{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T22:32:40Z","timestamp":1759617160108,"version":"build-2065373602"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejog.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.ejogrb.2023.08.391","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T03:18:19Z","timestamp":1693538299000},"page":"145-151","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["The role of mifepristone on first trimester miscarriage treatment \u2013 A double-blind randomized controlled trial \u2013 MiFirsT"],"prefix":"10.1016","volume":"289","author":[{"given":"Beatriz","family":"Bettencourt-Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa","family":"Rego","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Isabel","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filipa","family":"Br\u00e1s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia","family":"Lopes-Guerra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Miguelote","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Sousa-Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Manuel","family":"Furtado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ejogrb.2023.08.391_b0005","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0015-0282(02)04694-0","article-title":"Conception, early pregnancy loss, and time to clinical pregnancy: a population-based prospective study","volume":"79","author":"Wang","year":"2003","journal-title":"Fertil Steril"},{"issue":"3","key":"10.1016\/j.ejogrb.2023.08.391_b0010","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0015-0282(16)58144-8","article-title":"Estimates of human fertility and pregnancy loss","volume":"65","author":"Zinaman","year":"1996","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ejogrb.2023.08.391_b0015","doi-asserted-by":"crossref","unstructured":"American College of Obstetricians and Gynecologists. Practice Bulletin no. 150: Early pregnancy loss. Obstet Gynecol 2015;125(5):1258-67. DOI: 10.1097\/01.AOG.0000465191.27155.25.","DOI":"10.1097\/01.AOG.0000465191.27155.25"},{"key":"10.1016\/j.ejogrb.2023.08.391_b0020","unstructured":"National Institute for Health and Care Excellence. Ectopic Pregnancy and Miscarriage: Diagnosis and Initial Management in early pregnancy of ectopic pregnancy and miscarriage (CG154). NICE clinical guideline 2012."},{"issue":"Suppl 2","key":"10.1016\/j.ejogrb.2023.08.391_b0025","first-page":"S160","article-title":"Misoprostol: pharmacokinetic profiles, effects on the uterus and side-effects","volume":"99","author":"Tang","year":"2007","journal-title":"Int J Gynaecol Obstet"},{"issue":"1","key":"10.1016\/j.ejogrb.2023.08.391_b0030","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0020-7292(00)00257-5","article-title":"Vaginal misoprostol in the management of first-trimester missed abortions","volume":"71","author":"Ayres-de-Campos","year":"2000","journal-title":"Int J Gynaecol Obstet"},{"issue":"8","key":"10.1016\/j.ejogrb.2023.08.391_b0035","doi-asserted-by":"crossref","first-page":"726","DOI":"10.3109\/01443615.2014.930103","article-title":"Effectiveness of a single dose of oral misoprostol 600 mug for treatment in early pregnancy failure","volume":"34","author":"Benchamanon","year":"2014","journal-title":"J Obstet Gynaecol"},{"issue":"3","key":"10.1016\/j.ejogrb.2023.08.391_b0040","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0020-7292(96)02815-9","article-title":"Misoprostol in the management of missed abortion","volume":"56","author":"Herabutya","year":"1997","journal-title":"Int J Gynaecol Obstet"},{"issue":"5","key":"10.1016\/j.ejogrb.2023.08.391_b0045","first-page":"1445","article-title":"Misoprostol for uterine evacuation in patients with early pregnancy failures","volume":"190","author":"Murchison","year":"2004","journal-title":"Am J Obstet Gynecol"},{"issue":"7","key":"10.1016\/j.ejogrb.2023.08.391_b0050","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1093\/humrep\/16.7.1493","article-title":"Vaginal misoprostol as medical treatment for first trimester spontaneous miscarriage","volume":"16","author":"Ngai","year":"2001","journal-title":"Hum Reprod"},{"issue":"3","key":"10.1016\/j.ejogrb.2023.08.391_b0055","article-title":"Medical treatment for early fetal death (less than 24 weeks) (review)","author":"Neilson","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"10.1016\/j.ejogrb.2023.08.391_b0060","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1038\/s41598-017-01892-0","article-title":"Misoprostol for medical treatment of missed abortion: a systematic review and network meta-analysis","volume":"7","author":"Wu","year":"2017","journal-title":"Sci Rep"},{"issue":"8","key":"10.1016\/j.ejogrb.2023.08.391_b0065","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1056\/NEJMoa044064","article-title":"A comparison of medical management with misoprostol and surgical management for early pregnancy failure","volume":"353","author":"Zhang","year":"2005","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.ejogrb.2023.08.391_b0070","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev.med.48.1.129","article-title":"RU486 (mifepristone): mechanisms of action and clinical uses","volume":"48","author":"Cadepond","year":"1997","journal-title":"Annu Rev Med"},{"issue":"2","key":"10.1016\/j.ejogrb.2023.08.391_b0075","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1080\/01443610120113382","article-title":"Medical termination of missed abortion","volume":"22","author":"Chia","year":"2002","journal-title":"J Obstet Gynaecol"},{"issue":"1","key":"10.1016\/j.ejogrb.2023.08.391_b0080","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/01443610310001620332","article-title":"Medical management of first trimester miscarriage (blighted ovum and missed abortion): is it effective?","volume":"24","author":"Coughlin","year":"2004","journal-title":"J Obstet Gynaecol"},{"issue":"6","key":"10.1016\/j.ejogrb.2023.08.391_b0085","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.contraception.2006.07.007","article-title":"Mifepristone and misoprostol for the treatment of early pregnancy failure: a pilot clinical trial","volume":"74","author":"Schreiber","year":"2006","journal-title":"Contraception"},{"issue":"9","key":"10.1016\/j.ejogrb.2023.08.391_b0090","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1093\/humrep\/16.9.1849","article-title":"Medical management of early fetal demise using a combination of mifepristone and misoprostol","volume":"16","author":"Wagaarachchi","year":"2001","journal-title":"Hum Reprod"},{"issue":"11","key":"10.1016\/j.ejogrb.2023.08.391_b0095","first-page":"1060","article-title":"Management of missed abortion: comparison of medical treatment with either mifepristone + misoprostol or misoprostol alone with surgical evacuation. A multi-center trial in Copenhagen county, Denmark","volume":"81","author":"Gronlund","year":"2002","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"4","key":"10.1016\/j.ejogrb.2023.08.391_b0100","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.fertnstert.2006.03.032","article-title":"A randomized prospective study of misoprostol or mifepristone followed by misoprostol when needed for the treatment of women with early pregnancy failure","volume":"86","author":"Stockheim","year":"2006","journal-title":"Fertil Steril"},{"issue":"4","key":"10.1016\/j.ejogrb.2023.08.391_b0105","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/ajo.12747","article-title":"Combination therapy with mifepristone and misoprostol for the management of first trimester miscarriage: Improved success","volume":"58","author":"Dunford","year":"2017","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"10.1016\/j.ejogrb.2023.08.391_b0110","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ejogrb.2015.09.027","article-title":"The added value of mifepristone to non-surgical treatment regimens for uterine evacuation in case of early pregnancy failure: a systematic review of the literature","volume":"195","author":"van den Berg","year":"2015","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.ejogrb.2023.08.391_b0115","article-title":"Ectopic pregnancy and miscarriage: diagnosis and initial management: summary of updated NICE guidance","volume":"367","author":"Webster","year":"2019","journal-title":"BMJ"},{"issue":"15","key":"10.1016\/j.ejogrb.2023.08.391_b0120","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1056\/NEJMra1302417","article-title":"Diagnostic criteria for nonviable pregnancy early in the first trimester","volume":"369","author":"Campion","year":"2013","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.ejogrb.2023.08.391_b0125","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s13224-017-0992-5","article-title":"Comparison of mifepristone followed by misoprostol with misoprostol alone for treatment of early pregnancy failure: a randomized double-blind placebo-controlled trial","volume":"68","author":"Sinha","year":"2018","journal-title":"J Obstet Gynaecol India"},{"issue":"23","key":"10.1016\/j.ejogrb.2023.08.391_b0130","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1056\/NEJMoa1715726","article-title":"Mifepristone pretreatment for the medical management of early pregnancy loss","volume":"378","author":"Schreiber","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejogrb.2023.08.391_b0135","doi-asserted-by":"crossref","unstructured":"American College of Obstetricians and Gynecologists. Practice Bulletin No. 200: Early Pregnancy Loss. Obstet Gynecol 2018;132(5):e197-e207.","DOI":"10.1097\/AOG.0000000000002899"},{"issue":"10253","key":"10.1016\/j.ejogrb.2023.08.391_b0140","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/S0140-6736(20)31788-8","article-title":"Mifepristone and misoprostol versus misoprostol alone for the management of missed miscarriage (MifeMiso): a randomised, double-blind, placebo-controlled trial","volume":"396","author":"Chu","year":"2020","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.ejogrb.2023.08.391_b0145","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.1594","article-title":"Cost-effectiveness of mifepristone pretreatment for the medical management of nonviable early pregnancy: secondary analysis of a randomized clinical trial","volume":"3","author":"Nagendra","year":"2020","journal-title":"JAMA Netw Open"},{"issue":"Suppl 2","key":"10.1016\/j.ejogrb.2023.08.391_b0150","first-page":"S182","article-title":"Misoprostol to treat missed abortion in the first trimester","volume":"99","author":"Gemzell-Danielsson","year":"2007","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.ejogrb.2023.08.391_b0155","unstructured":"World Health Organization. Clinical Practice Handbook for Safe Abortion. Geneva, 2014."}],"container-title":["European Journal of Obstetrics & Gynecology and Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211523006978?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301211523006978?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T06:02:22Z","timestamp":1759557742000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301211523006978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":31,"alternative-id":["S0301211523006978"],"URL":"https:\/\/doi.org\/10.1016\/j.ejogrb.2023.08.391","relation":{},"ISSN":["0301-2115"],"issn-type":[{"type":"print","value":"0301-2115"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of mifepristone on first trimester miscarriage treatment \u2013 A double-blind randomized controlled trial \u2013 MiFirsT","name":"articletitle","label":"Article Title"},{"value":"European Journal of Obstetrics & Gynecology and Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejogrb.2023.08.391","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}