{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:30:35Z","timestamp":1793107835731,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.ejogrb.2021.10.022","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T18:00:00Z","timestamp":1634925600000},"page":"61-67","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Effect of metformin on adiponectin in PCOS: A meta-analysis and a systematic review"],"prefix":"10.1016","volume":"267","author":[{"given":"Xuan","family":"Duan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangqin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ejogrb.2021.10.022_b0005","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1021\/pr401130w","article-title":"Serum Metabolomics Study of Polycystic Ovary Syndrome Based on Liquid Chromatography-Mass Spectrometry","volume":"13","author":"Zhao","year":"2014","journal-title":"J Proteome Res"},{"key":"10.1016\/j.ejogrb.2021.10.022_b0010","article-title":"Insulin-sensitising drugs versus the combined oral contraceptive pill for hirsutism, acne, and risk of diabetes, cardiovascular disease, and endometrial cancer in polycystic ovary syndrome","volume":"1","author":"Costello","year":"2007","journal-title":"Cochrane Database System Rev."},{"issue":"04","key":"10.1016\/j.ejogrb.2021.10.022_b0015","first-page":"343","article-title":"Relationship between obesity and polycystic ovary syndrome and its potential mechanisms","volume":"38","author":"Liangshan","year":"2018","journal-title":"Chin J Reprod Contracep."},{"key":"10.1016\/j.ejogrb.2021.10.022_b0020","unstructured":"S.S. L, M.J. D, R.J. N, L.J. M. Overweight, obesity and central obesity in women with polycystic ovary syndrome: a systematic review and meta-analysis. Human Reproduction Update. 2012(6):6.."},{"issue":"4","key":"10.1016\/j.ejogrb.2021.10.022_b0025","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.rbmo.2009.05.010","article-title":"Adipose tissue, metabolic syndrome and polycystic ovary syndrome: from pathophysiology to treatment","volume":"19","author":"Garruti","year":"2009","journal-title":"Reprod Biomed Online."},{"key":"10.1016\/j.ejogrb.2021.10.022_b0030","first-page":"6","article-title":"Body composition characteristics and body fat distribution in lean women with polycystic ovary syndrome","volume":"6","author":"Kirchengast","year":"2001","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ejogrb.2021.10.022_b0035","doi-asserted-by":"crossref","unstructured":"Salley KES, Wickham EP, Cheang KI, Essah PA, Karjane NW, Nestler JE. POSITION STATEMENT: Glucose Intolerance in Polycystic Ovary Syndrome\u2014A Position Statement of the Androgen Excess Society. Journal of Clinical Endocrinology & Metabolism. 2007(12):12.","DOI":"10.1210\/jc.2007-1549"},{"issue":"2","key":"10.1016\/j.ejogrb.2021.10.022_b0040","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nri2921","article-title":"Adipokines in inflammation and metabolic disease","volume":"11","author":"Ouchi","year":"2011","journal-title":"Nat Rev Immunol."},{"issue":"8","key":"10.1016\/j.ejogrb.2021.10.022_b0045","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s40618-017-0650-x","article-title":"The association between polycystic ovary syndrome, obesity, and the serum concentration of adipokines","volume":"40","author":"Behboudi-Gandevani","year":"2017","journal-title":"J Endocrinol Invest"},{"issue":"3","key":"10.1016\/j.ejogrb.2021.10.022_b0050","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.bbrc.2017.05.076","article-title":"Direct action of adiponectin ameliorates increased androgen synthesis and reduces insulin receptor expression in the polycystic ovary","volume":"488","author":"Singh","year":"2017","journal-title":"Biochem Biophys Res Commun."},{"issue":"04","key":"10.1016\/j.ejogrb.2021.10.022_b0055","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1055\/a-0867-0886","article-title":"Assessment of the Relationship Between Serum High Molecular Weight Adiponectin Hormone Levels and Insulin Resistance in Patients with Polycystic Ovary Syndrome","volume":"51","author":"Pekcan","year":"2019","journal-title":"Horm Metab Res"},{"issue":"2","key":"10.1016\/j.ejogrb.2021.10.022_b0060","first-page":"165","article-title":"Evaluation of TNF-\u03b1 and IL-6 mRNAs expressions in visceral and subcutaneous adipose tissues of polycystic ovarian rats and effects of resveratrol","volume":"21","author":"Ghowsi","year":"2018","journal-title":"Iranian J Basic Med"},{"issue":"1","key":"10.1016\/j.ejogrb.2021.10.022_b0065","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1177\/2042018812437355","article-title":"The effects of old, new and emerging medicines on metabolic aberrations in PCOS. Ther","volume":"3","author":"Bargiota","year":"2012","journal-title":"Adv Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.ejogrb.2021.10.022_b0070","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/AOG.0000000000002698","volume":"132","author":"Polycystic","year":"2018","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2021.10.022_b0075","doi-asserted-by":"crossref","unstructured":"Wen K, Xun N, Zeng T, Lu M, Chen L, Susanne K. Impact of Treatment with Metformin on Adipocytokines in Patients with Polycystic Ovary Syndrome: A Meta-Analysis. Plos One. 2015;10(10):e0140565-.","DOI":"10.1371\/journal.pone.0140565"},{"key":"10.1016\/j.ejogrb.2021.10.022_b0080","doi-asserted-by":"crossref","unstructured":"None. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Human Reproduction. 2004;81(1):19-25.","DOI":"10.1016\/j.fertnstert.2003.10.004"},{"issue":"1","key":"10.1016\/j.ejogrb.2021.10.022_b0085","first-page":"1","article-title":"Diagnosis of polycystic ovary syndrome: from NIH criteria to ESHRE-ASRM guidelines","volume":"56","author":"Carmina","year":"2004","journal-title":"Minerva Ginecol."},{"key":"10.1016\/j.ejogrb.2021.10.022_b0090","article-title":"Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0","author":"Higgins","year":"2013","journal-title":"Cochr. Collab."},{"issue":"5","key":"10.1016\/j.ejogrb.2021.10.022_b0095","doi-asserted-by":"crossref","first-page":"679","DOI":"10.4103\/ijem.IJEM_154_17","article-title":"Effect of Metformin-sustained Release Therapy on Low-density Lipoprotein Size and Adiponectin in the South Indian Women with Polycystic Ovary Syndrome","volume":"21","author":"Kumar","year":"2017","journal-title":"Indian J Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.ejogrb.2021.10.022_b0100","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.dsx.2012.05.013","article-title":"Plasma adiponectin levels in women with polycystic ovary syndrome: impact of metformin treatment in a case-control study","volume":"6","author":"Singh","year":"2012","journal-title":"Diabetes Metab Syndr"},{"issue":"2","key":"10.1016\/j.ejogrb.2021.10.022_b0105","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1177\/193229680700100212","article-title":"Impact of treatment with rosiglitazone or metformin on biomarkers for insulin resistance and metabolic syndrome in patients with polycystic ovary syndrome","volume":"1","author":"Steiner","year":"2007","journal-title":"J Diabetes Sci Technol"},{"issue":"4","key":"10.1016\/j.ejogrb.2021.10.022_b0110","first-page":"272","article-title":"Impact of treatment with metformin on adipokines in patients with polycystic ovary syndrome","volume":"21","author":"Tarkun","year":"2010","journal-title":"Eur Cytokine Netw"},{"issue":"7","key":"10.1016\/j.ejogrb.2021.10.022_b0115","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1080\/09513590802128968","article-title":"Plasma cytokines in obese women with polycystic ovary syndrome, before and after metformin treatment","volume":"24","author":"Jakubowska","year":"2008","journal-title":"Gynecol Endocrinol"},{"issue":"7","key":"10.1016\/j.ejogrb.2021.10.022_b0120","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1210\/jc.2008-0115","article-title":"Comparison of single and combined treatment with exenatide and metformin on menstrual cyclicity in overweight women with polycystic ovary syndrome","volume":"93","author":"Elkind-Hirsch","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"10.1016\/j.ejogrb.2021.10.022_b0125","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1111\/jog.12101","article-title":"Role of adiponectin and its receptor in prediction of reproductive outcome of metformin treatment in patients with polycystic ovarian syndrome","volume":"39","author":"Hamed","year":"2013","journal-title":"J Obstet Gynaecol Res"},{"issue":"1","key":"10.1016\/j.ejogrb.2021.10.022_b0130","first-page":"2","article-title":"Proinsulin, adiponectin and hsCRP in reproductive age women with polycystic ovary syndrome (PCOS)\u2013the effect of metformin treatment","volume":"65","author":"Kruszynska","year":"2014","journal-title":"Endokrynol Pol"},{"issue":"2","key":"10.1016\/j.ejogrb.2021.10.022_b0135","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3109\/09513590.2014.975684","article-title":"The impact of metformin treatment on adiponectin and resistin levels in women with polycystic ovary syndrome: a prospective clinical study","volume":"31","author":"Basios","year":"2015","journal-title":"Gynecol Endocrinol"},{"issue":"8","key":"10.1016\/j.ejogrb.2021.10.022_b0140","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s40618-014-0103-8","article-title":"Adiponectin, interleukin-6, monocyte chemoattractant protein-1, and regional fat mass during 12-month randomized treatment with metformin and\/or oral contraceptives in polycystic ovary syndrome","volume":"37","author":"Glintborg","year":"2014","journal-title":"J Endocrinol Invest"},{"issue":"3","key":"10.1016\/j.ejogrb.2021.10.022_b0145","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.tjog.2018.04.015","article-title":"The effects of different therapeutic modalities on cardiovascular risk factors in women with polycystic ovary syndrome: A randomized controlled study","volume":"57","author":"Bodur","year":"2018","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2021.10.022_b0150","doi-asserted-by":"crossref","unstructured":"Toejing P, Khat-Udomkiri N, Intakhad J, Sirilun S, Chaiyasut C, Lailerd N. Putative Mechanisms Responsible for the Antihyperglycemic Action of Lactobacillus paracasei HII01 in Experimental Type 2 Diabetic Rats. Nutrients. 2020;12(10):3015. Published 2020 Oct 1. doi:10.3390\/nu12103015","DOI":"10.3390\/nu12103015"},{"key":"10.1016\/j.ejogrb.2021.10.022_b0155","doi-asserted-by":"crossref","unstructured":"Apostolova N, Iannantuoni F, Gruevska A, Muntane J, Victor VM. Mechanisms of action of metformin in type 2 diabetes: Effects on mitochondria and leukocyte-endothelium interactions. 2020.","DOI":"10.1016\/j.redox.2020.101517"},{"key":"10.1016\/j.ejogrb.2021.10.022_b0160","doi-asserted-by":"crossref","unstructured":"Diamanti-Kandarakis E, Paterakis T, Alexandraki K, Piperi C, Aessopos A, Katsikis I, et al. Indices of low-grade chronic inflammation in polycystic ovary syndrome and the beneficial effect of metformin. Human Reproduction. 2006;21(6):1426.","DOI":"10.1093\/humrep\/del003"},{"key":"10.1016\/j.ejogrb.2021.10.022_b0165","first-page":"73","article-title":"Adipokines: novel players in rheumatic diseases","volume":"15","author":"J C, M S, V L.","year":"2013","journal-title":"Discovery Med"},{"issue":"2","key":"10.1016\/j.ejogrb.2021.10.022_b0170","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1210\/er.2004-0004","article-title":"The Molecular-Genetic Basis of Functional Hyperandrogenism and the Polycystic Ovary Syndrome","volume":"26","author":"Escobar-Morreale","year":"2005","journal-title":"Endocr Rev"},{"issue":"8","key":"10.1016\/j.ejogrb.2021.10.022_b0175","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.1210\/jc.2004-2283","article-title":"Metformin and Weight Loss in Obese Women with Polycystic Ovary Syndrome: Comparison of Doses","volume":"90","author":"Harborne","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ejogrb.2021.10.022_b0180","doi-asserted-by":"crossref","unstructured":"Tan S, Hahn S, Benson S, Dietz T, Lahner H, Moeller LC, et al. Metformin improves polycystic ovary syndrome symptoms irrespective of pre-treatment insulin resistance. European Journal of Endocrinology. 2007;157(5):669-76.","DOI":"10.1530\/EJE-07-0294"},{"key":"10.1016\/j.ejogrb.2021.10.022_b0185","doi-asserted-by":"crossref","unstructured":"Corson SL. R.S. Legro, H.X. Barnhart, W.G. Schlaff, ,Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome N Engl J Med 356 (2007) 553 566. Journal of Minimally Invasive Gynecology. 2007.","DOI":"10.1056\/NEJMoa063971"},{"key":"10.1016\/j.ejogrb.2021.10.022_b0190","doi-asserted-by":"crossref","unstructured":"Lord JM, Flight IHK, Norman RJ. Metformin in polycystic ovary syndrome: systematic review and meta-analysis. Bmj British Medical Journal. 2003;327(7421):p.951-5.","DOI":"10.1136\/bmj.327.7421.951"},{"issue":"6","key":"10.1016\/j.ejogrb.2021.10.022_b0195","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1210\/jcem.87.6.8550","article-title":"Decreased plasma adiponectin concentrations in women with dyslipidemia","volume":"87","author":"Matsubara","year":"2002","journal-title":"J Clin Endocrinol Metab."},{"issue":"8","key":"10.1016\/j.ejogrb.2021.10.022_b0200","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1055\/s-2005-870318","article-title":"Relationship of Lipoprotein Lipase and Hepatic Triacylglycerol Lipase Activity to Serum Adiponectin Levels in Japanese Hyperlipidemic Men","volume":"37","author":"Kobayashi","year":"2005","journal-title":"Horm Metab Res"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030121152100511X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030121152100511X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:54:00Z","timestamp":1759557240000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030121152100511X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":40,"alternative-id":["S030121152100511X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2021.10.022","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of metformin on adiponectin in PCOS: A meta-analysis and a systematic review","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2021.10.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}