{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:32:54Z","timestamp":1793046774198,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.ejogrb.2022.08.029","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T19:03:18Z","timestamp":1662404598000},"page":"22-28","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["The role of melatonin in pregnancies complicated by placental insufficiency: A systematic review"],"prefix":"10.1016","volume":"278","author":[{"given":"Ilaria","family":"Fantasia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Bussolaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Stampalija","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L.","family":"Rolnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ejogrb.2022.08.029_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2018.12.005","article-title":"Oxidative stress: normal pregnancy versus preeclampsia","volume":"1866","author":"Chiarello","year":"2020","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"4","key":"10.1016\/j.ejogrb.2022.08.029_b0010","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s11325-014-0946-4","article-title":"A systematic review and quantitative assessment of sleep-disordered breathing during pregnancy and perinatal outcomes","volume":"18","author":"Ding","year":"2014","journal-title":"Sleep Breath"},{"key":"10.1016\/j.ejogrb.2022.08.029_b0015","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/813764","article-title":"Shift work, jet lag, and female reproduction","volume":"2010","author":"Mahoney","year":"2010","journal-title":"Int J Endocrinol"},{"issue":"2","key":"10.1016\/j.ejogrb.2022.08.029_b0020","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/OGX.0b013e31827f2500","article-title":"Maternal serum hormonal factors in the pathogenesis of preeclampsia","volume":"68","author":"Salustiano","year":"2013","journal-title":"Obstet Gynecol Surv"},{"issue":"2","key":"10.1016\/j.ejogrb.2022.08.029_b0025","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/humupd\/dmt054","article-title":"Melatonin and stable circadian rhythms optimize maternal, placental and fetal physiology","volume":"20","author":"Reiter","year":"2014","journal-title":"Hum Reprod Update"},{"issue":"1","key":"10.1016\/j.ejogrb.2022.08.029_b0030","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3390\/ijms21010300","article-title":"Melatonin promotes uterine and placental health: Potential molecular mechanisms","volume":"21","author":"Chuffa","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.ejogrb.2022.08.029_b0035","doi-asserted-by":"crossref","first-page":"R454","DOI":"10.1152\/ajpregu.00407.2011","article-title":"Melatonin supplementation alters uteroplacental hemodynamics and fetal development in an ovine model of intrauterine growth restriction","volume":"302","author":"Lemley","year":"2012","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"7","key":"10.1016\/j.ejogrb.2022.08.029_b0040","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.arcmed.2017.08.007","article-title":"Effects of melatonin on blood pressure, oxidative stress and placental expressions of TNF\u03b1, IL-6, VEGF and sFlt-1 in RUPP rat model of preeclampsia","volume":"48","author":"Uzun","year":"2017","journal-title":"Arch Med Res"},{"issue":"350","key":"10.1016\/j.ejogrb.2022.08.029_b0045","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: Elaboration and explanation","volume":"2","author":"Shamseer","year":"2015","journal-title":"BMJ"},{"key":"10.1016\/j.ejogrb.2022.08.029_b0050","unstructured":"International prospective register of systematic reviews [homepage on the Internet]."},{"issue":"8","key":"10.1016\/j.ejogrb.2022.08.029_b0055","doi-asserted-by":"crossref","first-page":"529","DOI":"10.7326\/0003-4819-155-8-201110180-00009","article-title":"QUADAS-2: A revised tool for the quality assessment of diagnostic accuracy studies","volume":"155","author":"Whiting","year":"2011","journal-title":"Ann Intern Med"},{"issue":"355","key":"10.1016\/j.ejogrb.2022.08.029_b0060","article-title":"ROBINS-I: A tool for assessing risk of bias in non-randomised studies of interventions","volume":"12","author":"Sterne","year":"2016","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.ejogrb.2022.08.029_b0065","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/jrsm.1411","article-title":"Risk-of-bias VISualization (robvis): An R package and shiny web app for visualizing risk-of-bias assessments","volume":"12","author":"McGuinness","year":"2021","journal-title":"Res Synth Methods"},{"issue":"1","key":"10.1016\/j.ejogrb.2022.08.029_b0070","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1034\/j.1600-079X.2001.300104.x","article-title":"Changes of serum melatonin level and its relationship to feto-placental unit during pregnancy","volume":"30","author":"Nakamura","year":"2001","journal-title":"J Pineal Res"},{"issue":"7","key":"10.1016\/j.ejogrb.2022.08.029_b0075","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.3109\/0886022X.2014.926216","article-title":"Melatonin secretion is impaired in women with preeclampsia and an abnormal circadian blood pressure rhythm","volume":"36","author":"Bouchlariotou","year":"2014","journal-title":"Ren Fail"},{"issue":"3","key":"10.1016\/j.ejogrb.2022.08.029_b0080","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1080\/09513590410001667841","article-title":"Circadian melatonin concentration rhythm is lost in pregnant women with altered blood pressure rhythm","volume":"18","author":"Tranquilli","year":"2004","journal-title":"Gynecol Endocrinol"},{"issue":"11","key":"10.1016\/j.ejogrb.2022.08.029_b0085","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/jhh.2016.37","article-title":"The reduction in circulating levels of melatonin may be associated with the development of preeclampsia","volume":"30","author":"Zeng","year":"2016","journal-title":"J Hum Hypertens"},{"issue":"1","key":"10.1016\/j.ejogrb.2022.08.029_b0090","doi-asserted-by":"crossref","first-page":"34","DOI":"10.5582\/bst.2015.01123","article-title":"Salivary melatonin levels and sleep-wake rhythms in pregnant women with hypertensive and glucose metabolic disorders: A prospective analysis","volume":"10","author":"Shimada","year":"2016","journal-title":"Biosci Trends"},{"issue":"4","key":"10.1016\/j.ejogrb.2022.08.029_b0095","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1600-079X.2012.01012.x","article-title":"Placental melatonin production and melatonin receptor expression are altered in preeclampsia: New insights into the role of this hormone in pregnancy","volume":"53","author":"Lanoix","year":"2012","journal-title":"J Pineal Res"},{"issue":"2","key":"10.1016\/j.ejogrb.2022.08.029_b0100","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3109\/10641955.2013.784779","article-title":"Increase of placental sensitivity to melatonin and the alteration to its local synthesis in hypertensive syndromes in pregnancy","volume":"32","author":"Yamamoto Dde","year":"2013","journal-title":"Hypertens Pregnancy"},{"issue":"3","key":"10.1016\/j.ejogrb.2022.08.029_b0105","doi-asserted-by":"crossref","first-page":"e12508","DOI":"10.1111\/jpi.12508","article-title":"Melatonin improves endothelial function in vitro and prolongs pregnancy in women with early-onset preeclampsia","volume":"65","author":"Hobson","year":"2018","journal-title":"J Pineal Res"},{"key":"10.1016\/j.ejogrb.2022.08.029_b0110","first-page":"1","article-title":"Melatonin decreases and cytokines increase in women with placental insufficiency","volume":"25","author":"Berbets","year":"2019","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"4","key":"10.1016\/j.ejogrb.2022.08.029_b0115","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3390\/antiox9040269","article-title":"Maternal antioxidant status in early pregnancy and development of fetal complications in twin pregnancies: A pilot study","volume":"9","author":"Ramiro-Cortijo","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.ejogrb.2022.08.029_b0120","article-title":"Melatonin 1A and 1B receptors' expression decreases in the placenta of women with fetal growth restriction","author":"Berbets","year":"2020","journal-title":"Reprod Sci"},{"issue":"3","key":"10.1016\/j.ejogrb.2022.08.029_b0125","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/jpi.12121","article-title":"Antenatal antioxidant treatment with melatonin to decrease newborn neurodevelopmental deficits and brain injury caused by fetal growth restriction","volume":"56","author":"Miller","year":"2014","journal-title":"J Pineal Res"},{"issue":"1","key":"10.1016\/j.ejogrb.2022.08.029_b0130","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1600-079X.2008.00555.x","article-title":"Human placental trophoblasts synthesize melatonin and express its receptors","volume":"45","author":"Lanoix","year":"2008","journal-title":"J Pineal Res"},{"key":"10.1016\/j.ejogrb.2022.08.029_b0135","article-title":"Poor sleep is associated with higher blood pressure and uterine artery pulsatility index in pregnancy: A prospective cohort study","volume":"3","author":"Tang","year":"2020","journal-title":"BJOG"},{"issue":"6","key":"10.1016\/j.ejogrb.2022.08.029_b0140","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1002\/uog.17455","article-title":"Multicenter screening for pre-eclampsia by maternal factors and biomarkers at 11\u201313 weeks' gestation: Comparison with NICE guidelines and ACOG recommendations","volume":"49","author":"O'Gorman","year":"2017","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.ejogrb.2022.08.029_b0145","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0143-4004(99)80035-6","article-title":"Study on melatonin in human and rat placental tissue","volume":"20","author":"Nakazawa","year":"1999","journal-title":"Placenta"},{"issue":"6","key":"10.1016\/j.ejogrb.2022.08.029_b0150","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3109\/19396368.2015.1069420","article-title":"Evidence for clock genes circadian rhythms in human full-term placenta","volume":"61","author":"P\u00e9rez","year":"2015","journal-title":"Syst Biol Reproductive Med"},{"issue":"1","key":"10.1016\/j.ejogrb.2022.08.029_b0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2011.08.025","article-title":"Melatonin: the smart killer: The human trophoblast as a model","volume":"348","author":"Lanoix","year":"2012","journal-title":"Mol Cell Endocrinol"},{"issue":"4","key":"10.1016\/j.ejogrb.2022.08.029_b0160","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1034\/j.1600-079X.2001.300402.x","article-title":"Melatonin stimulates glutathione peroxidase activity in human chorion","volume":"30","author":"Okatani","year":"2001","journal-title":"J Pineal Res"},{"issue":"7","key":"10.1016\/j.ejogrb.2022.08.029_b0165","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1056\/NEJMoa1704559","article-title":"Aspirin versus placebo in pregnancies at high risk for preterm preeclampsia","volume":"377","author":"Rolnik","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejogrb.2022.08.029_b0170","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/978-1-4939-7498-6_28","article-title":"A randomized double-blinded placebo-controlled intervention trial of melatonin for the prevention of preeclampsia in moderate- and high-risk women: The MELPOP trial","volume":"1710","author":"Hobson","year":"2018","journal-title":"Methods Mol Biol"}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211522004948?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211522004948?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T09:34:35Z","timestamp":1773826475000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211522004948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":34,"alternative-id":["S0301211522004948"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2022.08.029","relation":{},"ISSN":["0301-2115"],"issn-type":[{"value":"0301-2115","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of melatonin in pregnancies complicated by placental insufficiency: A systematic review","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2022.08.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2022 Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}