{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:34:43Z","timestamp":1786988083870,"version":"build-2736575974"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["RBMH\/Adhoc\/5\/2017-18"],"award-info":[{"award-number":["RBMH\/Adhoc\/5\/2017-18"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.ejogrb.2022.01.017","type":"journal-article","created":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T10:57:41Z","timestamp":1642849061000},"page":"190-194","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Serum biomarkers of maternal morbidity and adverse outcome in severe pre-eclampsia"],"prefix":"10.1016","volume":"270","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4881-0382","authenticated-orcid":false,"given":"Anish","family":"Keepanasseril","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Bharathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachariah","family":"Bobby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sitanshu Sekhar","family":"Kar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreejith","family":"Parameswaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajith Ananthakrishna","family":"Pillai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilip Kumar","family":"Maurya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9516","key":"10.1016\/j.ejogrb.2022.01.017_b0005","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/S0140-6736(06)68397-9","article-title":"WHO analysis of causes of maternal death: a systematic review","volume":"367","author":"Khan","year":"2006","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.ejogrb.2022.01.017_b0010","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1586\/eog.10.45","article-title":"Recent insights into the pathophysiology of preeclampsia","volume":"5","author":"George","year":"2010","journal-title":"Expert Rev Obstet Gynecol"},{"issue":"08","key":"10.1016\/j.ejogrb.2022.01.017_b0015","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1055\/s-0036-1592294","article-title":"Preeclampsia: vascular pathophysiological mechanism and the basis for early diagnosis and treatment","volume":"38","author":"Ch\u00e1vez","year":"2016","journal-title":"Rev Bras Ginecol Obstet"},{"issue":"1","key":"10.1016\/j.ejogrb.2022.01.017_b0020","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa1414838","article-title":"Predictive value of the sFlt-1:PlGF ratio in women with suspected preeclampsia","volume":"374","author":"Zeisler","year":"2016","journal-title":"N Engl J Med"},{"issue":"10183","key":"10.1016\/j.ejogrb.2022.01.017_b0025","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/S0140-6736(18)33212-4","article-title":"Placental growth factor testing to assess women with suspected pre-eclampsia: a multicentre, pragmatic, stepped-wedge cluster-randomised controlled trial","volume":"393","author":"Duhig","year":"2019","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.ejogrb.2022.01.017_b0030","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.tjog.2018.10.002","article-title":"Comprehensive analysis of oxidative stress markers and antioxidants status in preeclampsia","volume":"57","author":"Taravati","year":"2018","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2022.01.017_b0035","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/AOG.0000000000004149","article-title":"Biomarkers and the prediction of adverse outcomes in preeclampsia: a systematic review and meta-analysis","volume":"137","author":"Lim","year":"2021","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2022.01.017_b0040","unstructured":"Gynecologists ACoOa. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists' Task Force on Hypertension in Pregnancy. Obstet Gynecol. 2013;122:1122-31."},{"issue":"3","key":"10.1016\/j.ejogrb.2022.01.017_b0045","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/01443615.2017.1351931","article-title":"Prophylactic magnesium sulphate in prevention of eclampsia in women with severe preeclampsia: randomised controlled trial (PIPES trial)","volume":"38","author":"Keepanasseril","year":"2018","journal-title":"J Obstet Gynaecol"},{"key":"10.1016\/j.ejogrb.2022.01.017_b0050","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.preghy.2018.05.004","article-title":"The hypertensive disorders of pregnancy: ISSHP classification, diagnosis & management recommendations for international practice","volume":"13","author":"Brown","year":"2018","journal-title":"Pregnancy Hypertens"},{"key":"10.1016\/j.ejogrb.2022.01.017_b0055","series-title":"Acute Kidney Injury","author":"Goyal","year":"2021"},{"key":"10.1016\/j.ejogrb.2022.01.017_b0060","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.preghy.2019.12.004","article-title":"Angiogenesis biomarkers for the prediction of severe adverse outcomes in late-preterm preeclampsia","volume":"19","author":"Villalain","year":"2020","journal-title":"Pregnancy Hypertens"},{"issue":"23","key":"10.1016\/j.ejogrb.2022.01.017_b0065","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1080\/14767058.2016.1262842","article-title":"Maternal cardiac haemodynamics in severe pre-eclampsia complicated by acute pulmonary oedema: a review","volume":"30","author":"Bhorat","year":"2017","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"2","key":"10.1016\/j.ejogrb.2022.01.017_b0070","doi-asserted-by":"crossref","first-page":"e0211982","DOI":"10.1371\/journal.pone.0211982","article-title":"Factors associated with increased levels of brain natriuretic peptide and cardiac troponin I during the peripartum period","volume":"14","author":"Kimura","year":"2019","journal-title":"PLoS ONE"},{"issue":"4","key":"10.1016\/j.ejogrb.2022.01.017_b0075","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/uog.17495","article-title":"Maternal left ventricular hypertrophy and diastolic dysfunction and brain natriuretic peptide concentration in early- and late-onset pre-eclampsia","volume":"51","author":"Borges","year":"2018","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2022.01.017_b0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2018.04.048","article-title":"Acute cardiac effects of severe pre-eclampsia","volume":"72","author":"Vaught","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ejogrb.2022.01.017_b0085","doi-asserted-by":"crossref","unstructured":"Joyal D, Leya F, Koh M, Besinger R, Ramana R, Kahn S, et al. Troponin I levels in patients with preeclampsia. Am J Med. 2007;120:819 e13-4.","DOI":"10.1016\/j.amjmed.2006.05.068"},{"key":"10.1016\/j.ejogrb.2022.01.017_b0090","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1515\/cclm-2018-1228","article-title":"Elecsys(R) and Kryptor immunoassays for the measurement of sFlt-1 and PlGF to aid preeclampsia diagnosis: are they comparable?","volume":"57","author":"Stepan","year":"2019","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.ejogrb.2022.01.017_b0095","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1515\/CCLM.2010.216","article-title":"Improving the harmonisation of the International Normalized Ratio (INR): time to think outside the box?","volume":"48","author":"Favaloro","year":"2010","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.ejogrb.2022.01.017_b0100","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.preghy.2020.09.009","article-title":"Prediction of adverse maternal outcomes of early severe preeclampsia","volume":"22","author":"Mirkovic","year":"2020","journal-title":"Pregnancy Hypertens"}],"container-title":["European Journal of Obstetrics &amp; Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211522000252?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211522000252?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T11:05:08Z","timestamp":1777547108000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211522000252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":20,"alternative-id":["S0301211522000252"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2022.01.017","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum biomarkers of maternal morbidity and adverse outcome in severe pre-eclampsia","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2022.01.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}