{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:25:56Z","timestamp":1792301156724,"version":"4.4.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.ejogrb.2022.01.025","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T20:06:18Z","timestamp":1643745978000},"page":"38-62","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Does metformin improve reproduction outcomes for non-obese, infertile women with polycystic ovary syndrome? Meta-analysis and systematic review"],"prefix":"10.1016","volume":"271","author":[{"given":"Reem","family":"Magzoub","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elrasheid A.H.","family":"Kheirelseid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Perks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ejogrb.2022.01.025_b0005","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/humrep\/deh048","article-title":"The polycystic ovary syndrome health-related quality of life questionnaire (PCOSQ): a validation","volume":"19","author":"Jones","year":"2004","journal-title":"Hum Reprod"},{"issue":"12","key":"10.1016\/j.ejogrb.2022.01.025_b0010","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1210\/jc.2013-2350","article-title":"Diagnosis and Treatment of Polycystic Ovary Syndrome: An Endocrine Society Clinical Practice Guideline","volume":"98","author":"Legro","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.ejogrb.2022.01.025_b0015","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1210\/jc.2015-2682","article-title":"Contemporary Reproductive Outcomes for Patients With Polycystic Ovary Syndrome: A Retrospective Observational Study","volume":"101","author":"Rees","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"10.1016\/j.ejogrb.2022.01.025_b0020","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1093\/humrep\/deaa099","article-title":"Polycystic ovary syndrome as an independent risk factor for gestational diabetes and hypertensive disorders of pregnancy: A population-based study on 9.1 million pregnancies","volume":"35","author":"Mills","year":"2020","journal-title":"Hum Reprod"},{"issue":"9","key":"10.1016\/j.ejogrb.2022.01.025_b0025","first-page":"2421","article-title":"Is fertility reduced in ovulatory women with polycystic ovary syndrome?","volume":"36","author":"Palomba","year":"2021","journal-title":"An opinion paper. Human Reproduction."},{"issue":"3","key":"10.1016\/j.ejogrb.2022.01.025_b0030","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.tem.2016.11.008","article-title":"Oocyte Competence in Women with Polycystic Ovary Syndrome","volume":"28","author":"Palomba","year":"2017","journal-title":"TRENDS IN ENDOCRINOLOGY AND METABOLISM."},{"issue":"3","key":"10.1016\/j.ejogrb.2022.01.025_b0035","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1093\/humupd\/dmaa051","article-title":"Endometrial function in women with polycystic ovary syndrome: a comprehensive review","volume":"27","author":"Palomba","year":"2021","journal-title":"HUMAN REPRODUCTION UPDATE."},{"key":"10.1016\/j.ejogrb.2022.01.025_b0040","doi-asserted-by":"crossref","unstructured":"Bayram N, Van Wely M, Van der Veen F. Pulsatile gonadotrphinreleasing hormone for ovulation induction in subfertility associated with polycystic ovary syndrome. Cochrane database Systematic Review. 2004(2). CD000412.","DOI":"10.1002\/14651858.CD000412.pub2"},{"key":"10.1016\/j.ejogrb.2022.01.025_b0045","first-page":"626","article-title":"Polycystic ovarian syndrome","volume":"53","author":"Mustafa","year":"2010","journal-title":"Obstetrics and Gynaecology an Evidence-based Text for MRCOG."},{"issue":"7","key":"10.1016\/j.ejogrb.2022.01.025_b0050","first-page":"2108","article-title":"Troglitazone improves defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis in women with polycystic ovary syndrome","volume":"82","author":"Ehrmann","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"10.1016\/j.ejogrb.2022.01.025_b0055","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1093\/humrep\/deh440","article-title":"Insulin-sensitizing agents as primary therapy for patients with polycystic ovarian syndrome","volume":"19","author":"Kashyap","year":"2004","journal-title":"Hum Reprod"},{"issue":"2","key":"10.1016\/j.ejogrb.2022.01.025_b0060","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1210\/jc.2005-1666","article-title":"Adolescent girls with polycystic ovary syndrome have an increased risk of the metabolic syndrome associated with increasing androgen levels independent of obesity and insulin resistance","volume":"91","author":"Coviello","year":"2006","journal-title":"The Journal of Clinical Endocrinology and Metabolisim."},{"issue":"11","key":"10.1016\/j.ejogrb.2022.01.025_b0065","doi-asserted-by":"crossref","first-page":"765","DOI":"10.6061\/clinics\/2015(11)09","article-title":"Treatment of infertility in women with polycystic ovary syndrome: approach to clinical practice","volume":"70","author":"Melo","year":"2015","journal-title":"Clinics."},{"issue":"1","key":"10.1016\/j.ejogrb.2022.01.025_b0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/er.2008-0030","article-title":"Evidence-Based and Potential Benefits of Metformin in the Polycystic Ovary Syndrome: A Comprehensive Review","volume":"30","author":"Palomba","year":"2009","journal-title":"Endocr Rev"},{"issue":"12","key":"10.1016\/j.ejogrb.2022.01.025_b0075","first-page":"4075","article-title":"Lean women with polycystic ovary syndrome respond to insulin reduction with decreases in ovarian P450c17 \u03b1 activity and serum androgens","volume":"82","author":"Nestler","year":"1997","journal-title":"The Journal of Clinical Endocrinology and Metabolisim."},{"issue":"26","key":"10.1016\/j.ejogrb.2022.01.025_b0080","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1056\/NEJM199806253382603","article-title":"Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome","volume":"338","author":"Nestler","year":"1998","journal-title":"N Engl J Med"},{"issue":"9","key":"10.1016\/j.ejogrb.2022.01.025_b0085","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/aogs.12673","article-title":"Combined metformin-clomiphene in clomiphene-resistant polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials","volume":"94","author":"Abu Hashim","year":"2015","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"2","key":"10.1016\/j.ejogrb.2022.01.025_b0090","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1479-828X.2010.01274.x","article-title":"Metformin is a reasonable first-line treatment option for non-obese women with infertility related to anovulatory polycystic ovary syndrome \u2013 A meta-analysis of randomised trials","volume":"51","author":"Johnson","year":"2011","journal-title":"Aust N Z J Obstet Gynaecol"},{"issue":"6","key":"10.1016\/j.ejogrb.2022.01.025_b0095","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1097\/00001703-200412000-00008","article-title":"Metformin in polycystic ovary syndrome","volume":"16","author":"Lord","year":"2004","journal-title":"Curr Opin Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.ejogrb.2022.01.025_b0100","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.fertnstert.2018.05.004","article-title":"Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"110","author":"Teede","year":"2018","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2022.01.025_b0105","doi-asserted-by":"crossref","unstructured":"Morley LC, Tang TMH, Balen AH. Royal Coll Obstetricians G. Metformin Therapy for the Management of Infertility in Women with Polycystic Ovary Syndrome: Scientific Impact Paper No. 13. Bjog-an International Journal of Obstetrics and Gynaecology. 2017. 124(12). E306-E13.","DOI":"10.1111\/1471-0528.14764"},{"issue":"7","key":"10.1016\/j.ejogrb.2022.01.025_b0110","doi-asserted-by":"crossref","first-page":"e1000100","DOI":"10.1371\/journal.pmed.1000100","article-title":"The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration","volume":"6","author":"Liberati","year":"2009","journal-title":"PLoS Med"},{"issue":"1","key":"10.1016\/j.ejogrb.2022.01.025_b0115","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","author":"Chang","year":"2004","journal-title":"Fertil Steril"},{"issue":"2","key":"10.1016\/j.ejogrb.2022.01.025_b0120","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.fertnstert.2008.06.035","article-title":"The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report","volume":"91","author":"Azziz","year":"2009","journal-title":"Fertil Steril"},{"issue":"3","key":"10.1016\/j.ejogrb.2022.01.025_b0125","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/cen.13795","article-title":"Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"89","author":"Teede","year":"2018","journal-title":"Clin Endocrinol"},{"issue":"8","key":"10.1016\/j.ejogrb.2022.01.025_b0130","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1093\/humrep\/der154","article-title":"Use of metformin before and during assisted reproductive technology in non-obese young infertile women with polycystic ovary syndrome: a prospective, randomized, double-blind, multi-centre study","volume":"26","author":"Kjotrod","year":"2011","journal-title":"Hum Reprod"},{"issue":"7","key":"10.1016\/j.ejogrb.2022.01.025_b0135","doi-asserted-by":"crossref","first-page":"4068","DOI":"10.1210\/jc.2005-0110","article-title":"Prospective parallel randomized, double-blind, double-dummy controlled clinical trial comparing clomiphene citrate and metformin as the first-line treatment for ovulation induction in nonobese anovulatory women with polycystic ovary syndrome","volume":"90","author":"Palomba","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"10.1016\/j.ejogrb.2022.01.025_b0140","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1093\/humrep\/deq100","article-title":"PCOSMIC: a multi-centre randomized trial in women with PolyCystic Ovary Syndrome evaluating Metformin for Infertility with Clomiphene","volume":"25","author":"Johnson","year":"2010","journal-title":"Hum Reprod"},{"issue":"5","key":"10.1016\/j.ejogrb.2022.01.025_b0145","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1210\/jc.2011-3061","article-title":"Metformin Improves Pregnancy and Live-Birth Rates in Women with Polycystic Ovary Syndrome (PCOS): A Multicenter, Double-Blind, Placebo-Controlled Randomized Trial","volume":"97","author":"Morin-Papunen","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.ejogrb.2022.01.025_b0150","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.fertnstert.2009.02.078","article-title":"An assessment of lifestyle modification versus medical treatment with clomiphene citrate, metformin, and clomiphene citrate-metformin in patients with polycystic ovary syndrome","volume":"94","author":"Karimzadeh","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2022.01.025_b0155","doi-asserted-by":"crossref","unstructured":"Palomba S, Falbo A, Orio F, Manguso F, Russo T, Tolino A, et al. A randomized controlled trial evaluating metformin pre-treatment and co-administration in non-obese insulin-resistant women with polycystic ovary syndrome treated with controlled ovarian stimulation plus timed intercourse or intrauterine insemination. Human Reproduction. 2005. 20(10). 2879-86.","DOI":"10.1093\/humrep\/dei130"},{"issue":"6","key":"10.1016\/j.ejogrb.2022.01.025_b0160","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1056\/NEJMoa063971","article-title":"Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome","volume":"356","author":"Legro","year":"2007","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.ejogrb.2022.01.025_b0165","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1093\/humrep\/deh248","article-title":"Metformin treatment before IVF\/ICSI in women with polycystic ovary syndrome; a prospective, randomized, double blind study","volume":"19","author":"Kjotrod","year":"2004","journal-title":"Hum Reprod"},{"issue":"5","key":"10.1016\/j.ejogrb.2022.01.025_b0170","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.fertnstert.2011.08.020","article-title":"Does metformin affect the ovarian response to gonadotropins for in vitro fertilization treatment in patients with polycystic ovary syndrome and reduced ovarian reserve? A randomized controlled trial","volume":"96","author":"Palomba","year":"2011","journal-title":"Fertil Steril"},{"issue":"1","key":"10.1016\/j.ejogrb.2022.01.025_b0175","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ijgo.2009.04.022","article-title":"Short-term metformin treatment for clomiphene citrate-resistant women with polycystic ovary syndrome","volume":"107","author":"Kazerooni","year":"2009","journal-title":"International Journal of Gynecology & Obstetrics."},{"issue":"8","key":"10.1016\/j.ejogrb.2022.01.025_b0180","doi-asserted-by":"crossref","first-page":"635","DOI":"10.3109\/09513590.2015.1037269","article-title":"The adjuvant effect of metformin and N-acetylcysteine to clomiphene citrate in induction of ovulation in patients with Polycystic Ovary Syndrome","volume":"31","author":"Maged","year":"2015","journal-title":"Gynecol Endocrinol"},{"issue":"1","key":"10.1016\/j.ejogrb.2022.01.025_b0185","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ijgo.2005.04.004","article-title":"Ultra-short metformin pretreatment for clomiphene citrate-resistant polycystic ovary syndrome","volume":"90","author":"Hwu","year":"2005","journal-title":"International Journal of Gynecology & Obstetrics."},{"issue":"4","key":"10.1016\/j.ejogrb.2022.01.025_b0190","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1177\/147323001003800406","article-title":"Clinical Outcomes of Ovulation Induction with Metformin, Clomiphene Citrate and Human Menopausal Gonadotrophin in Polycystic Ovary Syndrome","volume":"38","author":"Cheng","year":"2010","journal-title":"J Int Med Res"},{"issue":"2","key":"10.1016\/j.ejogrb.2022.01.025_b0195","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ijgo.2015.06.063","article-title":"A randomized controlled trial of clomifene citrate, metformin, and pioglitazone versus letrozole, metformin, and pioglitazone for clomifene-citrate-resistant polycystic ovary syndrome","volume":"132","author":"El-khayat","year":"2016","journal-title":"International Journal of Gynecology & Obstetrics."},{"issue":"6","key":"10.1016\/j.ejogrb.2022.01.025_b0200","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1080\/09513590.2018.1549656","article-title":"Comparison of metformin plus myoinositol vs metformin alone in PCOS women undergoing ovulation induction cycles: randomized controlled trial","volume":"35","author":"Agrawal","year":"2019","journal-title":"Gynecol Endocrinol"},{"issue":"12","key":"10.1016\/j.ejogrb.2022.01.025_b0205","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1093\/humrep\/dew268","article-title":"A short course of metformin does not reduce OHSS in a GnRH antagonist cycle for women with PCOS undergoing IVF: a randomised placebo-controlled trial","volume":"31","author":"Jacob","year":"2016","journal-title":"Hum Reprod"},{"issue":"4","key":"10.1016\/j.ejogrb.2022.01.025_b0210","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1080\/09513590.2017.1395838","article-title":"Clomiphene citrate combined with metformin versus letrozole for induction of ovulation in clomiphene-resistant polycystic ovary syndrome: a randomized clinical trial","volume":"34","author":"Rezk","year":"2018","journal-title":"Gynecol Endocrinol"},{"issue":"5","key":"10.1016\/j.ejogrb.2022.01.025_b0215","first-page":"335","article-title":"Indication of metformin in the management of hormonal dysfunction secondary to polycystic ovarian syndrome: prospective comparative study of 63 cases. La","volume":"88","author":"Boudhr\u00e2a","year":"2010","journal-title":"Tunisie Medicale."},{"issue":"4","key":"10.1016\/j.ejogrb.2022.01.025_b0220","doi-asserted-by":"crossref","first-page":"197","DOI":"10.4103\/0974-1208.170373","article-title":"Clomiphene citrate, metformin or a combination of both as the first line ovulation induction drug for Asian Indian women with polycystic ovarian syndrome: A randomized controlled trial","volume":"8","author":"Kar","year":"2015","journal-title":"Journal of Human Reproductive Sciences."},{"issue":"11","key":"10.1016\/j.ejogrb.2022.01.025_b0225","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1080\/09513590.2017.1332174","article-title":"Comparison of clomiphene citrate and letrozole for ovulation induction in women with polycystic ovary syndrome: a prospective randomized trial","volume":"33","author":"Liu","year":"2017","journal-title":"Gynecol Endocrinol"},{"issue":"4","key":"10.1016\/j.ejogrb.2022.01.025_b0230","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3109\/09513590903366996","article-title":"Insulin sensitiser agents alone and in co-treatment with r-FSH for ovulation induction in PCOS women","volume":"26","author":"Raffone","year":"2010","journal-title":"Gynecol Endocrinol"},{"issue":"3","key":"10.1016\/j.ejogrb.2022.01.025_b0235","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1016\/S0015-0282(01)02126-4","article-title":"Co-administration of metformin during recombinant follicle stimulating hormone (recombinant FSH treatment using the low-dose step-up protocol in patients with clomiphene citrate resistant polycystic ovary syndrome (PCOS): a prospective randomized trial","volume":"76","author":"Yarali","year":"2001","journal-title":"Fertil Steril"},{"issue":"1","key":"10.1016\/j.ejogrb.2022.01.025_b0240","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4103\/0974-1208.112372","article-title":"Metformin-clomiphene citrate vs. clomiphene citrate alone: Polycystic ovarian syndrome. Journal of Human","volume":"6","author":"Farooq","year":"2013","journal-title":"Reproductive Sciences."},{"issue":"5","key":"10.1016\/j.ejogrb.2022.01.025_b0245","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1111\/j.1447-0756.2012.02072.x","article-title":"Pretreatment and co-administration of oral anti-diabetic agent with clomiphene citrate or rFSH for ovulation induction in clomiphene-citrate-resistant polycystic ovary syndrome","volume":"39","author":"Begum","year":"2013","journal-title":"Journal of Obstetrics and Gynaecology Research."},{"issue":"4","key":"10.1016\/j.ejogrb.2022.01.025_b0250","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s00404-019-05064-5","article-title":"The effectiveness of inositol and metformin on infertile polycystic ovary syndrome women with resistant to letrozole","volume":"299","author":"Pourghasem","year":"2019","journal-title":"Arch Gynecol Obstet"},{"issue":"4","key":"10.1016\/j.ejogrb.2022.01.025_b0255","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3109\/09513590.2012.743020","article-title":"Endocrine and clinical effects of myo-inositol administration in polycystic ovary syndrome","volume":"29","author":"Artini","year":"2013","journal-title":"A randomized study. Gynecological Endocrinology."},{"issue":"3","key":"10.1016\/j.ejogrb.2022.01.025_b0260","first-page":"299","article-title":"Ovulation induction with clomiphene citrate and metformin in women with polycystic ovary syndrome","volume":"66","author":"Leanza","year":"2014","journal-title":"Minerva Ginecol"},{"issue":"2","key":"10.1016\/j.ejogrb.2022.01.025_b0265","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ejogrb.2003.09.036","article-title":"The effects of metformin on insulin resistance, clomiphene-induced ovulation and pregnancy rates in women with polycystic ovary syndrome","volume":"113","author":"\u015eahin","year":"2004","journal-title":"European Journal of Obstetrics & Gynecology and Reproductive Biology."},{"issue":"8","key":"10.1016\/j.ejogrb.2022.01.025_b0270","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1093\/humrep\/16.8.1625","article-title":"Effects of metformin on ovulation rate, hormonal and metabolic profiles in women with clomiphene-resistant polycystic ovaries: a randomized, double-blinded placebo-controlled trial","volume":"16","author":"Ng","year":"2001","journal-title":"Hum Reprod"},{"issue":"10","key":"10.1016\/j.ejogrb.2022.01.025_b0275","first-page":"643","article-title":"Does metformin augment the ovulation inducing effects of clomiphene in non-obese women with polycystic ovary syndrome?","volume":"106","author":"Chaudhury","year":"2008","journal-title":"Journal of Indian Medival Association."},{"issue":"6","key":"10.1016\/j.ejogrb.2022.01.025_b0280","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1093\/humrep\/del025","article-title":"The use of metformin for women with PCOS undergoing IVF treatment","volume":"21","author":"Tang","year":"2006","journal-title":"Hum Reprod"},{"issue":"8","key":"10.1016\/j.ejogrb.2022.01.025_b0285","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1093\/humrep\/den182","article-title":"Does adding metformin to clomifene citrate lead to higher pregnancy rates in a subset of women with polycystic ovary syndrome?","volume":"23","author":"Moll","year":"2008","journal-title":"Hum Reprod"},{"issue":"12","key":"10.1016\/j.ejogrb.2022.01.025_b0290","first-page":"849","article-title":"The effect of metformin treatment on ICSI in infertile polycystic ovary syndrome","volume":"67","author":"Asbagh","year":"2010","journal-title":"Tehran University Medical Journal."},{"issue":"4","key":"10.1016\/j.ejogrb.2022.01.025_b0295","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1093\/humrep\/dep466","article-title":"Systemic and local effects of metformin administration in patients with polycystic ovary syndrome (PCOS): relationship to the ovulatory response","volume":"25","author":"Palomba","year":"2010","journal-title":"Hum Reprod"},{"issue":"12","key":"10.1016\/j.ejogrb.2022.01.025_b0300","doi-asserted-by":"crossref","first-page":"956","DOI":"10.3109\/09513590.2012.705368","article-title":"The effectiveness of metformin ovulation induction treatment in patients with PCOS: a systematic review and meta-analysis","volume":"28","author":"Xiao","year":"2012","journal-title":"Gynecol Endocrinol"},{"issue":"1","key":"10.1016\/j.ejogrb.2022.01.025_b0305","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/humupd\/dms036","article-title":"Metformin versus clomiphene citrate for infertility in non-obese women with polycystic ovary syndrome: a systematic review and meta-analysis","volume":"19","author":"Misso","year":"2013","journal-title":"Human Reproduction Update."},{"key":"10.1016\/j.ejogrb.2022.01.025_b0310","article-title":"Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility","volume":"11","author":"Morley","year":"2017","journal-title":"Cochrane Database of Systematic Reviews."}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211522000343?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211522000343?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:48:36Z","timestamp":1784641716000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211522000343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":62,"alternative-id":["S0301211522000343"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2022.01.025","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Does metformin improve reproduction outcomes for non-obese, infertile women with polycystic ovary syndrome? Meta-analysis and systematic review","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2022.01.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}