{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:09:38Z","timestamp":1777540178713,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.ejogrb.2022.03.022","type":"journal-article","created":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T18:41:29Z","timestamp":1647110489000},"page":"139-143","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Symptom-related Ki-67 expression in endometrial polyps"],"prefix":"10.1016","volume":"272","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4876-0573","authenticated-orcid":false,"given":"Zeliha","family":"Atak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezgi Isil","family":"Turhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakine","family":"Rahimli Ocakoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozlem Ozgun","family":"Uyaniklar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ejogrb.2022.03.022_b0005","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1067\/mob.2003.247","article-title":"Histopathologic features and risk factors for benignity, hyperplasia, and cancer in endometrial polyps","volume":"188","author":"Savelli","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2022.03.022_b0010","doi-asserted-by":"crossref","unstructured":"L. American Association of Gynecologic. AAGL practice report: practice guidelines for the diagnosis and management of endometrial polyps. J Minim Invasive Gynecol 2012;19(1):3\u201310.","DOI":"10.1016\/j.jmig.2011.09.003"},{"issue":"1","key":"10.1016\/j.ejogrb.2022.03.022_b0015","first-page":"68","article-title":"Utilizing routine sonohysterography to detect intrauterine pathology before initiating hormone replacement therapy","volume":"6","author":"Cohen","year":"1999","journal-title":"Menopause"},{"key":"10.1016\/j.ejogrb.2022.03.022_b0020","doi-asserted-by":"crossref","unstructured":"Adomaitiene L, et al. Proliferation in Postmenopausal Endometrial Polyps-A Potential for Malignant Transformation. Medicina (Kaunas), 2019;55(9).","DOI":"10.3390\/medicina55090543"},{"key":"10.1016\/j.ejogrb.2022.03.022_b0025","doi-asserted-by":"crossref","unstructured":"Bakour SH, Khan KS, Gupta JK. The risk of premalignant and malignant pathology in endometrial polyps. Acta Obstet Gynecol Scand 2000;79(4):317\u201320.","DOI":"10.1080\/j.1600-0412.2000.079004317.x"},{"issue":"37","key":"10.1016\/j.ejogrb.2022.03.022_b0030","first-page":"2041","article-title":"Hysteroscopic diagnosis and treatment of endometrial polyps","volume":"140","author":"Bacsko","year":"1999","journal-title":"Orv Hetil"},{"issue":"10","key":"10.1016\/j.ejogrb.2022.03.022_b0035","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1034\/j.1600-0412.1999.781009.x","article-title":"Endometrial polyps during menopause: characterization and significance","volume":"78","author":"Orvieto","year":"1999","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"8","key":"10.1016\/j.ejogrb.2022.03.022_b0040","doi-asserted-by":"crossref","first-page":"992","DOI":"10.3109\/00016349.2010.493196","article-title":"Treatment of endometrial polyps: a systematic review","volume":"89","author":"Lieng","year":"2010","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"4","key":"10.1016\/j.ejogrb.2022.03.022_b0045","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1080\/13697137.2020.1742107","article-title":"To treat or not to treat? An evidence-based practice guide for the management of endometrial polyps","volume":"23","author":"Sheng","year":"2020","journal-title":"Climacteric"},{"key":"10.1016\/j.ejogrb.2022.03.022_b0050","doi-asserted-by":"crossref","unstructured":"The Use of Hysteroscopy for the Diagnosis and Treatment of Intrauterine Pathology: ACOG Committee Opinion, Number 800. Obstet Gynecol 2020;135(3):e138\u2013e148.","DOI":"10.1097\/AOG.0000000000003712"},{"key":"10.1016\/j.ejogrb.2022.03.022_b0055","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.bpobgyn.2016.09.005","article-title":"Endometrial Polyps and Abnormal Uterine Bleeding (AUB-P): What is the relationship, how are they diagnosed and how are they treated?","volume":"40","author":"Clark","year":"2017","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"4","key":"10.1016\/j.ejogrb.2022.03.022_b0060","doi-asserted-by":"crossref","first-page":"498","DOI":"10.3109\/13697137.2014.966240","article-title":"What is the influence of cyclooxygenase-2 on postmenopausal endometrial polyps?","volume":"18","author":"Pereira","year":"2015","journal-title":"Climacteric"},{"issue":"6","key":"10.1016\/j.ejogrb.2022.03.022_b0065","first-page":"509","article-title":"Expression of p53 protein in the endometrial polyp in postmenopausal women","volume":"34","author":"Neto","year":"2013","journal-title":"Eur J Gynaecol Oncol"},{"issue":"3","key":"10.1016\/j.ejogrb.2022.03.022_b0070","first-page":"199","article-title":"Ki-67 and other proliferation markers useful for immunohistological diagnostic and prognostic evaluations in human malignancies","volume":"1","author":"Gerdes","year":"1990","journal-title":"Semin Cancer Biol"},{"issue":"3","key":"10.1016\/j.ejogrb.2022.03.022_b0075","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/modpathol.2016.203","article-title":"Ki-67 in endometrial cancer: scoring optimization and prognostic relevance for window studies","volume":"30","author":"Kitson","year":"2017","journal-title":"Mod Pathol"},{"issue":"9","key":"10.1016\/j.ejogrb.2022.03.022_b0080","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1111\/aogs.13587","article-title":"Immunohistochemical predictive markers of response to conservative treatment of endometrial hyperplasia and early endometrial cancer: A systematic review","volume":"98","author":"Travaglino","year":"2019","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"6","key":"10.1016\/j.ejogrb.2022.03.022_b0085","doi-asserted-by":"crossref","DOI":"10.17772\/gp\/1602","article-title":"The value of Ki-67 antigen expression in tissue microarray method in prediction prognosis of patients with endometrioid endometrial cancer","volume":"84","author":"Gottwald","year":"2013","journal-title":"Ginekol Pol"},{"issue":"4","key":"10.1016\/j.ejogrb.2022.03.022_b0090","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/path.5608","article-title":"Endometrial carcinoma: molecular subtypes, precursors and the role of pathology in early diagnosis","volume":"253","author":"Huvila","year":"2021","journal-title":"J Pathol"},{"issue":"4","key":"10.1016\/j.ejogrb.2022.03.022_b0095","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.maturitas.2007.04.010","article-title":"Endometrial polyps in pre- and postmenopausal women: factors associated with malignancy","volume":"57","author":"Antunes","year":"2007","journal-title":"Maturitas"},{"issue":"2","key":"10.1016\/j.ejogrb.2022.03.022_b0100","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ijgo.2006.07.007","article-title":"Hysteroscopic evaluation of endometrial polyps","volume":"95","author":"Fern\u00e1ndez-Parra","year":"2006","journal-title":"Int J Gynaecol Obstet"},{"issue":"1","key":"10.1016\/j.ejogrb.2022.03.022_b0105","first-page":"55","article-title":"Endometrial cancer in polyps: a clinical study of 27 cases","volume":"26","author":"Martin-Ondarza","year":"2005","journal-title":"Eur J Gynaecol Oncol"},{"issue":"3","key":"10.1016\/j.ejogrb.2022.03.022_b0110","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.fertnstert.2017.11.029","article-title":"High number of endometrial polyps is a strong predictor of recurrence: findings of a prospective cohort study in reproductive-age women","volume":"109","author":"Gu","year":"2018","journal-title":"Fertil Steril"},{"issue":"2","key":"10.1016\/j.ejogrb.2022.03.022_b0115","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/00004347-200204000-00008","article-title":"Dissociated expression of Bcl-2 and Ki-67 in endometrial lesions: diagnostic and histogenetic implications","volume":"21","author":"Risberg","year":"2002","journal-title":"Int J Gynecol Pathol"},{"issue":"4","key":"10.1016\/j.ejogrb.2022.03.022_b0120","doi-asserted-by":"crossref","first-page":"413.e1","DOI":"10.1016\/j.crad.2017.11.011","article-title":"Endometrial carcinoma: diffusion-weighted imaging diagnostic accuracy and correlation with Ki-67 expression","volume":"73","author":"Jiang","year":"2018","journal-title":"Clin Radiol"},{"issue":"8","key":"10.1016\/j.ejogrb.2022.03.022_b0125","first-page":"EC31-EC34","article-title":"Immunohistochemical Study of ER, PR, Ki67 and p53 in Endometrial Hyperplasias and Endometrial Carcinomas","volume":"11","author":"Masjeed","year":"2017","journal-title":"J Clin Diagn Res"},{"issue":"5","key":"10.1016\/j.ejogrb.2022.03.022_b0130","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1080\/09513590.2020.1862787","article-title":"Does obesity modify the expression of cyclin D1 and pten in endometrial polyps in postmenopausal women?","volume":"37","author":"Giordano","year":"2021","journal-title":"Gynecol Endocrinol"},{"issue":"6","key":"10.1016\/j.ejogrb.2022.03.022_b0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/mco.2020.2139","article-title":"Expression levels of BCL2 and MKI67 in endometrial polyps in postmenopausal women and their correlation with obesity","volume":"13","author":"Giordano","year":"2020","journal-title":"Mol Clin Oncol"},{"issue":"3","key":"10.1016\/j.ejogrb.2022.03.022_b0140","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.maturitas.2005.12.003","article-title":"Are endometrial polyps from pre-menopausal women similar to post-menopausal women? An immunohistochemical comparison of endometrial polyps from pre- and post-menopausal women","volume":"54","author":"McGurgan","year":"2006","journal-title":"Maturitas"},{"issue":"1","key":"10.1016\/j.ejogrb.2022.03.022_b0145","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1159\/000088018","article-title":"Hormone receptor expressions and proliferation markers in postmenopausal endometrial polyps","volume":"61","author":"Inceboz","year":"2006","journal-title":"Gynecol Obstet Invest"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211522002548?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211522002548?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T05:58:00Z","timestamp":1759557480000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211522002548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":29,"alternative-id":["S0301211522002548"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2022.03.022","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Symptom-related Ki-67 expression in endometrial polyps","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2022.03.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}