1016\/j.ejogrb.2021.09.012_b0210","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1097\/01.TA.0000096654.37009.B7","article-title":"Kleihauer-Betke testing is important in all cases of maternal trauma","volume":"57","author":"Muench","year":"2004","journal-title":"J Trauma Acute Care Surg."},{"issue":"3","key":"10.1016\/j.ejogrb.2021.09.012_b0215","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/0002-9378(90)90979-H","article-title":"Pregnancy outcome and fetomaternal hemorrhage after noncatastrophic trauma","volume":"162","author":"Goodwin","year":"1990","journal-title":"Am J Obstet Gynecol."},{"key":"10.1016\/j.ejogrb.2021.09.012_b0220","article-title":"ScienceDirect Traumatisme et grossesse : le test de Kleihauer est-il vraiment utile ? Trauma and pregnancy : Is the Kleihauer-Betke test really useful ?","volume":"6\u201311","author":"Girard","year":"2017","journal-title":"Gynecol Obstet Fertil Senol."},{"issue":"5","key":"10.1016\/j.ejogrb.2021.09.012_b0225","first-page":"1461","article-title":"The incidences of positive Kleihauer-Betke test in low-risk pregnancies and maternal trauma patients","volume":"190","author":"Dhanraj","year":"2004","journal-title":"Am J Obstet Gynecol."},{"issue":"3","key":"10.1016\/j.ejogrb.2021.09.012_b0230","article-title":"Usefulness of maternal fetal red blood cell count in rhesus-positive pregnant women. Horm Mol Biol","volume":"35","author":"Lebrun","year":"2018","journal-title":"Clin Investig."},{"key":"10.1016\/j.ejogrb.2021.09.012_b0235","doi-asserted-by":"crossref","unstructured":"Karafin MS, Glisch C, Souers RJ, et al. Use of Fetal Hemoglobin Quantitation for Rh-Positive Pregnant Females: A National Survey and Review of the Literature. Arch Pathol Lab Med. 2019;143(12):1539-1544.","DOI":"10.5858\/arpa.2018-0523-CP"},{"issue":"2","key":"10.1016\/j.ejogrb.2021.09.012_b0240","doi-asserted-by":"crossref","first-page":"208.e1","DOI":"10.1016\/j.ajog.2007.07.042","article-title":"Minor trauma in pregnancy\u2014is the evaluation unwarranted?","volume":"198","author":"Cahill","year":"2008","journal-title":"Am J Obstet Gynecol."},{"issue":"6","key":"10.1016\/j.ejogrb.2021.09.012_b0245","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1067\/mob.2003.393","article-title":"Is the incidence of fetal-to-maternal hemorrhage increased in patients with third-trimester bleeding?","volume":"188","author":"Balderston","year":"2003","journal-title":"Am J Obstet Gynecol."},{"issue":"3","key":"10.1016\/j.ejogrb.2021.09.012_b0250","first-page":"302","article-title":"Mild-to-moderate foeto-maternal haemorrhage in the third trimester and at term of pregnancy: quantitative determination and clinical-diagnostic evaluation","volume":"16","author":"Beneventi","year":"2018","journal-title":"Blood Transfus."}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211521004565?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211521004565?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:53:41Z","timestamp":1759557221000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211521004565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":50,"alternative-id":["S0301211521004565"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2021.09.012","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trauma and pregnancy: Is flow cytometry detection and quantification of fetal red blood cells useful?","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2021.09.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}