{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:51:33Z","timestamp":1790736693033,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.ejogrb.2021.10.004","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T17:30:20Z","timestamp":1633627820000},"page":"11-17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Single blastocyst stage versus single cleavage stage embryo transfer following fresh transfer: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"267","author":[{"given":"Yutao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejogrb.2021.10.004_b0005","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1093\/humrep\/den014","article-title":"Assisted reproductive technology in Europe, 2004: results generated from European registers by ESHRE","volume":"23","author":"Nyboe Andersen","year":"2008","journal-title":"Hum Reprod (Oxford, England)"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0010","doi-asserted-by":"crossref","unstructured":"Society for Assisted Reproductive T, American Society for Reproductive M. Assisted reproductive technology in the United States: 2000 results generated from the American Society for Reproductive Medicine\/Society for Assisted Reproductive Technology Registry. Fertility and sterility. 2004;81:1207-20.","DOI":"10.1016\/j.fertnstert.2004.01.017"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0015","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.fertnstert.2017.07.1167","article-title":"Patient and cycle characteristics predicting high pregnancy rates with single-embryo transfer: an analysis of the Society for Assisted Reproductive Technology outcomes between 2004 and 2013","volume":"108","author":"Mersereau","year":"2017","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0020","doi-asserted-by":"crossref","unstructured":"McLernon DJ, Harrild K, Bergh C, Davies MJ, de Neubourg D, Dumoulin JC, et al. Clinical effectiveness of elective single versus double embryo transfer: meta-analysis of individual patient data from randomised trials. BMJ (Clinical research ed). 2010;341:c6945.","DOI":"10.1136\/bmj.c6945"},{"issue":"23","key":"10.1016\/j.ejogrb.2021.10.004_b0025","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1056\/NEJMoa041032","article-title":"Elective single-embryo transfer versus double-embryo transfer in in vitro fertilization","volume":"351","author":"Thurin","year":"2004","journal-title":"N Engl J Med"},{"issue":"12","key":"10.1016\/j.ejogrb.2021.10.004_b0030","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1093\/humrep\/des315","article-title":"Single embryo transfer reduces the risk of perinatal mortality, a population study","volume":"27","author":"Sullivan","year":"2012","journal-title":"Hum Reprod (Oxford, England)"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0035","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.siny.2014.04.004","article-title":"The economic implications of multiple pregnancy following ART","volume":"19","author":"Chambers","year":"2014","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0040","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1056\/NEJMoa053524","article-title":"In vitro fertilization with single blastocyst-stage versus single cleavage-stage embryos","volume":"354","author":"Papanikolaou","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0045","doi-asserted-by":"crossref","unstructured":"Yang L, Cai S, Zhang S, Kong X, Gu Y, Lu C, et al. Single embryo transfer by Day 3 time-lapse selection versus Day 5 conventional morphological selection: a randomized, open-label, non-inferiority trial. Hum Reprod (Oxford, England). 2018;33:869-76.","DOI":"10.1093\/humrep\/dey047"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0050","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1093\/humrep\/dep018","article-title":"Single Day 2 embryo versus blastocyst-stage transfer: a prospective study integrating fresh and frozen embryo transfers","volume":"24","author":"Guerif","year":"2009","journal-title":"Hum Reprod (Oxford, England)"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0055","first-page":"I60","article-title":"Cumulative pregnancy rates after single cleavage-stage versus blastocyst-stage embryo transfer: A randomized and prospective study","volume":"25","author":"Brugnon","year":"2010","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0060","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2014.05.027","article-title":"Cryopreservation of human embryos and its contribution to in vitro fertilization success rates","volume":"102","author":"Wong","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0065","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s10815-014-0387-9","article-title":"Ongoing and cumulative pregnancy rate after cleavage-stage versus blastocyst-stage embryo transfer using vitrification for cryopreservation: impact of age on the results","volume":"32","author":"Fern\u00e1ndez-Shaw","year":"2015","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0070","doi-asserted-by":"crossref","unstructured":"Glujovsky D, Farquhar C, Quinteiro Retamar AM, Alvarez Sedo CR, Blake D. Cleavage stage versus blastocyst stage embryo transfer in assisted reproductive technology. Cochrane Database System Rev. 2016:CD002118.","DOI":"10.1002\/14651858.CD002118.pub5"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0075","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.fertnstert.2006.11.070","article-title":"Prospective evaluation of the optimal time for selecting a single embryo for transfer: day 3 versus day 5","volume":"88","author":"Zech","year":"2007","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0080","doi-asserted-by":"crossref","unstructured":"Kaser DJ, Bormann CL, Missmer SA, Farland LV, Ginsburg ES, Racowsky C. A pilot randomized controlled trial of Day 3 single embryo transfer with adjunctive time-lapse selection versus Day 5 single embryo transfer with or without adjunctive time-lapse selection. Hum Reprod (Oxford, England). 2017;32:1598-603.","DOI":"10.1093\/humrep\/dex231"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0085","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/332459a0","article-title":"Human gene expression first occurs between the four- and eight-cell stages of preimplantation development","volume":"332","author":"Braude","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0090","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1093\/humrep\/15.8.1781","article-title":"Chromosome mosaicism in day 3 aneuploid embryos that develop to morphologically normal blastocysts in vitro","volume":"15","author":"Magli","year":"2000","journal-title":"Hum Reprod (Oxford, England)"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0095","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.rbmo.2013.05.018","article-title":"Implantation in assisted reproduction: a look at endometrial receptivity","volume":"27","author":"Fatemi","year":"2013","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0100","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.fertnstert.2013.11.034","article-title":"Factors associated with monozygosity in assisted reproductive technology pregnancies and the risk of recurrence using linked cycles","volume":"101","author":"Luke","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0105","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.rbmo.2015.09.016","article-title":"Should we be promoting embryo transfer at blastocyst stage?","volume":"32","author":"Maheshwari","year":"2016","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0110","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/humupd\/dmu001","article-title":"Neonatal outcomes among singleton births after blastocyst versus cleavage stage embryo transfer: a systematic review and meta-analysis","volume":"20","author":"Dar","year":"2014","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0115","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.beem.2019.04.001","article-title":"Single embryo transfer: Why and how to identify the embryo with the best developmental potential","volume":"33","author":"Tiitinen","year":"2019","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0120","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.fertnstert.2018.02.013","article-title":"Time-lapse imaging","volume":"109","author":"Paulson","year":"2018","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0125","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.rbmo.2017.06.022","article-title":"Time-lapse culture with morphokinetic embryo selection improves pregnancy and live birth chances and reduces early pregnancy loss: a meta-analysis","volume":"35","author":"Pribenszky","year":"2017","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0130","doi-asserted-by":"crossref","unstructured":"Armstrong S, Bhide P, Jordan V, Pacey A, Marjoribanks J, Farquhar C. Time-lapse systems for embryo incubation and assessment in assisted reproduction. Cochrane Database System Rev. 2019;5:CD011320.","DOI":"10.1002\/14651858.CD011320.pub4"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0135","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1093\/humrep\/deu163","article-title":"Preimplantation genetic screening: back to the future","volume":"29","author":"Mastenbroek","year":"2014","journal-title":"Hum Reprod (Oxford, England)"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0140","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.fertnstert.2013.04.039","article-title":"Cleavage-stage biopsy significantly impairs human embryonic implantation potential while blastocyst biopsy does not: a randomized and paired clinical trial","volume":"100","author":"Scott Jr","year":"2013","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0145","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/j.fertnstert.2005.05.063","article-title":"Pregnancies and live births after trophectoderm biopsy and preimplantation genetic testing of human blastocysts","volume":"84","author":"McArthur","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0150","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1093\/humrep\/del506","article-title":"Blastocyst biopsy versus cleavage stage biopsy and blastocyst transfer for preimplantation genetic diagnosis of beta-thalassaemia: a pilot study","volume":"22","author":"Kokkali","year":"2007","journal-title":"Hum Reprod (Oxford, England)"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0155","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.fertnstert.2003.11.064","article-title":"Moving to blastocyst biopsy for preimplantation genetic diagnosis and single embryo transfer at Sydney IVF","volume":"82","author":"de Boer","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0160","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nrg3245","article-title":"Human aneuploidy: mechanisms and new insights into an age-old problem","volume":"13","author":"Nagaoka","year":"2012","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2019.07.1346","article-title":"Preimplantation genetic testing for aneuploidy versus morphology as selection criteria for single frozen-thawed embryo transfer in good-prognosis patients: a multicenter randomized clinical trial","volume":"112","author":"Munn\u00e9","year":"2019","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0170","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.fertnstert.2012.11.041","article-title":"Preimplantation genetic screening using fluorescence in situ hybridization in patients with repetitive implantation failure and advanced maternal age: two randomized trials","volume":"99","author":"Rubio","year":"2013","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0175","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.fertnstert.2016.04.027","article-title":"Preimplantation genetic screening: who benefits?","volume":"106","author":"Kang","year":"2016","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0180","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1093\/humrep\/dev159","article-title":"Reduction of multiple pregnancies in the advanced maternal age population after implementation of an elective single embryo transfer policy coupled with enhanced embryo selection: pre- and post-intervention study","volume":"30","author":"Ubaldi","year":"2015","journal-title":"Hum Reprod (Oxford, England)"},{"key":"10.1016\/j.ejogrb.2021.10.004_b0185","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1093\/humupd\/dmq013","article-title":"The costs and consequences of assisted reproductive technology: an economic perspective","volume":"16","author":"Connolly","year":"2010","journal-title":"Hum Reprod Update"}],"container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211521004930?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211521004930?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:53:18Z","timestamp":1759557198000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211521004930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":37,"alternative-id":["S0301211521004930"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2021.10.004","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single blastocyst stage versus single cleavage stage embryo transfer following fresh transfer: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2021.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}