{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T13:32:40Z","timestamp":1784208760334,"version":"3.55.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T00:00:00Z","timestamp":1636934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.ejogrb.2021.11.010","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T11:42:26Z","timestamp":1636630946000},"page":"213-220","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Long-term health and neurodevelopment in children after antenatal exposure to low-dose aspirin for the prevention of preeclampsia and fetal growth restriction: A systematic review of randomized controlled trials"],"prefix":"10.1016","volume":"267","author":[{"given":"Anadeijda J.E.M.C.","family":"Landman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie V.J.","family":"van Limburg Stirum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjon A.","family":"de Boer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janneke","family":"van 't Hooft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes C.F.","family":"Ket","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleid G.","family":"Leemhuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn J.J.","family":"Finken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn A.","family":"Oudijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca C.","family":"Painter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.ejogrb.2021.11.010_b0005","article-title":"Antiplatelet agents for preventing pre-eclampsia and its complications","volume":"2019","author":"Duley","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ejogrb.2021.11.010_b0010","doi-asserted-by":"crossref","unstructured":"ACOG Committee Opinion No. 743: Low-Dose Aspirin Use During Pregnancy. Obstet Gynecol. 2018;132(1):e44-e52.","DOI":"10.1097\/AOG.0000000000002708"},{"key":"10.1016\/j.ejogrb.2021.11.010_b0015","unstructured":"Library WRH. WHO recommendation on low-dose acetylsalicylic acid (aspirin) for pre-eclampsia prevention in high-risk women (October 2011). The WHO Reproductive Health Library; Geneva: World Health Organization."},{"key":"10.1016\/j.ejogrb.2021.11.010_b0020","article-title":"Diagnosis and management of hypertension in pregnancy: summary of updated NICE guidance","volume":"366","author":"Webster","year":"2019","journal-title":"BMJ (Clinical research ed)."},{"key":"10.1016\/j.ejogrb.2021.11.010_b0025","doi-asserted-by":"crossref","unstructured":"Morris T, Stables M, Hobbs A, de Souza P, Colville-Nash P, Warner T, et al. Effects of low-dose aspirin on acute inflammatory responses in humans. Journal of immunology (Baltimore, Md : 1950). 2009;183(3):2089-96.","DOI":"10.4049\/jimmunol.0900477"},{"issue":"5-6","key":"10.1016\/j.ejogrb.2021.11.010_b0030","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0049-3848(03)00379-7","article-title":"The mechanism of action of aspirin","volume":"110","author":"Vane","year":"2003","journal-title":"Thromb Res"},{"issue":"4","key":"10.1016\/j.ejogrb.2021.11.010_b0035","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/0002-9378(91)90444-V","article-title":"Transfer of aspirin across the perfused human placental cotyledon","volume":"165","author":"Jacobson","year":"1991","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.ejogrb.2021.11.010_b0040","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1542\/peds.53.2.201","article-title":"Kinetics of salicylate elimination by newborn infants of mothers who ingested aspirin before delivery","volume":"53","author":"Levy","year":"1974","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.ejogrb.2021.11.010_b0045","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/cpt1975182210","article-title":"Distribution of salicylate between neonatal and maternal serum at diffusion equilibrium","volume":"18","author":"Levy","year":"1975","journal-title":"Clin Pharmacol Ther"},{"issue":"10","key":"10.1016\/j.ejogrb.2021.11.010_b0050","doi-asserted-by":"crossref","first-page":"695","DOI":"10.7326\/M13-2844","article-title":"Low-dose aspirin for prevention of morbidity and mortality from preeclampsia: a systematic evidence review for the U.S. Preventive Services Task Force","volume":"160","author":"Henderson","year":"2014","journal-title":"Ann Intern Med"},{"issue":"9646","key":"10.1016\/j.ejogrb.2021.11.010_b0055","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/S0140-6736(08)61203-9","article-title":"Childhood outcomes after prescription of antibiotics to pregnant women with spontaneous preterm labour: 7-year follow-up of the ORACLE II trial","volume":"372","author":"Kenyon","year":"2008","journal-title":"Lancet"},{"issue":"sup6","key":"10.1016\/j.ejogrb.2021.11.010_b0060","doi-asserted-by":"crossref","first-page":"588S","DOI":"10.1080\/07315724.2004.10719428","article-title":"The developmental origins of adult disease","volume":"23","author":"Barker","year":"2004","journal-title":"J Am Coll Nutr"},{"key":"10.1016\/j.ejogrb.2021.11.010_b0065","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.earlhumdev.2016.09.007","article-title":"Preeclampsia; short and long-term consequences for mother and neonate","volume":"102","author":"Bokslag","year":"2016","journal-title":"Early Hum Dev."},{"key":"10.1016\/j.ejogrb.2021.11.010_b0070","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.preghy.2018.02.003","article-title":"Maternal pre-eclampsia and long-term offspring health: Is there a shadow cast?","volume":"12","author":"Goffin","year":"2018","journal-title":"Pregnancy Hypertens."},{"issue":"1","key":"10.1016\/j.ejogrb.2021.11.010_b0075","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1542\/peds.2009-0994","article-title":"Prenatal low-dose aspirin and neurobehavioral outcomes of children born very preterm","volume":"125","author":"Marret","year":"2010","journal-title":"Pediatrics"},{"issue":"4","key":"10.1016\/j.ejogrb.2021.11.010_b0080","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/uog.14818","article-title":"Impact of cerebral redistribution on neurodevelopmental outcome in small-for-gestational-age or growth-restricted babies: a systematic review","volume":"46","author":"Meher","year":"2015","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"9","key":"10.1016\/j.ejogrb.2021.11.010_b0085","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1111\/1471-0528.16683","article-title":"Preeclampsia and long-term health outcomes for mother and infant: An umbrella review","volume":"128","author":"Pittara","year":"2021","journal-title":"BJOG"},{"issue":"5","key":"10.1016\/j.ejogrb.2021.11.010_b0090","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41390-019-0526-1","article-title":"Assessment of long-term neurodevelopmental outcome following trials of medicinal products in newborn infants","volume":"86","author":"Marlow","year":"2019","journal-title":"Pediatr Res"},{"key":"10.1016\/j.ejogrb.2021.11.010_b0095","series-title":"Cochrane Handbook for Systematic Reviews of Interventions","year":"2019"},{"key":"10.1016\/j.ejogrb.2021.11.010_b0100","doi-asserted-by":"crossref","unstructured":"Liberati A, Altman DG, Tetzlaff J, Mulrow C, G\u00f8tzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ (Clinical research ed). 2009;339:b2700.","DOI":"10.1136\/bmj.b2700"},{"key":"10.1016\/j.ejogrb.2021.11.010_b0105","doi-asserted-by":"crossref","unstructured":"Sterne JAC, Savovi\u0107 J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ (Clinical research ed). 2019;366:l4898.","DOI":"10.1136\/bmj.l4898"},{"issue":"4","key":"10.1016\/j.ejogrb.2021.11.010_b0110","doi-asserted-by":"crossref","first-page":"280","DOI":"10.7326\/0003-4819-158-4-201302190-00009","article-title":"Assessing bias in studies of prognostic factors","volume":"158","author":"Hayden","year":"2013","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ejogrb.2021.11.010_b0115","unstructured":"Review Manager (RevMan) [Computer program]. Version 5.3. Copenhagen: The Nordic Cochrane Centre TCC, 2014."},{"issue":"11","key":"10.1016\/j.ejogrb.2021.11.010_b0120","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1111\/j.1471-0528.1995.tb10872.x","article-title":"Low dose aspirin in pregnancy and early childhood development: follow up of the collaborative low dose aspirin study in pregnancy. CLASP collaborative group","volume":"102","author":"Group CC","year":"1995","journal-title":"Br J Obstet Gynaecol"},{"issue":"8907","key":"10.1016\/j.ejogrb.2021.11.010_b0125","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/S0140-6736(94)92452-X","article-title":"Follow-up of children in the Italian Study of Aspirin in Pregnancy","volume":"343","author":"Parazzini","year":"1994","journal-title":"Lancet"},{"issue":"8898","key":"10.1016\/j.ejogrb.2021.11.010_b0130","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0140-6736(94)92633-6","article-title":"CLASP: a randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women. CLASP (Collaborative Low-dose Aspirin Study in Pregnancy) Collaborative Group","volume":"343","author":"Group CC","year":"1994","journal-title":"Lancet"},{"issue":"8842","key":"10.1016\/j.ejogrb.2021.11.010_b0135","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/0140-6736(93)92988-6","article-title":"Low-dose aspirin in prevention and treatment of intrauterine growth retardation and pregnancy-induced hypertension. Italian study of aspirin in pregnancy","volume":"341","author":"Italian Study of Aspirin in Pregnancy","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.ejogrb.2021.11.010_b0140","series-title":"The abilities of babies","author":"Griffiths","year":"1954"},{"issue":"3","key":"10.1016\/j.ejogrb.2021.11.010_b0145","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1469-8749.1987.tb02489.x","article-title":"Parental developmental assessment of 18-month-old children: reliability and predictive value","volume":"29","author":"Sonnander","year":"1987","journal-title":"Dev Med Child Neurol"},{"issue":"4","key":"10.1016\/j.ejogrb.2021.11.010_b0150","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1469-8749.1974.tb03372.x","article-title":"The Denver Developmental Screening Test. Achievement of test items in the first year of life by Denver and Cardiff infants","volume":"16","author":"Bryant","year":"1974","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.ejogrb.2021.11.010_b0155","doi-asserted-by":"crossref","unstructured":"Degos V, Favrais G, Kaindl AM, Peineau S, Guerrot AM, Verney C, et al. Inflammation processes in perinatal brain damage. Journal of neural transmission (Vienna, Austria : 1996). 2010;117(8):1009-17.","DOI":"10.1007\/s00702-010-0411-x"},{"issue":"4","key":"10.1016\/j.ejogrb.2021.11.010_b0160","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/ana.22620","article-title":"Inflammation during fetal and neonatal life: implications for neurologic and neuropsychiatric disease in children and adults","volume":"71","author":"Hagberg","year":"2012","journal-title":"Ann Neurol"},{"issue":"4","key":"10.1016\/j.ejogrb.2021.11.010_b0165","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/nrneurol.2015.13","article-title":"The role of inflammation in perinatal brain injury","volume":"11","author":"Hagberg","year":"2015","journal-title":"Nature reviews Neurology."},{"issue":"12","key":"10.1016\/j.ejogrb.2021.11.010_b0170","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1002\/glia.23212","article-title":"Reactive astrocyte COX2-PGE2 production inhibits oligodendrocyte maturation in neonatal white matter injury","volume":"65","author":"Shiow","year":"2017","journal-title":"Glia."},{"issue":"7","key":"10.1016\/j.ejogrb.2021.11.010_b0175","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1001\/jamapediatrics.2019.1260","article-title":"Aspirin for the Prevention of Preeclampsia and Potential Consequences for Fetal Brain Development","volume":"173","author":"Voutetakis","year":"2019","journal-title":"JAMA pediatrics."},{"key":"10.1016\/j.ejogrb.2021.11.010_b0180","doi-asserted-by":"crossref","unstructured":"Petersen TG, Liew Z, Andersen AN, Andersen GL, Andersen PK, Martinussen T, et al. Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child. International journal of epidemiology. 2018;47(1):121-30.","DOI":"10.1093\/ije\/dyx235"},{"issue":"5","key":"10.1016\/j.ejogrb.2021.11.010_b0185","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1097\/EDE.0000000000000519","article-title":"In Utero Exposure to Aspirin and Risk of Asthma in Childhood","volume":"27","author":"Chu","year":"2016","journal-title":"Epidemiology (Cambridge, Mass)."},{"issue":"5","key":"10.1016\/j.ejogrb.2021.11.010_b0190","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/1471-0528.15561","article-title":"Association of intrauterine exposure to aspirin and blood pressure at 7 years of age: a secondary analysis","volume":"126","author":"Chen","year":"2019","journal-title":"BJOG"},{"issue":"3","key":"10.1016\/j.ejogrb.2021.11.010_b0195","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ajog.2017.11.561","article-title":"Aspirin for the prevention of preterm and term preeclampsia: systematic review and metaanalysis","volume":"218","author":"Roberge","year":"2018","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2021.11.010_b0200","doi-asserted-by":"crossref","unstructured":"Olmedo-Requena R, Amezcua-Prieto C, Al Wattar BH, Rogozinska E, Bueno-Cavanillas A, Juan Jim\u00e9nez-Mole\u00f3n J, et al. Variations in long-term outcome reporting among offspring followed up after lifestyle interventions in pregnancy: a systematic review. Journal of perinatal medicine. 2020;48(2):89-95.","DOI":"10.1515\/jpm-2019-0302"},{"key":"10.1016\/j.ejogrb.2021.11.010_b0205","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/1471-2393-14-199","article-title":"The CROWN initiative: journal editors invite researchers to develop core outcomes in women's health","volume":"14","author":"Khan","year":"2014","journal-title":"BMC Pregnancy Childbirth."},{"issue":"1","key":"10.1016\/j.ejogrb.2021.11.010_b0210","doi-asserted-by":"crossref","first-page":"A70","DOI":"10.1186\/1745-6215-12-S1-A70","article-title":"The COMET (Core Outcome Measures in Effectiveness Trials) Initiative","volume":"12","author":"Williamson","year":"2011","journal-title":"Trials."},{"key":"10.1016\/j.ejogrb.2021.11.010_b0215","doi-asserted-by":"crossref","unstructured":"Leventhal T, Brooks-Gunn J. The neighborhoods they live in: the effects of neighborhood residence on child and adolescent outcomes. Psychological bulletin. 2000;126(2):309-37.","DOI":"10.1037\/0033-2909.126.2.309"},{"key":"10.1016\/j.ejogrb.2021.11.010_b0220","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.healthplace.2014.05.010","article-title":"Neighborhood socioeconomic deprivation characteristics in child (0\u201318 years) health studies: a review","volume":"29","author":"van Vuuren","year":"2014","journal-title":"Health & place."},{"issue":"2","key":"10.1016\/j.ejogrb.2021.11.010_b0225","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.clp.2017.01.003","article-title":"Long-Term Impact of Preterm Birth: Neurodevelopmental and Physical Health Outcomes","volume":"44","author":"Luu","year":"2017","journal-title":"Clin Perinatol"}],"container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211521005546?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211521005546?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T14:32:01Z","timestamp":1778682721000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211521005546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":45,"alternative-id":["S0301211521005546"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2021.11.010","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term health and neurodevelopment in children after antenatal exposure to low-dose aspirin for the prevention of preeclampsia and fetal growth restriction: A systematic review of randomized controlled trials","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2021.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}